Urban Agriculture and Community Food Security in the United States: Farming from the City Center To the Urban Fringe

Urban Agriculture and Community Food Security in the United States: Farming from the City Center To the Urban Fringe is prepared by the Urban Agriculture Committee of the Community Food Security Coalition to raise awareness of the ways that urban agriculture can respond to food insecurity. The document advocates for policies that promote small-scale urban and peri-urban farming, and thereby prepare the next generation of urban farming leaders

First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation

In this issue, Zhang et al. (2017) report the birth of a healthy boy after mitochondrial replacement therapy (MRT) by spindle transfer to prevent transmission of mitochondrial disease from mother to child. The case was first publicized in the lay press (Hamzelou, 2016; see also editorial by Johnson, 2016) and then presented during the 2016 Annual Meeting of the American Society for Assisted Reproduction (ASRM) in October 2016 (Zhang et al., 2016a). It followed an earlier report of an unsuccessful attempt at MRT by pronuclear transfer by the same group (Zhang et al., 2016b). This world-first birth represents an achievement and a steppingstone, and it has played a role in encouraging the Human Fertilization and Embryology Authority (HFEA) in the UK to issue a final recommendation that the technique ‘be approved for cautious use in specific circumstances’. (http://www.hfea.gov.uk/10559.html) We, the editors, were unanimous in deciding that this paper should be published in RBMO, based on our conviction that the scientific community must be informed of the details of the work in full in order to evaluate it critically and discuss it openly. We decided this despite the fact that the work has weaknesses and limitations in a number of areas. Moreover, although we were able to encourage the authors to include more details of their work in the submission, some uncertainties concerning methodologies and results still remain. Here we outline our concerns regarding the approach and the treatment process described by Zhang and colleagues

Winter Mass Mortality of Animals in Texas Bays

The Texas coast experienced three unusually cold weather periods in the 1980\u27s, one in 1983 and two in 1989, that caused massive fish kills. Identification of organisms killed and estimation of the number of estuarine fishes and invertebrates killed was accomplished through a systematic standardized approach utilizing airplanes, ground qualitative observations and quantitative counts, and trawling. Of 159 species identified, 103 were fishes, 45 were invertebrates, and 11 were vertebrates other than fishes. About 14 million fishes were killed in December 1983, 11 million in February 1989 and 6 million in December 1989; number of invertebrates killed ranged from 13,000 in February 1989 to 1,000,000 in 1983. These assessments are the largest in area and most comprehensive to be documented in the literature with known levels of precision. Methodology used provides reasonably precise estimates which managers can use to assess extensive widespread kills and subsequent impacts on affected populations. It is recommended that managers consider reducing fishing mortality on the remaining economically important populations after extensive kills to speed recovery of those populations

Robust resource allocation in weather data processing systems

Includes bibliographical references (pages [9-10]).Reliability of weather data processing systems is of prime importance to ensure the efficient operation of space-based weather monitoring systems. This work defines a heterogeneous weather data processing system that is susceptible to uncertainties in data set arrival times. The resource allocation must be robust with respect to these uncertainties. The tasks to be executed by the data processing system are classified into three broad categories: telemetry, tracking and control (high priority); data processing (medium priority); and data research (low priority).The high priority tasks must be completed before considering medium and low priority tasks. The goal of this research is to find a resource allocation that minimizes makespan of the high priority tasks, and to find a mapping that maximizes a function of the completion time and priority of the medium and low priority tasks. Different heuristic techniques to find near optimal solutions are studied, and their performance is evaluated

Dendritic Cell-Mediated, DNA-Based Vaccination Against Hepatitis C Induces the Multi-Epitope-Specific Response of Humanized, HLA Transgenic Mice

