32 research outputs found
The Indian Ocean Dipole and Cholera Incidence in Bangladesh: A Time-Series Analysis
- Author
- Publication venue
- National Institute of Environmental Health Sciences
- Publication date
- 01/01/2010
- Field of study
Background: It has been reported that the El NiñoâSouthern Oscillation (ENSO) influences the interannual variation of endemic cholera in Bangladesh. There is increased interest in the influence of the Indian Ocean dipole (IOD), a climate mode of coupled oceanâatmosphere variability, on regional ocean climate in the Bay of Bengal and on Indian monsoon rainfall. Objectives: We explored the relationship between the IOD and the number of cholera patients in Bangladesh, controlling for the effects of ENSO. Me t h o d s: Time-series regression was performed. Negative binomial models were used to estimate associations between the monthly number of hospital visits for cholera in Dhaka and Matlab (1993â2007) and the dipole mode index (DMI) controlling for ENSO index [NINO3, a measure of the average sea surface temperature (SST) in the Niño 3 region], seasonal, and interannual variations. Associations between cholera cases and SST and sea surface height (SSH) of the northern Bay of Bengal were also examined. Re s u l t s: A 0.1-unit increase in average DMI during the current month through 3 months before was associated with an increase in cholera incidence of 2.6 % [(95 % confidence interval (CI), 0.0â5.2; p = 0.05] in Dhaka and 6.9 % (95 % CI, 3.2â10.8; p < 0.01) in Matlab. Cholera incidence in Dhaka increased by 2.4 % (95 % CI, 0.0â5.0; p = 0.06) after a 0.1âunit decrease in DMI 4â7 months before. Hospital visits for cholera in both areas were positively associated with SST 0â3 months before, after adjusting for SSH (p < 0.01). Con c l u s i o n s: These findings suggest that both negative and positive dipole events are associated with an increased incidence of cholera in Bangladesh with varying time lags. Key w o r d s: Bangladesh, cholera, El NiñoâSouthern Oscillation, Indian Ocean dipole, timeseries analysis. Environ Health Perspect 119:239â244 (2011). doi:10.1289/ehp.1002302 [Onlin
Macrophages inhibit Coxiella burnetii by the ACOD1 âitaconate pathway for containment of Q fever
- Author
- Andrack Jennifer
- Berger Raffaela
- Bodendorfer Barbara
- Bogdan Christian
- Bozec Aline
- Daniel Christoph
- Degrandi Daniel
- Dettmer Katja
- Hayek Inaya
- Jantsch Jonathan
- Kohl Lisa
- Krönke Gerhard
- Lang Roland
- LieblerâTenorio Elisabeth
- LĂŒhrmann Anja
- Mauermeir Michael
- MertensâScholz Katja
- Murray Peter J.
- Oefner Peter J.
- Pfeffer Klaus
- Preikschat Annica
- Rauber Simon
- Schatz Valentin
- Schleicher Ulrike
- SchulzeâLuehrmann Jan
- Siddique Md Nur A. Alam
- Szperlinski Manuela
- Wirtz Stefan
- Yamamoto Masahiro
- Yang KaiâTing
- Ălke Martha
- Publication venue
- 'EMBO'
- Publication date
- 07/12/2022
- Field of study
Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication, while other antimicrobial pathways were dispensable. Intratracheal or intraperitoneal infection of Acod1-/- mice caused increased C. burnetii burden, weight loss and stronger inflammatory gene expression. Exogenously added itaconate restored pathogen control in Acod1-/- mouse macrophages and blocked replication in human macrophages. In axenic cultures, itaconate directly inhibited growth of C. burnetii. Finally, treatment of infected Acod1-/- mice with itaconate efficiently reduced the tissue pathogen load. Thus, ACOD1-derived itaconate is a key factor in the macrophage-mediated defense against C. burnetii and may be exploited for novel therapeutic approaches in chronic Q fever
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
- Author
- A Adhikari
- A Hirata
- A Krueger
