GTI-space : the space of generalized topological indices

A new extension of the generalized topological indices (GTI) approach is carried out torepresent 'simple' and 'composite' topological indices (TIs) in an unified way. Thisapproach defines a GTI-space from which both simple and composite TIs represent particular subspaces. Accordingly, simple TIs such as Wiener, Balaban, Zagreb, Harary and Randićconnectivity indices are expressed by means of the same GTI representation introduced for composite TIs such as hyper-Wiener, molecular topological index (MTI), Gutman index andreverse MTI. Using GTI-space approach we easily identify mathematical relations between some composite and simple indices, such as the relationship between hyper-Wiener and Wiener index and the relation between MTI and first Zagreb index. The relation of the GTI space with the sub-structural cluster expansion of property/activity is also analysed and some routes for the applications of this approach to QSPR/QSAR are also given

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. We show that connectivity between primary nociceptors and their downstream neurons scales with animal size. We further identified the conserved Ste20-like kinase Tao as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity. Loss of Tao kinase resulted in exuberant postsynaptic specializations and aberrant connectivity during larval growth. Using functional imaging and behavioral analysis we show that loss of Tao-induced ectopic synapses with inappropriate partner neurons are functional and alter behavioral responses in a connection-specific manner. Our data show that fine-tuning of synaptic growth by Tao kinase is required for maintaining specificity and behavioral output of the neuronal network during animal growth

Evolution of massive stars with new hydrodynamic wind models

Here we present evolutionary models for a set of massive stars, introducing a new prescription for the mass-loss rate obtained from hydrodynamical calculations in which the wind velocity profile, $v(r)$, and the line-acceleration, $g_\text{line}$, are obtained in a self consistently way. Replacing mass-loss rates at the Main Sequence stage from the standard Vink's formula by our new recipe, we generate a new set of evolutionary tracks for $M_\text{ZAMS}=25,40,70$ and $120\,M_\odot$ and metallicities $Z=0.014$ (Galactic), $Z=0.006$ (LMC), and $Z=0.002$ (SMC). Our new derived formula for mass-loss rate predicts a dependence $\dot M\propto Z^a$, where $a$ is not longer constant but dependent on the stellar mass: ranging from $a\sim0.53$ when $M_*\sim120\;M_\odot$, to $a\sim1.02$ when $M_*\sim25\;M_\odot$. We found that models adopting the new recipe for $\dot M$ retain more mass during their evolution, which is expressed in larger radii and consequently more luminous tracks over the Hertzsprung-Russell diagram. These differences are more prominent for the cases of $M_\text{ZAMS}=70$ and 120 $M_\odot$ at solar metallicity, where we found self-consistent tracks are $\sim0.1$ dex brighter and keep extra mass up to 20 $M_\odot$, compared with the classical models using the previous formulation for mass-loss rate. Moreover, we observed remarkable differences for the evolution of the radionuclide isotope $^{26}$Al in the core and the surface of the star. Since $\dot M_\text{sc}$ are weaker than the commonly adopted values for evolutionary tracks, self-consistent tracks predict a later modification in the abundance number of $^{26}$Al in the stellar winds. This new behaviour could provide useful information about the real contribution of this isotope from massive stars to the Galactic interstellar medium.Comment: Accepted for publication in Astronomy & Astrophysic

Accessible opera : overcoming linguistic and sensorial barriers

The desire to make media available for all has been rapidly accepted and implemented by most European countries. Opera, as one of the many audiovisual representations, also falls under the category of production which needs to be made accessible and this article aims to analyse how opera has gone through a complete transformation to become a cultural event for all, overcoming not only linguistic but also sensorial barriers. The first part of the article analyses the various forms of translation associated with opera and the main challenges they entail. The second presents different systems used to make opera accessible to the sensorially challenged, highlighting their main difficulties. Examples from research carried out at the Barcelona's Liceu opera house are presented to illustrate various modalities, especially audio description. All in all, it is our aim to show how translated-related processes have made it possible to open opera to a wider audience despite some initial reluctance

Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment

Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the majority of patients experiencing multiple relapses from different drugs. The MM tumor microenvironment (TME) and in particular bone-marrow stromal cells (BMSCs) play a crucial role in the development of drug resistance. Metabolic reprogramming is emerging as a hallmark of cancer that can potentially be exploited for cancer treatment. Recent studies show that metabolism is further adjusted in MM cells during the development of drug resistance. However, little is known about the role of BMSCs in inducing metabolic changes that are associated with drug resistance. In this Perspective, we summarize current knowledge concerning the metabolic reprogramming of MM, with a focus on those changes associated with drug resistance to the proteasome inhibitor Bortezomib (BTZ). In addition, we present proof-of-concept fluxomics (glucose isotope-tracing) and Seahorse data to show that co-culture of MM cells with BMSCs skews the metabolic phenotype of MM cells towards a drug-resistant phenotype, with increased oxidative phosphorylation (OXPHOS), serine synthesis pathway (SSP), TCA cycle and glutathione (GSH) synthesis. Given the crucial role of BMSCs in conveying drug resistance, insights into the metabolic interaction between MM and BMSCs may ultimately aid in the identification of novel metabolic targets that can be exploited for therapy

Improving dental service utilization rate using a proactive telephone-based scheduling strategy in primary healthcare

Indexación: Scopus.Objective: To determine the effect of a proactive telephone-based scheduling strategy to improve dental service utilization rate in primary healthcare. Material and Methods: A retrospective study was carried out based on the dental appointments’ records of a primary healthcare center before-strategy and after-strategy periods. The variables studied for both periods were the number of dental appointments requested, dental appointments undergone, no-shows, and available quotas. Data collection was performed by two researchers between May and June 2018. Descriptive statistics were used to calculate the absolute and relative frequencies. Results: A total of 10,193 records of dental appointments were registered within the two periods. After-strategy period, dental appointments undergone increased by 16,7%, no-shows decreased by 3%, and available quotas decreased by 21.3%. Conclusion: A proactive telephone-based scheduling strategy increased the dental service utilization rate in primary healthcare.https://www.scielo.br/j/pboci/a/BcvDVYfLp3xBpKhPddFmQCn/?lang=e

Variations on the Pear Tree Experiment : different variables, new results?

Inspired by the Pear Stories Project, the Pear Tree Project has investigated how different cultures and languages describe the same film in order to apply its findings to audio description (AD). Participants from different countries were asked to "write down what they saw" in a controlled setting. This article proposes an alternative experiment, also based on the original Pear Stories Project, which aims to shed light on two issues: how different describer profiles (translation students with AD training/without AD training) and different instructions concerning the target audience profiles (blind/non-blind) could alter the final production. The results are analysed in this paper, taking into account the elements covered in the original Pear Stories Project as well as some additional elements proposed by the authors

Terminological challenges in the translation of science documentaries: a case-study

This article aims to describe some of the main terminological problems audiovisual translators have to face when dealing with the translation of science documentaries, specifically in the English-Catalan combination. The first section of the article presents some theoretical concepts which underlie this research and which are taken, for the most part, from Cabré's Communicative Theory of Terminology. Then, specific terminological problems audiovisual translators have to solve are described using the data provided by a corpus of four science documentaries lasting approximately 50 minutes each. These challenges include identifying a term, understanding a term, finding the right equivalent, dealing with the absence of an adequate equivalent, solving denominative variations, choosing between in vivo and in vitro terminology, and overcoming mistranscriptions