Hepatitis C virus (HCV) is the etiologic agent of chronic liver disease, hepatitis C. Spontaneous resolution of viral infection is associated with vigorous HLA class I- and class II-restricted T cell responses to multiple viral epitopes. Unfortunately, only 20% of patients clear infection spontaneously, most develop chronic disease and require therapy. The response to chemotherapy varies, however; therapeutic vaccination offers an additional treatment strategy. To date, therapeutic vaccines have demonstrated only limited success. Vector-mediated vaccination with multi-epitope-expressing DNA constructs alone or in combination with chemotherapy offers an additional treatment approach. Gene sequences encoding validated HLA-A2- and HLA-DRB1-restricted epitopes were synthesized and cloned into an expression vector. Dendritic cells (DCs) derived from humanized, HLA-A2/DRB1 transgenic (donor) mice were transfected with these multi-epitope-expressing DNA constructs. Recipient HLA-A2/DRB1 mice were vaccinated s.c. with transfected DCs; control mice received non-transfected DCs. Peptide-specific IFN-γ production by splenic T cells obtained at 5 weeks post-immunization was quantified by ELISpot assay; additionally, the production of IL-4, IL-10 and TNF-α were quantified by cytokine bead array. Splenocytes derived from vaccinated HLA-A2/DRB1 transgenic mice exhibited peptide-specific cytokine production to the vast majority of the vaccine-encoded HLA class I- and class II-restricted T cell epitopes. A multi-epitope-based HCV vaccine that targets DCs offers an effective approach to inducing a broad immune response and viral clearance in chronic, HCV-infected patients

Probing for Exoplanets Hiding in Dusty Debris Disks: Disk Imaging, Characterization, and Exploration with HST/STIS Multi-Roll Coronagraphy

Spatially resolved scattered-light images of circumstellar (CS) debris in exoplanetary systems constrain the physical properties and orbits of the dust particles in these systems. They also inform on co-orbiting (but unseen) planets, systemic architectures, and forces perturbing starlight-scattering CS material. Using HST/STIS optical coronagraphy, we have completed the observational phase of a program to study the spatial distribution of dust in ten CS debris systems, and one "mature" protoplanetrary disk all with HST pedigree, using PSF-subtracted multi-roll coronagraphy. These observations probe stellocentric distances > 5 AU for the nearest stars, and simultaneously resolve disk substructures well beyond, corresponding to the giant planet and Kuiper belt regions in our Solar System. They also disclose diffuse very low-surface brightness dust at larger stellocentric distances. We present new results inclusive of fainter disks such as HD92945 confirming, and better revealing, the existence of a narrow inner debris ring within a larger diffuse dust disk. Other disks with ring-like sub-structures, significant asymmetries and complex morphologies include: HD181327 with a posited spray of ejecta from a recent massive collision in an exo-Kuiper belt; HD61005 suggested interacting with the local ISM; HD15115 & HD32297, discussed also in the context of environmental interactions. These disks, and HD15745, suggest debris system evolution cannot be treated in isolation. For AU Mic's edge-on disk, out-of-plane surface brightness asymmetries at > 5 AU may implicate one or more planetary perturbers. Time resolved images of the MP Mus proto-planetary disk provide spatially resolved temporal variability in the disk illumination. These and other new images from our program enable direct inter-comparison of the architectures of these exoplanetary debris systems in the context of our own Solar System.Comment: 109 pages, 43 figures, accepted for publication in the Astronomical Journa

Detectors and cryostat design for the SuMIRe Prime Focus Spectrograph (PFS)

We describe the conceptual design of the camera cryostats, detectors, and detector readout electronics for the SuMIRe Prime Focus Spectrograph (PFS) being developed for the Subaru telescope. The SuMIRe PFS will consist of four identical spectrographs, each receiving 600 fibers from a 2400 fiber robotic positioner at the prime focus. Each spectrograph will have three channels covering wavelength ranges 3800 {\AA} - 6700 {\AA}, 6500 {\AA} - 10000 {\AA}, and 9700 {\AA} - 13000 {\AA}, with the dispersed light being imaged in each channel by a f/1.10 vacuum Schmidt camera. In the blue and red channels a pair of Hamamatsu 2K x 4K edge-buttable CCDs with 15 um pixels are used to form a 4K x 4K array. For the IR channel, the new Teledyne 4K x 4K, 15 um pixel, mercury-cadmium-telluride sensor with substrate removed for short-wavelength response and a 1.7 um cutoff will be used. Identical detector geometry and a nearly identical optical design allow for a common cryostat design with the only notable difference being the need for a cold radiation shield in the IR camera to mitigate thermal background. This paper describes the details of the cryostat design and cooling scheme, relevant thermal considerations and analysis, and discusses the detectors and detector readout electronics

Tracking counterpart signatures in Saturn's auroras and ENA imagery during large-scale plasma injection events

Saturn's morningside auroras consist mainly of rotating, transient emission patches, following periodic reconnection in the magnetotail. Simultaneous responses in global energetic neutral atom (ENA) emissions have been observed at similar local times, suggesting a link between the auroras and large‐scale injections of hot ions in the outer magnetosphere. In this study, we use Cassini's remote sensing instruments to observe multiple plasma injection signatures within coincident auroral and ENA imagery, captured during 9 April 2014. Kilometric radio emissions also indicate clear injection activity. We track the motion of rotating signatures in the auroras and ENAs to test their local time relationship. Two successive auroral signatures—separated by ~4 hr UT—form postmidnight before rotating to the dayside while moving equatorward. The first has a clear ENA counterpart, maintaining a similar local time mapping throughout ~9 hr observation. Mapping of the ionospheric equatorward motion post‐dawn indicates a factor ~5 reduction of the magnetospheric source region's radial speed at a distance of ~14‐20 RS, possibly a plasma or magnetic boundary. The second auroral signature has no clear ENA counterpart; viewing geometry was relatively unchanged, so the ENAs were likely too weak to detect by this time. A third, older injection signature, seen in both auroral and ENA imagery on the nightside, may have been sustained by field‐aligned currents linked with the southern planetary period oscillation system, or the re‐energization of ENAs around midnight local times. The ENA injection signatures form near magnetic longitudes associated with magnetotail thinning

The GALEX Ultraviolet Atlas of Nearby Galaxies

We present images, integrated photometry, and surface-brightness and color profiles for a total of 1034 nearby galaxies recently observed by the Galaxy Evolution Explorer (GALEX) satellite in its far-ultraviolet (FUV; λ_(eff) = 1516 Å) and near-ultraviolet (NUV; λ_(eff) = 2267 Å) bands. Our catalog of objects is derived primarily from the GALEX Nearby Galaxies Survey (NGS) supplemented by galaxies larger than 1' in diameter serendipitously found in these fields and in other GALEX exposures of similar of greater depth. The sample analyzed here adequately describes the distribution and full range of properties (luminosity, color, star formation rate [SFR]) of galaxies in the local universe. From the surface brightness profiles obtained we have computed asymptotic magnitudes, colors, and luminosities, along with the concentration indices C31 and C42. We have also morphologically classified the UV surface brightness profiles according to their shape. This data set has been complemented with archival optical, near-infrared, and far-infrared fluxes and colors. We find that the integrated (FUV − K) color provides robust discrimination between elliptical and spiral/irregular galaxies and also among spiral galaxies of different subtypes. Elliptical galaxies with brighter K-band luminosities (i.e., more massive) are redder in (NUV − K) color but bluer in (FUV − NUV) (a color sensitive to the presence of a strong UV upturn) than less massive ellipticals. In the case of the spiral/irregular galaxies our analysis shows the presence of a relatively tight correlation between the (FUV − NUV) color (or, equivalently, the slope of the UV spectrum, β) and the total infrared-to-UV ratio. The correlation found between (FUV − NUV) color and K-band luminosity (with lower luminosity objects being bluer than more luminous ones) can be explained as due to an increase in the dust content with galaxy luminosity. The images in this Atlas along with the profiles and integrated properties are publicly available through a dedicated Web page