- A Niinuma
- A Ress
- A Tanaka
- AB Bouzar
- BJ Poiesz
- C Arpin-Andre
- C Journo
- C Nicot
- C Tsubata
- CR Bangham
- CZ Giam
- D Nagakubo
- DJ Volkman
- DW Ballard
- DW Ballard
- EW Harhaj
- F Bex
- F Kashanchi
- F Majone
- FA Proietti
- G Feuer
- G Xiao
- H Iha
- H Kawakami
- H Teruya
- I Lamsoul
- I Miyoshi
- J Arnold
- J Chen
- J Li
- J Lodewick
- JL Round
- JL Round
- JM Bogenberger
- JM Mariner
- JM Peloponese Jr
- JM Peloponese Jr
- JM Peloponese Jr
- K Fraedrich
- K Haller
- K Haller
- K Hieshima
- K Ishioka
- K Kinoshita
- K Matsumoto
- K Ohtani
- K Okamoto
- K Pichler
- K Pichler
- K Silbermann
- K Takatsuki
- K Waldele
- K Waldele
- KC Wilson
- KG Low
- KK Frese
- L Bernal-Mizrachi
- L Xie
- L Zhang
- LC Cantley
- LM Stephenson
- M Boxus
- M Boxus
- M Halin
- M Higuchi
- M Karin
- M Liu
- M Maruyama
- M Matsuoka
- M Matsuoka
- M Miyazaki
- M Mizuguchi
- M Ohashi
- M Okajima
- M Osame
- M Thomas
- M Tomita
- M Tomita
- Masahiro Fujii
- Masaya Higuchi
- MD Robek
- MJ Ludford-Menting
- ML Gatza
- ML Yeung
- N Arima
- N Azimi
- N Higashimura
- N Mori
- N Mori
- N Mori
- N Shembade
- N Shembade
- N Yamamoto
- ND Wolfe
- NS Fracchiolla
- O Rosin
- OJ Semmes
- PO Humbert
- R Fukuda
- R Grassmann
- R Grassmann
- R Iwanaga
- R Kondo
- R Merling
- R Nasr
- R Pankow
- R Rousset
- R Xavier
- RH Arch
- RI Fukuda
- RJ Shaw
- RT Javier
- S Calattini
- S Miura
- S Ruben
- S Takeda
- S Tamiya
- S Vallabhapurapu
- S Yamaoka
- S Yamaoka
- SC Sun
- SC Sun
- SJ Jeong
- SJ Marriott
- SK Arya
- SM Ruben
- SS Lee
- T Akagi
- T Ikezoe
- T Koiwa
- T Shoji
- T Suzuki
- T Suzuki
- T Suzuki
- T Tsukahara
- T Usui
- TL Yuan
- TM Ross
- WM Switzer
- X Wu
- Y Furukawa
- Y Hinuma
- Y Iwanaga
- Y Satou
- Y Taniguchi
- Z Jin
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
While the human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), to date, its close relative HTLV-2 is not associated with ATL or other types of malignancies. Accumulating evidence shows that HTLV-1 Tax1 and HTLV-2 Tax2 have many shared activities, but the two proteins have a limited number of significantly distinct activities, and these distinctions appear to play key roles in HTLV-1 specific pathogenesis. In this review, we summarize the functions of Tax1 associated with cell survival, cell proliferation, persistent infection as well as pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2
Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology
- Author
- Adair Linda S
- Adeyemo Adebowale
- Aguilar-Salinas Carlos A
- Ahlqvist Emma
- Ahluwalia Tarunveer S
- Ahsan Habibul
- An Ping
- Anand Sonia S
- Arruda Ana Luiza
- Becker Diane M
- Below Jennifer E
- Bertoni Alain
- Bharadwaj Dwaipayan
- Bielak Lawrence F
- Bocher Ozvan
- Boehnke Michael
- Bonnefond Amélie
- Bork-Jensen Jette
- Bowden Donald W
- Bragg Fiona
- Brandslund Ivan
- Broadaway K Alaine
- Brody Jennifer A
- Buchanan Thomas A
- Burant Charles F
- Butterworth Adam S
- Cade Brian E
- Canouil Mickaël
- Chai Jin-Fang
- Chambers John C
- Chan Juliana C N
- Chandak Giriraj R
- Chang Kyong-Mi
- Chang Li-Ching
- Chee Miao-Li
- Chen Chien-Hsiun
- Chen Guanjie
- Chen Ji
- Chen Shyh-Huei
- Chen Wei-Min
- Chen Yii-Der Ida
- Chen Yuan-Tsong
- Chen Zhengming
- Cheng Ching-Yu
- Cho Yoon Shin
- Choi Hyeok Sun
- Chuang Lee-Ming
- Collins Francis S
- Cook James P
- Cruz Miguel
- Cui Jinrui
- Cushman Mary
- Danesh John
- Das Swapan K
- de Silva H Janaka
- Dedoussis George
- Denny Joshua C
- Dimitrov Latchezar
- Doumatey Ayo P
- Du Shufa
- Duan Qing
- Dupuis Josee
- Eckardt Kai-Uwe
- Emery Leslie S
- Engert James C
- Evans Daniel S
- Evans Michele K
- Finer Sarah
- Fischer Krista
- Florez Jose C
- Floyd James S
- Ford Ian
- Fornage Myriam
- Franco Oscar H
- Frayling Timothy M
