National and International Dimension in Indonesia's Exclusive Economic Zone

With both national and International dimensions influencing the utilization of marine fisheries resources in Indonesia's Exclusive Economic Zone, a comprehensive regulation is needed. Hence the importance of making sure that National Regulations are in accordance with International Regulations, while still maintaining the best of interests for the people and accommodating for the people's welfare. In reality, International community depends heavily on natural marine fisheries resources for their people's nutrients need

Seeking And Evaluating The Regulations Of Indonesia's Exclusive Economic Zone

Regulation is the cornerstone for utilizing marine fisheries resources, and thus Indonesian Government had implemented its Constitution as basic laws and rules. Those regulations need further elaboration. Therefore, Indonesian Government established sets of laws related to the utilization of marine fisheries resources, and in its implementation, those laws and regulations should never deviate from the Constitution of the Republic of Indonesia. The utilization of marine fisheries resources in Indonesia's Exclusive Economic Zone enables the possibility of cooperation and colaboration with other countries. Therefore, Indonesia is required to seek by evaluating and complementing the laws in accordance with its Constitution. Pengaturan merupakan landasan utama pemanfaatan sumber daya perikanan, Indonesia telah menyiapkan aturan dasar yaitu Landasan Konstitusional. Pengaturan tersebut perlu penjabaran lebih lanjut. Oleh karena itu Indonesia membentuk aturan-aturan yang terkait dengan pemanfaatan sumber daya ikan dan dalam implementasinya aturan tersebut tidak boleh menyimpang dari aturan yang paling dasar. Pemanfaatan sumber daya ikan di Zona Ekonomi Eksklusif adalah pemanfaatan yang memungkinkan adanya pemanfaatan berbagi dengan negara lain maka Indonesia dituntut untuk segera dapat mencari dengan cara mengevaluasi dan melengkapi aturan sesuai dengan Landasan Konstitusional

Endovenous laser ablation: the role of intraluminal blood

AbstractObjectiveIn this histological study, the role of the intraluminal blood during endovenous laser ablation was assessed.MethodsIn 12 goats, 24 lateral saphenous veins were treated with a 1500-nm diode laser. Four goats were treated in an anti-Trendelenburg position (group 1). The next four goats were treated in a Trendelenburg position (group 2) and the remaining four goats in the Trendelenburg position with additional injection of tumescent liquid (group 3). Postoperatively, the veins were removed after 1 week and sent for histological examination. We measured the number of perforations. Vein wall necrosis and the perivenous tissue destruction were quantified using a graded scale.ResultsThe ‘calculated total vein wall destruction’ was significantly higher in the third group (81.83%), as compared with groups one (61.25%) (p < 0.001) and two (65.92%) (p < 0.001). All three groups showed a significant difference in the perivenous tissue destruction scale (p < 0.001) with the lowest score occurring in the third group. Vein wall perforations were significantly more frequent in groups one and two as compared with the third group (T-test respectively p < 0.001, p = 0.02).ConclusionA higher intraluminal blood volume results in reduced total vein wall destruction. Injection of tumescent liquid prevents the perivenous tissue destruction and minimises the number of perforations

Evaluation of the phosphomannose isomerase-based selection system for gene transfer in grape

The suitability of the PMI-based system for efficient gene transfer in grape was assessed on V. vinifera ‘Brachetto’ and ‘Chardonnay’ and the rootstock '110 Richter'. The effect of mannose on non-transformed tissues was evaluated during a long culture period in the crucial stages of morphogenesis from callus to plantlet. Grape tissues of the genotypes used were affected by mannose as the carbohydrate source, damage, however, appeared after extremely long culture times. In addition, plantlets were regenerated from embryogenic calli after co-culture with Agrobacterium LBA 4404 carrying the manA gene in the PMI-GUS-Intron plasmid based on the pNOV2819 vector by Syngenta (Positech® system). Plants recovered after selection in the presence of mannose were found to be non-transgenic for the manA gene. Accordingly, PMI seems to be an unsuitable alternative to traditional marker gene selection for successful gene transfer in grape.

Relaxation times of kinetically constrained spin models with glassy dynamics

We analyze the density and size dependence of the relaxation time $\tau$ for kinetically constrained spin systems. These have been proposed as models for strong or fragile glasses and for systems undergoing jamming transitions. For the one (FA1f) or two (FA2f) spin facilitated Fredrickson-Andersen model at any density $\rho<1$ and for the Knight model below the critical density at which the glass transition occurs, we show that the persistence and the spin-spin time auto-correlation functions decay exponentially. This excludes the stretched exponential relaxation which was derived by numerical simulations. For FA2f in $d\geq 2$, we also prove a super-Arrhenius scaling of the form $\exp(1/(1-\rho))\leq \tau\leq\exp(1/(1-\rho)^2)$. For FA1f in $d$=$1,2$ we rigorously prove the power law scalings recently derived in \cite{JMS} while in $d\geq 3$ we obtain upper and lower bounds consistent with findings therein. Our results are based on a novel multi-scale approach which allows to analyze $\tau$ in presence of kinetic constraints and to connect time-scales and dynamical heterogeneities. The techniques are flexible enough to allow a variety of constraints and can also be applied to conservative stochastic lattice gases in presence of kinetic constraints.Comment: 4 page

Polarized and Unpolarized Nucleon Structure Functions from Lattice QCD

We report on a high statistics quenched lattice QCD calculation of the deep-inelastic structure functions $F_1$, $F_2$, $g_1$ and $g_2$ of the proton and neutron. The theoretical basis for the calculation is the operator product expansion. We consider the moments of the leading twist operators up to spin four. Using Wilson fermions the calculation is done for three values of $\kappa$, and we perform the extrapolation to the chiral limit. The renormalization constants, which lead us from lattice to continuum operators, are calculated in perturbation theory to one loop order.Comment: 17 pages, uuencoded postscript file. Renormalization constant of now include

The cell cycle checkpoint inhibitors in the treatment of leukemias

open3noThe study was funded by the University of Bologna and by the Italian Association for Cancer Research (AIRC).The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several clinical trials in cancer patients. Although the great amount of pre-clinical and clinical data are from the solid tumor experience, only few studies have been done on leukemias using specific cell cycle checkpoint inhibitors. This review aims to summarize the most recent data found on the biological mechanisms of the response to DNA damages highlighting the role of the different elements of the DDR pathway in normal and cancer cells and focusing on the main genetic alteration or aberrant gene expression that has been found on acute and chronic leukemias. This review, for the first time, outlines the most important pre-clinical and clinical data available on the efficacy of cell cycle checkpoint inhibitors in single agent and in combination with different agents normally used for the treatment of acute and chronic leukemias.openGhelli Luserna di Rora', A; Iacobucci, I; Martinelli, GGhelli Luserna di Rora', A; Iacobucci, I; Martinelli,