¿Tenemos suficiente experiencia con los Videolaringoscopios? ¿Hay accesibilidad en nuestros hospitales a los equipos de Vía Aérea Avanzada? Rachel L. Gill, Audrey S. Y. Jeffrey, Alistair F. McNarry and Geoffrey H. C. Liew The Availability of Advanced Airway Equipment and Experience with Videolaryngoscopy in the UK: Two UK Surveys. Anesthesiology Research and Practice, Volume 2015 (2015), Article ID 152014, 7 pages.

En el año 2010 el Real Colegio de Anestesistas del Reino Unido (RCoA) instauró un módulo obligatorio de formación en el manejo de la Vía Aérea que suele realizarse entre el 5º y el 7º año de formación. Entre las conclusiones que se extraen de estos 5 años de andadura destaca que hay dos elementos necesarios para proporcionar la formación adecuada para usar cualquier equipo. En primer lugar, el equipo debe estar disponible, y en segundo lugar debe haber suficientes entrenadores cualificados con dicho dispositivo. Las publicaciones sobre videolaringoscopia demuestran la eficacia de estos dispositivos ópticos en situaciones de Vía Aérea Difícil Prevista y en los Obesos Mórbidos, donde al compararlos con el laringoscopio estándar Macintosh se han demostrado más fáciles de utilizar para los principiantes, además de útiles en la docencia de la Vía Aérea, ya que el entrenador comparte la visión obtenida por el alumno

Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study

Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes

Quality and Quantity of Protein Intake Influence Incidence of Type 2 Diabetes Mellitus in Coronary Heart Disease Patients: From the CORDIOPREV Study

Evidence suggests that enriching a diet with plant-based proteins could reduce the risk of developing type 2 diabetes mellitus. In the present work, we evaluated the association between the change in plant protein intake (adjusted by energy) and incidence of type 2 diabetes mellitus in patients with coronary heart disease from the CORDIOPREV (coronary diet intervention with olive oil and cardiovascular prevention) study. At baseline and during the follow-up, patients underwent medical examination and blood and oral glucose tolerance tests. Information on patient’s dietary intake was gathered by registered dietitians using a validated food frequency questionnaire. A total of 106 out of 436 nondiabetic patients at baseline developed type 2 diabetes mellitus after a median follow-up of 60 months. Cox regression analyses showed that patients who belonged to the group that increased plant protein intake exhibited a lower risk of developing the disease (HR = 0.64, (0.43–0.96)). Changes in plant protein intake were positively correlated with changes in carbohydrates, fibre, and legumes intake and negatively correlated with changes in saturated fatty acids intake. Results of the present study support the need of improving diet with plant-based proteins to prevent the onset of type 2 diabetes mellitus

Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial

In order to assess whether previous hepatic IR (Hepatic-IR fasting) and beta-cell functionality could modulate type 2 diabetes remission and the need for starting glucose- lowering treatment, newly-diagnosed type 2 diabetes participants who had never received glucose-lowering treatment (190 out of 1002) from the CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (a prospective, randomized and controlled clinical trial), were randomized to consume a Mediterranean or a low-fat diet. Type 2 diabetes remission was defined according to the American Diabetes Association recommendation for levels of HbA1c, fasting plasma glucose and 2h plasma glucose after oral glucose tolerance test, and having maintained them for at least 2 consecutive years. Patients were classified according to the median of Hepatic-IR fasting and beta-cell functionality, measured as the disposition index (DI) at baseline. Cox proportional hazards regression determined the potential for Hepatic-IR fasting and DI indexes as predictors of diabetes remission and the probability of starting pharmacological treatment after a 5-year follow-up. Low-Hepatic-IR fasting or high-DI patients had a higher probability of diabetes remission than high-Hepatic-IR fasting or low-DI subjects (HR:1.79; 95% CI 1.06_3.05; and HR:2.66; 95% CI 1.60_4.43, respectively) after a dietary intervention with no pharmacological treatment and no weight loss. The combination of low- Hepatic-IR fasting and high-DI presented the highest probability of remission (HR:4.63; 95% CI 2.00_10.70). Among patients maintaining diabetes, those with high- Hepatic-IR fasting and low-DI showed the highest risk of starting glucose-lowerin

Mission ORCA: orbit refinement for collision avoidance

Forecasting of collisions between resident space objects (RSOs) is becoming critical for the future exploitation of near-Earth space. A constellation of 28 spacecrafts (plus in-orbit spares) in sun synchronous orbits is proposed as a solution for improving the current space situational awareness capabilities. Each satellite uses an optical payload to track target RSOs, with the satellite's position precisely determined. Multiple pictures of the RSO are taken, and the spacecraft attitude used to calculate the target's position relative to the spacecraft. The target's orbit is then determined from the movement of the target through the field of view over time. The system outputs orbit state vectors of the tracked object, allowing precise orbit characterisation and collision forecasting to be delivered. The constellation's design allows high temporal resolution, so reliable information can be supplied to end-users. The paper shows the results of the system design of a demonstration mission meant to verify the feasibility of the concept, performed by a team of students of Cranfield University. The exercise addresses all the aspects of the preliminary design, including the definition of the mission and system requirements, the selection of the overall mission architecture, operations, and mission phases. A cap on the overall cost allows for the realisation of the platform within a university budget. The outline of the design includes not only the selection and sizing of all the subsystems and payload but also suggests a new strategy for deploying the constellation if the demonstration mission is successful. The utilisation of high TRL and COTS components, as well as mass, power, and link budgets, demonstrate the feasibility of the overall mission concept

Implantación de metodologías de aprendizaje y evaluación continua en la docencia de la Edafología en el ámbito de la ingeniería agronómica