- Freedman Barry I
- Froguel Philippe
- Genter Pauline
- Gerstein Hertzel C
- Ghanbari Mohsen
- Giedraitis Vilmantas
- Gieger Christian
- GonzĂĄlez-Villalpando Clicerio
- GonzĂĄlez-Villalpando Maria Elena
- Goodarzi Mark O
- Gordon-Larsen Penny
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Gross Myron
- Guare Lindsay A
- Guo Xiuqing
- Hackinger Sophie
- Hai Yang
- Haiman Christopher A
- Hakaste Liisa
- Han Sohee
- Hanis Craig L
- Hansen Torben
- Hattersley Andrew T
- Hatzikotoulas Konstantinos
- Hayes M Geoffrey
- Herder Christian
- Horikoshi Momoko
- Howard Annie-Green
- Hsueh Willa
- Huang Mengna
- Huang Wei
- Huerta-Chagoya Alicia
- Hung Yi-Jen
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Igase Michiya
- Ikram Mohammad Arfan
- Ingelsson Erik
- Ingelsson Martin
- Ipp Eli
- Islam Md Tariqul
- Isono Masato
- Jang Hye-Mi
- Jasmine Farzana
- Jiang Guozhi
- Jonas Jost B
- Joo Yoonjung Yoonie
- Jukema J Wouter
- JĂžrgensen Torben
- Kabagambe Edmond
- Kadowaki Takashi
- Kals Mart
- Kamali Zoha
- Kamanu Frederick K
- Kandeel Fouad R
- Kanoni Stavroula
- Kardia Sharon L R
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kaur Varinderpal
- Kawaguchi Takahisa
- Keaton Jacob M
- Kho Abel N
- Khor Chiea-Chuen
- Kibriya Muhammad G
- Kim Bong-Jo
- Kim Duk-Hwan
- Kim Young Jin
- Koh Woon-Puay
- Kooner Jaspal S
- Kooperberg Charles
- Kronenberg Florian
- Kuusisto Johanna
- Kwak Soo-Heon
- Köttgen Anna
- Laakso Markku
- Lamri Amel
- Lange Leslie A
- Langenberg Claudia
- Lee Jung-Jin
- Lee Juyoung
- Lee Kyung Min
- Lee Myung-Shik
- Lee Nanette R
- Lee Simon S K
- Leong Aaron
- Li Liming
- Li Yun
- Li-Gao Ruifang
- Ligthart Symen
- Lim Victor J Y
- Lin Kuang
- Lind Lars
- Lindgren Cecilia M
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Simin
- Liu Yongmei
- Locke Adam E
- Long Jirong
- Loos Ruth J F
- Lorenz Kim M
- Louie Tin
- Luan Jian\u27an
- Luk Andrea O
- Luo Xi
- Lv Jun
- Lynch Julie A
- Lyssenko Valeriya
- LĂ€ll Kristi
- Ma Ronald C W
- Maeda Shiro
- Mahajan Anubha
- Mamakou Vasiliki
- Mandla Ravi
- Mansuri Sohail Rafik
- Marston Nicholas A
- Matsuda Fumihiko
- Matsuda Koichi
- McCarthy Mark I
- McKean-Cowdin Roberta
- Meigs James B
- Meitinger Thomas
- Melander Olle
- Melloni Giorgio E M
- Mercader Josep M
- Metspalu Andres
- Millwood Iona Y
- Mo Huan
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Moon Sanghoon
- Morris Andrew D
- Morris Andrew P
- Motala Ayesha A
- Moura Filipe A
- MĂ€gi Reedik
- Nadler Jerry L
- Nakatochi Masahiro
- Nalls Michael A
- Namba Shinichi
- Nano Jana
- Nayak Uma
- Ng Maggie C Y
- Nicolas Aude
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Nousome Darryl
- Ntalla Ioanna
- Okada Yukinori
- Orozco Lorena
- Palmer Colin N A
- Pan Ian
- Pankow James S
- Park Kyong-Soo
- Parra Esteban J
- Paré Guillaume
- Patel Sanjay R
- Patil Snehal
- Pedersen Oluf
- Pei Pei
- Pereira Mark A
- Peters Annette
- Petty Lauren E
- Peyser Patricia A
- Pirie Fraser J
- Polikowsky Hannah G
- Porneala Bianca
- Prasad Gauri
- Preuss Michael H
- Prins Bram Peter
- Province Michael A
- Psaty Bruce M
- Rader Daniel J
- Raffel Leslie J
- Raffield Laura M
- Rasmussen-Torvik Laura J
- Rayner Nigel W
- Redline Susan
- Reiner Alexander P
- Rich Stephen S
- Ritchie Marylyn D
- Roden Michael
- Rohde Rebecca
- Roll Katheryn
- Rotimi Charles N
- Rotter Jerome I
- Ruff Christian T
- Sabanayagam Charumathi
- Sale MichĂšle M
- Saleheen Danish
- Sandow Kevin
- Sankareswaran Alagu
- Sarnowski Chloé
- Sattar Naveed
- Schroeder Philip
- Schönherr Sebastian
- Scott Robert A
- Shahriar Mohammad
- Shen Botong
- Sheu Wayne H H
- Shi Jinxiu
- Shin Dong Mun
- Shojima Nobuhiro
- Shu Xiao-Ou
- Sim Xueling
- Smith Jennifer A
- So Wing Yee
- Sofer Tamar
- Sonehara Kyuto
- Southam Lorraine
