Improved photodynamic activities of liposome‐incorporated [60]fullerene derivatives bearing a polar group

[60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method involving the transfer of the fullerene from the cavity of two γ‐cyclodextrin molecules to a liposome. A lipid‐membrane‐incorporated C60 derivative bearing a polar group showed much higher photodynamic activity than the analogous system incorporating pristine C60.This work was supported by JSPS KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982)

The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population

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ANALISIS PUTUSAN HAKIM NOMOR 41/PID.SUS/2018/PN BATU LICIN, TENTANG PERKARA SEDIAAN FARMASI OBAT DAFTAR G JENIS CARNOPEN YANG TIDAK MEMILIKI IJIN DITINJAU DARI ASPEK KEADILAN

The main task of the judge is to accept, examine and try and settle every case submitted to him. It seems very simple for the judge's duties as referred to in Article 2 paragraph 1 of Law Number 48 of 2009, but in reality it is not easy and that simple. The formulation of the problem in this study is 1) What is the Basic Consideration of Judge Judge Number 41 / Pid.Sus / 2018 / PN Batu Licin about the case of circulating pharmaceutical preparations for the list of G types of carnopen that do not have permission? 2) How is the Decision Number 41 / Pid.Sus / 2018 / PN Batu Licin concerning the case of circulating pharmaceutical preparations of the list of drugs G type carnopen that do not have permission in terms of aspects of justice? The approach used in this writing is normative juridical. The data used in this study are primary and secondary data. Analysis of legal materials used in this study is descriptive quality. The results of the analysis show that the basis for the Judgment of Judge Number 41 / Pid.Sus / 2018 / PN Batu Licin about the case of circulating pharmaceutical drug preparations list G types of carnopen which do not have permission, namely subjectively in this case, which is concerning a priori behavioral attitudes, behavioral attitudes emotional, arrogant and moral attitude. Objectively, that is regarding social, cultural and economic backgrounds, professionally. Decision Number 41 / Pid.Sus / 2018 / PN Batu Licin concerning cases circulating pharmaceutical preparations of the list of G types of carnopen which do not have permission in terms of justice, namely 1) declaring the aforementioned Defendant Candra Bin Rahmadi legally and convincingly guilty committing a criminal offense "intentionally circulating Pharmaceutical preparations that do not have marketing authorization" as in the primary indictment 2) Imposing a sentence to the Defendant because of that with imprisonment for 1 (one) year and 2 (two) months and a fine of Rp.2,000,000 00 (two million rupiahs) with the provision that if the fine is not paid is replaced by a confinement for 1 (one) month; and 3) Determine the period of arrest and detention that has been carried out by the Defendant entirely deducted from the sentence imposed

Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs

AbstractBackground aimsTransplantation of synovial mesenchymal stromal cells (MSCs) may induce repair of cartilage defects. We transplanted synovial MSCs into cartilage defects using a simple method and investigated its usefulness and repair process in a pig modelMethodsThe chondrogenic potential of the porcine MSCs was compared in vitro. Cartilage defects were created in both knees of seven pigs, and divided into MSCs treated and non-treated control knees. Synovial MSCs were injected into the defect, and the knee was kept immobilized for 10min before wound closure. To visualize the actual delivery and adhesion of the cells, fluorescence-labeled synovial MSCs from transgenic green fluorescent protein (GFP) pig were injected into the defect in a subgroup of two pigs. In these two animals, the wounds were closed before MSCs were injected and observed for 10min under arthroscopic control. The defects were analyzed sequentially arthroscopically, histologically and by magnetic resonance imaging (MRI) for 3 monthsResultsSynovial MSCs had a higher chondrogenic potential in vitro than the other MSCs examined. Arthroscopic observations showed adhesion of synovial MSCs and membrane formation on the cartilage defects before cartilage repair. Quantification analyses for arthroscopy, histology and MRI revealed a better outcome in the MSC-treated knees than in the non-treated control kneesConclusionsLeaving a synovial MSC suspension in cartilage defects for 10min made it possible for cells to adhere in the defect in a porcine cartilage defect model. The cartilage defect was first covered with membrane, then the cartilage matrix emerged after transplantation of synovial MSCs

