On the development of idShare, a platform to support interaction design activities of small co-located teams

Externalizations and boundary objects are crucial for effectively communicating between stakeholders in multidisciplinary design teams. Especially when discussing ideas for new interactions, practitioners are increasingly finding themselves in need of new tools that allow them to rapidly, easily and more explicitly describe the dynamically changing aspects of their designs. For this purpose, we are investigating, in collaboration with the design departments of three industrial companies, the development and evaluation of a platform to support co-located (interaction) design activities. Previous research has already resulted in innovations in both hardware and software infrastructure, and in this workshop paper we therefore mostly report on some recent and planned activities towards a more coherent vision for an environment that we have named idShare. This is an interactive space that consists of two areas, an area for individual work and an area for the coordination of collaborative activities. In this paper we describe the aim and motivation of our research, the current stage of the development of the tools, and the design process and evaluations that are conducted in collaboration with the industrial partners

On the development of idShare, a platform to support interaction design activities of small co-located teams

Externalizations and boundary objects are crucial for effectively communicating between stakeholders in multidisciplinary design teams. Especially when discussing ideas for new interactions, practitioners are increasingly finding themselves in need of new tools that allow them to rapidly, easily and more explicitly describe the dynamically changing aspects of their designs. For this purpose, we are investigating, in collaboration with the design departments of three industrial companies, the development and evaluation of a platform to support co-located (interaction) design activities. Previous research has already resulted in innovations in both hardware and software infrastructure, and in this workshop paper we therefore mostly report on some recent and planned activities towards a more coherent vision for an environment that we have named idShare. This is an interactive space that consists of two areas, an area for individual work and an area for the coordination of collaborative activities. In this paper we describe the aim and motivation of our research, the current stage of the development of the tools, and the design process and evaluations that are conducted in collaboration with the industrial partners

Gene Expression Profiling in Rodent Models for Schizophrenia

The complex neurodevelopmental disorder schizophrenia is thought to be induced by an interaction between predisposing genes and environmental stressors. In order to get a better insight into the aetiology of this complex disorder, animal models have been developed. In this review, we summarize mRNA expression profiling studies on neurodevelopmental, pharmacological and genetic animal models for schizophrenia. We discuss parallels and contradictions among these studies, and propose strategies for future research

Cloning and sequence analysis of brain cDNA encoding a Xenopus D2 dopamine receptor

AbstractA D2 dopamine receptor pharmacologically different from the mammalian D2 receptor has previously been characterized in the amphibian Xenopus laevis. Here we report the cloning of a Xenopus D2 receptor which revealed about 75% amino acid sequence identity with its mammalian counterpart and the presence of an additional 33 amino acid sequence in the 3rd cytoplasmic loop instead of the additional 29 residues in the large form of the mammalian D2 receptor, All 7 predicted transmembrane domains are highly conserved between the Xenopus and mammalian D2 receptors, as are the 1st and 2nd intracellular loop, the 1st and 3rd extracellular loop and the carboxy-terminal portion of the receptors. The amino-terminal portion, the 2nd extracellular loop and the middle portion of the 3rd intracellular loop of these receptors, however, differ considerably, Knowledge of the locations of these regions of conservation and divergence within the D2 receptors or Xenopus and mammals will help to delineate portions of the receptor molecule that are functionally important. Interestingly, the 5-untranslated region of the Xenopus D2 receptor mRNA contains 4 small open reading frames which may affect translational efficiency

