Enabling adaptability in web forms based on user characteristics detection through A/B testing and machine learning

[EN] This paper presents an original study with the aim of improving users' performance in completing large questionnaires through adaptability in web forms. Such adaptability is based on the application of machine-learning procedures and an A/B testing approach. To detect the user preferences, behavior, and the optimal version of the forms for all kinds of users, researchers built predictive models using machine-learning algorithms (trained with data from more than 3000 users who participated previously in the questionnaires), extracting the most relevant factors that describe the models, and clustering the users based on their similar characteristics and these factors. Based on these groups and their performance in the system, the researchers generated heuristic rules between the different versions of the web forms to guide users to the most adequate version (modifying the user interface and user experience) for them. To validate the approach and con rm the improvements, the authors tested these redirection rules on a group of more than 1000 users. The results with this cohort of users were better than those achieved without redirection rules at the initial stage. Besides these promising results, the paper proposes

Uncertainty quantification and predictability of wind speed over the Iberian Peninsula

During recent decades, the use of probabilistic forecasting methods has increased markedly. However, these predictions still need improvement in uncertainty quantification and predictability analysis. For this reason, the main aim of this paper is to develop tools for quantifying uncertainty and predictability of wind speed over the Iberian Peninsula. To achieve this goal, several spread indexes extracted from an ensemble prediction system are defined in this paper. Subsequently, these indexes were evaluated with the aim of selecting the most appropriate for the characterization of uncertainty associated to the forecasting. Selection is based on comparison of the average magnitude of ensemble spread (ES) and mean absolute percentage error (MAPE). MAPE is estimated by comparing the ensemble mean with wind speed values from different databases. Later, correlation between MAPE and ES was evaluated. Furthermore, probability distribution functions (PDFs) of spread indexes are analyzed to select the index with greater similarity to MAPE PDFs. Then, the spread index selected as optimal is used to carry out a spatiotemporal analysis of model uncertainty in wind forecasting. The results indicate that mountainous regions and the Mediterranean coast are characterized by strong uncertainty, and the spread increases more rapidly in areas affected by strong winds. Finally, a predictability index is proposed for obtaining a tool capable of providing information on whether the predictability is higher or lower than average. The applications developed may be useful in the forecasting of wind potential several days in advance, with substantial importance for estimating wind energy production

Evaluation of Early Cholecystectomy versus Delayed Cholecystectomy in the Treatment of Acute Cholecystitis

Objective. To evaluate if early cholecystectomy (EC) is the most appropriate treatment for acute cholecystitis compared to delayed cholecystectomy (DC). Patients and Methods. A retrospective cohort study of 1043 patients was carried out, with a group of 531 EC cases and a group of 512 DC patients. The following parameters were recorded: (1) postoperative hospital morbidity, (2) hospital mortality, (3) days of hospital stay, (4) readmissions, (5) admission to the Intensive Care Unit (ICU), (6) type of surgery, (7) operating time, and (8) reoperations. In addition, we estimated the direct cost savings of implementing an EC program. Results. The overall morbidity of the EC group (29.9%) was significantly lower than the DC group (38.7%). EC demonstrated significantly better results than DC in days of hospital stay (8.9 versus 15.8 days), readmission percentage (6.8% versus 21.9%), and percentage of ICU admission (2.3% versus 7.8%), which can result in reducing the direct costs. The patients who benefited most from an EC were those with a Charlson index > 3. Conclusions. EC is safe in patients with acute cholecystitis and could lead to a reduction in the direct costs of treatmen