- Spracklen Cassandra N
- StanÄĂĄkovĂĄ Alena
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stilp Adrienne M
- Strauch Konstantin
- Sun Meng
- Suzuki Ken
- Tabara Yasuharu
- Tai E-Shyong
- Takeuchi Fumihiko
- Taliun Daniel
- Tam Claudia H T
- Tan Jingyi
- Taylor Henry J
- Taylor Kent D
- Thangam Manonanthini
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tomlinson Brian
- Tong Lin
- Tran Tam C
- Trompet Stella
- Tsai Fuu-Jen
- Tsao Philip S
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tusie-Luna Teresa
- Udler Miriam S
- Valladares-Salgado Adan
- van Dam Rob M
- van Dijk Ko Willems
- van Heel David A
- van Klinken Jan B
- Vanderwerff Brett
- Varma Rohit
- Voight Benjamin F
- Vujkovic Marijana
- Wacher-Rodarte Niels
- Walters Robin G
- Wang Ya-Xing
- Wareham Nicholas J
- Wheeler Eleanor
- Wickremasinghe Ananda R
- Williamson Alice
- Wilson James G
- Witte Daniel R
- Wong Tien-Yin
- Wu Jer-Yuarn
- Wuttke Matthias
- Xiang Anny H
- Yajnik Chittaranjan S
- Yamamoto Ken
- Yamamoto Kenichi
- Yamauchi Toshimasa
- Yanek Lisa R
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yu Canqing
- Yuan Jian-Min
- Yusuf Salim
- Zawistowski Matthew
- Zeggini Eleftheria
- Zhang Liang
- Zhang Weihua
- Zheng Wei
- Zonderman Alan B
- Zöllner Sebastian
- Publication venue
- DigitalCommons@TMC
- Publication date
- 01/03/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 Ă 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Author
- Adair Linda S.
- Adeyemo Adebowale
- Aguilar-Salinas Carlos A.
- Ahlqvist Emma
- Ahluwalia Tarunveer S.
- Ahsan Habibul
- An Ping
- Anand Sonia S.
- Arruda Ana Luiza
- Becker Diane M.
- Below Jennifer E.
- Bertoni Alain
- Bharadwaj Dwaipayan
- Bielak Lawrence F.
- Bocher Ozvan
- Boehnke Michael
- Bonnefond Amélie
- Bork-Jensen Jette
- Bowden Donald W.
- Bragg Fiona
- Brandslund Ivan
- Broadaway K. Alaine
- Brody Jennifer A.
- Buchanan Thomas A.
- Burant Charles F.
- Butterworth Adam S.
- Cade Brian E.
- Canouil Mickaël
- Chai Jin-Fang
- Chambers John C.
- Chan Juliana C. N.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chang Li-Ching
- Chee Miao-Li
- Chen Chien-Hsiun
- Chen Guanjie
- Chen Ji
- Chen Shyh-Huei
- Chen Wei-Min
- Chen Yii-Der Ida
- Chen Yuan-Tsong
- Chen Zhengming
- Cheng Ching-Yu
- Cho Yoon Shin
- Choi Hyeok Sun
- Chuang Lee-Ming
- Collins Francis S.
- Cook James P.
- Cruz Miguel
- Cui Jinrui
- Cushman Mary
- Dam Rob M. van
- Danesh John
- Das Swapan K.
- de Silva H. Janaka
- Dedoussis George
- Denny Joshua C.
- Dijk Ko Willems van
- Dimitrov Latchezar
- Doumatey Ayo P.
- Du Shufa
- Duan Qing
- Dupuis Josee
- Eckardt Kai-Uwe
- Emery Leslie S.
- Engert James C.
- Evans Daniel S.
- Evans Michele K.
- Finer Sarah
- Fischer Krista
- Florez Jose C.
- Floyd James S.
- Ford Ian
- Fornage Myriam
- Franco Oscar H.
- Frayling Timothy M.
- Freedman Barry I.
- Froguel Philippe
- Genter Pauline
- Gerstein Hertzel C.
- Ghanbari Mohsen
- Giedraitis Vilmantas
- Gieger Christian
- GonzĂĄlez-Villalpando Clicerio
- GonzĂĄlez-Villalpando Maria Elena
- Goodarzi Mark O.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Grallert Harald
- Grarup Niels
- Gross Myron
- Guare Lindsay A.
- Guo Xiuqing
- Hackinger Sophie
- Hai Yang
- Haiman Christopher A.
- Hakaste Liisa
- Han Sohee
- Hanis Craig L.
- Hansen Torben
- Hattersley Andrew T.
- Hatzikotoulas Konstantinos
- Hayes M. Geoffrey
- Heel David A. van
- Herder Christian
- Horikoshi Momoko
- Howard Annie-Green
- Hsueh Willa
- Huang Mengna
- Huang Wei
- Huerta-Chagoya Alicia
- Hung Yi-Jen
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Igase Michiya
- Ikram Mohammad Arfan
- Ingelsson Erik
- Ingelsson Martin
- Ipp Eli
- Islam Md. Tariqul
- Isono Masato
- Jang Hye-Mi
- Jasmine Farzana
- Jiang Guozhi
- Jonas Jost B.
