Elaboración de mezclas de fertilizantes para papa y maíz en el valle de Toluca, Estado de México

La evaluación de proyectos optimiza el uso de los recursos y mejora la productividad de empresas e inversiones factibles. El objetivo de esta investigación fue proporcionar elementos de decisión técnico-económico sobre la conveniencia o no de poner en marcha un agronegocio para la producción de agromezclas de fertilizantes: papera y maicera para siembra y reabonado en papa y maíz, en el Valle de Toluca, Estado de México, usando la metodología de formulación y evaluación de proyectos. El mercado principal son los Municipios: Toluca, Zinacantepec, Sultepec, Valle de Bravo y Temascaltepec. Con una tasa de descuento de 13.1 % el Valor Presente Neto estimado fue $ 2 981 061, la Tasa Interna de Retorno (TIR) 78.36 % y la Tasa Interna de Retorno Modificada (TIRM) de 181.44 %. Los indicadores de evaluación superaron sus valores críticos, por tanto, es viable y factible decidir sobre la inversión

Click chemistry of multi-walled carbon nanotubes-G-1,3-diazido-2-isopropanol with alkyne groups

The click chemistry was employed on oxidized multiwall carbon nanotubes for their functionalization with 1,3-diazido-2-isopropanol (2N3OH). Phenylacetylene and propargylamine are used as alkyne groups, catalyzed with copper iodide (I). The chemical and structural characterization are described starting from the Raman and infrared spectroscopy as well as the realization of an elemental combustion analysis, transmission electron microscopy and nuclear magnetic resonance (NMR)CONACY

Paraneoplastic Cerebellar Degeneration Secondary to BRAF Mutant Melanoma Metastasis from an Occult Primary Cancer

Melanoma metastasis from an unknown primary cancer has an incidence of 3.2% among melanoma patients. Furthermore, paraneoplastic neurological syndromes (PNS) are rare, occurring in 1-3% of patients with malignancies. Paraneoplastic cerebellar degeneration (PCD) is one of the classic PNS and is characterized by acute or subacute onset of ataxia and/or presence of onconeural antibodies. A 61-year-old male with ataxia, vertigo, and headache later developed dysarthria, multidirectional nystagmus, hyperactive delirium, auditory hallucinations, psychomotor agitation, and myoclonus. Toxicological, metabolic, infectious, and autoimmune etiologies were assessed and reported negative. An osteolytic lesion was observed in the right iliac crest via computed tomography (CT). A positron emission tomography-CT reported increased fluorodeoxyglucose uptake of a right iliac and right inguinal ganglion. After biopsy of the right inguinal ganglion, a BRAF mutation-positive melanoma metastasis from an occult primary cancer was diagnosed. Dermatologic, ophthalmologic, and endoscopic gastrointestinal assessment did not reveal a primary malignant melanoma. The patient's movement disorders and neuropsychiatric symptoms improved with quetiapine, prednisone, azathioprine, and cyclophosphamide. Oncological management was conducted with MAPK pathway inhibitors (i.e., dabrafenib and trametinib). Movement disorders associated with neuropsychiatric symptoms are complex to diagnose. PNS are rare and often associated with antibodies against neural antigens expressed by the tumor. The case presented above describes a patient with a BRAF-positive malignant melanoma metastasis from an occult primary associated with PCD - to the best of our knowledge, the first reported in the literature.</p

Chronobiology: Proper Feeding to Sleep Cycles

Chronobiology is the process that studies the biological rhythms of living beings, in which each organism has its own biological clock. Sleep is a state of unconsciousness, characterized by the active inhibitory process, and that has an important relationship with feeding, mainly due to the possibility of sleep privation increasing starvation through hormonal regulation. In addition, starvation can lead to obesity, contributing to the risk factors for chronic non-communicable diseases, such as high blood pressure, hypercholesterolemia, diabetes mellitus, cardiovascular diseases, and some forms of cancer. The cycle of bad sleep may cause direct health problems, such as the diseases mentioned above; and indirect, may result in traffic accidents, unemployment, and difficulties in interpersonal relationships, with the possibility of progressing to anxiety disorders.&nbsp; This study aims to analyze whether there is a relationship between healthy eating and the standard of sleep quality, providing better performance of daily activities.&nbsp;For this study, the 133 participants answered 3 feeding records and, later, questionnaires on sleep quality (Pittsburgh Sleep Quality Index) in three moments.&nbsp;Considering the three questionnaires, there were no significant differences obtained by calculating the statistical tests, however, the analysis of the gross medians with the proposed score showed a strict relationship between sleep and food.&nbsp;In addition to the relationship between food and sleep quality, other factors such as stress and anxiety can contribute to hormonal dysregulation, thus changing the pattern of sleep quality of individuals

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

BACKGROUND: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. METHODS AND RESULTS: Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio = 4.60; p-value < 0.001). Besides, the discriminant power of miRNA-MRS was significantly higher than the observed for age and gender (AUROC = 0.970 vs. 0.881; p = 0.042). CONCLUSIONS: SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality

Diseño de una herramienta que permita identificar los riesgos laborales que se puedan presentar en la empresa La Fleche & Cía. S.A.S., en la ciudad de Bogotá, para el segundo semestre del año 2022.