Impact of EV penetration in the interconnected urban environment of a smart city

The smart city seeks a highly interconnected, monitored and globally optimized environment to profit from the synergies among systems such as energy, transports or waste management. From an energy perspective, transport systems and facilities are among the bigger energy consumers inside cities. However, despite the research available on such systems, few works focus on their interactions and potential synergies to increase their efficiencies. This paper address this problem by assessing the benefits of the interconnection and joint management of different energy systems in a smart city context. This is done using a linear programming problem, modelling a district with residential loads, distributed energy resources (DER) and electric vehicles (EV), which are also connected to an electrical metro substation. This connection allows to store the metro regenerative braking energy into EVs' batteries to be used later for other trains or for the EVs themselves. The objective of the linear programming model is to find the optimal planning and operation of all the considered systems, achieving minimum energy costs. Therefore, the main contributions of this paper are the assessment of synergies of the interconnection of these systems and the detailed analysis of the impact of different EV penetration levels. Results show important economic benefits for the overall system (up to 30%) when the investments and its operation are globally optimized, especially reducing the metro energy costs. Also, analysing the energy transfers between metro-EV, it is evident that the metro takes advantages of the cheaper energy coming from the district (through the EVs), showing the existence of "opportunistic" synergies. Lastly, EV saturation points (where extra EVs represent more load but do not provide additional useful storage to the system) can be relatively small (200–300 EVs) when the energy transfer to the metro electrical substation is restricted, but it is also reduced by the presence of DER systems

Validación de dos algoritmos para la localización 3D del instrumental laparoscópico a partir de la imagen de vídeo endoscópico

Uno de los aspectos fundamentales en un sistema de cirugía guiada por imagen (CGI) es la localización del instrumental quirúrgico con respecto a la anatomía del paciente. Los sistemas basados en sensores ofrecen buenos niveles de precisión, pero son sensibles a distintas fuentes de ruido en el quirófano y contribuyen a la sobrecarga tecnológica del mismo. Una alternativa novedosa es analizar la imagen del vídeo endoscópico para llevar a cabo la detección y localización espacial del instrumental. Se presenta en este trabajo la validación de dos métodos, basados en el diámetro aparente y en la sección transversal del instrumental, para la localización espacial del instrumental a partir de los bordes y la posición 2D de la punta en la imagen. La validación, llevada a cabo en un simulador físico, se realiza comparando los resultados con el sistema Kinescan/IBV. Los resultados muestran para cada método un error medio de 12,7 y 12,8 mm respectivamente. La incorporación de estos algoritmos dentro del paradigma de navegación propuesto en el proyecto THEMIS permitirá al cirujano conocer la posición del instrumental de forma no intrusiva y transparente, sin necesidad de equipamiento adicional en el quirófano

Development of a Real-Time PCR method for the identification of Atlantic mackerel (Scomber scombrus)

5 páginas, 3 tablas, 2 figurasA Real Time-PCR method based on TaqMan technology for the identification of Scomber scombrus has been developed. A system of specific primers and a Minor Groove Binding (MGB) TaqMan probe based on sequences of the mitochondrial cytochrome b region was designed. The method was successfully tested in 81 specimens of S. scombrus and related species and validated in 26 different commercial samples. An average Threshold Cycle (Ct) value of 15.3 was obtained with S. scombrus DNA. With the other species tested fluorescence signal was not detected or Ct was significantly higher (P < 0.001). The efficiency of the assay was estimated to be 92.41%, with 100% specificity, and no cross reactivity was detected with any other species. These results reveal that the developed method is a rapid and efficient tool to unequivocally identify S. scombrus and may aid in the prevention of fraud or mislabelling in mackerel productsThe work was supported by the project “Traceability control mechanisms in the mackerel food chain between Norway and Japan – TraCtrolMac” (No: 251810704011000009)Peer reviewe

Miocene evolution of the External Rif Zone (Morocco): comparison with similar and lateral southern Mediterranean Tethyan margins

