Cutting off Cardiologists: The Disappeared in “Puro corazón” by Luisa Valenzuela

Luisa Valenzuela’s neglected short story “Puro corazón” (\u27All Heart\u27) uses surreal imagery and plot to write about the increasing violence in Buenos Aires during the time immediately prior to the Dirty War (la Guerra Sucia). By mimicking a police report, Valenzuela’s story manages to reproduce the experience of censorship and repression that denied the fate of the disappeared. This article shows how the story forges ludic connections between the human body (especially hearts, blood, and cardiologists), the censorship and repression in the early 1970s in Argentina, and the discourse that marked the official response to los desaparecidos, the disappeared

Targeting the ‘Oligomerization Region’ of the Epidermal Growth Factor Receptor using Small Molecule Inhibitors as Novel Anticancer Agents

There are two main types of ErbB-RTK subfamily inhibitors, viz, a) the mAbs and b) the RTKIs, which act at different domains of the receptors. The mAbs act at the ectodomain locale either by interfering with the ligand such as EGF or the receptor such as EGFR, in each case interference with dimerization occurs. The RTKIs inhibit numerous biochemical processes beginning with the recruitment of accessory proteins by the dimerized complexes. However, little has been done specifically in the ‘oligomerization region’ in developing active anti-EGFR anti-oligomeric small molecules that can inhibit the oligomerization processes in spite the ligands are bound to their canonical ErbB receptors. The concept of the oligomerization mechanisms, particularly heterotetramerization, has shown leading clues to untangle some of the probes dimerization has limited explanations for, wherein lies the scope of our work. We have designed four small molecules, namely, 3-(furan-2-yl)-4-(8-hydroxyquinolin-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[3,4-c]pyridin-5-one (%IG50,3.98 µM; %IC50, 8.90 µM), 3,3,3-trifluoro-2-hydroxy-N-((2-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)propanamide (%IG50, 0.25 µM; %IC50, 0.40 µM), 2-((2-(3-isopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)methyl)quinolin-8-ol (%IG50, 1.59 µM; %IC50, 1.50 µM) and 4-(1-cyclopentylpyrrolidin-2-yl)-N-((3,5-dimethyl-1H-pyrazol-4-yl)methyl)thiophene-2-carboxamide (%IG50, 1.59 µM; %IC50, 1.10 µM) that act at the ‘oligomerization region’, using the Schrodinger Software v10.4Maestro, v6.9Glide (Schrödinger, LLC, New York, NY, 2015-4) on scrutinizing ≥ 9 x 106 ligands from different chemical databases

Greenmission: An off-grid energy system

In alignment with Santa Clara University\u27s sustainability ideology, the outdoor science school WaldenWest desired to further its students\u27 education through a greenhouse with working electricity. Following greenhouse purchase and assembly, underground wiring for AC, DC and Ethernet lines were sized and installed. A substation was then designed and built in a designated shed, integrating wind turbines and photovoltaics rom past capstone projects. New charge controllers, batteries and circuit breakers were urchased and configured for the system. Worst-case electrical load and solar shading analyses also revealed that these older energy sources were collectively inadequate, so a secondary solar array was designed and flush-mounted to the shed roof; the system falls lightly short of desired year-round performance, but is otherwise a drastic improvement. Electrical measurements show that power is received at the greenhouse with a less than 3% voltage drop, meeting national Electric Code standards. To maintain the greenhouse environment, substation loads are specifically selected to allow for temperature control. These are driven by the Supervisory Control And Data Acquisition (SCADA) system, which never leaves the greenhouse; an enclosed Raspberry Pi automates load operation through SainSmart relays and simple comparative logic. To account for both varying seasonal weather conditions and client accessibility, a Graphical User Interface (GUI) is programmed to allow adjustment of all relevant control parameters via Wi-Fi in real-time. A battery monitor from a past capstone project is also reconfigured to run on Linux to estimate remaining stored energy. Project analyses include ethical, aesthetics, commercial benefit and basic photovoltaic rate-of-return analyses. Hypothetical scenarios are frequently presented to investigate the potential consequences of client and residentially-replicated usage of the entire system. It is also estimated that the combined photovoltaics will result in a lifetime net zero energy in 4.3 years of continuous expected use. Future project work involves tasks that could not be accomplished within the project time frame and budget. Among these include a larger solar array; the 24VDC integration of the horizontal wind turbine; rigorous seasonally-based testing of temperature controlling mechanisms for better parameter adjustments; and finally, the propagation of electrical power beyond the immediate premises and into the entire Walden West garden. Based on client needs, inspiration for future project work will likely draw from the tremendous success of the Milwaukee, Wisconsin non-profit organization, Growing Power

