Epistemic Vigilance

Humans massively depend on communication with others, but this leaves them open to the risk of being accidentally or intentionally misinformed. To ensure that, despite this risk, communication remains advantageous, humans have, we claim, a suite of cognitive mechanisms for epistemic vigilance. Here we outline this claim and consider some of the ways in which epistemic vigilance works in mental and social life by surveying issues, research and theories in different domains of philosophy, linguistics, cognitive psychology and the social sciences

Comparison between topical use of ketotifen and olopatadine in the treatment of allergic conjunctivitis

Purpose: To evaluate and compare the efficacy and tolerance to the topical use of 0.05% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of patients with allergic conjunctivitis. Methods: A masked, randomized clinical study was performed in order to compare the efficacy, safety and side effects of the use of 0.05% ketotifen fumarate and 0.1% olopatadine hydrochloride ophthalmic solutions for the alleviation of symptoms and signs in patients with allergic conjunctivitis. Thirty-four patients, fulfilling the inclusion criteria of the protocol were divided into two groups and received a flask with the masked drug, instilling one drop twice daily in each eye for 30 days. Signs and symptoms of these patients were evaluated on a visit before treatment and on five visits during the treatment (days 1, 2, 7, 14 and 30). Results: Severity of allergic conjunctivitis was the same in both studied groups. Both ketotifen and olopatadine were equivalent and efficient regarding decrease in itching, burning and lacrimation symptoms. Bulbar conjunctival hyperemia was attenuated in both groups. Evaluation of adverse reactions showed the occurrence of burning on administration of both drugs and ketotifen led to occurrence of itching. No hypersensitivity reaction to the studied drugs was observed. Conclusions: This study evidences that 0.05% ketotifen fumarate and 0.1% olopatadine hydrochloride ophthalmic solutions, when instilled twice daily for 30 days, were efficient and safe regarding alleviation of the main symptoms and signs of allergic conjunctivitis.Objetivo: Avaliar e comparar a eficácia e tolerância do uso tópico do fumarato de cetotifeno a 0,05% e cloridrato de olopatadina a 0,1% no tratamento de pacientes com conjuntivite alérgica. Método: Foi realizado estudo clínico mascarado, randomizado comparando a eficácia, segurança e os efeitos colaterais com o uso da solução oftálmica de fumarato de cetotifeno a 0,05% e cloridrato de olopatadina a 0,1% no alívio dos sintomas e sinais em pacientes com conjuntivite alérgica. Trinta e quatro pacientes obedecendo aos critérios de inclusão do protocolo receberam um frasco com a droga mascarada e instilaram uma gota duas vezes por dia em cada olho durante 30 dias. Os sintomas e sinais dos pacientes foram avaliados em uma visita pré-tratamento e cinco com tratamento (1º dia, 2º dia, 7º dia, 14º dia e 30º dia). Resultados: A gravidade da conjuntivite alérgica foi semelhante nos dois grupos do estudo. Tanto cetotifeno como a olopatadina foram equivalentes e eficazes na diminuição dos sintomas de prurido, ardor e lacrimejamento. Quanto aos sinais, a hiperemia em conjuntiva bulbar foi atenuada nos dois grupos. Na avaliação das reações adversas observou-se ardor após a administração de ambos colírios e a ocorrência de prurido no grupo do cetotifeno. Não foi observada nenhuma reação de hipersensibilidade das drogas estudadas. Conclusões: Este estudo evidencia que a solução oftálmica de fumarato de cetotifeno a 0,05% e o cloridrato de olopatadina a 0,1% quando instilados duas vezes ao dia durante 30 dias, são eficazes e seguros no alívio dos principais sintomas das conjuntivites alérgicas.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de OftalmologiaUNIFESP, EPM, Depto. de OftalmologiaSciEL

BIOGENIC AMINE CONTENT AND CHEMICAL AND PHYSICAL FEATURES OF ITALIAN FORMAGGIO DI FOSSA

Formaggio di Fossa is an Italian traditional cheese of the Montefeltro area (Emilia Romagna and Marche regions) characterized by a particular step of ripening that is carried out into pits (infossamento) borne in the sandstone. Since the XIV century, the inhabitants were used to set food, especially cereals and cheese, into pits to preserve them during winter and to protect them from invaders. The aim of the present work is to study physical and chemical features of this product with particular reference to the presence of the most important biogenic amines ( -Phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermine and spermidine), compared with a control cheese fully ripened in factory. Formaggio di Fossa showed higher values of Aw, pH, humidity, proteins, pH 4,6-soluble nitrogen (NCN) and water soluble nitrogen (NPN) and much lower amounts of fat. Much higher amounts of total biogenic amines were detected in Formaggio di Fossa than in control cheese, where their concentration was very low. Cadaverine, putrescine and tyramine were the most concentrated biogenic amines. Nevertheless, thyramine was present at levels suggested as compatible with GMPs. Histamine was detected at low amounts, far from potentially toxic levels

