Association between chronic irritability and depressive symptoms in children and adolescents.

Association between chronic irritability and depressive symptoms in children and adolescents. Busto-Garrido, M.; Gutierrez-Castillo, D; Navas- Gonzalez, JR; Gutierrez-Bedmar, M; Gutierrez-Casares, JR; Martin-Lunar, MT; Rodríguez-Rosado, A; Pena-Andreu, JM. European Psychiatry 415(2017) 5221.Chronic irritability is the most frequently reported symptom in child and adolescent depression. The association of both has been linked with high rates of chronicity, comorbility and impairment. Objectives To study the association between chronic irritability and depressive symptoms in children and adolescents. Methods We have studied 857 participants recruited from the only Child and Adolescent Mental Health Clinic in a catchment area of 122968 people under 18 (2004-2010). A sample of 677 participants (57 controls and 620 patients) was included to carry out a cross-sectional study. Chronic irritability was measured by a Visual Analog Scale (VAS irritability) -scored from 0 to 10-, and depressive symptoms by the Children's Depression Inventory (CDI). The participants were categorized into controls and patients, and according to their chronic irritability (≤4 [I],5 [II] and ≥6 [III]). The mean of CDI score was calculated for each of the groups, adjusted by sex and age, and analyzed by ANCOVA. Results The following means were obtained from the controls: 13,71 (group I), 9,82 (group II) and 17,45 (group III). Regarding to the patients: 13,92 (group I), 11,54 (group II) and 15,64 (group III). A quadratic association (p <0,0015) was found between VAS irritability score and CDI score. Conclussions There is not a lineal association between chronic irritability and depressive symptoms in children and adolescent. High rates of depressive symptoms were associated both with high and low rates of irritability. Several questions remain unexplained about the status of irritability in psychiatry as Stringaris group has been pointed out. Disclosure statement I have no potential conflict of interest to discloseUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Hotel y Resort 4 Estrellas en la Ciudad de Zorritos - Tumbes

El tema surgió debido a partir de un interés propio por contribuir al desarrollo turístico de la zona norte del país, según las estadísticas analizadas con las cuales contamos en el desarrollo de la tesis, se ha concluido que esta zona cuenta con las condiciones propicias para la realización de este proyecto. Es así que se propuso el desarrollo de un Hotel Resort 4 estrellas en la ciudad de Zorritos- Tumbes, con este proyecto se busca realzar el sector turístico, así como la inversión nacional y extranjera. Consideramos que la ciudad de tumbes se ha convertido en una ciudad de paso; ya que no cuenta con un espacio de recreación diferente y exclusivo alejado de la dinámica urbana aprovechando el eje costero en este caso las playas e integrándolo con el medio para satisfacer las necesidades del usuario turista, actualmente la inversión como el usuario ya mencionado dirige su interés hacia la ciudad vecina de Piura siendo esta una mejor opción para pasar unas vacaciones o unos días de relajo debido a que esta ciudad si explota los recursos con los cuales cuenta es ahí donde se centra el desarrollo de la tesis buscando la solución a los problemas como la insuficiente inversión nacional o privada que ha ocasionado la poca exigencia en la infraestructura y los servicios brindados al usuario así como el desinterés social que ha ocasionado que la población no tenga un crecimiento adecuado, a pesar de que el turismo presenta un crecimiento sostenido y ascendente; y consecuencia una alta rentabilidad para así ser viable cualquier proyecto de inversión en este sector. El negocio hotelero se convierte en un desafío en sí mismo personas que atienden personas; para ello es necesario contar además de la infraestructura adecuada con los recursos humanos idóneos. Actualmente existen 9 establecimientos hoteleros que según encuestas al usuario turista no cuentan con los servicios básicos para satisfacer sus necesidades o demandas es así que con la puesta en marcha del proyecto se busca generar un cambio en la manera que se vienen utilizando los recursos naturales presentes en la zona, principalmente de las playas, siempre respetando el entorno natural y social de la Provincia, de esta manera ser parte de un proyecto a futuro que fomente el aumento de la inversión público – privada, ofreciendo establecimientos con mejor infraestructura para el desarrollo de las actividades turísticas del lugar.Tesi