Synthesis of donor–acceptor chromophores by the [2 + 2] cycloaddition of arylethynyl-2H-cyclohepta[b]furan-2-ones with 7,7,8,8-tetracyanoquinodimethane

Arylethynyl-2H-cyclohepta[b]furan-2-ones reacted with 7,7,8,8-tetracyanoquinodimethane (TCNQ) in a formal [2 + 2] cycloaddition reaction, followed by ring opening of the initially formed cyclobutene derivatives, to afford the corresponding dicyanoquinodimethane (DCNQ) chromophores in excellent yields. The intramolecular charge-transfer (ICT) interactions between the 2H-cyclohepta[b]furan-2-one ring and DCNQ acceptor moiety were investigated by UV/Vis spectroscopy and theoretical calculations. The redox behavior of the novel DCNQ derivatives was examined by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), which revealed their multistep electrochemical reduction properties depended on the number of DCNQ units in the molecule. Moreover, a significant color change was observed by visible spectroscopy under electrochemical reduction conditions.ArticleORGANIC & BIOMOLECULAR CHEMISTRY. 10(12):2431-2438 (2012)journal articl

Prevention of hypoglycemia by intermittent-scanning continuous glucose monitoring device combined with structured education in patients with type 1 diabetes mellitus : A randomized, crossover trial

Aims: We conducted a randomized, crossover trial to compare intermittent-scanning continuous glucose monitoring (isCGM) device with structured education (Intervention) to self-monitoring of blood glucose (SMBG) (Control) in the reduction of time below range. Methods: This crossover trial involved 104 adults with type 1 diabetes mellitus (T1DM) using multiple daily injections. Participants were randomly allocated to either sequence Intervention/Control or sequence Control/Intervention. During the Intervention period which lasted 84 days, participants used the first-generation FreeStyle Libre (Abbott Diabetes Care, Alameda, CA, USA) and received structured education on how to prevent hypoglycemia based on the trend arrow and by frequent sensor scanning (≥10 times a day). Confirmatory SMBG was conducted before dosing insulin. The Control period lasted 84 days. The primary endpoint was the decrease in the time below range (TBR; <70 mg/dL). Results: The time below range was significantly reduced in the Intervention arm compared to the Control arm (2.42 ± 1.68 h/day [10.1 %±7.0 %] vs 3.10 ± 2.28 h/day [12.9 %±9.5 %], P = 0.012). The ratio of high-risk participants with low blood glucose index >5 was significantly reduced (8.6 % vs 23.7 %, P < 0.001). Conclusions: The use of isCGM combined with structured education significantly reduced the time below range in patients with T1DM

Immune-related aseptic meningitis diagnosed by Cube FLAIR on enhanced magnetic resonance imaging for a lung cancer patient administered atezolizumab: A case report

Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), such as neurological toxicity. A 46-year-old man was diagnosed with squamous cell lung cancer. Lung cancer recurred 3 years after he experienced left segmental lung rejection. Therefore, he received atezolizumab as fourth-line chemotherapy. He experienced fever, headache, and decreased consciousness 10 days after the first dose of atezolizumab. Plain head computed tomography and cerebrospinal fluid examination showed no significant findings. Magnetic resonance imaging (MRI) with a Gadolinium (Gd)-enhanced Cube fluid-attenuated inversion recovery (FLAIR) sequence showed nodular abnormalities with contrast enhancement. Thus, aseptic meningitis caused by ICIs was suspected. His consciousness level gradually improved with glucocorticoid therapy. Moreover, most nodular abnormalities observed on cerebral MRI disappeared concurrently. Thus, Gd-enhanced Cube FLAIR sequence has the unique ability to reveal immune-related aseptic meningiti