Nucleation and growth of dendritic islands during platinum oxidation-reduction cycling

Platinum is the model catalyst in fuel cells because of its high activity toward oxygen reduction and hydrogen oxidation. However, its applicability is limited due to the degradation of the catalyst under operating conditions. This degradation process has been extensively studied by repeatedly oxidizing and reducing the electrode, which leads to the roughening of the surface due to the nucleation and growth of platinum nano-islands. Although the general picture of this surface roughening is well known, the atomic details concerning the nucleation and early growth of the islands are still under debate. In this work, we use Density Functional Theory (DFT) to calculate formation energies and diffusion barriers of an adatom, in both the unoxidized and the oxidized state, with the aim to provide further insight into the nucleation phenomena. Moreover, we analyze from STM images obtained experimentally the shape of the nano-islands during the first stages of growth. Our results show not only that the islands form during the reduction of the surface, but also that they grow with a dendritic island shape, similarly to the platinum islands formed in vacuum by Molecular Beam Epitaxy (MBE).Catalysis and Surface Chemistr

Thrips (Thysanoptera: Thripidae, Phlaeothripidae) damaging peach in Paranapanema, São Paulo State, Brazil.

Objetivando identificar as espécies de tripes associadas ao pessegueiro e as injúrias causadas, pomares das cultivares Aurora e Tropic Beauty foram monitorados semanalmente, de maio a agosto de 2005, no Distrito de Holambra II, em Paranapanema, SP. Flores e frutos de cada seis plantas por hectare foram amostrados pela técnica da batida. Foram identificadas Frankliniella occidentalis (Pergande), F. schultzei (Trybom), F. gardenia (Moulton), F. condei John, F. insularis (Franklin) e Thrips tabaci Lindeman em Thripidae, e, Haplothrips gowdeyi (Franklin) em Phlaeothripidae. F. occidentalis foi dominante compondo 55,7% do total de espécimes amostrado. Injúrias leves e severas foram registradas nos frutos. Seeking to identify thrips species associated to peach and the injuries they cause, plants of Aurora and Tropic Beauty cultivars were weekly monitored, from May to August of 2005, in Holambra II district, in Paranapanema, SP. Flowers and fruits from six plants per hectare were sampled by the hitting technique. Frankliniella occidentalis (Pergande), F. schultzei (Trybom), F. gardenia (Moulton), F. condei John, F. insularis (Franklin) and Thrips tabaci Lindeman, in Thripidae,and Haplothrips gowdeyi (Franklin), in Phlaeothripidae were identifi ed. F. occidentalis was dominant, comprising 55.7% of the total specimens sampled. Slight and severe injuries were registered in fruits.KEY WORDS: Rosaceae, thysanopteran, pest species, habitDisponível também no formato online

Contrasting Transient Photocurrent Characteristics for Thin Films of Vacuum-Doped “Grey” TiO2 and “Grey” Nb2O5

Photo-catalytic performance for oxide films, here for inkjet-printed TiO2 (ca. 1 μm thickness on FTO) and for spray-pyrolysis-coated Nb2O5 (ca. 1 μm thickness on FTO), is affected by oxygen vacancies that form during vacuum-heat treatment at 550 °C. The effects of the oxygen vacancies are associated with formation of Ti(III) and Nb(IV) sites, respectively, and therefore optically visible as “grey” coloration. Photo-electrochemical light-on-off transient experiments are performed in the limit of thin film photoanodes, where front and back illumination result in the same photo-current responses (i.e. with negligible effects from internal light absorption gradients). It is shown that generally the magnitude of photo-currents correlates linearly with light intensity, which is indicative of dominant “photo-capacitive” behaviour. At an applied voltage of 0.4 V vs. SCE (in the plateau region of the photo-current responses) the potential and also the pH (going from 1.0 M KOH to 0.1 M HClO4 in the presence of methanol quencher) have no significant effect on photo-currents; that is, surface chemical/kinetic effects appear to be unimportant and interfacial hole transfer may be rate limiting. Under these conditions (and based on a simplistic mechanistic model) changes in photo-currents introduced by oxygen vacancy doping (detrimental for TiO2 and beneficial for Nb2O5) are assigned primarily to changes in electron mobility