Solving Machine Scheduling Problem under Fuzzy Processing Time using the Simulated Annealing Method

In this paper, we describe the problem of sequencing a set of n jobs on single machine was considered to minimize multiple objectives function (MOF). The objective is to find the approximate solutions for scheduling n independent jobs to minimize the objective function consists from a sum of weighted number of early jobs and the weighted number of tardy jobs with fuzzy processing time. This problem is denoted by: (1/ / ). To resolve it we proposed the Average High Ranking (AHR) method to obtain a processing time generated from fuzzy processing time, calculate the costs and reach to total penalty cost. Since our problem is Strongly NP-hard in normal form, we used Simulated Annealing. It solved the problem with up to 12000 jobs in 30 seconds

Development and Validation for High Performance Liquid Chromatography Method of Assay of Metronidazole

دواء المیترونیدازول هو من مجموعة المضادات البكتیریة المستخدمة في علاج الالتهابات البكتیریة اللاهوائیة والذي یمكن ان یتحلل بواسطة التحلیل الكروماتوجرافي العالي الكفاءة للسوائل لمعرفة وزن المادة الفعالة للدواء في الصیغة الدوائیة المعینه يهدف البحث الي تطوير طريقه جديده لتحليل الميترو ناديزول ونواتج انحلاله مع اختبار معلمات خصائصه التثبيتيه من ملائمه الطريقه لاستخدمها في مجال التحليل وذلك باستخدام كروماتوجرافيا السائل ذو الضغط العالي العديد من المحاولات اجريت باستخدام مخلوط من الماء والمثيانول، الماء و الاسيتونيترايت، الماء: تتراهيدروفيوران ، والماء: ميثانول: اسيتونيترايت بنسب متفاوتة. لقد تم اختبار الاحكام، والدقة، والعلاقة الخطية بين التركيز والمساحة التابعة للذروة الناتجة من المتروناديزول و نواتجه المنحلة. لقد تم اختيار الطور المتحرك المناسب الذي يتكون من محلول منظم ذو رقم هيدروجين 4.3 وخليط من الميثانول: 0.01م بوتاسيوم هيدروجين اورثو فوسفيت بنسبه (30:70) باستخدام الطور المتحرك ابعاد عموده (20 سم4.6*ملم) كربون 18 كربون 8 وكان سرعه انسياب الطةر المتحرك 1ملتر\ثانيه في طول موجي 315 نانو متر. الطريقة الجديدة كانت دقيقه ومحكمه، وكان هناك علاقة خطية بين التركيز للماده و المساحة الخاصة بالذروة. الطريقة الجديدة تعتبر سهله واقتصادية، دقيقة، ومحكمة ويمكن استخدمها في تحليل ادوية الميترونيدازول ونواتجه المنحلة في الاقراص

