Identifying rent pressures [on housing market] in your neighbourhood: a new model of Irish regional rent indicators. ESRI WP567, June 2017

Since 2013, researchers in the Economic and Social Research Institute (ESRI) have compiled a hedonic rental index for the Residential Tenancies Board (RTB). The indicator estimates a standardised rental index on a national, Dublin and outside of Dublin basis based on the 950,000 rental properties registered with the RTB. The provision in late 2016 of detailed geographical identifiers has enabled an alternative series of indicators to be estimated. In particular, hedonic rental indicators for 137 local electoral areas (LEAs) are now available on a quarterly basis from 2007 quarter 3 to 2016 quarter 4. By providing a more accurate assessment of regional trends in rental supply and demand, the indicators should enable a more precise implementation of policies in the rental market. They should also serve as a proxy for measuring underlying economic activity in these regions on an ongoing basis

Implications of Domestic Support Disciplines for Further Agricultural Trade Liberalization

This paper employs the GTAP computable general equilibrium model and dataset to analyse the implications of domestic support reductions in the context of agricultural trade liberalisation. Three specific issues are addressed: overhang in domestic support, the accurate distinction of the boxes in the GTAP dataset and the treatment of market price support in the amber box. An extensive domestic support database is used to calculate the change in applied domestic support rates from a specified cut in bound rates, and to identify the impact on the different domestic support boxes and the required reductions in each support category. The GTAP model is extended to incorporate an explicit representation of the market price support element of the AMS. The results from these extensions of the standard database and model support the view that the impact of an agreement to reduce domestic support will be limited and lower than conventionally estimated. Results of simulations combining domestic support cuts with market access and export competition disciplines show that the effect of import tariff reductions dominate the gains from domestic support cuts once full account is taken of the issues addressed in this paper.WTO agricultural negotiations, domestic support, agricultural protection, Aggregate Measure of Support

Efficient endoscope inner channel surface disinfection using a two-step atmospheric pressure plasma treatment

Flexible endoscopes are ubiquitously used in modern medicine to diagnose and treat a variety of gastrointestinal ailments; however, the inner channels of these complex devices provide an ideal environment for biofilm development. Incomplete or ineffective endoscope reprocessing introduces the potential for cross-contamination between patients, highlighting the need for a new approach to disinfection. In this study, the antibiofilm potential of a two-step disinfection process using cold atmospheric pressure plasma and plasma activated water is considered. It was revealed that the combined approach achieved a 5.72 log reduction of clinically relevant mixed species biofilms from the narrow lumens found within a typical endoscope. To investigate potential surface damage resulting from the decontamination process, the surface composition and morphology were examined using XPS, FTIR and AFM. Following multiple disinfection cycles, few changes to the surface composition or morphology were detected and the corresponding ability of bacteria to adhere on the surface was not enhanced

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

Background Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. Methods We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosis < 60) and 141 non-aggressive (low clinical grade, age of diagnosis ≥60) PrCa cases. We conducted rare variant association analyses at gene and gene set levels using SKAT and Bayesian risk index techniques. GO term enrichment analysis was performed for genes with the highest differential burden of rare disruptive variants. Results Protein truncating variants (PTVs) in specific DNA repair genes were significantly overrepresented among patients with the aggressive phenotype, with BRCA2, ATM and NBN the most frequently mutated genes. Differential burden of rare variants was identified between metastatic and non-aggressive cases for several genes implicated in angiogenesis, conferring both deleterious and protective effects. Conclusions Inherited PTVs in several DNA repair genes distinguish aggressive from non-aggressive PrCa cases. Furthermore, inherited variants in genes with roles in angiogenesis may be potential predictors for risk of metastases. If validated in a larger dataset, these findings have potential for future clinical application

High resolution ancient sedimentary DNA shows that alpine plant diversity is associated with human land use and climate change.

The European Alps are highly rich in species, but their future may be threatened by ongoing changes in human land use and climate. Here, we reconstructed vegetation, temperature, human impact and livestock over the past ~12,000 years from Lake Sulsseewli, based on sedimentary ancient plant and mammal DNA, pollen, spores, chironomids, and microcharcoal. We assembled a highly-complete local DNA reference library (PhyloAlps, 3923 plant taxa), and used this to obtain an exceptionally rich sedaDNA record of 366 plant taxa. Vegetation mainly responded to climate during the early Holocene, while human activity had an additional influence on vegetation from 6 ka onwards. Land-use shifted from episodic grazing during the Neolithic and Bronze Age to agropastoralism in the Middle Ages. Associated human deforestation allowed the coexistence of plant species typically found at different elevational belts, leading to levels of plant richness that characterise the current high diversity of this region. Our findings indicate a positive association between low intensity agropastoral activities and precipitation with the maintenance of the unique subalpine and alpine plant diversity of the European Alps

RNA recognition by human TLR8 can lead to autoimmune inflammation.

Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed severe inflammation targeting the pancreas, salivary glands, and joints; and the severity of the specific phenotypes closely correlated with the huTLR8 expression levels. Mice with relatively low expression levels survived and bred successfully but had increased susceptibility to collagen-induced arthritis, and the levels of huTLR8 correlated with proinflammatory cytokines in the joints of the animals. At the cellular level, huTLR8 signaling exerted a DC-intrinsic effect leading to up-regulation of co-stimulatory molecules and subsequent T cell activation. A pathogenic role for TLR8 in human diseases was suggested by its increased expression in patients with systemic arthritis and the correlation of TLR8 expression with the elevation of IL-1β levels and disease status. We found that the consequence of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from those related to TLR7 signaling, and points to specific inflammatory diseases that may benefit from inhibition of TLR8 in humans