Nonel approaches in the field of gastric cancer surgical treatment

The aim of the study: to estimate the impact of different cellular phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research.The work presents the results of a study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology and surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (GC) in the period 2007-2013. The average age of patients was 60.88 ± 10.5 years, men - 180, women - 41. Of the total number of operated, 143 patients underwent surgery in the amount of gastrectomy, 78 - subtotal distal resection. Results. All patients included in the study underwent radical surgery. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained results are monitored for the presence/absence of clinical parallels and mathematical correlations. It was concluded that some combinations of immunohistochemical (IHC) markers were effective in separating groups of patients with different biology of gastric cancer. Conclusions. Performing more advanced operations (including the use of D2 lymph dissections) is the most effective option for surgical treatment of microsatellite-unstable and Epstein-Barr virus-associated gastric cancer

Successful resection of a retroperitoneal giant sarcoma: a case report

Описан клинический случай успешной хирургической резекции гигантскойй 38 килограммовой ретроперитонеальной саркомы у 52 летнего пациента.Описаний клінічний випадок успішної хірургічної резекції гигантскойй 38 кілограмової ретроперитонеальної саркоми у 52 річного пацієнта

Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients. Journal of Education

Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa regional oncological dispensary. It was retrospective, one-center, nonrandomized research. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. The main group includes 33 patients to whom D3 lymph node dissections is executed and, finally, control group – 65 patients dissected up to the D2 volume. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60% of patients, represented with initially hematologicaly disseminated disease. 40% of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved. In the absence of a SC perinevral invasion appeared to be the most precise predictive marker. The conclusion is made some brand new additional53 prognostic factors could play a crucial role in more accurate patients selection for expanded lymph node dissections

Molecular genetic characteristics of gastric cancers from the surgeon’s point of view

Dubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394 http://ojs.ukw.edu.pl/index.php/johs/article/view/4063 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016. MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2, D. V. Raciborsky2, S. N. Lee2 1Odessa National Medical university 2Odessa Regional Oncology center Summary A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ). Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins

The method of controlled growth for the correction of axial deformities of lower extremities in children

Aim: to estimate the outcomes of the method of controlled growth in the correction of axial deformities of lower extremities in children. Material and Methods. We fulfilled the analysis of surgical results of 37 children aged 3-13 yrs. with leg axial deformities, valgus (20) and varus (17) leg deformities at the level of knee joints. All patients were operated in the growth area with the method of controlled growth — temporary epiphysiodesis of external portions of distal growth areas in femoral bones. The assessment of controlled growth method was conducted at 3-14 months for valgus and 6-15 months for varus leg deformities. Results. The assessment of controlled growth method use indicated clinically and X-ray proved reduction in femoral-tibial angle before the elimination of metal construction in valgus deformity 4.1 times, in varus 3.8 times. Conclusion. The method of controlled growth is highly effective correction method for axial deformities of lower extremities in children, and is minimally traumatizing.</p

Some novel ways of gastric cancer patients treatment personification

In this paper the authors perform the analysis of molecular and morphological factors influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2, Ki-67. Measured role in the survival such factors as the degree of differentiation of primary gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as a comparison of the areas under the curves of survival

Significance of basic clinical tests changing after the Hypec procedure in patients with gastric cancer and some other tumors