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Introduction In November 2011 archaeologists of City of Rotterdam Archaeological Service (BOOR) conducted underwater research in the Yangtze harbour, Rotterdam Maasvlakte, The Netherlands. The research was carried out by order of Port of Rotterdam Authority and supervised by the Cultural Heritage Agency of the Netherlands. The results of geological, botanical, zoological and archaeological analyses of the retrieved material generated new information on the occupation of a relatively high river dune by prehistoric hunter-gatherers, and on the development history of the surrounding landscape ca. 9,000 years ago. Methods Rather than employing divers the underwater investigations were carried out on board a vessel using a wire-operated, horizontal closing grab. Three small trenches (total area ca. 375m²) were excavated in layers in a fairly controlled fashion. Underwater excavations cannot achieve the same level of precision as is possible on land, but the many soil core samples taken in the project’s preliminary phase allowed detailed descriptions of the geomorphological stratigraphy. The excavation resulted in 316 bulk bags of soil. All soil was sieved on land, using sieves with mesh sizes of 10 and 2mm, after which archaeologists and volunteers carefully sorted the residues, documenting a total of ca. 46,000 finds. Results Plenty of Mesolithic occupation remains were retrieved at all three grab locations, from depths ranging between 17 to 21m below modern MSL. The finds span the age range from ca. 8400 to 6500BC, when the site transformed from dryland (an inland dune) to wetland (drowned delta subsurface). At the foot of the inland dune, the depositional conditions allowed for excellent preservation of bone, charcoal and plant material as well as stone artefacts. The site provides an unusually rich and detailed body of evidence on environmental conditions and the Middle Mesolithic palaeo-economy. The landscape ecotones around the site yielded an abundance of food while gradually being transformed, due to rising sea levels, from a valley containing the rivers Rhine and Meuse into the mouth area of those rivers. At 6500 BC, the site was finally transgressed: drowned in an estuary and swallowed up by the sea. Conclusion The Rotterdam Yangtze Harbour research project demonstrates the preservation of Mesolithic sites along the river Rhine, at depths in nowadays coastal and offshore areas. Furthermore, it demonstrates the feasibility of archaeological investigation of such submerged sites, even at depths of 18 to 20 m beneath sea, lake and harbour floors. Never before had such a submerged site been excavated at such a great depth. The scientific report (in English) will appear in the autumn of 2014, providing a full description of all finds as well as their landscape context

Maternal sensitivity during mealtime and free play: differences and explanatory factors

Mealtime is a parent-toddler interaction that occurs multiple times a day. This study examined whether observed maternal sensitivity differed between a mealtime and free-play setting, aiming to explain differences between the two situations by studying moderating effects of children's eating behavior. The sample consisted of 103 first-time mothers and their 18-month-old children. Maternal sensitivity was assessed by coding videotaped interactions of free-play sessions and mealtimes, using the Ainsworth Sensitivity Scale (range 1-9). Additionally, child eating behavior during the meal was coded and also assessed through the Child Eating Behavior Questionnaire-Toddlers. First, a small but significant amount of stability was found between sensitivity during mealtime and sensitivity during play (r = 0.24). Second, mothers were more sensitive during free play (mean = 7.11) than during mealtime (mean = 6.52). Third, observed child eating behavior was related to maternal sensitivity during mealtime, with more food enjoyment being associated with higher levels of sensitivity, and more challenging child behavior with lower levels of sensitivity. Finally, when children showed a high degree of challenging behavior during the meal, there was more discrepancy between sensitivity during mealtime and free play. Our results highlight the importance of taking context into account when observing parental sensitivity.Education and Child Studie

Elements Discrimination in the Study of Super-Heavy Elements using an Ionization Chamber

Dedicated ionization chamber was built and installed to measure the energy loss of very heavy nuclei at 2.7 MeV/u produced in fusion reactions in inverse kinematics (beam of 208Pb). After going through the ionization chamber, products of reactions on 12C, 18O targets are implanted in a Si detector. Their identification through their alpha decay chain is ambiguous when their half-life is short. After calibration with Pb and Th nuclei, the ionization chamber signal allowed us to resolve these ambiguities. In the search for rare super-heavy nuclei produced in fusion reactions in inverse or symmetric kinematics, such a chamber will provide direct information on the nuclear charge of each implanted nucleus.Comment: submitted to NIMA, 10 pages+4 figures, Latex, uses elsart.cls and grahpic