Exploring host genetic polymorphisms involved in SARS-CoV infection autcomes: implications for personalized medicine in COVID-19

Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments

Laboratory and industrial testing of silica bricks for coke ovens

In order to rationalize the reconstruction of coke ovens' walls in a local steelmaking, a set of laboratory and industrial tests was carried out on silica KN bricks. Two types of bricks that are currently used in oven construction were analyzed, one being less expensive than the other. On the other hand, 25 year-old original bricks were also studied. The results of laboratory tests were analyzed taking into account the requirements of DIN 1089 standard. Additionally, an evaluation of costs was carried out.Fil: Camerucci, Maria Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Tomba Martinez, Analia Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Cavalieri, Ana Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: de Córdova, M.. SIDERAR; ArgentinaFil: Beltrán, D.. SIDERAR; ArgentinaFil: Topolevsky, R.. SIDERAR; Argentin

Joint effect of physical activity and sedentary behaviour on cardiovascular risk factors in Chilean adults

Background: To investigate the associations between combined categories of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) with markers of adiposity and cardiovascular risk in adults. Methods: Overall, 5040 participants (mean age 46.4 years and 59.3% women) from the cross-sectional Chilean National Health Survey 2009–2010 were included in this study. MVPA and SB were measured using the Global Physical Activity questionnaire. Four categories were computed using MVPA- and SB-specific cut-offs (‘High-SB &#38; Active’, ‘Low-SB &#38; Active’, ‘High-SB &#38; Inactive’ and ‘Low-SB &#38; Inactive’). Results: Compared to the reference group (‘High-SB &#38; Inactive’), those in ‘High-SB &#38; Active’ and ‘Low-SB &#38; Active’ were less likely to have an obese BMI (OR: 0.67 [0.54; 0.85], P = 0.0001 and 0.74 [0.59; 0.92] P = 0.0007, respectively) and less likely to have metabolic syndrome (OR: 0.63 [0.49; 0.82], P &lt; 0.0001 and 0.72 [0.57; 0.91], P = 0.007), central obesity (OR: 0.79 [0.65; 0.96], P = 0.016 and 0.71 [0.59; 0.84], P &lt; 0.0001), diabetes (OR: 0.45 [0.35; 0.59], P &lt; 0.0001 and 0.44 [0.34; 0.56], P &lt; 0.0001) and hypertension (OR: 0.52 [0.43; 0.63], P &lt; 0.0001 and 0.60 [0.50; 0.72], P &lt; 0.0001), respectively. Conclusions: Being physically active and spending less time in SBs was associated with lower adiposity and improvements in cardiovascular risk factors

Presence of Gardnerella vaginalis in healthy portuguese women: a pilot study

Bacterial vaginosis (BV) has an important position worldwide, as the leading vaginal disorder in women, and affects 30-50% of African women and 10-20% of White women of reproductive age. This condition although not mortal causes great discomfort and may lead to other complications such as pre-term labour or increase susceptibility for HIV infection. During BV occur a decrease of Lactobacillus spp. present in the vaginal epithelium and an increase in the number of anaerobic microorganisms like Gardnerella vaginalis, Pretovella spp., Mobilincus spp.; Mycoplasma hominis and Atopobium vaginae. Gardnerella vaginalis is also responsible for the formation of a biofilm in the vaginal epithelium in sick women’s. However, the direct correlation between the pathology and the causing agent (or agents) has not been clearly established. Currently there is only one article in PubMed (Guerreiro et. al, 1998) referring to the prevalence of bacterial vaginosis in Portugal and we aim to extend the research in this field specifically to the portuguese population. As part of this effort one of our aims it to characterise the bacterial population of portuguese women both healthy and diagnosed with BV. As such we collected swab samples of vaginal fluids from protuguese women with the help of health professionals and using self collection. The swabs were collected and treated within 24 hours at the University of Minho for the characterization of the bacterial population present, by using conventional microbiological growth techniques, PNA-FISH microscopy and 16S PCR. It was found that about 20% of the samples tested possessed G. vaginalis and all possessed Lactobacillus spp. using all 3 identification techniques described. This result is consistent with previous reports of G. vaginalis prevalence althought slightly lower, and shows that traditional microbiological techniques, microscopy and molecular methods were consistent in terms of results