The Miocene evolution of the External Rif Zone (NW Africa Plate) was determined through the multidisciplinary analysis of fourteen successions. The updated stratigraphic framework shows how Miocene sediments rest on the Cretaceous–Paleogene terrains through unconformity surfaces, whereas it rests with sedimentary continuity in two sectors. After recognition of lithofacies and three unconformities located near the Oligocene–Aquitanian, Aquitanian–Burdigalian and Serravallian–Tortonian boundaries, the Miocene sedimentary record was divided into three stratigraphic intervals representing deep to shallow marine deposits as Aquitanian–Burdigalian, Langhian and Upper Serravallian–Missinian. The two oldest unconformites are restricted to the central sector, while the upper one is generalized and probably related to the nappe tectonics registered in all sectors of the External Rif. Data from analysis of tectofacies, petrology, mineralogy, meaning and implications of unconformities, and subsidence indicate that: (i) mass flow deposits (turbidites, slumps, olistostromes) are common in all successions but more frequent during the Lower Miocene; (ii) petrology of the detrital components of the arenites indicates recycled orogen-derived sediments, with quartz coming from erosion of metamorphic rocks of the Atlas orogen and/or the African craton; (iii) mineralogy of mudstones suggests a complex erosional evolution of local emerged areas derived from a mixture of contributions coming from the erosion of Upper Jurassic to Paleogene suites, and especially from kaolinite-rich Albian–Cenomanian to Paleogene successions with absence of a clear unroofing. The conjunction of all these clues reinforce the idea of a synsedimentary tectonics affecting the margin/basin system during the Miocene. A thickness analysis of the studied sedimentary successions allows proposing the evolution of the orogenic front and main depozones (foredeep, bulges, wedge-top and intramontane sub-basins) integrated in a complex foreland system migrating from north to south with the Atlas-Mesetas area acting as foreland during MIocene. The orogenic front moved from the Internal Intrarif to Mesorif and later to Internal Prerif. The main wedge-top basin also migrated from the Internal Intrarif to External Intrarif. The foredeep migrated from the Mesorif to the Internal Prerif, while the main forebulge was located in the External Prerif and a asecondary bulge developed in the External Intrarif. Intramontane basins developed behind the orogenic front in relative extensional conditions moving from the Internal Extrarif to External Intrarif. The reconstructed Miocene evolution was inserted into a 2D paleogeographic-geodynamic evolutionary model using Gplates software, and then compared to those reported in other external margins of the western Tethys (Betic Chain, Tunisian Tell, Sicilian Maghrebids and Apennines), revealing important similarities and local differences.Research supported by PID2020-114381GB-I00 Research Project (Spanish Ministry of Education and Science), EU HORIZON project CiROCCO under Grant Agreement No 101086497, Research Groups and projects of the Generalitat Valenciana from Alicante University (CTMA-IGA), and Research Group RNM-188 of the Junta de Andalucía from EEZA–CSIC

Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

9 p.-2 figPhase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging that are involved in drug metabolism but also in the generation of danger or costimulatory signals. Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites. In addition, their metabolic activity can have important consequences for the cellular redox status, and impacts the inflammatory response as well as the balance of inflammatory mediators, which can modulate epigenetic factors and cooperate or interfere with drug-adduct formation. These enzymes are, in turn, targets for covalent modification and regulation by oxidative stress, inflammatory mediators, and drugs. Therefore, they constitute a platform for a complex set of interactions involving drug metabolism, protein haptenation, modulation of the inflammatory response, and/or generation of danger signals with implications in drug hypersensitivity reactions. Moreover, increasing evidence supports their involvement in allergic processes. Here, we will focus on GSTP1-1 and aldose reductase (AKR1B1) and provide a perspective for their involvement in drug hypersensitivityThis work has been supported by grants SAF2012-36519 from MINECO and SAF-2015-68590-R from MINECO/FEDER and ISCIII RETIC RIRAAF RD12/0013/0008 to DP,and RD12/0013/0002 to J A.Peer reviewe

Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9

Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten proteins from wheat, barley and rye. The a-gliadin gene family of wheat contains four highly stimulatory peptides, of which the 33-mer is the main immunodominant peptide in patients with coeliac. We designed two sgRNAs to target a conserved region adjacent to the coding sequence for the 33-mer in the a-gliadin genes. Twenty-one mutant lines were generated, all showing strong reduction in a-gliadins. Up to 35 different genes were mutated in one of the lines of the 45 different genes identified in the wild type, while immunoreactivity was reduced by 85%. Transgene-free lines were identified, and no off-target mutations have been detected in any of the potential targets. The low-gluten, transgene-free wheat lines described here could be used to produce low-gluten foodstuff and serve as source material to introgress this trait into elite wheat varieties.Ministerio de Economía y Competitividad AGL2013-48946-C3-1-R ; AGL2016-80566-