- Joo Yoonjung Yoonie
- Jukema J. Wouter
- JĂžrgensen Torben
- Kabagambe Edmond
- Kadowaki Takashi
- Kals Mart
- Kamali Zoha
- Kamanu Frederick K.
- Kandeel Fouad R.
- Kanona Stavroula
- Kanoni Stavroula
- Kardia Sharon L. R.
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kaur Varinderpal
- Kawaguchi Takahisa
- Keaton Jacob M.
- Kho Abel N.
- Khor Chiea-Chuen
- Kibriya Muhammad G.
- Kim Bong-Jo
- Kim Duk-Hwan
- Kim Young Jin
- Klinken Jan B. van
- Koh Woon-Puay
- Kooner Jaspal S.
- Kooperberg Charles
- Kronenberg Florian
- Kuusisto Johanna
- Kwak Soo-Heon
- Köttgen Anna
- Laakso Markku
- Lamri Amel
- Lange Leslie A.
- Langenberg Claudia
- Lee Jung-Jin
- Lee Juyoung
- Lee Kyung Min
- Lee Myung-Shik
- Lee Nanette R.
- Lee Simon S. K.
- Leong Aaron
- Li Liming
- Li Yun
- Li-Gao Ruifang
- Ligthart Symen
- Lim Victor J. Y.
- Lin Kuang
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Simin
- Liu Yongmei
- Locke Adam E.
- Long Jirong
- Loos Ruth J. F.
- Lorenz Kim M.
- Louie Tin
- Luan Jianâan
- Luk Andrea O.
- Luo Xi
- Lv Jun
- Lynch Julie A.
- Lyssenko Valeriya
- LĂ€ll Kristi
- Ma Ronald C. W.
- Maeda Shiro
- Mahajan Anubha
- Mamakou Vasiliki
- Mandla Ravi
- Mansuri Sohail Rafik
- Marston Nicholas A.
- Matsuda Fumihiko
- Matsuda Koichi
- McCarthy Mark I.
- McKean-Cowdin Roberta
- Meigs James B.
- Meitinger Thomas
- Melander Olle
- Melloni Giorgio E. M.
- Mercader Josep M.
- Metspalu Andres
- Millwood Iona Y.
- Mo Huan
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moon Sanghoon
- Morris Andrew D.
- Morris Andrew P.
- Motala Ayesha A.
- Moura Filipe A.
- MĂ€gi Reedik
- Nadler Jerry L.
- Nakatochi Masahiro
- Nalls Michael A.
- Namba Shinichi
- Nano Jana
- Nayak Uma
- Ng Maggie C. Y.
- Nicolas Aude
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Nousome Darryl
- Ntalla Ioanna
- Okada Yukinori
- Orozco Lorena
- Palmer Colin N. A.
- Pan Ian
- Pankow James S.
- Park Kyong-Soo
- Parra Esteban J.
- Paré Guillaume
- Patel Sanjay R.
- Patil Snehal
- Pedersen Oluf
- Pei Pei
- Pereira Mark A.
- Peters Annette
- Petty Lauren E.
- Peyser Patricia A.
- Pirie Fraser J.
- Polikowsky Hannah G.
- Porneala Bianca
- Prasad Gauri
- Preuss Michael H.
- Prins Bram Peter
- Province Michael A.
- Psaty Bruce M.
- Rader Daniel J.
- Raffel Leslie J.
- Raffield Laura M.
- Rasmussen-Torvik Laura J.
- Rayner Nigel W.
- Redline Susan
- Reiner Alexander P.
- Rich Stephen S.
- Ritchie Marylyn D.
- Roden Michael
- Rohde Rebecca
- Roll Katheryn
- Rotimi Charles N.
- Rotter Jerome I.
- Ruff Christian T.
- Sabanayagam Charumathi
- Sale MichĂšle M.
- Saleheen Danish
- Sandow Kevin
- Sankareswaran Alagu
- Sarnowski Chloé
- Sattar Naveed
- Schroeder Philip
- Schönherr Sebastian
- Scott Robert A.
- Shahriar Mohammad
- Shen Botong
- Sheu Wayne H. H.
- Shi Jinxiu
- Shin Dong Mun
- Shojima Nobuhiro
- Shu Xiao-Ou
- Sim Xueling
- Smith Jennifer A.
- So Wing Yee
- Sofer Tamar
- Sonehara Kyuto
- Southam Lorraine
- Spracklen Cassandra N.
- StanÄĂĄkovĂĄ Alena
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stilp Adrienne M.
- Strauch Konstantin
- Sun Meng
- Suzuki Ken
- Tabara Yasuharu
- Tai E-Shyong
- Takeuchi Fumihiko
- Taliun Daniel
- Tam Claudia H. T.
- Tan Jingyi
- Taylor Henry J.
- Taylor Kent D.
- Thangam Manonanthini
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tomlinson Brian
- Tong Lin
- Tran Tam C.