Human Herpetic Viruses and Immune Profiles

Herpesviruses are large, spherical, enveloped viral particles with linear double-stranded DNA genome. Herpesvirus virion consists of an icosahedral capsid containing viral DNA, surrounded by a protein layer called tegument, and enclosed by an envelope consisting of a lipid bilayer with various glycoproteins. Herpesviruses persist lifelong in their hosts after primary infection by establishing a latent infection interrupted recurrently by reactivations. The Herpesviridae family is divided into three subfamilies; α-herpesviruses, β-herpesviruses, and γ-herpesviruses based on the genome organization, sequence homology, and biological properties. There are eight human herpes viruses: Herpes simplex virus type 1 and 2 (HSV-1, −2) andVaricella-zoster virus (VZV), which belong to the α-herpesvirus subfamily; Human cytomegalovirus (HCMV), and Human herpesvirus type 6 and 7 (HHV-6,HHV-7), which belong to the β-herpesvirus subfamily; and Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) or Human herpesvirus 8 (HHV-8), which belong to the γ-herpesvirus subfamily. Within this chapter, we summarize the current knowledge about EBV and CMV, regarding their genome organization, structural characteristics, mehanisms of latency, types of infections, mechanisms of immune escape and prevention. Epstein–Barr Virus (EBV) genome encodes over 100 proteins, of which only (30) proteins are well characterized, including the proteins expressed during latent infection and lytic cycle proteins. Based on major variation in the EBNA-2 gene sequence, two types of EBV are recognized, EBV type 1 and 2. Epstein–Barr virus types occur worldwide and differ in their geographic distribution depending on the type of virus. EBV spreads most commonly through bodily fluids, especially saliva. However, EBV can also spread through blood, blood transfusions, and organ transplantations. The EBV is associated with many malignant diseases such as lymphomas, carcinomas, and also more benign such as infectious mononucleosis, chronic active infection. The EBV has also been suggested as a trigger/cofactor for some autoimmune diseases. Overall, 1–1.5% of the cancer burden worldwide is estimated to be attributable to EBV The latently infected human cancer cells express the most powerful monogenic proteins, LMP-1 and LMP-2(Latent Membrane Protein-1,-2), as well as Epstein–Barr Nuclear Antigens (EBNA) and two small RNAs called Epstein–Barr Encoded Small RNAs (EBERs). The EBV can evade the immune system by its gene products that interfering with both innate and adaptive immunity, these include EBV-encoded proteins as well as small noncoding RNAs with immune-evasive properties. Currently no vaccine is available, although there are few candidates under evaluation. Human cytomegalovirus (HCMV) is a ubiquitous beta herpesvirus type 5 with seroprevalence ranges between 60 to 100% in developing countries. CMV is spread from one person to another, usually by direct and prolonged contact with bodily fluids, mainly saliva, but it can be transmitted by genital secretions, blood transfusion and organ transplantation. In addition, CMV can be transmitted vertically from mother to child. CMV infection can result in severe disease for babies, people who receive solid organ transplants or bone marrow/stem cell transplants and people with severe immune suppression such as advanced human immunodeficiency virus (HIV) infection. The HCMV has several mechanisms of immune system evasion. It interferes with the initiation of adaptive immune responses, as well as prevent CD8+ and CD4+ T cell recognition interfering with the normal cellular MHC Class I and MHC Class II processing and presentation pathways. Challenges in developing a vaccine include adeptness of CMV in evading the immune system. Though several vaccine candidates are under investigation

Recent Guidelines in Bronchial Asthma Management in Children: Review Article

Background: A common childhood and adolescent illness, asthma is a chronic inflammatory condition marked by episodes of wheezing, dyspnea, tightness in the chest, and coughing. A mix of genetic and environmental factors is likely to be responsible for its occurrence. A short-acting beta-2 agonist (such as salbutamol) breathed into the lungs is mainly used to treat acute symptoms. Inhaling corticosteroids and avoiding triggers like allergens and irritants can help prevent symptoms. Objective: to determine the recent treatment modalities in bronchial asthma management in children. Conclusion: many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services

Application of R.E.N.A.L Nephrometry Score in Planning Type of Surgery and Predicting Complications in RCC Patients in Gezira Hospital

Background: Adult renal cell carcinomas account for 80–85% of all renal tumors, making them the most common primary renal tumors. As a method for categorizing renal masses by anatomical characteristics, R.E.N.A.L score is suggested to study the effect on surgical approach in addition to perioperative outcomes and complications. Methods: A cross-sectional prospective hospital-based study enrolled 48 RCC patients in GHRDS in the period between September 2020 and September 2021. Data regarding demographics, histological subtypes, surgical approach, intraoperative and postoperative complications were collected. Based on R.E.N.A.L score, the complexity of renal tumors is grouped into low, moderate, and high. Results: The study sample size was 48. Twenty-five participants (52.1%) were men with a mean age of 51 years. Most cases had clear cell RCC 22 (45.8%) and papillary RCC 19 (39.6%). Thirty-nine (81.5%) patients underwent radical nephrectomy (flank incision [extraperitoneal] in 32 [82.1%] and midline incision [transperitoneal] in 7 [17.3%]), and 9 (18.5%) patients underwent partial nephrectomy. One-third of the patients 15 (31.2%) had intraoperative complications and 7 (14.6%) had postoperative complications. All intraoperative and most postoperative complications were associated with radical nephrectomy (P = 0.001). According to complexity, 21 (43.8%) patients had moderate complexity, 15 (31.2%) high complexity, and 12 (25%) low complexity. Conclusion: Most RCC patients had moderate complexity and were subjected to radical nephrectomy. High complexities were linked to the decision of radical nephrectomy, and intraoperative and postoperative complications. More prospective research with large sample size and multi-centered studies is essential to ensure the generalizability of study findings