The effect of organic management on soil quality indicators

This report was presented at the UK Organic Research 2002 Conference. A range of physical, biological and chemical parameters were measured in organic soil that had been managed in different ways and in a conventional control. Factors were identified that could be used to construct an index of soil quality

Causas de la disminución de las ventas y factores de la retención de clientes en el restaurante Cilantro y Jengibre entre 2009 y 2010 estudio del consumidor mediante investigación de mercados

Administrador (a) de EmpresasPregrad

Ik, farizeeër? : de betekenis van de wee-uitspraken van Jezus in Mattheüs 23:13-36 volgens de socio-retorische methode

Masterthesis Nieuwe Testamen

O PAPEL DO ENFERMEIRO NO ACOLHIMENTO ÀS FAMÍLIAS DE PACIENTES DIAGNOSTICADOS COM PARALISIA CEREBRAL NO PRIMEIRO ANO DE VIDA (ENFERMAGEM)

o papel do enfermeiro no acolhimento às famílias de pacientes diagnosticados com paralisia cerebral no primeiro ano de vida. Objetivo: Aplicar como o enfermeiro irá acolher, acompanhar, conduzir, e auxiliar corretamente famílias que recebem diagnóstico de paralisia cerebral durante o primeiro ano de vida da criança. Materiais e Métodos: Trata-se de um estudo do tipo revisão integrativa de literatura, exploratório e descritivo realizado após acesso e busca nas bases de dados da biblioteca virtual da saúde ( BVS) e periódicos da Scielo, onde irá ser abordados os seguintes temas: conceituar paralisia cerebral; identificar tratamento de terapias para crianças portadoras de paralisia cerebral nos primeiros 12 meses de vida; descrever a função do enfermeiro no acompanhamento e acolhimento a famílias com crianças acometidas de paralisia cerebral no primeiro ano de vida. Resultado: A partir da revisão da literatura, os resultados encontrados mostram que o papel do enfermeiro no acolhimento às famílias de pacientes diagnosticados com paralisia cerebral no primeiro ano de vida é de suma importância, pois a família ao receberem o diagnóstico tem dificuldades de aceitação, essas  famílias ao procurar os serviços desses profissionais, sejam, em hospitais ou em UBS, ainda enfrentam e esbarram com uma rede de profissionais sem conhecimento em relação de como lidar com o portador de paralisia cerebral. Conclusão: Através das leituras conclui-se que não há um interesse ou investimento de políticas públicas e nem uma rede de profissionais, em particular do enfermeiro, capacitados na questão do acolhimento às famílias de portadores de paralisia cerebral.Palavras-Chave: Acolhimento Familiar; Paralisia Cerebral e Enfermagem

Physiology of vocal images in singing: A preliminary project on “online” singing training [abstract]

Abstract only availableThis online program will help students understand the art and science of singing. During voice training, students and teachers may not have the same understanding of certain voice production techniques. While the teacher and student produce the same voice qualities, they may result from different physiological representations. For example, a loud voice can be produced by increasing lung pressure, or by increasing the extent of vocal fold squeezing, where the latter is detrimental to voice production. Learning about the mechanics of speech and voice production can help singers avoid dysphonia and other voice problems State of the art equipment will be used to decipher the art of singing. It will transcribe artistic images to physiological definitions of voice production by analyzing acoustic, aerodynamic, and kinematic parameters of voice samples. These physiological descriptions, as well as audio samples of teachers' voices will be used to create an online program. Feedback and instruction of vocal tract physiology have proven to be useful in improving the voice of professional singers (Pershal & Boone, 1987). This program will enhance students' learning experience by providing additional feedback. Various studies have been done that support efforts to "integrate curricula in vocal performance and speech-language pathology" (DeBoer & Shealy, 1995) and this online program will be an important step in improving vocal instruction.eResearch Fellowshi