Connecting nth order generalised quantum Rabi models: Emergence of nonlinear spin-boson coupling via spin rotations

We establish an approximate equivalence between a generalised quantum Rabi model and its nth order counterparts where spin-boson interactions are nonlinear as they comprise a simultaneous exchange of $n$ bosonic excitations. Although there exists no unitary transformation between these models, we demonstrate their equivalence to a good approximation in a wide range of parameters. This shows that nonlinear spin-boson couplings, i.e. nth order quantum Rabi models, are accessible to quantum systems with only linear coupling between boson and spin modes by simply adding spin rotations and after an appropriate transformation. Furthermore, our result prompts novel approximate analytical solutions to the dynamics of the quantum Rabi model in the ultrastrong coupling regime improving previous approaches.Comment: 9 pages, 3 figures plus Supplemental Informatio

El papel moderador de la frecuencia de visitas en la influencia de la venta orientada y la venta ética en las variables relacionales del cliente

El presente trabajo se enmarca dentro del paradigma relacional de la venta personal, en un contexto de empresas industriales de pequeño y mediado tamaño (PYMES). Supone una aportación a la literatura de ventas en tanto se analizan simultáneamente los efectos de la venta orientada al cliente y la venta ética sobre la satisfacción, confianza y lealtad con la empresa proveedora. Asimismo, se estudia el efecto intensificador de la frecuencia de visitas sobre los efectos de la venta orientada y la venta ética en la satisfacción y la confianza. Se diseñó una muestra de conveniencia formada por 600 clientes de varios distribuidores de maquinaria industrial. Para la recogida de datos se utilizó la encuesta postal, obteniéndose 341 cuestionarios válidos. Los análisis preliminares confirman el efecto de los comportamientos relacionales sobre los resultados planteados y el efecto moderador de la frecuencia de visitas

Learning Physics from Data: a Thermodynamic Interpretation

Experimental data bases are typically very large and high dimensional. To learn from them requires to recognize important features (a pattern), often present at scales different to that of the recorded data. Following the experience collected in statistical mechanics and thermodynamics, the process of recognizing the pattern (the learning process) can be seen as a dissipative time evolution driven by entropy from a detailed level of description to less detailed. This is the way thermodynamics enters machine learning. On the other hand, reversible (typically Hamiltonian) evolution is propagation within the levels of description, that is also to be recognized. This is how Poisson geometry enters machine learning. Learning to handle free surface liquids and damped rigid body rotation serves as an illustration.Comment: Submitted to the proceedings of the Les Houches Summer Schoo

Control de una silla de ruedas a través de un sistema BCI basado en la discriminación de dos tareas mentales

Dicho trabajo ha sido publicado en la revista Cognitive Area Networks, vol. 1, nº1, junio 2014, pp. 43-48.En este trabajo se presenta una propuesta de control de una silla de ruedas a través de una interfaz cerebro computadora mediante la discriminación de sólo dos tareas mentales. Con el paradigma de control propuesto se pretende minimizar los porcentajes de error en la clasificación de estados mentales, proporcionando a su vez un conjunto suficiente de comandos que permita dirigir la silla de ruedas en todas direcciones (avanzar, retroceder, girar a la derecha, girar a la izquierda y parar).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Design of a case management model for people with chronic disease (Heart Failure and COPD). Phase I: modeling and identification of the main components of the intervention through their actors: patients and professionals (DELTA-ICE-PRO Study

Background Chronic diseases account for nearly 60% of deaths around the world. The extent of this silent epidemic has not met determined responses in governments, policies or professionals in order to transform old Health Care Systems, configured for acute diseases. There is a large list of research about alternative models for people with chronic conditions, many of them with an advanced practice nurse as a key provider, as case management. But some methodological concerns raise, above all, the design of the intervention (intensity, frequency, components, etc). Methods/Design Objectives: General: To develop the first and second phases (theorization and modeling) for designing a multifaceted case-management intervention in people with chronic conditions (COPD and heart failure) and their caregivers. Specific aims: 1) To identify key events in people living with chronic disease and their relation with the Health Care System, from their point of view. 2) To know the coping mechanisms developed by patients and their caregivers along the story with the disease. 3) To know the information processing and its utilization in their interactions with health care providers. 4) To detect potential unmet needs and the ways deployed by patients and their caregivers to resolve them. 5) To obtain a description from patients and caregivers, about their itineraries along the Health Care System, in terms of continuity, accessibility and comprehensiveness of care. 6) To build up a list of promising case-management interventions in patients with Heart Failure and COPD with this information in order to frame it into theoretical models for its reproducibility and conceptualization. 7) To undergo this list to expert judgment to assess its feasibility and pertinence in the Andalusian Health Care. Design: Qualitative research with two phases: For the first five objectives, a qualitative technique with biographic stories will be developed and, for the remaining objectives, an expert consensus through Delphi technique, on the possible interventions yielded from the first phase. The study will be developed in the provinces of Almería, Málaga and Granada in the Southern Spain, from patients included in the Andalusian Health Care Service database with the diagnosis of COPD or Heart Failure, with the collaboration of case manager nurses and general practitioners for the assessment of their suitability to inclusion criteria. Patients and caregivers will be interviewed in their homes or their Health Centers, with their family or their case manager nurse as mediator. Discussion First of a series of studies intended to design a case-management service for people with heart failure and COPD, in the Andalusian Health Care System, where case management has been implemented since 2002. Accordingly with the steps of a theoretical model for complex interventions, in this study, theorization and intervention modeling phases will be developed.This research was carried out with the support of one research grant, awarded by the Regional Health Ministry of Andalusia (Exp. 0222/2008

