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Medical-Legal Partnerships to Support Continuity of Care for Immigrants Impacted by HIV: Lessons Learned from California.
The United States (US) has experienced a surge of anti-immigrant policies and rhetoric, raising concerns about the influence on health outcomes for immigrants living in the US. We conducted qualitative interviews (n = 20) with health care and social service providers, attorneys, and legal/policy experts in California to understand how agencies were maintaining access to HIV care and prevention for immigrant clients. We conducted a thematic analysis to describe the role of medical-legal partnerships (MLPs) and document best practices. Informants reported high demand for legal services. Referrals were facilitated by case managers, medical providers, and pre-existing relationships between clinics and legal agencies. Informants identified a need for additional funding and further guidance on screening for and supporting patients with legal needs. MLPs have the capacity to create sustainable, efficient, comprehensive structural changes that minimize barriers to HIV prevention and treatment and improve health outcomes among immigrant populations
Final-State Interactions in the Superscaling Analysis of Neutral-Current Quasielastic Neutrino Scattering
Effects of strong final-state interactions in the superscaling properties of
neutral-current quasielastic neutrino cross sections are investigated using the
Relativistic Impulse Approximation as guidance. First- and second-kind scaling
are analyzed for neutrino beam energies ranging from 1 to 2 GeV for the cases
of 12C, 16O and 40Ca. Different detection angles of the outgoing nucleon are
considered in order to sample various nucleon energy regimes. Scaling of the
second kind is shown to be very robust. Validity of first-kind scaling is found
to be linked to the kinematics of the process. Superscaling still prevails even
in the presence of very strong final-state interactions, provided that some
kinematical restrains are kept, and the conditions under which superscaling can
be applied to predict neutral-current quasielastic neutrino scattering are
determined.Comment: 39 pages, 16 figures, accepted for publication in Phys. Rev.
Valence instability of cerium under pressure in the Kondo-like perovskite LaCeSrMnO
Effect of hydrostatic pressure and magnetic field on electrical resistance of
the Kondo-like perovskite manganese oxide,
LaCeSrMnO with a ferrimagnetic ground state, have
been investigated up to 2.1 GPa and 9 T. In this compound, the Mn-moments
undergo double exchange mediated ferromagnetic ordering at
280 K and there is a resistance maximum, at about 130 K which is
correlated with an antiferromagnetic ordering of {\it cerium} with respect to
the Mn-sublattice moments. Under pressure, the shifts to lower
temperature at a rate of d/d = -162 K/GPa and disappears at a
critical pressure 0.9 GPa. Further, the coefficient, of
term due to Kondo scattering decreases linearly with increase of
pressure showing an inflection point in the vicinity of . These
results suggest that {\it cerium} undergoes a transition from Ce state
to Ce/Ce mixed valence state under pressure. In contrast to
pressure effect, the applied magnetic field shifts to higher
temperature presumably due to enhanced ferromagnetic Mn moments.Comment: to be published in Phys. Rev. B (rapid commun
High energy neutrino oscillation at the presence of the Lorentz Invariance Violation
Due to quantum gravity fluctuations at the Planck scale, the space-time
manifold is no longer continuous, but discretized. As a result the Lorentz
symmetry is broken at very high energies. In this article, we study the
neutrino oscillation pattern due to the Lorentz Invariance Violation (LIV), and
compare it with the normal neutrino oscillation pattern due to neutrino masses.
We find that at very high energies, neutrino oscillation pattern is very
different from the normal one. This could provide an possibility to study the
Lorentz Invariance Violation by measuring the oscillation pattern of very high
energy neutrinos from a cosmological distance.Comment: 11 pages, 6 figure
On the toughness of thermoplastic polymer nanocomposites as assessed by the essential work of fracture (EWF) approach
The essential work of fracture (EWF) approach is widely used to determine the plane stress fracture toughness of highly ductile polymers and related systems. To shed light on how the toughness is affected by nanofillers EWF-suited model polymers, viz. amorphous copolyester and polypropylene block copolymer were modified by multiwall carbon nanotube (MWCNT), graphene (GR), boehmite alumina (BA), and organoclay (MMT) in 1 wt% each. EWF tests were performed on deeply double-edge notched tensile-loaded specimens under quasistatic loading conditions. Data reduction occurred by energy partitioning between yielding and necking/tearing. The EWF prerequisites were not met with the nanocomposites containing MWCNT and GR by contrast to those with MMT and BA. Accordingly, the toughness of nanocomposites with homogeneously dispersed and low aspect ratio fillers may be properly determined using the EWF. Results indicated that incorporation of nanofillers may result in an adverse effect between the specific essential and non-essential EWF parameters
Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: potential impact on angiogenesis and tumor growth
In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were analyzed by multiplex protein assays in conditioned medium (CM) from irradiated and non-irradiated CAFs. Additionally, the profile of secreted proteins was examined by proteomics. In functional assays, effects of CAF-CM on proliferative and migratory capacity of lung tumor cells (H-520/H-522) and endothelial cells (HUVECs), and on the tube-forming capacity of endothelial cells was assessed. Our data show that exposure of CAFs to ablative doses of ionizing radiation results in a) down-regulated release of angiogenic factors SDF-1, angiopoietin and thrombospondin-2; b) up-regulated release of growth factor bFGF from most donors, and c) unaffected expression-levels of HGF and inflammatory mediators IL-6, IL-8, IL-1ƒÒ and TNF-£. Conditioned medium from irradiated and control CAFs did not affect differently the proliferative or migratory capacity of tumor cells (H-520/H-522), whereas migratory capacity of endothelial HUVEC cells was partially reduced in the presence of irradiated CAF conditioned medium. Overall we conclude that AIR mediates a transformation on the secretory profile of CAFs that could influence the behavior of other cells in the tumor tissue and hence guide to some extent therapeutic outcomes. The downstream consequences of the changes observed in this study merits further investigations
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