Vitamin B6 and diabetes: Relationship and molecular mechanisms

Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated an evident inverse association between vitamin B6 levels and diabetes, as well as a clear protective effect of vitamin B6 on diabetic complications. Interestingly, by exploring the mechanisms that govern the relationship between this vitamin and diabetes, vitamin B6 can be considered both a cause and effect of diabetes. This review aims to report the main evidence concerning the role of vitamin B6 in diabetes and to examine the underlying molecular and cellular mechanisms. In addition, the relationship between vitamin B6, genome integrity, and diabetes is examined. The protective role of this vitamin against diabetes and cancer is discussed

Earables for Detection of Bruxism: A Feasibility Study

Bruxism is a disorder characterised by teeth grinding and clenching, and many bruxism sufferers are not aware of this disorder until their dental health professional notices permanent teeth wear. Stress and anxiety are often listed among contributing factors impacting bruxism exacerbation, which may explain why the COVID-19 pandemic gave rise to a bruxism epidemic. It is essential to develop tools allowing for the early diagnosis of bruxism in an unobtrusive manner. This work explores the feasibility of detecting bruxism-related events using earables in a mimicked in-the-wild setting. Using inertial measurement unit for data collection, we utilise traditional machine learning for teeth grinding and clenching detection. We observe superior performance of models based on gyroscope data, achieving an 88% and 66% accuracy on grinding and clenching activities, respectively, in a controlled environment, and 76% and 73% on grinding and clenching, respectively, in an in-the-wild environment

The genetics of diabetes: What we can learn from Drosophila

Diabetes mellitus is a heterogeneous disease characterized by hyperglycemia due to impaired insulin secretion and/or action. All diabetes types have a strong genetic component. The most frequent forms, type 1 diabetes (T1D), type 2 diabetes (T2D) and gestational diabetes mellitus (GDM), are multifactorial syndromes associated with several genes’ effects together with environmental factors. Conversely, rare forms, neonatal diabetes mellitus (NDM) and maturity onset diabetes of the young (MODY), are caused by mutations in single genes. Large scale genome screenings led to the identification of hundreds of putative causative genes for multigenic diabetes, but all the loci identified so far explain only a small proportion of heritability. Nevertheless, several recent studies allowed not only the identification of some genes as causative, but also as putative targets of new drugs. Although monogenic forms of diabetes are the most suited to perform a precision approach and allow an accurate diagnosis, at least 80% of all monogenic cases remain still undiag-nosed. The knowledge acquired so far addresses the future work towards a study more focused on the identification of diabetes causal variants; this aim will be reached only by combining expertise from different areas. In this perspective, model organism research is crucial. This review traces an overview of the genetics of diabetes and mainly focuses on Drosophila as a model system, describing how flies can contribute to diabetes knowledge advancement

Everywhere regularity for a class of vectorial functionals under subquadratic general growth conditions

n/

Local boundedness of weak solutions to elliptic equations with p, q−growth

This article is dedicated to Giuseppe Mingione for his 50th birthday, a leading expert in the regularity theory and in particular in the subject of this manuscript. In this paper we give conditions for the local boundedness of weak solutions to a class of nonlinear elliptic partial differential equations in divergence form of the type considered below in (1.1), under p, q-growth assumptions. The novelties with respect to the mathematical literature on this topic are the general growth conditions and the explicit dependence of the differential equation on u, other than on its gradient Du and on the x variable

Local boundedness for solutions of a class of nonlinear elliptic systems

In this paper we are concerned with the regularity of solutions to a nonlinear elliptic system of m equations in divergence form, satisfying p growth from below and q growth from above, with p <= q; this case is known as p, q-growth conditions. Well known counterexamples, even in the simpler case p = q, show that solutions to systems may be singular; so, it is necessary to add suitable structure conditions on the system that force solutions to be regular. Here we obtain local boundedness of solutions under a componentwise coercivity condition. Our result is obtained by proving that each component u(alpha) of the solution u = (u(1),..., u(m)) satisfies an improved Caccioppoli's inequality and we get the boundedness of u(alpha) by applying De Giorgi's iteration method, provided the two exponents p and q are not too far apart. Let us remark that, in dimension n = 3 and when p = q, our result works for 3/2 < p <= 3, thus it complements the one of Bjorn whose technique allowed her to deal with p <= 2 only. In the final section, we provide applications of our result

On the H\uf6lder continuity for a class of vectorial problems

In this paper we prove local H\uf6lder continuity of vectorial local minimizers of special classes of integral functionals with rank-one and polyconvex integrands. The energy densities satisfy suitable structure assumptions and may have neither radial nor quasi-diagonal structure. The regularity of minimizers is obtained by proving that each component stays in a suitable De Giorgi class and, from this, we conclude about the H\uf6lder continuity. In the final section, we provide some non-trivial applications of our results

Lipschitz regularity for degenerate elliptic integrals with p, q-growth

We establish the local Lipschitz continuity and the higher differentiability of vector-valued local minimizers of a class of energy integrals of the Calculus of Variations. The main novelty is that we deal with possibly degenerate energy densities with respect to the x -variable