Cultura tributaria y obligaciones tributarias en los comerciantes de calzado del Mercado Micaela Bastidas de la ciudad de Juliaca - 2019

La finalidad de este trabajo de investigación es determinar cómo se relaciona la cultura tributaria con las obligaciones tributarias en los comerciantes de calzado del Mercado Micaela Bastidas de la ciudad de Juliaca – 2019, como objetivo específico es determinar qué relación existe entre la normatividad tributaria y la obligación sustancial, y determinar cuál es la relación entre los valores y la obligación formal, la investigación es de tipo cuantitativo, descriptivo, correlacional, desarrollada bajo el diseño no experimental de corte transversal, para el procesamiento de datos, se utilizó el instrumento de un cuestionario sobre cultura tributaria y obligaciones tributarias que consta de 20 preguntas, las cuales fueron validadas por juicio de expertos. Con un valor de fiabilidad de instrumento con el alpha de Cronbach donde se obtuvo 0.896 que representa una alta fiabilidad. Este instrumento fue aplicado a una muestra de 98 comerciantes y se tuvo como resultados según la prueba de Pearson. Como resultados se obtuvo con una r = 0.630 (significancia = .000) lo que significa que existe una correlación positiva moderada entre la variable cultura tributaria y obligaciones tributarias. La relación entre normatividad tributaria y obligación sustancial con una r = 0.399 (significancia = .000) lo que significa que existe una correlación positiva baja y relación entre los valores y obligación formal con una r = 0.608 (significancia = .000) lo que significa que existe una correlación positiva moderada. Se concluye que existe una relación significativa.Trabajo de investigaciónJULIACAEscuela Profesional de ContabilidadTributo

Rapid vesicle replenishment after the immediately releasable pool exocytosis is tightly linked to fast endocytosis, and depends on basal calcium and cortical actin in chromaffin cells

The maintenance of the secretory response requires a continuous replenishment of releasable vesicles. It was proposed that the immediately releasable pool (IRP) is important in chromaffin cell secretion during action potentials applied at basal physiological frequencies, because of the proximity of IRP vesicles to voltage-dependent Ca2+ channels. However, previous reports showed that IRP replenishment after depletion is too slow to manage such a situation. In this work, we used patch-clamp measurements of membrane capacitance, confocal imaging of F-actin distribution, and cytosolic Ca2+ measurements with Fura-2 to re-analyze this problem in primary cultures of mouse chromaffin cells. We provide evidence that IRP replenishment has one slow (time constant between 5 and 10 s) and one rapid component (time constant between 0.5 and 1.5 s) linked to a dynamin-dependent fast endocytosis. Both, the fast endocytosis and the rapid replenishment component were eliminated when 500 nM Ca2+ was added to the internal solution during patch-clamp experiments, but they became dominant and accelerated when the cytosolic Ca2+ buffer capacity was increased. In addition, both rapid replenishment and fast endocytosis were retarded when cortical F-actin cytoskeleton was disrupted with cytochalasin D. Finally, in permeabilized chromaffin cells stained with rhodamine-phalloidin, the cortical F-actin density was reduced when the Ca2+ concentration was increased in a range of 10–1000 nM. We conclude that low cytosolic Ca2+ concentrations, which favor cortical F-actin stabilization, allow the activation of a fast endocytosis mechanism linked to a rapid replenishment component of IRP. (Figure presented.).Fil: Montenegro, Mauricio Norman. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Bayonés, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Moya Diaz, José Abelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Borassi, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gallo, Luciana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Marengo, Fernando Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentin