Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

Intrarectal infection between men who have sex with men represents a predominant form of human immunodeficiency virus (HIV) transmission in developed countries. Currently there are no adequate small animal models that recapitulate intrarectal HIV transmission. Here we demonstrate that human lymphocytes generated in situ from hematopoietic stem cells reconstitute the gastrointestinal tract of humanized mice with human CD4+ T cells rendering them susceptible to intrarectal HIV transmission. HIV infection after a single intrarectal inoculation results in systemic infection with depletion of CD4+ T cells in gut-associated lymphoid tissue and other pathologic sequela that closely mimics those observed in HIV infected humans. This novel model provides the basis for the development and evaluation of novel approaches aimed at immune reconstitution of human gut-associated lymphoid tissue and for the development, testing, and implementation of microbicides to prevent intrarectal HIV-1 transmission

Personality profiles of cultures: aggregate personality traits

Personality profiles of cultures can be operationalized as the mean trait levels of culture members. College students from 51 cultures rated an individual from their country whom they knew well (N = 12, 156). Aggregate scores on Revised NEO Personality Inventory scales generalized across age and gender groups, approximated the individual-level Five-Factor Model, and correlated with aggregate self-report personality scores and other culture-level variables. Results were not attributable to national differences in economic development or to acquiescence. Geographical differences in scale variances and mean levels were replicated, with Europeans and Americans generally scoring higher in Extraversion than Asians and Africans. Findings support the rough scalar equivalence of NEO-PI-R factors and facets across cultures, and suggest that aggregate personality profiles provide insight into cultural differences

National character does not reflect mean personality trait levels in 49 cultures

Most people hold beliefs about psychological characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal experience, or stereotypes with or without a “ kernel of truth." We obtained national character ratings from 49 cultures and compared them to average personality scores of culture members as assessed by observer ratings and self-reports. National character ratings appeared to be reliable and valid measures, but they did not converge with assessed personality traits. Perceptions of national character thus appear to be unfounded stereotypes that may serve the function of maintaining a national identity

Universal features of personality traits from the observer’ s perspective: data from 50 cultures

To test hypotheses about the universality of personality traits, college students in 50 cultures identified an adult or college-age man or woman whom they knew well and rated the 11, 985 targets using the third-person version of the Revised NEO Personality Inventory. Factor analyses within cultures showed that the normative American self-report structure was clearly replicated in most cultures, and was recognizable in all. Sex differences replicated earlier self-report results, with the most pronounced differences in Western cultures. Cross-sectional age differences for three factors followed the pattern identified in self-reports, with moderate rates of change during college age and very slow changes after age 40. With a few exceptions, these data support the hypothesis that features of personality traits are common to all human groups