Binary metal oxides for composite ultrafiltration membranes

A new ultrafiltration membrane was developed by the incorporation of binary metal oxides inside polyethersulfone. Physico-chemical characterization of the binary metal oxides demonstrated that the presence of Ti in the TiO2?ZrO2 system results in an increase of the size of the oxides, and also their dispersity. The crystalline phases of the synthesized binary metal oxides were identified as srilankite and zirconium titanium oxide. The effect of the addition of ZrO2 can be expressed in terms of the inhibition of crystal growth of anocrystalline TiO2 during the synthesis process. For photocatalytic applications the band gap of the synthesized semiconductors was determined, confirming a gradual increase (blue shift) in the band gap as the amount of Zr loading increases. Distinct distributions of binary metal oxides were found along the permeation axis for the synthesized membranes. Particles with Ti are more uniformly dispersed throughout the membrane cross-section. The physico-chemical characterization of membranes showed a strong correlation between some key membrane properties and the spatial particle distribution in the membrane structure. The proximity of metal oxide fillers to the membrane surface determines the hydrophilicity and porosity of modified membranes. Membranes incorporating binary metal oxides were found to be promising candidates for wastewater treatment by ultrafiltration, considering the observed improvement influx and anti-fouling properties of doped membranes. Multi-run fouling tests of doped membranes confirmed the stability of permeation through membranes embedded with binary TiO2?ZrO2 particles

GOLD COPD DOCUMENT 2023: a brief update for practicing cardiologists.

Many patients seen by cardiologists suffer chronic obstructive pulmonary disease (COPD) in addition to their primary cardiovascular problem. Yet, quite often COPD has not been diagnosed and, consequently, patients have not been treated of their pulmonary disease. Recognizing and treating COPD in patients with CVDs is important because optimal treatment of the COPD carries important benefits on cardiovascular outcomes. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) publishes an annual report that serves as a clinical guideline for the diagnosis and management of COPD around the world and has very recently released the 2023 annual report. Here, we provide a summary of the GOLD 2023 recommendations that highlights those aspects of more interest for practicing cardiologists dealing with patients with CVD who may suffer COPD.S

Rapid fabrication of pressure-driven open-channel microfluidic devices in omniphobic RF paper

This paper describes the fabrication of pressure-driven, open-channel microfluidic systems with lateral dimensions of 45-300 microns carved in omniphobic paper using a craft-cutting tool. Vapor phase silanization with a fluorinated alkyltrichlorosilane renders paper omniphobic, but preserves its high gas permeability and mechanical properties. When sealed with tape, the carved channels form conduits capable of guiding liquid transport in the low-Reynolds number regime (i.e. laminar flow). These devices are compatible with complex fluids such as droplets of water in oil. The combination of omniphobic paper and a craft cutter enables the development of new types of valves and switches, such as “fold” valves and “porous switches,” which provide new methods to control fluid flow.Chemistry and Chemical Biolog

Vegetation Changes Following Biosolids Applications at an Old Boer Lovegrass Pasture in Northern Sonora, México

Short grass prairies (Bouteloua-Aristida) are the main vegetation type in northern Sonora, México, however, factors such as land fragmentation, overgrazing, severe droughts and lack of infrastructure in most ranches poor grazing management has caused land degradation. Boer lovegrass (Eragrostis curvula var. conferta) is an introduced species planted to increase productivity on deteriorated rangelands. Forage production with Boer lovegrass increases two to three fold as compared to native grasses after range seeding but productivity declines as stands become old. Biosolids have been recognized as a useful soil amendment and source of nitrogen, phosphorus, organic matter and other nutrients, which can enhance soil physical properties as well as plant yield (US Environmental Protection Agency 1999, Kinney et al. 2006). These organic compounds of human origins may play an important role in rangelands increasing soil fertility, however data do not exist to justify its use in México. This study was conducted to evaluate forage responses of old Boer lovegrass stands to biosolids applications