- Trompet Stella
- Tsai Fuu-Jen
- Tsao Philip S.
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tusie-Luna Teresa
- Udler Miriam S.
- Valladares-Salgado Adan
- van Heel David A.
- Vanderwerff Brett
- Varma Rohit
- Voight Benjamin F.
- Vujkovic Marijana
- Wacher-Rodarte Niels
- Walters Robin G.
- Wang Ya-Xing
- Wareham Nicholas J.
- Wheeler Eleanor
- Wickremasinghe Ananda R.
- Williamson Alice
- Wilson James G.
- Witte Daniel R.
- Wong Tien-Yin
- Wu Jer-Yuarn
- Wuttke Matthias
- Xiang Anny H.
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yamamoto Kenichi
- Yamauchi Toshimasa
- Yanek Lisa R.
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yu Canqing
- Yuan Jian-Min
- Yusuf Salim
- Zawistowski Matthew
- Zeggini Eleftheria
- Zhang Liang
- Zhang Weihua
- Zheng Wei
- Zonderman Alan B.
- Zöllner Sebastian
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (Pâ<â5âĂâ10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- AfroditeÌ NeÌmeth
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija LineÌ
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano CaÌceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-ValdeÌs
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro CompanÌ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- AmeÌlie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- AnaiÌs BeÌcot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- AndraÌs I FoÌrsoÌnits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas MoÌller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- AndreÌ Cronemberger-Andrade
- AndreÌ GoÌrgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo MusicoÌ
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- AnnaiÌg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila OlaÌh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- AureÌlie Ledreux
- Avital A Rodal
- Ayesha Saleem
- AÌkos M LoÌrincz
- AÌurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E BenediktsdoÌttir
- Bernadett R BodnaÌr
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
- Camille V Trinidad
- Cansu Gorgun
- Carla Mazzeo
- Carlos Salomon
- Carmen Campos-Silva
- Carmen Carceller
- Carmen Fernandez-Becerra
- Carmen JeroÌnimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A SaÌnchez
- Catherine Martel
- Cecilia Bucci
- Cecilia LaÌsser
- Celine Elie-Caille
- CeÌcile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
- Chelsea N Davis
- Cherie Blenkiron
- Chiew Yong Ng
- Chihchen Chen
- Chitranshi Nitin
- Christian Neri
- Christian P Pallasch
- Christian PreuĂer
- Christina Nedeva
- Christopher Fernandez-Prada
- Chungmin Han
- Claudia M Radu
- ClaÌudio Pinheiro
- CleÌmence BelleanneÌe
- Clotilde Billottet
- Clotilde TheÌry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- CristoÌbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele NoeÌl
- Danielle J Beetler
- Danilo MladenovicÌ
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-SebestyeÌn
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo MarbaÌn
- Eduardo MartiÌnez-MartiÌnez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa LaÌzaro-IbaÌnÌez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- ElzÌbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- ErdbruÌgger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- EstefaniÌa Lozano-AndreÌs
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter AÌ ToÌth
- Etienne DoreÌ
- Etienne Moussay
- Eva Rohde
- Eva-Maria KraÌmer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ć SteÌšpienÌ
- EÌmilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- FalconâPerez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E BorraÌs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu QingâLing
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- GenevieÌve Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- GeÌraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique GiraÌo
- Heon-Jin Lee
- Hernando A Del Portillo
- HernaÌn GonzaÌlez-King Garibotti
- HeÌctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs SzigyaÌrtoÌ
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica MaricÌ
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan LoÌtvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A MuÌller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
- Jason P Webber
- Javier Ramirez-Ricardo
- Javier Sotillo
- Jean-Marie Bach
- Jeff Bouffard
- Jeff Wm Bulte
- Jeffrey L Franklin
- Jeffrey S Schorey
- Jen Alexander-Brett
- Jenifer Pendiuk Goncalves
- Jennifer C Jones
- Jens C Luoto
- Jens Gruber
- Jerome Paggetti
- Jessica Gobbo
- Jessica Schiavi-Tritz
- Jessie Santoro
- Jiao Jiao Li
- Jing Jin
- Jiri Hrdy
- Jisook Moon
- Joanne Lannigan
- Joao N Ferreira
- Joaquin Seras-Franzoso
- Joel Ej Beaumont
- Johan Skog
- Johann M Gudbergsson
- Johanna Mm Puutio
- Johannes Oesterreicher
- John J Bissler
- John J Miklavcic
- John J Tomes
- John P Nolan
- Johnathon D Anderson
- Jonathan Degosserie
- Jonathan Leor
- Joost Pg Sluijter
- Jordi Roca
- Joseph Whitley
- Joshua A Welsh
- Joshua D Spitzberg
- JovanovicâTalisman Tijana
- Joy Wolfram
- Juan M Falcon-Perez
- Juan P Tosar
- Juhee Park
- Julia C Gross
- Julia Kuligowski
- Julia V Burnier
- Julian Swatler
- Julie A Saugstad
- Julie Constanzo
- Julien Saint-Pol
- Juntaro Matsuzaki
- Justus C Ndukaife
- JuÌlia Costa
- Kaiping Burrows
- Kaloyan Takov
- Kanchana K Ayyar
- Karen Forbes
- Karin EkstroÌm
- Karolina SoroczynÌska
- Kasper M Rouschop
- Kasra Khalaj
- Katelyn A Bruno
- Katherine E White
- Kathleen M Lennon
- Kathrin GaÌrtner
- Kathryn L Howe
- Katrin S Reiners
- Kazunari Akiyoshi
- Kelly Coutant
- Kelly Cs Roballo
- Kendall R Van Keuren-Jensen
- Kenneth W Witwer
- Kenny Man
- Kentaro Jingushi
- Kerstin Menck
- Kevin Leandro
- Khairul I Ansari
- Kieran Brennan
- Kimberley L Alexander
- Kirsi Rilla
- Kirsty M Danielson
- Kiyotaka Shiba
- Koen Breyne
- Koji Ueda
- Konxhe Kulaj
- Krishna P Maremanda
- Krishnan Anand
- Kristyna Turkova
- Krisztina Buzas
- Krisztina NeÌmeth
- Krisztina PaÌloÌczi
- Krisztina V Vukman
- KruhâGarcia Nicole A.
