Avulsión del tubérculo tibial asociada a epifisiólisis proximal de tibia

Las lesiones de la tuberosidad tibial anterior son fracturas poco frecuentes que se presentan generalmente en adolescentes. Su extensión fisaria hacia la cortical posterior constituye un hecho infrecuente. Algunos autores consideran necesaria la modificación de la clasifícacion de Watson-Jones añadiéndole un tipo IV. Se presenta un caso de epifisiólisis proximal de tibia asociada a avulsión del tubérculo tibial, se discute dicha clasificación, el mecanismo de producción y revisión de la literaturaFractures of the anterior tibial tubercle are uncommon lesions, adolescents being more frequently affected. Physeal extension through the posterior tibial cortical bone is rare. Some authors have suggested that a new type IV can be added to the Watson-Jones classiflcation. In this paper, we report a case with epiphysiolisis of the proximal tibia associated to an avulsion fracture of the anterior tibial tubercle. The Watson-Jones classiflcation, the mechanism of injury are discussed together a review of the literature

The Compact Linear Collider (CLIC) - 2018 Summary Report

The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years

Binding of the ERα Nuclear Receptor to DNA Is Coupled to Proton Uptake

Nuclear receptors act as ligand-modulated transcription factors and orchestrate a plethora of cellular functions central to health and disease. Although studied for more than half a century, many mysteries surrounding the mechanism of action of nuclear receptors remain unresolved. Herein, using isothermal titration calorimetry (ITC) in conjunction with macromolecular modeling (MM), we provide evidence that the binding of ERα nuclear receptor to its DNA response element is coupled to proton uptake by two ionizable residues, H196 and E203, located at the protein-DNA interface. Alanine substitution of these ionizable residues decouples protonation and hampers the binding of ERα to DNA by nearly an order of magnitude. Remarkably, H196 and E203 are predominantly conserved across ~50 members of the nuclear receptor family, implying that proton-coupled equilibrium may serve as a key regulatory switch for modulating protein-DNA interactions central to nuclear receptor function and regulation. Taken together, our findings unearth an unexpected but a critical step in the molecular action of nuclear receptors and suggest that they may act as sensors of intracellular pH