258 research outputs found
Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events.
Abstract
Background: Several studies have demonstrated a link between cardiovascular disease (CVD) susceptibility
and the genetic background of populations.
Endothelial activation and dysfunction induced by oxidized low-density lipoprotein (ox-LDL) is one of
the key steps in the initiation of atherosclerosis. The oxidized low density lipoprotein (lectin-like)
receptor 1 (OLR1) gene is the main receptor of ox-LDL. We have previously characterized two
polymorphisms (rs3736235 and rs11053646) associated with the risk for coronary artery disease
(CAD) and acute myocardial infarction (AMI).
Aim: Given their clinical significance, it is of interest to know the distribution of these variants in
populations from different continents.
Subjects and methods: A total of 1229 individuals from 17 different African, Asian and European
populations was genotyped for the two considered markers.
Results: The high frequencies of ancestral alleles in South-Saharan populations is concordant with the
African origin of our species. The results highlight that African populations are closer to Asians, and
clearly separated from the Europeans.
Conclusion: The results confirm significant genetic structuring among populations and suggest a
possible basis for varying susceptibility to CVD among groups correlated with the geographical
location of populations linked with the migrations out of Africa, or with different lifestyle
Radon and material radiopurity assessment for the NEXT double beta decay experiment
The Neutrino Experiment with a Xenon TPC (NEXT), intended to investigate the
neutrinoless double beta decay using a high-pressure xenon gas TPC filled with
Xe enriched in 136Xe at the Canfranc Underground Laboratory in Spain, requires
ultra-low background conditions demanding an exhaustive control of material
radiopurity and environmental radon levels. An extensive material screening
process is underway for several years based mainly on gamma-ray spectroscopy
using ultra-low background germanium detectors in Canfranc but also on mass
spectrometry techniques like GDMS and ICPMS. Components from shielding,
pressure vessel, electroluminescence and high voltage elements and energy and
tracking readout planes have been analyzed, helping in the final design of the
experiment and in the construction of the background model. The latest
measurements carried out will be presented and the implication on NEXT of their
results will be discussed. The commissioning of the NEW detector, as a first
step towards NEXT, has started in Canfranc; in-situ measurements of airborne
radon levels were taken there to optimize the system for radon mitigation and
will be shown too.Comment: Proceedings of the Low Radioactivity Techniques 2015 workshop
(LRT2015), Seattle, March 201
Measurement of radon-induced backgrounds in the NEXT double beta decay experiment
The measurement of the internal Rn activity in the NEXT-White
detector during the so-called Run-II period with Xe-depleted xenon is
discussed in detail, together with its implications for double beta decay
searches in NEXT. The activity is measured through the alpha production rate
induced in the fiducial volume by Rn and its alpha-emitting progeny.
The specific activity is measured to be ~mBq/m. Radon-induced electrons have also been
characterized from the decay of the Bi daughter ions plating out on the
cathode of the time projection chamber. From our studies, we conclude that
radon-induced backgrounds are sufficiently low to enable a successful NEXT-100
physics program, as the projected rate contribution should not exceed
0.1~counts/yr in the neutrinoless double beta decay sample.Comment: 28 pages, 10 figures, 6 tables. Version accepted for publication in
JHE
Sensitivity of a tonne-scale NEXT detector for neutrinoless double beta decay searches
The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless
double-beta decay of Xe-136 using high-pressure xenon gas TPCs with
electroluminescent amplification. A scaled-up version of this technology with
about 1 tonne of enriched xenon could reach in less than 5 years of operation a
sensitivity to the half-life of neutrinoless double-beta decay decay better
than 1E27 years, improving the current limits by at least one order of
magnitude. This prediction is based on a well-understood background model
dominated by radiogenic sources. The detector concept presented here represents
a first step on a compelling path towards sensitivity to the parameter space
defined by the inverted ordering of neutrino masses, and beyond.Comment: 22 pages, 11 figure
Evaluation of turbulent dissipation rate retrievals from Doppler Cloud Radar
Turbulent dissipation rate retrievals from cloud radar Doppler velocity measurements are evaluated using independent, in situ observations in Arctic stratocumulus clouds. In situ validation data sets of dissipation rate are derived using sonic anemometer measurements from a tethered balloon and high frequency pressure variation observations from a research aircraft, both flown in proximity to stationary, ground-based radars. Modest biases are found among the data sets in particularly low- or high-turbulence regimes, but in general the radar-retrieved values correspond well with the in situ measurements. Root mean square differences are typically a factor of 4-6 relative to any given magnitude of dissipation rate. These differences are no larger than those found when comparing dissipation rates computed from tetheredballoon and meteorological tower-mounted sonic anemometer measurements made at spatial distances of a few hundred meters. Temporal lag analyses suggest that approximately half of the observed differences are due to spatial sampling considerations, such that the anticipated radar-based retrieval uncertainty is on the order of a factor of 2-3. Moreover, radar retrievals are clearly able to capture the vertical dissipation rate structure observed by the in situ sensors, while offering substantially more information on the time variability of turbulence profiles. Together these evaluations indicate that radar-based retrievals can, at a minimum, be used to determine the vertical structure of turbulence in Arctic stratocumulus clouds
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