- Ku'uleiâLyn Faustino Vroniqa
- Kyburz Diego
- Kyle I Mentkowski
- Kyle P Bramich
- Kyungmoo Yea
- Laura Bongiovanni
- Laura Grech
- Laura J Vella
- Laura Yedigaryan
- Lauren A Newman
- Lausonia Ramaswamy
- Lawrence W Chamley
- LaÌsser Cecilia
- Leandra K Figueroa-Hall
- Lei Zheng
- Lenassi Metka
- Lennon Kathleen M.
- Leon G Coleman Jr
- Leonardo Nimrichter
- Leonid Margolis
- Leonidas A Phylactou
- Leonora Balaj
- Lesley Cheng
- Liang Dong
- Liang Wu
- Lien Lippens
- Lifang Yang
- Lila Drittanti
- Liliia Paniushkina
- Lim Sai Kiang
- Ling-Qing Yuan
- Linglei Jiang
- Lissette Retana Moreira
- Loes Teeuwen
- LoiÌc Steiner
- Lorena Martin-Jaular
- Lorena Urbanelli
- Lorraine O'Driscoll
- Lothar C Dieterich
- Louise C Laurent
- LoÌtvall Jan
- Luca Musante
- Lucas Walther
- Lucia Paolini
- Lucia R Languino
- Lucienne Tritten
- Lucio Barile
- Ludovic Vinay
- Ludwig Ermann Lundberg
- Luis A Ortiz
- Luis Arteaga-Blanco
- Luis MarinÌas-Pardo
- Luis Pereira de Almeida
- Luisa Weiss
- Luke C McIlvenna
- Luke van der Koog
- Lynn Pulliam
- M Helena Vasconcelos
- M Madhy Garcia Garcia
- M. AlbaneseMembro del Collaboration Group
- Maarten P Bebelman
- Maddox Adam L.
- Magdalena E WysmoĆek
- Magdalena J Lorenowicz
- Mahlegha Ghavami
- Mahoney MyÌ G.
- Maiken Mellergaard
- Maimonah E Al-Masawa
- Maja KosanovicÌ
- Makon-SeÌbastien Njock
- Malene MĂžller JĂžrgensen
- Malgorzata Czystowska-Kuzmicz
- Mangesh D Hade
- Manuel Gomez-Florit
- Manuel Varas-Godoy
- Manuela Basso
- Marc-AndreÌ Langlois
- Marca Hm Wauben
- Marcel I Ramirez
- Marcela A Cucher
- Marcelo A Mori
- Marcin Jurga
- Marcio L Rodrigues
- Marco Brucale
- Marco Falasca
- Margaret M Mc Gee
- Margarida Viola
- Maria D Mayan
- Maria Eldh
- Maria Elena Cicardi
- Maria Harmati
- Maria I GuilleÌn
- Maria Kaparakis-Liaskos
- Maria NoeÌ Garcia
- Mariama Mbengue
- Marianne S Joerger-Messerli
- Marieke T Roefs
- Marija Holcar
- Marije E Kuipers
- Marina Cretich
- Mario Gimona
- Mariola J Ferraro
- Marit Inngjerdingen
- MariÌa FernaÌndez-Rhodes
- MariÌa JoseÌ Alcaraz
- MariÌa YaÌnÌez-MoÌ
- Mark C Allenby
- Mark D Hulett
- Mark J McCann
- Mark J McVey
- Mark L Weiss
- Mark Samuels
- Mark Santos
- Marni D Boppart
- Marta Garcia-Contreras
- Marta MonguioÌ-Tortajada
- MartensâUzunova Elena S.