Synthesis and Application of Cobalt Oxide (Co3O4)-Impregnated Olive Stones Biochar for the Removal of Rifampicin and Tigecycline: Multivariate Controlled Performance

Cobalt oxide (Co3O4) nanoparticles supported on olive stone biochar (OSBC) was used as an efficient sorbent for rifampicin (RIFM) and tigecycline (TIGC) from wastewater. Thermal stabilities, morphologies, textures, and surface functionalities of two adsorbents; OSBC and Co-OSBC were compared. BET analysis indicated that Co-OSBC possesses a larger surface area (39.85 m2/g) and higher pore-volume compared to the pristine OSBC. FT-IR analysis showed the presence of critical functional groups on the surface of both adsorbents. SEM and EDX analyses showed the presence of both meso- and macropores and confirmed the presence of Co3O4 nanoparticles on the adsorbent surface. Batch adsorption studies were controlled using a two-level full-factorial design (2k-FFD). Adsorption efficiency of Co-OSBC was evaluated in terms of the % removal (%R) and the sorption capacity (qe, mg/g) as a function of four variables: pH, adsorbent dose (AD), drug concentration, and contact time (CT). A %R of 95.18% and 75.48% could be achieved for RIFM and TIGC, respectively. Equilibrium studies revealed that Langmuir model perfectly fit the adsorption of RIFM compared to Freundlich model for TIGC. Maximum adsorption capacity (qmax) for RIFM and TIGC was 61.10 and 25.94 mg/g, respectively. Adsorption kinetics of both drugs could be best represented using the pseudo-second order (PSO) model.This research was funded by Qatar University under the National Science Promotion Program, QUNSPP-(CAS)-2021-(108). The NSPP is managed by Qatar University Young Scientists Center (QUYSC), Doha, Qatar. The findings achieved herein are solely the responsibility of the author

Association of the serum chemerin level with the development of diabetic retinopathy in patients with type 1 diabetes mellitus

Background: In patients with type 2 diabetes mellitus, the development of diabetic retinopathy (DR) correlates positively with elevated serum chemerin levels. This study was aimed at investigating the probable association between the serum chemerin level and the development of DR in patients with type 1 diabetes mellitus (T1DM). Methods: In this cross-sectional study, we included Egyptians and classified them into four groups: group 1, including healthy individuals; group 2, including patients with T1DM without DR; group 3, including patients with T1DM with non-proliferative DR (NPDR); and group 4, including patients with T1DM with proliferative DR (PDR). The assessment included best-corrected distance visual acuity assessment, slit-lamp biomicroscopy, funduscopy, fundus fluorescein angiography, and macular ocular coherence tomography. Fasting blood samples were obtained from all participants to measure serum chemerin, glycated hemoglobin (HbA1c), total cholesterol, triglyceride, and creatinine levels. Serum chemerin levels were compared among the groups, and their correlations with age, duration of diabetes, HbA1c, total cholesterol, triglyceride, and creatinine levels were analyzed. Results: We recruited 209 participants, including 46 healthy individuals in group 1, 52 patients (T1DM and no DR) in group 2, 61 patients (T1DM and NPDR) in group 3, and 50 patients (T1DM and PDR) in group 4, with comparable mean ages and sex ratios among groups. The diabetes duration, body mass index, HbA1c, total cholesterol, triglyceride, and serum chemerin levels differed significantly among the groups (all P < 0.001), whereas the creatinine level did not (P > 0.05). The serum chemerin level was significantly higher in group 4 than in groups 3 and 2, in group 3 than in group 2, and in groups 3 and 4 than in group 1 (all P < 0.001). However, it was comparable between groups 1 and 2 (P > 0.05). It correlated with the duration of T1DM and HbA1c, total cholesterol, triglyceride, and creatinine levels but not with age. Conclusions: Patients with T1DM with DR showed higher serum chemerin levels than those with T1DM without DR or healthy individuals. Serum chemerin levels were higher in those with PDR than in those with NPDR. Thus, serum chemerin levels are a potential biomarker of the development and severity of DR in patients with T1DM. Nevertheless, future diagnostic accuracy studies are required to confirm these potential applications