11 research outputs found
Determination of 137Ba Isotope Abundances in Water Samples by Inductively Coupled Plasma-optical Emission Spectrometry Combined with Least-squares Support Vector Machine Regression
A simple and rapid method for the determination of 137Ba isotope abundances in water samples by inductively coupled plasma-optical emission spectrometry (ICP-OES) coupled with least-squares support vector machine regression (LS-SVM) is reported. By evaluation of emission lines of barium, it was found that the emission line at 493.408 nm provides the best results for the determination of 137Ba abundances. After recording the emission spectra in the range of 493.362-493.467 nm, quantification of 137Ba abundances was performed with the aid of LS-SVM algorithm. The obtained results revealed that using LS-SVM as a nonlinear modeling approach improves the predictive quality of the developed models compared with partial least squares (PLS) method. The calculated results proved that the combination of ICP-OES and LS-SVM is a suitable and low cost technique for the determination of 137Ba abundances. Performance of the proposed method was examined through measuring 137Ba abundances in synthetic mixtures and water samples
Correction to Capturing the Crystal: Prediction of Enthalpy of Sublimation, Crystal Lattice Energy, and Melting Points of Organic Compounds
Capturing the Crystal: Prediction of Enthalpy of Sublimation, Crystal Lattice Energy, and Melting Points of Organic Compounds
Accurate computational prediction of melting points and
aqueous
solubilities of organic compounds would be very useful but is notoriously
difficult. Predicting the lattice energies of compounds is key to
understanding and predicting their melting behavior and ultimately
their solubility behavior. We report robust, predictive, quantitative
structure–property relationship (QSPR) models for enthalpies
of sublimation, crystal lattice energies, and melting points for a
very large and structurally diverse set of small organic compounds.
Sparse Bayesian feature selection and machine learning methods were
employed to select the most relevant molecular descriptors for the
model and to generate parsimonious quantitative models. The final
enthalpy of sublimation model is a four-parameter multilinear equation
that has an r<sup>2</sup> value of 0.96 and an average absolute error
of 7.9 ± 0.3 kJ.mol<sup>–1</sup>. The melting point model
can predict this property with a standard error of 45° ±
1 K and r<sup>2</sup> value of 0.79. Given the size and diversity
of the training data, these conceptually transparent and accurate
models can be used to predict sublimation enthalpy, lattice energy,
and melting points of organic compounds in general
Capturing the Crystal: Prediction of Enthalpy of Sublimation, Crystal Lattice Energy, and Melting Points of Organic Compounds
Accurate computational prediction of melting points and
aqueous
solubilities of organic compounds would be very useful but is notoriously
difficult. Predicting the lattice energies of compounds is key to
understanding and predicting their melting behavior and ultimately
their solubility behavior. We report robust, predictive, quantitative
structure–property relationship (QSPR) models for enthalpies
of sublimation, crystal lattice energies, and melting points for a
very large and structurally diverse set of small organic compounds.
Sparse Bayesian feature selection and machine learning methods were
employed to select the most relevant molecular descriptors for the
model and to generate parsimonious quantitative models. The final
enthalpy of sublimation model is a four-parameter multilinear equation
that has an r<sup>2</sup> value of 0.96 and an average absolute error
of 7.9 ± 0.3 kJ.mol<sup>–1</sup>. The melting point model
can predict this property with a standard error of 45° ±
1 K and r<sup>2</sup> value of 0.79. Given the size and diversity
of the training data, these conceptually transparent and accurate
models can be used to predict sublimation enthalpy, lattice energy,
and melting points of organic compounds in general
Aqueous Solubility Prediction: Do Crystal Lattice Interactions Help?
Aqueous
solubility is a very important physical property of small
molecule drugs and drug candidates but also one of the most difficult
to predict accurately. Aqueous solubility plays a major role in drug
delivery and pharmacokinetics. It is believed that crystal lattice
interactions are important in solubility and that including them in
solubility models should improve the accuracy of the models. We used
calculated values for lattice energy and sublimation enthalpy of organic
molecules as descriptors to determine whether these would improve
the accuracy of the aqueous solubility models. Multiple linear regression
employing an expectation maximization algorithm and a sparse prior
(MLREM) method and a nonlinear Bayesian regularized artificial neural
network with a Laplacian prior (BRANNLP) were used to derive optimal
predictive models of aqueous solubility of a large and highly diverse
data set of 4558 organic compounds over a normal ambient temperature
range of 20–30 °C (293–303 K). A randomly selected
test set and compounds from a solubility challenge were used to estimate
the predictive ability of the models. The BRANNLP method showed the
best statistical results with squared correlation coefficients of
0.90 and standard errors of 0.645–0.665 logÂ(<i>S</i>) for training and test sets. Surprisingly, including descriptors
that captured crystal lattice interactions did not significantly improve
the quality of these aqueous solubility models