Este proyecto de grado es un estudio que se aplica a la microempresa La Fleche & Cía. S.A.S. ubicada en la ciudad de Bogotá D.C., cuya actividad principal son las Actividades Jurídicas, donde permitirá identificar a profundidad los diferentes peligros y riesgos laborales que se pueden presentar dentro de la empresa, determinando las condiciones en las cuales se realizan las funciones en cada cargo que tiene la empresa. Esta investigación bajo su objetivo general de diseñar una herramienta que permita identificar los riesgos laborales que se puedan presentar en la empresa La Fleche & Cía. S.A.S. teniendo en cuenta lo establecido por el Ministerio de Trabajo mediante el Decreto 1072 de 2015, basa sus estudios e investigación de acuerdo a los resultados obtenidos a través de la metodología, método de recolección como son las encuestas realizadas a los trabajadores de las distintas áreas laborales de la empresa, la cual fue aplicada electrónicamente; en la cual los trabajadores expresaron sus opiniones, fortalezas y deficiencias sobre cada uno de sus entornos de trabajo. La intención principal de este proyecto es que la empresa La Fleche & Cía. S.A.S. conozca de manera clara y efectiva cuales son los peligros y riesgos laborales a los cuales están expuestos sus empleados durante la jornada laboral como pueden ser: riesgos físicos, químicos, ergonómicos, psicosociales y ambientales; de este modo poder analizar las posibles consecuencias que se puedan presentar para brindar un conocimiento más específico de cada cargo a la Gerencia la cual es la encargada de generar, promover la protección y atención integral del trabajo sano y seguro ofreciendo una garantía a los trabajadores.This degree project is a study that is applied to the microenterprise La Fleche & Cía. S.A.S. located in the city of Bogotá D.C., whose main activity is Legal Activities, where it will allow an in-depth identification of the different occupational hazards and risks that may arise within the company, determining the conditions in which the functions are carried out in each position that has the company. This research, under its general objective of designing a tool that allows the identification of occupational risks that may arise in the company La Fleche & Cía. S.A.S. Taking into account what is established by the Ministry of Labor through Decree 1072 of 2015, it bases its studies and research according to the results obtained through the methodology, collection method such as the surveys carried out on workers in the different work areas. of the company, which was applied electronically; in which the workers expressed their opinions, strengths and deficiencies about each of their work environments. The main intention of this project is that the company La Fleche & Cía. S.A.S. Know clearly and effectively what are the occupational hazards and risks to which your employees are exposed during the working day, such as: physical, chemical, ergonomic, psychosocial and environmental risks; In this way, we can analyze the possible consequences that may arise to provide a more specific knowledge of each position to Management, which is in charge of generating, promoting the protection and comprehensive care of healthy and safe work, offering a guarantee to workers

Growth factor-enriched autologous plasma improves wound healing after surgical debridement in odontogenic necrotizing fasciitis: a case report

<p>Abstract</p> <p>Background</p> <p>Odontogenic necrotizing fasciitis of the neck is a fulminant infection of odontogenic origin that quickly spreads along the fascial planes and results in necrosis of the affected tissues. It is usually polymicrobial, occurs frequently in immunocompromised patients, and has a high mortality rate.</p> <p>Case presentation</p> <p>A 69-year old Mexican male had a pain in the maxillar right-canine region and a swelling of the submental and submandibular regions. Our examination revealed local pain, tachycardia, hyperthermia (39°C), and the swelling of bilateral submental and submandibular regions, which also were erythematous, hyperthermic, crepitant, and with a positive Godet sign. Mobility and third-degree caries were seen in the right mandibular canine. Bacteriological cultures isolated <it>streptococcus pyogenes </it>and <it>staphylococcus aureus</it>. The histopathological diagnosis was odontogenic necrotizing fasciitis of the submental and submandibular regions. The initial treatment was surgical debridement and the administration of antibiotics. After cultures were negative, the surgical wound was treated with a growth factor-enriched autologous plasma eight times every third day until complete healing occurred.</p> <p>Conclusions</p> <p>The treatment with a growth factor-enriched autologous plasma caused a rapid healing of an extensive surgical wound in a patient with odontogenic necrotizing fasciitis. The benefits were rapid tissue regeneration, an aesthetic and a functional scar, and the avoidance of further surgery and possible complications.</p

Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer.

In resected non-small cell lung cancer (NSCLC), post-surgical recurrence occurs in around 40% of patients, highlighting the necessity to identify relapse biomarkers. An analysis of the extracellular vesicle (EV) cargo from a pulmonary tumor-draining vein (TDV) can grant biomarker identification. We studied the pulmonary TDV EV-miRNAome to identify relapse biomarkers in a two-phase study (screening and validation). In the screening phase, a 17-miRNA relapse signature was identified in 18 selected patients by small RNAseq. The most expressed miRNA from the signature (EV-miR-203a-3p) was chosen for further validation. Pulmonary TDV EV-miR-203a-3p was studied by qRT-PCR in a validation cohort of 70 patients, where it was found to be upregulated in relapsed patients (p = 0.0194) and in patients with cancer spread to nearby lymph nodes (N+ patients) (p = 0.0396). The ROC curve analysis showed that TDV EV-miR-203a-3p was able to predict relapses with a sensitivity of 88% (AUC: 0.67; p = 0.022). Moreover, patients with high TDV EV-miR-203a-3p had a shorter time to relapse than patients with low levels (43.6 vs. 97.6 months; p = 0.00703). The multivariate analysis showed that EV-miR-203a-3p was an independent, predictive and prognostic post-surgical relapse biomarker. In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients