Checklist of the centipedes (Chilopoda) of Hispaniola

Ten years have passed since the last checklist of Hispaniolan Chilopoda was done and the last bibliographic compendium was published. In this work we expand the former list of species and bibliography, update the taxonomic classification and provide an assessment on Chilobase records. A new intensive literature review was performed and both recent and formerly overlooked myriapodological works were included. The treatment of supraspecific taxonomic ranks was updated and follows Chilobase 2.0. This catalogue lists 4 fossil taxa as well as 24 extant species of centipedes from Hispaniola, 9 of which are endemic. For each extant species considered, there is information on Hispaniolan synonymies and geographic distribution. Included are some clarifications on synonymies and locality problems, and species with uncertain taxonomic status are indicated. Chilobase 2.0 was tested for completeness and accuracy. We propose several updates, grouped by incorrect species records, records not  backed by known literature and species not under their currently accepted synonym. We also recommend chilopodologists to maintain active collaboration and send their updates to this useful database

Checklist of the centipedes (Chilopoda) of Hispaniola

Ten years have passed since the last checklist of Hispaniolan Chilopoda was done and the last bibliographic compendium was published. In this work we expand the former list of species and bibliography, update the taxonomic classification and provide an assessment on Chilobase records. A new intensive literature review was performed and both recent and formerly overlooked myriapodological works were included. The treatment of supraspecific taxonomic ranks was updated and follows Chilobase 2.0. This catalogue lists 4 fossil taxa as well as 24 extant species of centipedes from Hispaniola, 9 of which are endemic. For each extant species considered, there is information on Hispaniolan synonymies and geographic distribution. Included are some clarifications on synonymies and locality problems, and species with uncertain taxonomic status are indicated. Chilobase 2.0 was tested for completeness and accuracy. We propose several updates, grouped by incorrect species records, records not backed by known literature and species not under their currently accepted synonym. We also recommend chilopodologists to maintain active collaboration and send their updates to this useful database.</p

IAA : Información y actualidad astronómica (15)

Sumario : INVESTIGACIÓN. Aerosoles atmosféricos: sus efectos en el clima de las atmósferas del sistema solar.-- El gas molecular en las galaxias.-- VENTANA ABIERTA. Todo un privilegio.-- CHARLAS CON...Vicent Martínez.-- ACTUALIDAD CIENTÍFICA. Un sistema planetario joven en torno a Beta Pictores.-- Una nueva visita a Canis Major .-- ACTIVIDADES IAA.-- AGENDA.Esta revista se publica con la ayuda de la Accion Especial DIF 2001-4284-E del Programa Nacional de Difusión de la Ciencia y la Tecnología, del Ministerio de Ciencia y Tecnología.N

Solución a la vivienda transicional por medio de la aplicación de domos geodésicos autoconstruibles

Tener una vivienda digna es uno de los derechos a los que cualquier persona debería de acceder, a lo largo de este documento PAP se abordará un nuevo sistema de vivienda transicional en el cual su principal objetivo es proveer de vivienda digna a personas de escasos recursos. Para lograr esto se propone un domo geodésico modular, cuya principal característica es la adaptación a cualquier programa o estilo de vida y uso y su fácil adaptación o mejoramiento posterior. Además de lo anteriormente mencionado, se provee de recursos gráficos que ayuden a entender tanto el funcionamiento como el ensamble de dicho sistema de vivienda

Process mining for healthcare: Characteristics and challenges

Process mining techniques can be used to analyse business processes using the data logged during their execution. These techniques are leveraged in a wide range of domains, including healthcare, where it focuses mainly on the analysis of diagnostic, treatment, and organisational processes. Despite the huge amount of data generated in hospitals by staff and machinery involved in healthcare processes, there is no evidence of a systematic uptake of process mining beyond targeted case studies in a research context. When developing and using process mining in healthcare, distinguishing characteristics of healthcare processes such as their variability and patient-centred focus require targeted attention. Against this background, the Process-Oriented Data Science in Healthcare Alliance has been established to propagate the research and application of techniques targeting the data-driven improvement of healthcare processes. This paper, an initiative of the alliance, presents the distinguishing characteristics of the healthcare domain that need to be considered to successfully use process mining, as well as open challenges that need to be addressed by the community in the future.This work is partially supported by ANID FONDECYT 1220202, Dirección de Investigación de la Vicerrectoría de Investigación de la Pontificia Universidad Católica de Chile - PUENTE [Grant No. 026/ 2021]; and Agencia Nacional de Investigación y Desarrollo [Grant Nos. ANID-PFCHA/Doctorado Nacional/2019–21190116, ANID-PFCHA/ Doctorado Nacional/2020–21201411]. With regard to the co-author Hilda Klasky, this manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-accessplan).Peer ReviewedArticle signat per 55 autors/es: Jorge Munoz-Gama (a)* , Niels Martin (b,c)* , Carlos Fernandez-Llatas (d,g)* , Owen A. Johnson (e)* , Marcos Sepúlveda (a)* , Emmanuel Helm (f)* , Victor Galvez-Yanjari (a)* , Eric Rojas (a) , Antonio Martinez-Millana (d) , Davide Aloini (k) , Ilaria Angela Amantea (l,q,r) , Robert Andrews (ab), Michael Arias (z) , Iris Beerepoot (o) , Elisabetta Benevento (k) , Andrea Burattin (ai), Daniel Capurro (j) , Josep Carmona (s) , Marco Comuzzi (w), Benjamin Dalmas (aj,ak), Rene de la Fuente (a) , Chiara Di Francescomarino (h) , Claudio Di Ciccio (i) , Roberto Gatta (ad,ae), Chiara Ghidini (h) , Fernanda Gonzalez-Lopez (a) , Gema Ibanez-Sanchez (d) , Hilda B. Klasky (p) , Angelina Prima Kurniati (al), Xixi Lu (o) , Felix Mannhardt (m), Ronny Mans (af), Mar Marcos (v) , Renata Medeiros de Carvalho (m), Marco Pegoraro (x) , Simon K. Poon (ag), Luise Pufahl (u) , Hajo A. Reijers (m,o) , Simon Remy (y) , Stefanie Rinderle-Ma (ah), Lucia Sacchi (t) , Fernando Seoane (g,am,an), Minseok Song (aa), Alessandro Stefanini (k) , Emilio Sulis (l) , Arthur H. M. ter Hofstede (ab), Pieter J. Toussaint (ac), Vicente Traver (d) , Zoe Valero-Ramon (d) , Inge van de Weerd (o) , Wil M.P. van der Aalst (x) , Rob Vanwersch (m), Mathias Weske (y) , Moe Thandar Wynn (ab), Francesca Zerbato (n) // (a) Pontificia Universidad Catolica de Chile, Chile; (b) Hasselt University, Belgium; (c) Research Foundation Flanders (FWO), Belgium; (d) Universitat Politècnica de València, Spain; (e) University of Leeds, United Kingdom; (f) University of Applied Sciences Upper Austria, Austria; (g) Karolinska Institutet, Sweden; (h) Fondazione Bruno Kessler, Italy; (i) Sapienza University of Rome, Italy; (j) University of Melbourne, Australia; (k) University of Pisa, Italy; (l) University of Turin, Italy; (m) Eindhoven University of Technology, The Netherlands; (n) University of St. Gallen, Switzerland; (o) Utrecht University, The Netherlands; (p) Oak Ridge National Laboratory, United States; (q) University of Bologna, Italy; (r) University of Luxembourg, Luxembourg; (s) Universitat Politècnica de Catalunya, Spain; (t) University of Pavia, Italy; (u) Technische Universitaet Berlin, Germany; (v) Universitat Jaume I, Spain; (w) Ulsan National Institute of Science and Technology (UNIST), Republic of Korea; (x) RWTH Aachen University, Germany; (y) University of Potsdam, Germany; (z) Universidad de Costa Rica, Costa Rica; (aa) Pohang University of Science and Technology, Republic of Korea; (ab) Queensland University of Technology, Australia; (ac) Norwegian University of Science and Technology, Norway; (ad) Universita degli Studi di Brescia, Italy; (ae) Lausanne University Hospital (CHUV), Switzerland; (af) Philips Research, the Netherlands; (ag) The University of Sydney, Australia; (ah) Technical University of Munich, Germany; (ai) Technical University of Denmark, Denmark; (aj) Mines Saint-Etienne, France; (ak) Université Clermont Auvergne, France; (al) Telkom University, Indonesia; (am) Karolinska University Hospital, Sweden; (an) University of Borås, SwedenPostprint (published version

Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer

This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals

Human prefoldin modulates co-transcriptional pre-mRNA splicing.

Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, including a positive contribution to transcription elongation and chromatin dynamics in yeast. Here we show that prefoldin perturbations provoked transcriptional alterations across the human genome. Severe pre-mRNA splicing defects were also detected, particularly after serum stimulation. We found impairment of co-transcriptional splicing during transcription elongation, which explains why the induction of long genes with a high number of introns was affected the most. We detected genome-wide prefoldin binding to transcribed genes and found that it correlated with the negative impact of prefoldin depletion on gene expression. Lack of prefoldin caused global decrease in Ser2 and Ser5 phosphorylation of the RNA polymerase II carboxy-terminal domain. It also reduced the recruitment of the CTD kinase CDK9 to transcribed genes, and the association of splicing factors PRP19 and U2AF65 to chromatin, which is known to depend on CTD phosphorylation. Altogether the reported results indicate that human prefoldin is able to act locally on the genome to modulate gene expression by influencing phosphorylation of elongating RNA polymerase II, and thereby regulating co-transcriptional splicing.Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación [BFU2016-77728-C3-1-P to S.C. and BFU2017-85420-R to J.C.R.] co-financed with European Union funds (FEDER); Andalusian Government [P12-BIO1938MO, BIO271, US-1256285 to S.C., BIO321 to J.C.R.]; Junta de Andalucía (to L.P.-B.). Funding for open access charge: Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación [BFU2016-77728-C3-1-P]

Microencapsulation of Erythrocytes Extracted from Cavia porcellus Blood in Matrices of Tara Gum and Native Potato Starch

Ferropenic anemy is the leading iron deficiency disease in the world. The aim was to encapsulate erythrocytes extracted from the blood of Cavia porcellus, in matrices of tara gum and native potato starch. For microencapsulation, solutions were prepared with 20% erythrocytes; and encapsulants at 5, 10, and 20%. The mixtures were spray-dried at 120 and 140 ◦C. The iron content in the erythrocytes was 3.30 mg/g and between 2.32 and 2.05 mg/g for the encapsulates (p < 0.05). The yield of the treatments varied between 47.84 and 58.73%. The moisture, water activity, and bulk density were influenced by the temperature and proportion of encapsulants. The total organic carbon in the atomized samples was around 14%. The particles had diverse reddish tonalities, which were heterogeneous in their form and size; openings on their surface were also observed by SEM. The particle size was at the nanometer level, and the zeta potential (ζ) indicated a tendency to agglomerate and precipitation the solutions. The presence of iron was observed on the surface of the atomized by SEM-EDX, and FTIR confirmed the encapsulation due to the presence of the chemical groups OH, C-O, C-H, and N-H in the atomized. On the other hand, high percentages of iron release in vitro were obtained between 88.45 and 94.71%. The treatment with the lowest proportion of encapsulants performed at 140 ◦C obtained the best results and could potentially be used to fortify different functional foods