Avaliação processual e emancipação humana

Trabalho de Conclusão de Curso, apresentado para obtenção do grau de licenciado no curso de Educação Física da Universidade do Extremo Sul Catarinense, UNESC.O presente trabalho aborda uma proposta curricular, para mediante a avaliação processual, apontar caminhos que contribuam para a emancipação humana. A avaliação processual vem como mediadora de uma proposta pedagógica, que em Marx, pelo materialismo histórico vem contribuir para uma criticidade da classe proletária, em que mediados pelo conhecimento, inseridos no processo histórico [classe proletária] tenham capacidade de argumentação diante do conservadorismo imposto. Assim, no âmbito escolar, a avaliação processual vem para formar um cidadão critico, não seguindo um etapismo, onde o conhecimento é transmitido, absorvido e posteriormente reproduzido pelo aluno como método de aprovação, mas o processo de ensino-aprendizagem na avaliação processual tem por base uma construção ontológica no ser humano, fazendo-se modificante na estrutura social em que está inserido

Characterization of phylogenetic networks with NetTest

<p>Abstract</p> <p>Background</p> <p>Typical evolutionary events like recombination, hybridization or gene transfer make necessary the use of phylogenetic networks to properly depict the evolution of DNA and protein sequences. Although several theoretical classes have been proposed to characterize these networks, they make stringent assumptions that will likely not be met by the evolutionary process. We have recently shown that the complexity of simulated networks is a function of the population recombination rate, and that at moderate and large recombination rates the resulting networks cannot be categorized. However, we do not know whether these results extend to networks estimated from real data.</p> <p>Results</p> <p>We introduce a web server for the categorization of explicit phylogenetic networks, including the most relevant theoretical classes developed so far. Using this tool, we analyzed statistical parsimony phylogenetic networks estimated from ~5,000 DNA alignments, obtained from the NCBI PopSet and Polymorphix databases. The level of characterization was correlated to nucleotide diversity, and a high proportion of the networks derived from these data sets could be formally characterized.</p> <p>Conclusions</p> <p>We have developed a public web server, <it>NetTest </it>(freely available from the software section at <url>http://darwin.uvigo.es</url>), to formally characterize the complexity of phylogenetic networks. Using NetTest we found that most statistical parsimony networks estimated with the program TCS could be assigned to a known network class. The level of network characterization was correlated to nucleotide diversity and dependent upon the intra/interspecific levels, although no significant differences were detected among genes. More research on the properties of phylogenetic networks is clearly needed.</p

Pelatihan Keterampilan Mengajar sebagai Bekal Mewujudkan Program Merdeka Belajar bagi Calon Guru PPKn di Prodi PPKn, FKIP, Universitas Nusa Cendana

Permasalahan calon guru di Prodi PPKn dan upaya mewujudkan Program Merdeka Belajar Kemdikbudristek adalah juga merupakan tugas dan tanggung jawab FKIP Undana termasuk Prodi PPKn di dalamnya sebagai LPTK penghasil guru untuk kebutuhan guru di Indonesia pada umumnya dan NTT pada khususnya. Calon guru di didik untuk menguasai kompetensi sebagaimana halnya seorang guru profesional, yakni kompetensi pedagogik, kompetensi kepribadian, kompetensi sosial dan kompetensi profesional. Ketrampilan mengajar merupakan bagian dari kompetensi yang harus dimiliki seorang calon guru maupun guru tersebut, begitu juga calon guru PPKn diperhadapkan dengan era revolusi industry 4.0 dan society 5.0 dituntut untuk mampu mengelola dan menguasai kelas dengan menerapkan keterampilan-keterampilan mengajar yang adaptif dalam mendukung program merdeka belajar. Tujuan PKM ini ialah adanya peningkatan kemampuan dan keterampilan mengajar sebagai bekal mewujudkan Program Merdeka Belajar bagi calon guru PPKn di Prodi PPKn FKIP, Universitas Nusa Cendana. Metode yang diterapkan metode ceramah, diskusi, tanya jawab, dan praktik pembuatan perangkat pembelajaran, metode Simulasi digunakan untuk mensimulasi 8 (delapan) ketrampilan dasar mengajar guru menurut C.Turney (1973) dalam bukunya “Sydney Micro Skills” dan menerapkan metode Among

Desenvolvimento do Back-end do “Portal Acervus cultura escrita e memória literária Parte II”

A pesquisa propôs a conclusão do back-end e a realização dos testes de funções do Portal Acervus: cultura escrita e memória literária. As atividades foram iniciadas anteriormente (plano de trabalho PIBIC 2020-2021), mas a criação e implementação de algumas funções como o banco de dados precisou de mais uma etapa para ser implementado e testado