[SPA] El objetivo fundamental de este trabajo es la evaluación de la implantación de metodologías de enseñanza-aprendizaje en la materia de Edafología en diferentes grados del ámbito agronómico y analizar los resultados académicos obtenidos en cada uno de los grados. El Grupo de Innovación edu-SOIL (UPM) aprovechando los recursos de las TIC, con materiales interactivos de consulta y apoyo de Webquest para elaborar un trabajo de curso, ha establecido un proceso de enseñanza aprendizaje acorde con los sistemas metodológicos previstos en el EEES. Se presentan en el trabajo, además de una breve recopilación de la metodología aplicada, la evolución de las tasas de eficiencia y éxito a lo largo de 2-3 años desde la implantación de los planes de estudio. Se pone de manifiesto la influencia de la estructura de cada plan de estudios en los resultados alcanzados así como la influencia del número de ECTS en la impartición de la materia. [ENG] The main objective of this study was to evaluate the implementation of teaching-learning methodologies in the field of Soil Science in different degrees of the agronomic ambits and to analyze the results obtained in each degree. The edu-SOIL Innovation Group (UPM) taking advantage of TIC resources, using interactive course material and using a Webquest for a class project has established a process of teaching and learning in line with the methodological systems under the European system. This work presents a brief description of the methodology used along with the evolution of efficiency and success rates over 2-3 years since the implementation of the curriculum. The study shows the influence of the structure of each curriculum in the results achieved and also the effect of the number of ECTS in teaching the subject

Mission ORCA: Orbit Refinement for Collision Avoidance

With new launches every year, and the use of 'mega-constellations' becoming commonplace, there is an increasing number of active satellites and other resident space objects (RSOs) in low Earth orbit. However, a collision between objects could be disastrous, having wide-ranging impacts on the collision orbit and all the satellites users within it. Collision forecasting currently has large degrees of uncertainty, causing satellite operators to often ignore collision warnings. It is therefore critical that a system becomes operational to track RSOs and determine the likelihood of collisions with greater accuracy than is currently available. The proposed solution uses a constellation of 28 spacecraft (plus in-orbit spares) in Sun Synchronous Orbits. CubeSats will be used to reduce the cost and the time required for the constellation to become operational. Each satellite uses an optical payload to track target RSOs, with the satellite's position precisely determined. Multiple pictures of the RSO are taken, and the spacecraft attitude used to calculate the target's position relative to the spacecraft. The target's orbit is then determined from the movement of the target through the field of view over time. The system outputs orbit state vectors of the tracked object, allowing precise orbit characterisation and collision forecasting to be delivered. The constellation's design allows high temporal resolution, so reliable information can be supplied to end-users. The paper shows the results of the system design of a demonstration mission meant to verify the feasibility of the concept, performed by a team of students of Cranfield University. The exercise addresses all the aspects of the preliminary design, including the definition of the mission and system requirements, the selection of the overall mission architecture, operations, and mission phases. A cap on the overall cost allows for the realisation of the platform within a university budget. The outline of the design includes not only the selection and sizing of all the subsystems and payload but also suggests a new strategy for deploying the constellation if the demonstration mission is successful. The utilisation of high TRL and COTS components, as well as mass, power, and link budgets, demonstrate the feasibility of the overall mission concep

Valoración del nivel de actividad física y aptitud física en una muestra de universitarios: Comparativa tras la pandemia de covid-19

The transition from secondary education to university education has become a critical moment for the lifestyle of young people, especially for the practice of physical activity. Therefore, the main objective of the present study was to assess the levels of physical activity in university students, by correlating the results of the IPAQ-SF and the different physical fitness variables (Eurofit). The sample consisted of 194 students of the Primary Education Degree, with a mean age of 21.37 ± 2.66 years. The main results obtained reflect the direct relationship between the practice of physical activity in general, and vigorous physical activity in particular, and optimal physical fitness of university students, linked above all to the strength component. As for the comparison between pre-pandemic (18/19) and post-pandemic (21/22) university students, the increase in physical activity after the pandemic did not show substantial differences in the physical fitness components. In conclusion, these results should lead us to reflect on the influence of an active lifestyle on physical fitness, which has an impact on overall health status and quality of life.El tránsito de la educación secundaria a la enseñanza universitaria se ha convertido en un momento crítico para el estilo de vida de los jóvenes, especialmente para la práctica de actividad física. Por ello, el principal objetivo del presente estudio fue valorar los niveles de actividad física en universitarios, mediante la correlación entre los resultados del IPAQ-SF y las distintas variables de condición física (Eurofit). La muestra estuvo conformada por 194 estudiantes del Grado de Educación Primaria, con una edad media de 21,37 ± 2,66 años. Los principales resultados obtenidos reflejan la relación directa entre la práctica de actividad física en general, y la actividad física vigorosa en particular y una óptima aptitud física de los estudiantes universitarios, vinculada sobre todo con el componente fuerza. En cuanto a la comparación entre los universitarios del curso prepandémico (18/19) y el curso pospandémico (21/22), el aumento de la actividad física tras la pandemia no reportó diferencias sustanciales en los componentes de la condición física. A modo de conclusión, estos resultados deben conducirnos a una reflexión sobre la influencia de un estilo de vida activo en la aptitud física, la cual tiene repercusión en el estado de salud general y la calidad de vida

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2-7 m, while providing data at sub-mm to mm scales. We report on SuperCam's science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.In France was provided by the Centre National d'Etudes Spatiales (CNES). Human resources were provided in part by the Centre National de la Recherche Scientifique (CNRS) and universities. Funding was provided in the US by NASA's Mars Exploration Program. Some funding of data analyses at Los Alamos National Laboratory (LANL) was provided by laboratory-directed research and development funds