Hyperthermic intraperitoneal chemotherapy is a popular method of palliative treatment in patients with malignant abdominal tumors. This review is devoted to trace changes in general clinical tests in patients with carcinomatosis. The patients were operated on at the Clinic of Reconstructive and Plastic Medicine of the Odessa National Medical University. All patients satisfactorily tolerated this procedure. The object of the study was to track those changes with patients that took place in the immediate (prior to discharge) postoperative period. 25 patients have recruited to the study. In the group changes in 11 basic clinical and laboratory parameters among those included were monitored in the study. Hemoglobin, leukocytes, platelets, total protein, bilirubin, serum glucose concentration, liver enzymes alanine aminotransferase and aspartate aminotransferase levels, thymol test and coagulogram indices. Thus, the most significant indicators, such as the concentration of hemoglobin, leukocytes and platelets, have not undergone significant changes after HIPEC. Hemoglobin decreased by 6 units (g / l), the concentration of leukocytes, on the contrary, increased by 2 units (T/l), platelet levels dropped by 61 units (also G/l). The concentration of total protein decreased by 7 units. The concentration of total bilirubin practically did not change, decreasing by about 1 unit. Indicators of AST and ALT did not increase, decreasing by 8 and 3 units, respectively. The average concentration value of blood glucose level slightly increased by almost 1 unit. Thymol levels have not changed. The prothrombin index decreased by 3 units; the concentration of fibrinogen in serum remained at approximately the same level. HIPEC procedure does not significantly affect the clinical and laboratory parameters. However, the tendency of this category of patients to hypercoagulation, hypoproteinemia and hyperglucosemia was noted

Comparison of survival rates made by the 6-th and 7-th editions of TNM classification in stomach cancer patients

The available classifications of malignant tumors reflect various aspects of their growth and some biological features. The most commonly used in Ukraine is the 6-th revision of TNM classification, which differs from the previous classifications of the section "Gastric cancer", mainly staging of category N, reflecting the presence of metastases in regional lymph nodes. Transition to the 7-th classification of TNM translates a part of patients from one stage to another, there is a so-called "stage migration" phenomenon. The famous mathematical phenomenon of Will Rogers describes this transition and theoretically substantiates its objectivity. The authors tracked the migration of patients and the change in the stage mainly from the point of view of the effect of this event on the survival of patients with stomach cancer

Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center

The survival of patients with the locally advanced stage of stomach cancer (SC), who underwent various variants of preventive lymphatic nodes dissection, was considered. The survival of patients was compared with the stage and T, N indexes. Lymphadenectomy D2 were effective and increased cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo, stage III A, and in groups of patients where D2 lymphadenectomy were ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo, stage IIIB. D2 were more efficient operation in the case of tumor serosa invasion and invasion to the peritoneal cavity (SE) in the absence of multiple metastases to the regional lymph nodes (N1 according to the 7th revision of the classification - 1-2 metastatic lymph nodes), and when the tumor infiltrated the surrounding organs (SI) and the presence of multiple regional metastases, D2 lymphodissection did not gave positive results, comparising with D1

Оптимізація хірургічного лікування хворих на рак яєчників

In the article the authors show their own experience with the technique of intraoperative intraperitoneal hypertermic intrapentoneal chemioperfusion (HYPEC) in patients with disseminated ovarian cancer. Based on analysis of 25 clinical cases, the authors note that the technique is innovative and effective. Having the many advantages of the method the authors found no difference in the toxicity of the drugs between traditional and advanced ovarian cancer treatment method using HYPEC. The authors consider, that hyperthermia is one of the possible mechanisms for overcoming resistance to platinum.В данной статье, основываясь на собственном клиническом опыте университетская клиника Одесского национального медицинского университета, предложено тактику ведения пациенток с местно распространенным раком шейки матки, осложненным кровотечением, и, как следствие, невозможностью предоставления специального лечения. Использовали такие малоинвазивные методики, как лапароскопия и эмболизация внутренних подвздошных артерий, как подготовительный этап перед специальным лечениемУ статті автори показують власний досвід застосування методики інтраопераційної гіпертермічної інтраперитонеальної хіміоперфузії (HYPEC) у хворих на розповсюджений рак яєчників. На підставі аналізу 25 клінічних випадків автори зазначають, що розроблена методика є інноваційною та ефективною. На фоні багатьох переваг методу не було виявлено відмінностей в токсичності застосовуваних препаратів між традиційною терапією раку яєчників і вдосконаленою методикою із застосуванням HYPEC. Автори вважають, що гіпертермія є одним із можливих механізмів подолання резистентності до платини