- Martijn Jc van Herwijnen
- Martin E van Royen
- Martin Olivier
- Martin Wolf
- Martina Gabrielli
- Marvin Droste
- Mary Bebawy
- Maryam Azlan
- Marzena Kurzawa-Akanbi
- Masaharu Somiya
- Masahiko Kuroda
- Masahiro Morimoto
- Masako Harada
- Masamitsu Kanada
- Masood Kamali-Moghaddam
- Massimo Bottini
- Massimo Dominici
- Mateja E Kreft
- Mathilde Bergamelli
- Mathilde Mosser
- Matias Ostrowski
- Mats Van Delen
- Mattia I Morandi
- Maurizio Muraca
- Mauro Manno
- Max Piffoux
- MaÌtyaÌs Bukva
- Md Matiur Rahman
- Md Mostafizur Rahman
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- Mehdi Mirzaei
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- Metka Lenassi
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- Migara K Jayasinghe
- Migmar Tsamchoe
- Miguel Flores-Bellver
- Mikael Klingeborn
- Mikhail Skliar
- Miriam Romano
- Miroslava Katsur
- Miroslaw T Kornek
- Mizenko Rachel R.
- Modeline N Longjohn
- Mohammad Rahbari
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- Monika Baj-Krzyworzeka
- Monika Pietrowska
- MoÌller Andreas
- Muhammad Nawaz
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- Muthuvel Jayachandran
- Myltykbay S Rysmakhanov
- MyÌ G Mahoney
- Nadezhda Nikiforova
- Nadim Tawil
- Namita N Kashyap
- Nandini Asokan
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- Natasha S Barteneva
- NatasÌa Resnik
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- Naveed Akbar
- Navneet Dogra
- Neslihan P Taşlı
- Neta Regev-Rudzki
- Newman Lauren A.
- Nicholas J Peake
- Nicholas R Hoyle
- Nico G Menjivar
- Nicole A Kruh-Garcia
- Nicole Meisner-Kober
- Nicole Noren Hooten
- Nieuwland Rienk
- Nihal Altan-Bonnet
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- Oleg S Tutanov
- Olesia Gololobova
- Olga Shatnyeva
- Olivier Blanc-Brude
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- Olivier G de Jong
- Olivier Loudig
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- Ornella UrziÌ
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- Oumaima Stambouli
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- Paschalia Pantazi
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- Paul D Robbins
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- Ramin Khanabdali
- Ramkumar Menon
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- Randy P Carney
- Randy Schekman
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- Raphael Schneider
- Raymond M Schiffelers
- Rebecca A Dragovic
- Rebecca L Davies
- Rebecca Lim
- Reem Bagabas
- Reihaneh Safavi-Sohi
- Renata ChalupskaÌ
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- Riccardo Vago
- Richard Chahwan
- Richard Jr Kelwick
- Ridolfi Andrea
- Rienk Nieuwland
- Rikinari Hanayama
- Rita Romani
- Rob Knight
- Robert J Coffey
- Robert L Raffai
- Roberta Palmulli
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- RociÌo PeÌrez-GonzaÌlez
- Roger Olofsson Bagge
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- Rowland Andrew
- Rucha Trivedi
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- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- ZoltaÌn Varga
- ZoltaÌn Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
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- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
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- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
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- Bartos I.
- Basak Soummyadip
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- Bayley Joseph
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- Beirnaert Freija
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- Benedetto V.
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- Bergamin Fabio
- Berger Beverly
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- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
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- Chalathadka Subrahmanya Shreevathsa
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- Chanial Pierre
- Chao Shiuh
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- CHIOFALO MARIA. LUISA.
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- Danilishin Stefan
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- De Rosa Rosario
- de rossi camilla
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- Elizabeth Ramirez Guevara Karla
- Emma Mattia
- Engelby E.
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- Erasmo Peña Arellano Fabiån
- Errico L.
- error error
- error error
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- Fabrizi Federica
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- Gayathri V.
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- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
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- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartoletti A. M.
- Barton Mark Andrew
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- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- ArĂšne M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Bartlett J.
- Barton Mark Andrew
- Bartos I.
- Basak S.
- Bassiri Riccardo
- Basti A.
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- Beatrice Cummings Rebecca
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- Beirnaert Freija
- Bejger MichaĆ
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- Cella Giancarlo
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- Chalathadka Subrahmanya Shreevathsa
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- Chanial Pierre
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- Chapman-Bird Christian
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen ChianShu
- Chen Dan
- Chen Hsin-Yu
- Chen Junxin
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- Chen Y.
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- Cheng H.
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- Chu Q.
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- Creighton Jolien
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- Dal Canton Tito
- DALL'OSSO Simone
- Dana A.
- Danilishin Stefan
- Danzmann K.
- Darsow-Fromm Christian
- Dasgupta A.
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- Sheridan E.
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- shimode katsuhiko
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- Yu Hang
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- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
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- Zhang Y.
- Zhao C.
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- Zhao Yuhang
- Zheng Yanyan
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects