Apologia of Modernity

Received 6 June 2017. Accepted 21 August 2017. Published online 29 September 2017.The article considers key factors and directions of the value-institutional evolution of Modernity as a political project. It is argued that the movement of humankind towards the globalised world paradoxically turned not into a denial, but rather into a consistent radicalisation of the axiological political foundations of Modernity. The thesis of the axiological unity and institutional diversity of global Modernity is advanced in opposition to the concept of pluralist modernity as a rhetorically veiled civilisational approach. It is asserted that the constant self-adjustment of the central value system of globalised Modernity is carried out in the context of a non-simultaneity effect, providing grounds for discussions about the insurmountability of pre-modern cultural barriers and traditions of different civilisations. The conclusion is justified that the success of the globalisation of Modernity is contingent upon the possibility of building out the already existing world economy to include world politics, since the economic assimilation of the world by capitalism has largely outstripped the counterbalancing possibilities of its global political regulatory and compensatory systems, contributing to the intensification of conflicts and various inequalities. The increasingly intensive interaction and interdependence of humanity at the global level first implies the creation of ethical mechanisms of world politics based on concern for the interests of humanity as a whole. In seeking the solution to this problem, it is increasingly necessary to go beyond archaised political forms and the logic of decision-making that relates to territorial nation-states. In the discussion about the ethical and political values and institutions of the global, second or late Modernity, the positionsof those subjects capable of presenting a moral game to humanity – open, egalitarian, universal, cosmopolitan approaches for solving general problems – will be a priori strengthened

Strategi Komunikasi Riau Vaper Community dalam Kampanye Anti Rokok pada Usia Remaja di Kota Pekanbaru

Based on data from the Ministry of Health, Riau Province included into the top 5 highest register of the smokers in adolescence with a percentage of 51.3%. As for the city of Pekanbaru, according to data from the Provincial Health Office of Riau percentage of smokers at an early age is increasing every year. The purpose of the study is to determine the communication strategy used by Riau Vaper Community as one community in Pekanbaru city that has a special concern with tobacco cigarettes and tried to give the campaign a way to educate the youth who are vulnerable to the use of tobacco cigarettes.This research using qualitative descriptive methods and data collection techniques are grouped through observation, interviews and documentation. The informant in this research were five people who were taken by purposive sampling technique. Interactive data analysis model the author uses to describe the results of research into techniques for data analysis and data validity checking researchers used a technique extension of participation and triangulation.These results indicate that communication strategies Riau Vaper Community in the campaign is to use the media, especially social media is already widely used youth. The use of social media like Instagram, Facebook, Twitter and Path became the focus of a campaign to be conducted Riau Vaper Community. In addition to social media, Riau Vaper Community also use print media such as newspapers and radio. Riau campaign conducted by the Community Vaper do with the nature of education, choice of words is not complicated and does not use the word term is done so that the audience does not have any errors in response to the message delivered or saturation in listening to the message

Revolution and Modernity

Received 16 April 2018. Accepted 5 June 2018. Published online 1 July 2018.Revolution simultaneously legitimises and denies the coordinate centre of the political order of Modernity. It is difficult to describe the historical evolution from the early industrial, class-national forms of political organisation to late or global Modernity other than in terms of a low-intensity revolution in the rate of social change. On the other hand, this permanent modernisation is not revolutionary in the sense that the periodic splits of elites, colour revolutions, coups and national liberation movements do not in and of themselves make demands for fundamental change in the value-institutional core of the political order of Modernity. The potential for a new revolution can be consequent only on a repudiation of Modernity in favour of an alternative political project having a greater capability for universalisation and totalisation. If, in legitimising its liberal consensus and nation-state models as the dominant political format of their synthesis, capitalism is the value-institutional quintessence of the political order of Modernity, it is precisely in challenges to capitalism, the liberal consensus and nationalism that provide the most obvious means for crystallising revolutionary movements. From such a perspective, capitalism increasingly comes up against the global limits of its expansion, with class ideologies degenerating into a fragmented, technologically-intermediated populism, and nationstates experiencing increasing pressure from alternative political formats (city networks, multinational corporations, etc.) as they attempt to preserve the model of the social state. While various discourses and social groups profess to play the role of revolutionary utopias and subjects, in essence, their ability to present a totalising alternative to late Modernity remains an open question. A utopian systemic challenge to Modernity, connected with a morally more justified configuration and associated hierarchy of legitimate violence, is yet to emerge, whether from within Modernity or some source external to it. It is demonstrated that in the long term a serious (and possibly revolutionary) correction of the political order of modern societies will be capable of producing a rental transformation of capitalism and an expansion of the rent-class stratification mechanisms associated with precarisation, along with a reduction of social mobility trajectories and the prospects of active social groups.The article is prepared with the support of RFBR grant No. 18-011-00211 “Social Consensus in Russia: Mechanisms for Ideological and Institutional Regulation”

The Rise and Decline of Soviet Morality: Culture, Ideology, Collective Practices

Received 11 May 2020. Accepted 19 July 2020. Published online 9 October 2020.In the article, it is proposed that the collapse of Soviet society was presaged by a growing crisis in late Soviet morality. On the periphery of late Soviet morality, collective cultural practices are seen to have successfully functioned based on a limited ethics of virtue. In the absence of an alternative to Soviet ideology, social regulation started to draw upon values intended for the reproduction of local communities. A growing contradiction between the limited values of the new social class/corporate entities and the need to develop universal values for a big society is currently the key ideological legitimation problem facing the Russian political order.The work was supported by the research project “Social Cohesion in Russia and the Construction of Civil Identity as a Way to Achieve It” under the guidance of V. N. Rudenko (research program “Ethnic and Cultural Diversity of Russian Society and the Strengthening of Russian National Identity”)

Terpene analogues of dithiophospate pesticides

New optically active O,O-diterpenyl dithiophosphoric and O-terpenyl aryldithiophosphonic acids were prepared when chiral terpenols such as (1R)-endo-(+)-fenchyl alcohol, (1S)-endo-(-)-borneol, (1R)-(-)-nopol, and (1R,2S,3S,5R)-(+)-isopinocampheol were involved in reactions with tetraphosphorus decasulfide and 2,4-diaryl 1,3,2,4- dithiadiphosphetane-2,4- disulfides. Copyright © Taylor & Francis Group, LLC

Thiophosphorylation of pharmacophoric phenols, diols, and triols

Novel organyldithiophosphonic and bis(aryldithiophosphonic) acids were obtained by the reaction of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4- disulfides with paracetamol, 4-(1H-pyrrol-1-yl)phenol, ethambutol dihydrochloride, vitamin B6, and its acetonide derivatives. © 2013 Copyright Taylor and Francis Group, LLC

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome

The TATA binding protein (TBP) plays a pivotal role in RNA polymerase II (Pol II) transcription through incorporation into the TFIID and B-TFIID complexes. The role of mammalian B-TFIID composed of TBP and B-TAF1 is poorly understood. Using a complementation system in genetically modified mouse cells where endogenous TBP can be conditionally inactivated and replaced by exogenous mutant TBP coupled to tandem affinity purification and mass spectrometry, we identify two TBP mutations, R188E and K243E, that disrupt the TBP–BTAF1 interaction and B-TFIID complex formation. Transcriptome and ChIP-seq analyses show that loss of B-TFIID does not generally alter gene expression or genomic distribution of TBP, but positively or negatively affects TBP and/or Pol II recruitment to a subset of promoters. We identify promoters where wild-type TBP assembles a partial inactive preinitiation complex comprising B-TFIID, TFIIB and Mediator complex, but lacking TFIID, TFIIE and Pol II. Exchange of B-TFIID in wild-type cells for TFIID in R188E and K243E mutant cells at these primed promoters completes preinitiation complex formation and recruits Pol II to activate their expression. We propose a novel regulatory mechanism involving formation of a partial preinitiation complex comprising B-TFIID that primes the promoter for productive preinitiation complex formation in mammalian cells

Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells

Background: CREB and CREM are closely related factors that regulate transcription in response to various stress, metabolic and developmental signals. The CREMτ activator isoform is selectively expressed in haploid spermatids and plays an essential role in murine spermiogenesis.Results: We have used chromatin immunoprecipitation coupled to sequencing (ChIP-seq) to map CREM and CREB target loci in round spermatids from adult mouse testis and spermatogonia derived GC1-spg cells respectively. We identify more than 9000 genomic loci most of which are cell-specifically occupied. Despite the fact that round spermatids correspond to a highly specialised differentiated state, our results show that they have a remarkably accessible chromatin environment as CREM occupies more than 6700 target loci corresponding not only to the promoters of genes selectively expressed in spermiogenesis, but also of genes involved in functions specific to other cell types. The expression of only a small subset of these target genes are affected in the round spermatids of CREM knockout animals. We also identify a set of intergenic binding loci some of which are associated with H3K4 trimethylation and elongating RNA polymerase II suggesting the existence of novel CREB and CREM regulated transcripts.Conclusions: We demonstrate that CREM and CREB occupy a large number of promoters in highly cell specific manner. This is the first study of CREM target promoters directly in a physiologically relevant tissue in vivo and represents the most comprehensive experimental analysis of CREB/CREM regulatory potential to date

Thiophosphorylated resorcinol, calix[4]resorcinols, and other hydroxyphenols

Perdithiophosphonic acids are new types of tetracoordinated phosphorus thioacids bearing many dithiophosphoryl groups. Novel perdithiophosphonic acids were obtained by the reactions of 2,4-diaryl-1,3,2,4-dithiadiphosphetane-2,4- disulfides with hydroxyphenols such as resorcinol, 4,4'-iso- propylidenebisphenol, pyrogallol, and calix[4]resorcinols. Copyright © Taylor & Francis Group, LLC

Discovering Regulatory Overlapping RNA Transcripts

STEREO is a novel algorithm that discovers cis-regulatory RNA interactions by assembling complete and potentially overlapping same-strand RNA transcripts from tiling expression data. STEREO first identifies coherent segments of transcription and then discovers individual transcripts that are consistent with the observed segments given intensity and shape constraints. We used STEREO to identify 1446 regions of overlapping transcription in two strains of yeast, including transcripts that comprise a new form of molecular toggle switch that controls gene variegation