Desenvolvimento do Back-end do “Portal Acervus cultura escrita e memória literária”

A natureza dos documentos digitais permite a ampla produção e disseminação de informações no mundo de hoje. Na verdade, na era da informação digital, muita ênfase é colocada na geração e/ou aquisição de materiais digitais, em vez de manter a preservação e o acesso a longo prazo às coleções eletrônicas existentes

Structural and electronic analysis of the atomic scale nucleation of Ag on α-Ag2WO4 induced by electron irradiation

In this work, we utilise a combination of theory, computation and experiments to understand the early events related to the nucleation of Ag filaments on α-Ag2WO4 crystals, which is driven by an accelerated electron beam from an electron microscope under high vacuum. The growth process and the chemical composition and elemental distribution in these filaments were analysed in depth at the nanoscale level using TEM, HAADF, EDS and XPS; the structural and electronic aspects were systematically studied in using first-principles electronic structure theory within QTAIM framework. The Ag nucleation and formation on α-Ag2WO4 is a result of the order/disorder effects generated in the crystal by the electron-beam irradiation. Both experimental and theoretical results show that this behavior is associated with structural and electronic changes of the [AgO2] and [AgO4] clusters and, to a minor extent, to the [WO6] cluster; these clusters collectively represent the constituent building blocks of α-Ag2WO4

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We have recently reported that anxiety associated with prenatal exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates with a gender-specific remodeling of microglia in the medial prefrontal cortex (mPFC), a core brain region in anxiety-related disorders. Gender differences in microglia morphology, the higher prevalence of anxiety in women and the negative impact of anxiety in cognition, led us to specifically evaluate cognitive behavior and associated circuits (namely mPFC-dorsal hippocampus, dHIP), as well as microglia morphology in female rats prenatally exposed to dexamethasone (in utero DEX, iuDEX). We report that iuDEX impaired recognition memory and deteriorated neuronal synchronization between mPFC and dHIP. These functional deficits are paralleled by microglia hyper-ramification in the dHIP and decreased ramification in the mPFC, showing a heterogeneous remodeling of microglia morphology, both postnatally and at adulthood in different brain regions, that differently affect mood and cognition. The chronic blockade of adenosine A2A receptors (A2A R), which are core regulators of microglia morphology and physiology, ameliorated the cognitive deficits, but not the anxiety-like behavior. Notably, A2A R blockade rectified both microglia morphology in the dHIP and the lack of mPFC-dHIP synchronization, further heralding their role in cognitive function.Santa Casa da Misericórdia, Prémio Maratona da Saúde, and Centro 2020 Regional Operational Programme (CENTRO‐01‐0145‐FEDER‐000008: BrainHealth 2020) and through FCT and through FCT and COMPETE (Strategic project: UID/NEU/04539/2013 and Project POCI‐01‐0145‐FEDER‐007440 and PTDC/NEU‐NMC/4154/2014). Rita Gaspar are supported by fellowship from the Portuguese Foundation for Science and Tecnhology (PD/BD/114116/2015)info:eu-repo/semantics/publishedVersio

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression

Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression. Through re-exposure to an unpredictable chronic mild stress protocol in rats, we observed the re-appearance of emotional and cognitive deficits. Furthermore, treatment with the antidepressants fluoxetine and imipramine was effective to promote sustained reversion of a depressive-like phenotype; however, their differential impact on adult hippocampal neuroplasticity triggered a distinct response to stress re-exposure: while imipramine re-established hippocampal neurogenesis and neuronal dendritic arborization contributing to resilience to recurrent depressive-like behavior, stress re-exposure in fluoxetine-treated animals resulted in an overproduction of adult-born neurons along with neuronal atrophy of granule neurons, accounting for an increased susceptibility to recurrent behavioral changes typical of depression. Strikingly, cell proliferation arrest compromised the behavior resilience induced by imipramine and buffered the susceptibility to recurrent behavioral changes promoted by fluoxetine. This study shows that previous exposure to a depressive-like episode impacts on the behavioral and neuroanatomical changes triggered by subsequent re-exposure to similar experimental conditions and reveals that the proper control of adult hippocampal neuroplasticity triggered by antidepressants is essential to counteract recurrent depressive-like episodes.FCT (IF/01079/2014). This article has been developed under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the FCT, under the scope of the project POCI-01-0145-FEDER-007038info:eu-repo/semantics/publishedVersio