117 research outputs found
La Spagna dalla Prima alla Seconda Transizione : intervista a Fausto Miguélez : a cura di Paolo Giovannini, Giulia Mascagni, Angela Perulli
Background of INCASI Project H2020-MSCA-RISE-2015 GA 691004. WP1: Compilatio
HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
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Weakly Supervised Temporal Convolutional Networks for Fine-grained Surgical Activity Recognition
Automatic recognition of fine-grained surgical activities, called steps, is a
challenging but crucial task for intelligent intra-operative computer
assistance. The development of current vision-based activity recognition
methods relies heavily on a high volume of manually annotated data. This data
is difficult and time-consuming to generate and requires domain-specific
knowledge. In this work, we propose to use coarser and easier-to-annotate
activity labels, namely phases, as weak supervision to learn step recognition
with fewer step annotated videos. We introduce a step-phase dependency loss to
exploit the weak supervision signal. We then employ a Single-Stage Temporal
Convolutional Network (SS-TCN) with a ResNet-50 backbone, trained in an
end-to-end fashion from weakly annotated videos, for temporal activity
segmentation and recognition. We extensively evaluate and show the
effectiveness of the proposed method on a large video dataset consisting of 40
laparoscopic gastric bypass procedures and the public benchmark CATARACTS
containing 50 cataract surgeries
Image-guided thermal ablation of central renal tumors with retrograde cold pyeloperfusion technique: a monocentric experience
Purpose: To evaluate feasibility, safety and efficacy of image-guided thermal ablations associated with retrograde pyeloperfusion in patients with centrally located renal tumors. Materials and methods: 48 patients (15 women, 33 men, mean age 69.1 ± 11.8) were treated with image-guided thermal ablation associated with pyeloperfusion for 58 centrally located renal tumors (mean diameter 32.3 ± 7.32 mm). 7 patients had a single kidney. Microwave and radiofrequency ablation were used. All treatments were performed with ultrasound, CT, or fusion imaging guidance under general anesthesia and simultaneous retrograde cold pyeloperfusion technique. Results: Procedure was feasible in all cases. Technical success and primary technical efficacy were reached in 51/58 (88%) and 45/54 tumors (83%). With a second ablation performed in 5 tumors, secondary technical efficacy was achieved in 50/50 (100%) tumors. Minor and major complications occurred in 8/58 (13%) and 5/58 (8%) tumors. No significative change in renal function occurred after treatment. During follow-up, 5 recurrences occurred, that were retreated with a second ablation. At last follow up (mean 32.2 ± 22.0 months), 41/48 (85%) treated patients were free from disease. The median TTP and PFS were 27.0 (range, 2.3–80.0) and 26.5 months (range, 2.3–80.0), respectively. Conclusion: Image-guided thermal ablation associated with protective pyeloperfusion is a feasible, safe, and effective treatment option for patients with central renal tumors with a minimal impact on renal function and relevant potential to avoid nephrectomy
Crystallization, X-ray diffraction and preliminary structure analysis of Mycobacterium tuberculosis
Dermatome mapping test in the analysis of anatomo-clinical correlations after inguinal hernia repair
Abstract
Background: Nerve identification is recommended in inguinal hernia repair to reduce or avoid postoperative pain.
The aim of this prospective observational study was to identify nerve prevalence and find a correlation between neuroanatomy
and chronic neuropathic postoperative inguinal pain (CPIP) after 6 months.
Material: A total of 115 patients, who underwent inguinal hernia mesh repair (Lichtenstein tension-free mesh
repair) between July 2018 and January 2019, were included in this prospective observational study. The mean age
and BMI respectively resulted 64 years and 25.8 with minimal inverse distribution of BMI with respect to age. Most
of the hernias were direct (59.1%) and of medium dimension (47.8%). Furthermore, these patients were undergoing
Dermatome Mapping Test in preoperatively and postoperatively 6 months evaluation.
Results: Identification rates of the iliohypogastric (IH), ilioinguinal (II) and genitofemoral (GF) nerves were 72.2%,
82.6% and 48.7% respectively. In the analysis of nerve prevalence according to BMI, the IH was statistically significant
higher in patients with BMI < 25 than BMI ≥ 25 P (< 0.05). After inguinal hernia mesh repair, 8 patients (6.9%) had
chronic postoperative neuropathic inguinal pain after 6 months. The CPIP prevailed at II/GF dermatome. The relation
between the identification/neurectomy of the II nerve and chronic postoperative inguinal pain after 6 months was
not significant (P = 0.542).
Conclusion: The anatomy of inguinal nerve is very heterogeneous and for this reason an accurate knowledge of
these variations is needed during the open mesh repair of inguinal hernias. The new results of our analysis is the statistically
significant higher IH nerve prevalence in patients with BMI < 25; probably the identification of inguinal nerve
is more complex in obese patients. In the chronic postoperative inguinal pain, the II nerve may have a predominant
role in determining postoperative long-term symptoms. Dermatome Mapping Test in an easy and safe method for
preoperative and postoperative 6 months evaluation of groin pain. The most important evidence of our analysis is
that the prevalence of chronic pain is higher when the nerves were not identified.
Keywords: Inguinal hernia, Inguinal nerves, Nerve identification, Pain, Follow-up
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The genome sequence and transcriptome of Potentilla micrantha and their comparison to Fragaria vesca (the woodland strawberry)
Background
The genus Potentilla is closely related to that of Fragaria, the economically important strawberry genus. Potentilla micrantha is a species that does not develop berries, but shares numerous morphological and ecological characteristics with F. vesca. These similarities make P. micrantha an attractive choice for comparative genomics studies with F. vesca
Findings
In this study, the Potentilla micrantha genome was sequenced and annotated, and RNA-Seq data from the different developmental stages of flowering and fruiting were used to develop a set of gene predictions. A 327 Mbp sequence and annotation of the genome of P. micrantha, spanning 2,674 sequence contigs, with an N50 size of 335,712, estimated to cover 80% of the total genome size of the species was developed. The genus Potentilla has a characteristically larger genome size than Fragaria, but the recovered sequence scaffolds were remarkably collinear at the micro-syntenic level with the genome of F. vesca, its closest sequenced relative. A total of 33,602 genes were predicted, and 95.1% of BUSCO genes were complete within the presented sequence. Thus, we argue that the majority of the gene-rich regions of the genome have been sequenced
Conclusions
Comparisons of RNA-Seq data from the stages of floral and fruit development revealed genes differentially expressed between P. micrantha and F. vesca. The data presented are a valuable resource for future studies of berry development in Fragaria and the Rosaceae and they also shed light on the evolution of genome size and organization in this family
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