Protection Strategies for the Connection of Diode Rectifier-Based Wind Power Plants to HVdc Interconnectors

The connection of diode rectifier (DR)-based wind power plants (WPPs) to existing or planned high-voltage dc (HVdc) interconnectors can lead to important savings on cost and system robustness. Since the DR station usually operates in a bipolar configuration, its connection to symmetric monopoles is particularly challenging. However, there are no published detailed studies on the protection of DR connection WPPs to symmetric monopole interconnectors or even to bipolar interconnectors. This article includes the comparative study of five different protection strategies for such systems, including both solid and resistive DR station grounding and strategies with and without the use of dc-circuit breakers (dcCBs). An analytical study allows for the calculation of fault current during fault onset for both half-bridge and hybrid modular multilevel converter (MMC) stations. Using detailed electromagnetic transient (EMT) simulation studies, the different protection strategies are evaluated in terms of current, voltage, and isolation requirements of each element, as well as the need for dcCBs, fast communication, or larger surge arresters. Moreover, a distance fault detection algorithm is included for the wind turbine converters to distinguish between local ac-grid and dc-cable faults. From the simulation results, it is possible to conclude that DR high-impedance grounding, together with wind turbine distance protection, can be used for the protection of DR-based offshore WPPs connected to symmetric monopole interconnectors without requiring dcCBs

Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR

Selective estrogen receptor modulators (SERMs) are nonsteroidal drugs that display an estrogen‐agonist or estrogen‐antagonist effect depending on the tissue targeted. SERMs have attracted great clinical interest for the treatment of several pathologies, most notably breast cancer and osteoporosis. There is strong evidence that SERMs secondarily affect cholesterol metabolism, although the mechanism has not been fully elucidated. In this study, we analysed the effect of the SERMs tamoxifen, raloxifene, and toremifene on the expression of lipid metabolism genes by microarrays and quantitative PCR in different cell types, and ascertained the main mechanisms involved. The three SERMs increased the expression of sterol regulatory element‐binding protein (SREBP) target genes, especially those targeted by SREBP-2. In consonance, SERMs increased SREBP‐2 processing. These effects were associated to the interference with intracellular LDL-derived cholesterol trafficking. When the cells were exposed to LDL, but not to cholesterol/methyl-cyclodextrin complexes, the SERM-induced increases in gene expression were synergistic with those induced by lovastatin. Furthermore, the SERMs reduced the stimulation of the transcriptional activity of the liver X receptor (LXR) by exogenous cholesterol. However, their impact on the expression of the LXR canonical target ABCA1 in the presence of LDL was cell-type dependent. These actions of SERMs were independent of estrogen receptors. We conclude that, by inhibiting the intracellular trafficking of LDL-derived cholesterol, SERMs promote the activation of SREBP-2 and prevent the activation of LXR, two master regulators of cellular cholesterol metabolism. This study highlights the impact of SERMs on lipid homeostasis regulation beyond their actions as estrogen receptor modulators

Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR

Altres ajuts: Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020; Fondo Europeo de Desarrollo Regional (FEDER); European Cooperation in Science and Technology (BM0904); Comunidad de Madrid (Programme ALIBIRD S2013/ABI-2728).Selective estrogen receptor modulators (SERMs) are nonsteroidal drugs that display an estrogen-agonist or estrogen-antagonist effect depending on the tissue targeted. SERMs have attracted great clinical interest for the treatment of several pathologies, most notably breast cancer and osteoporosis. There is strong evidence that SERMs secondarily affect cholesterol metabolism, although the mechanism has not been fully elucidated. In this study, we analysed the effect of the SERMs tamoxifen, raloxifene, and toremifene on the expression of lipid metabolism genes by microarrays and quantitative PCR in different cell types, and ascertained the main mechanisms involved. The three SERMs increased the expression of sterol regulatory element-binding protein (SREBP) target genes, especially those targeted by SREBP-2. In consonance, SERMs increased SREBP-2 processing. These effects were associated to the interference with intracellular LDL-derived cholesterol trafficking. When the cells were exposed to LDL, but not to cholesterol/methyl-cyclodextrin complexes, the SERM-induced increases in gene expression were synergistic with those induced by lovastatin. Furthermore, the SERMs reduced the stimulation of the transcriptional activity of the liver X receptor (LXR) by exogenous cholesterol. However, their impact on the expression of the LXR canonical target ABCA1 in the presence of LDL was cell-type dependent. These actions of SERMs were independent of estrogen receptors. We conclude that, by inhibiting the intracellular trafficking of LDL-derived cholesterol, SERMs promote the activation of SREBP-2 and prevent the activation of LXR, two master regulators of cellular cholesterol metabolism. This study highlights the impact of SERMs on lipid homeostasis regulation beyond their actions as estrogen receptor modulators

Mathematics in physics education: scanning historical evolution of the differential to find a more appropriate model for teaching differential calculus in physics

Despite its frequent use, there is little understanding of the concept of differential among upper high school and undergraduate students of physics. As a first step to identify the origin of this situation and to revert it, we have done a historic and epistemological study aimed at clarifying the role and the meaning of the differential in physics and at improving curricular and teaching models in the sense of Gilbert et al. (Gilbert J.K., Boulter C., & Rutherford, M.: 1998a, International Journal of Science Education 20(1), 83–97, Gilbert J.K., Boulter C., & Rutherford, M.: 1998b, International Journal of Science Education 20(2),187–203). We describe the contributions of Leibniz and Cauchy and stress their shortcomings, which are overcome by the alternative definition proposed by the French mathematician Frechet, dating from early 20th century. As a result of this study, we answer to some fundamental questions related to a proper understanding of the differential in physics education(for 17–19 years old students)