TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells

The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation. To identify chromatin and epigenetic factors possibly involved in the process of EMT, we compare the levels of expression of epigenetic genes in a transformed human breast epithelial cell line (HMEC-RAS) versus a stable clone of the same cell line expressing the EMT master regulator ZEB1 (HMEC-RAS-ZEB1). One of the factors strongly induced in the HMEC-RAS-ZEB1 cells was Transducin beta-like 1 (TBL1), a component of the NCoR complex, which has both corepressor and coactivator activities. We show that TBL1 interacts with ZEB1 and that both factors cooperate to repress the promoter of the epithelial gene E-cadherin (CDH1) and to autoactivate the ZEB1 promoter. Consistent with its central role, TBL1 is required for mesenchymal phenotypes of transformed breast epithelial and breast cancer cell lines of the claudin-low subtype. Importantly, a high expression of the TBL1 gene correlates with poor prognosis and increased proportion of metastasis in breast cancer patients, indicating that the level of TBL1 expression can be used as a prognostic marker.Ministerio de Economía y Competitividad BFU2014-53543-P, BFU2017-85420-RJunta de Andalucía BIO-32

New trends in education: the use of ICT in different ways

In the 21st century and due to the exponential growth of the Internet and Information and Communication Technologies (ICT), people live in a technological age, in all areas and in all contexts, we have daily contact with technology, with access to Information. This dynamic requires a constant update of the services and technological tools that change the method that we study, work, communicate and socialize on an unprecedented scale. These constant changes force everyone, regardless of age, gender or profession, to possess a range of functional and critical thinking skills, such as information literacy, media literacy and technological literacy. The evolution of technologies, forces the promoters of education, to always be aware of the changes that society is introducing outside the classroom. Today, students don't have the same pattern as before, regardless of age, they are very active and are no longer the same introverted child who studied a few years ago in the classroom. According to this, students are eager for different forms of motivation inside and outside the classroom, they need the learning and teaching process to move along with changes in society and ICT. To ensure the success of today's students, it is important to provide them with the technological skills to make the correct use of ICTs, to perform tasks essential to their learning process, such as researching and selecting information, creating content, information sharing, use of collaboration tools or environment simulation tools. The main objective of this chapter is to show how ICT tools that can be used in educational environments to help students, helping them develop key skills in their training process, is also relevant to show how these tools can help teachers achieve these goals in daily activities with their students

Un catálogo de utopías de la Ilustración española

Here I introduce to you a catalogue which contain some spanish literary utopias wrote up during the Spanish Enlightement. Due to the measure of term literature in this epoch, out of speak about the measure of term utopic, the catalogue includes independent texts, journalist articles and romans’ chapters that properly shape a utopia although to be included in the narration. To realize this catalogue, that contain twenty texts, all of those wroten during the kingdom of Carlos III and his son Carlos IV, I follow a chronological arrangement.Lo que aquí presento es un catálogo de obras que pueden enmarcarse dentro del género utópico y que fueron redactadas durante la Ilustración española. Dada la dimensión del término literatura en dicha época, por no hablar de la dimensión del término utópico, el catálogo incluye textos independientes, discursos periodísticos y capítulos de novelas que conforman una utopía con entidad propia a pesar de estar incluidas dentro de la narración. Para la conformación del catálogo, que contiene un total de veinte obras, todas ellas escritas durante los reinados de Carlos III y su hijo Carlos IV, sigo un orden cronológico, por considerarlo el más adecuado

miraQA: Initial experiments in Question Answering

We present the miraQA system that constitutes MIRACLE first experience in Question Answering for monolingual Spanish and has been developed for QA@CLEF 2004. The architecture of the system is described and details of our approach to Statistical Answer Extraction based on Hidden Markov Models are presented. One run that uses last year question set for training purposes has been submitted. The results are presented together with ideas for improvement

An ontology for event detection and its application in surveillance video

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. J. C. SanMiguel, J. M. Martínez, and Á. García, "An ontology for event detection and its application in surveillance video", in Sixth IEEE International Conference on Advanced Video and Signal Based Surveillance, AVSS 2009, p. 220 - 225In this paper, we propose an ontology for representing the prior knowledge related to video event analysis. It is composed of two types of knowledge related to the application domain and the analysis system. Domain knowledge involves all the high level semantic concepts in the context of each examined domain (objects, events, context...) whilst system knowledge involves the capabilities of the analysis system (algorithms, reactions to events...). The proposed ontology has been structured in two parts: the basic ontology (composed of the basic concepts and their specializations) and the domain-specific extensions. Additionally, a video analysis framework based on the proposed ontology is defined for the analysis of different application domains showing the potential use of the proposed ontology. In order to show the real applicability of the proposed ontology, it is specialized for the underground video-surveillance domain showing some results that demonstrate the usability and effectiveness of the proposed ontology.This work is partially supported by the Spanish Administration agency CDTI (CENIT-VISION 2007-1007), by the Spanish Government (TEC2007- 65400 SemanticVideo), by the Comunidad de Madrid (S-050/TIC- 0223 - ProMultiDis), by the Consejería de Educación of the Comunidad de Madrid and by The European Social Fun

El aprendizaje-servicio como propuesta didáctica para la enseñanza práctica de la geografía. Una experiencia de puesta en valor del patrimonio natural

