La colaboración en la Formación Continua de profesores: el proyecto M-Learning

El artículo presenta los principales resultados del proyecto «M-Learning: Una implantación innovadora» , desarrollado por el Laboratorio de Innovación Tecnológica Aplicado a la Educación lantec/unicamp. Éste proyecto ha tenido como objetivo desarrollar un ambiente colaborativo de aprendizaje para los profesores de matemáticas de enseñanza obligatoria, pertenecientes a centros educativos con un Índice de Desarrollo de la Educación Básica (ideb) inferior o igual a 4. Se ha realizado un cuestionario semi-estructurado para evaluar la percepción de los profesores-alumnos sobre la contribución del curso para el desarrollo de procesos colaborativos entre los participantes. Se buscaba asimismo la producción de conocimientos que puedan transformar cualitativamente las prácticas escolares de los profesores. Han participado en la investigación 123 individuos de diferentes regiones de Brasil. Los datos recogidos han sido sometidos a un análisis descriptivo y de contenido. Los resultados han mostrado que a lo largo del curso, los profesores han intensificado su interacción con sus compañeros, mejorando en el dominio de los recursos tecnológicos y en su uso e intercambio con los colegas de profesión. De esta forma se ha posibilitado la creación de nuevas modalidades de enseñanza y de aprendizaje de las matemáticas en la escuela

Glomerular Hyperfiltration: A Marker of Fibrosis Severity in Metabolic Associated Steatotic Liver Disease in an Adult Population

Glomerular hyperfiltration (GH) is an increase in the glomerular filtration rate, possibly progressing to chronic kidney disease (CKD). Metabolic-associated steatotic liver disease (MASLD) is linked to an increased risk of CKD, especially if fibrosis is present; however, the association between GH and MASLD has not been explored. To evaluate GH prevalence in MASLD and its possible correlation with liver fibrosis. 772 consecutive patients with ultrasound MASLD (mean age 47.3 ± 8.9 years, 67.1% males) were enrolled. GH was defined as estimated glomerular filtration rate (eGFR) greater than the upper quartile of values in the cohort. Liver stiffness measurement (LSM) by FibroScan ≥ 7.2 kPa suggested liver fibrosis. GH was present in 20% of patients, liver fibrosis in 30%. In total, 53.4% of the cohort was obese, 40.9% hypertensive, 36.3% diabetic and 70.8% dyslipidaemic. GH patients compared to non-GH were significantly younger (38.4 ± 8.3 vs. 49.5 ± 7.7, p < 0.001), with higher prevalence of LSM > 7.2 kPa (35.5% vs. 29%, p < 0.001), without any difference in metabolic comorbidities. In multivariate analysis, age (OR 0.85, CI 95% 0.82–0.87) and significant fibrosis (OR 1.83; CI 95%1.10–3.03) remained independently associated with GH, regardless of the presence of metabolic alterations and nephrotoxic drugs. GH, an early marker of renal damage, is highly prevalent in MASLD and is associated with hepatic fibrosis. GH may be considered an early marker of both liver and renal disease and its recognition could prompt the management of risk factors aimed at preventing the progression of both hepatic and renal disease

XXIV. mezinárodní kolokvium o regionálních vědách

Title in English: 24th International Colloquium on Regional Sciences: Conference proceedings. The conference proceedings consists of papers presented at the 24rd International Colloquium on Regional Sciences that was organized by Department of Regional Economics and Administration FEA MU. It contains 79 articles arranged by topic. The individual articles deal with e.g. socioeconomic disparities among regions, regional policy, territory attractiveness, tourism or regional public administration

An Anatomical, Sonographic, and Computed Tomography Study of the Transversus Abdominis Plane Block in Cat Cadavers

This study compared the distribution of a bupivacaine–iopamidol–dye solution following ultrasound-guided in-plane TAP injection using a 1-point (TAP-L) or 2-point (TAP-SL) approach in cat cadavers. Two cadavers were used to study the TAP sonoanatomy while eight cadavers were enrolled in a randomized, prospective, blinded investigation. Each cat randomly received a TAP-L with 0.5 mL/kg in one hemiabdomen and a TAP-SL with 0.25 mL/kg/point in the contralateral hemiabdomen. After injection, computed tomography and dissection were performed to assess contrast distribution and number of stained target nerves. TAP-SL resulted in a wider contrast spread (mm) compared with TAP-L (87 ± 7 versus 71 ± 9; p = 0.002). The prevalence of nerve staining was higher using TAP-SL than TAP-L (p = 0.001). The ventral branches of T10, T11, T12, T13, L1 and L2 were stained in 2/8, 2/8, 5/8, 7/8, 4/8 and 1/8, and in 7/8, 7/8, 8/8, 8/8, 8/8 and 1/8 using TAP-L and TAP-SL approaches, respectively. Computed tomography and dissection identified minimal injectate intraperitoneally or within the falciform ligament fat following 1 TAP-L and 2 TAP-SL. Ultrasound-guided TAP-SL provided better injectate distribution around the thoracolumbar spinal nerve branches than TAP-L

In-Plane Strengthening of Clay Brick and Block Masonry Walls Using Textile-Reinforced Mortar

This study evaluates the use of a composite material composed of multiaxial hybrid glass-fibers and polypropylene fabric coated in a hydraulic lime-based mortar (referred to as textile-reinforced mortar) to improve the in-plane shear strength and displacement capacity of solid clay-brick and hollow clay-block masonry walls with the aim of defining a comprehensive test protocol. Design parameters of the adopted strengthening system are investigated, and both single-sided and double-sided configurations for application on wall surfaces are considered. The influence of the presence of an external thermal insulation layer on walls' in-plane performance is also considered. The first stage characterizes the materials, their bonding properties, and the initial shear strength of the masonry bed-joints. The second stage investigates the in-plane behavior of strengthened masonry wall panels using diagonal compression testing. No premature debonding is observed, even with no mechanical anchorage between the masonry substrate and the strengthening layer. Out-of-plane deformation due to structural asymmetry is observed in the single-sided strengthening configuration

Revista iberoamericana de educación

Resumen basado en el de la publicaciónTítulo, resumen y palabras clave en portugués, español e inglésMonográfico con el título: "Formación docente continua y nuevas tecnologías: el desafío de cambiar mientras se enseña"Se presentan los principales resultados del proyecto «M-Learning: Una implantación innovadora», desarrollado por el Laboratorio de Innovación Tecnológica Aplicado a la Educación lantec/unicamp. El objetivo fue desarrollar un ambiente colaborativo de aprendizaje para los profesores de matemáticas de enseñanza obligatoria, pertenecientes a centros educativos con un Índice de Desarrollo de la Educación Básica (ideb) inferior o igual a 4. Se ha realizado un cuestionario semi-estructurado para evaluar la percepción de los profesores-alumnos sobre la contribución del curso para el desarrollo de procesos colaborativos entre los participantes. Han participado en la investigación 123 individuos de diferentes regiones de Brasil. Los resultados han mostrado que a lo largo del curso, los profesores han intensificado su interacción con sus compañeros, mejorando en el dominio de los recursos tecnológicos y en su uso e intercambio con los colegas de profesión. De esta forma se ha posibilitado la creación de nuevas modalidades de enseñanza y de aprendizaje de las matemáticas en la escuela.ES

Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes

The link between being pregnant and overweight or obese and the infectivity and virulence of the SARS CoV-2 virus is likely to be caused by SARS-CoV-2 spike protein glycosylation, which may work as a glycan shield. Methylglyoxal (MGO), an important advanced glycation end-product (AGE), and glycated albumin (GA) are the results of poor subclinical glucose metabolism and are indices of oxidative stress. Forty-one consecutive cases of SARS-CoV-2-positive pregnant patients comprising 25% pre-pregnancy overweight women and 25% obese women were recruited. The aim of our study was to compare the blood levels of MGO and GA in pregnant women with asymptomatic and symptomatic SARS-CoV-2 infection with pregnant women without SARS-CoV-2 infection with low risk and uneventful pregnancies and to evaluate the relative perinatal outcomes. The MGO and GA values of the SARS-CoV-2 cases were statistically significantly higher than those of the negative control subjects. In addition, the SARS-CoV-2-positive pregnant patients who suffered of moderate to severe COVID-19 syndrome had higher values of GA than those infected and presenting with mild symptoms or those with asymptomatic infection. Premature delivery and infants of a small size for their gestational age were overrepresented in this cohort, even in mild-asymptomatic patients for whom delivery was not indicated by the COVID-19 syndrome. Moreover, ethnic minorities were overrepresented among the severe cases. The AGE–RAGE oxidative stress axis on the placenta and multiple organs caused by MGO and GA levels, associated with the biological mechanisms of the glycation of the SARS-CoV-2 spike protein, could help to explain the infectivity and virulence of this virus in pregnant patients affected by being overweight or obese or having gestational diabetes, and the increased risk of premature delivery and/or low newborn weight