Producción CientíficaSe analizan los resultados de la experiencia de aprendizaje-servicio desarrollada como soporte didáctico de la asignatura Geomorfología Práctica y Aplicada -cuarto curso del Grado de Geografía y Ordenación del Territorio de la Universidad de Valladolid-. La actividad ha consistido en la elaboración del “Inventario del patrimonio geomorfológico, valoración de la geodiversidad y propuesta de rutas turísticas por la Reserva de la Biosfera de los Ancares Leoneses”, contando para su realización con un convenio de colaboración entre la RBALE y la Universidad de Valladolid. Se explican los detalles organizativos de la experiencia, haciéndose especial énfasis en el balance participativo y en la implicación de los agentes locales

Service-learning, educational innovation and geography: an experience in assessing territorial heritage in the Biosphere Reserve of the area known as the Ancares Leoneses (Cantabrian mountain range, Spain)

Producción CientíficaThe article weighs up the didactic proposal carried out by the authors in the Biosphere Reserve of the Ancares Leoneses (RBALE) with students enrolled in the Practical and Applied Geomorphology class of the fourth year of the Undergraduate Degree in Geography and Land-use Planning of the University of Valladolid. Its development has served, firstly, as a basis and a tool for geographical work in a mountain site of heritage value, a key objective of the matter. At the same time, it has allowed students to take part in a real service-learning experience, interacting with local parties and management entities of the RBALE. This experience was awarded the “Prize for Educational Innovation by the Social Council of the University of Valladolid -2013-”.CSO2012-39564-C07-0

MIRACLE evaluation of results for ImageCLEF 2003

ImageCLEF is a new pilot experiment introduced in CLEF 2003. It is devoted to the cross language retrieval of images using textual descriptions related to images contents. This paper presents MIRACLE research team experiments and results obtained for this track

Evaluation of MIRACLE approach results for CLEF 2003

This paper describes MIRACLE (Multilingual Information RetrievAl for the CLEf campaign) approach and results for the mono, bi and multilingual Cross Language Evaluation Forum tasks. The approach is based on the combination of linguistic and statistic techniques to perform indexing and retrieval tasks

Interacción dipolar y de canje en la histéresis magnética anómala de sistemas multifásicos blando/duro basados en cintas amorfas

En los últimos años los materiales nanomagnéticos han sido objeto de gran interés debido a que un control apropiado de sus características morfológicas permite conseguir una amplia variedad de comportamientos magnéticos en lo que a su dureza se refiere [1,2]. Entre los efectos magnéticos particulares que pueden conseguirse en estos sistemas resulta especialmente interesante el desplazamiento horizontal de los ciclos de histéresis, debido a su potencial aplicación tecnológica. Existen al menos dos tipos de sistemas en los que los ciclos de histéresis aparecen horizontalmente desplazados: los sistemas ferromagnético¿antiferromagnético, en los que el desplazamiento tiene su origen en la anisotropía de canje [3,4], y los sistemas duro¿blando en los que la causa del desplazamiento está en las interacciones dipolar y de canje entre las fases magnéticas [5]. Al estudio de este último fenómeno se dirige este proyecto de tesis. En diversos sistemas magnéticos duro¿blando se ha constatado la aparición de una histéresis anómala consistente, no sólo en el desplazamiento horizontal, sino en una distorsión del ciclo de histéresis con pérdida de la simetría curva ascendente¿curva descendente [6]. Los detalles del fenómeno dependen obviamente de las características magnéticas de las distintas fases que componen el material, pero sobre todo de la interacción entre ellas. La tesis presente analiza la histéresis anómala de cintas amorfas de base cobalto nanocristalizadas mediante tratamientos térmicos, tanto desde el punto vista experimental como desde el teórico. Se han hecho para ello caracterizaciones magnéticas y estructurales y, en base a dichos resultados, se han modelizado las interacciones dipolar y de canje en este tipo de sistemas. Los distintos estudios permiten extraer como principal conclusión la preeminencia de la interacción de intercambio sobre la dipolar en el origen del fenómeno. Se trata por tanto de un particular tipo de anisotropía de canje ferromagnético-ferromagnético causada por la enorme diferencia en la dureza magnética de las fases amorfa y cristalina. Se concluye así mismo que el tipo de morfología cristalina que favorece este efecto es la cristalización aislada de nanocristales ferromagnéticos monodominio, cuya fase cristalina, especialmente a través de la constante de intercambio, es un parámetro clave. Referencias bibliográficas [1] G. Herzer, IEEE Trans. Magn. MAG-26 (1990) 1397. [2] J.M.D. Coey, J. Magn. Magn. Mater. 140¿144 (1995) 1041. [3] O. Kohmoto, N. Yamaguchi, K. Ohya, H. Fujishima, Jpn. J. Appl. Phys. 17 (1978) 257. [4] W.H. Meiklejohn, C.P. Bean, Phys. Rev. 102 (1956) 1413. [5] D.X. Chen, Y.-F. Li, L. Pascual, M. Vázquez, A. Hernando, J. Magn. Magn. Mater. 212 (2000) 373. [6] M. Rivas, J.A. García, M. Tejedor, E. Bertrán, J.G. Céspedes, J. Appl. Phys. 97 (2005) 023903