2,199 research outputs found
Smart Safeguard
Smart Safeguard is designed to provide people with an affordable device that will notify the authorities when the buyer gets in a car crash. The device will operate off the 12V car power that is present in every car and use an accelerometer to detect if an accident has occurred. If an accident is detected the device will proceed to light up and make a noise until the passenger pushes a button on the device. If the passenger doesn’t push the button within 15 seconds the device, which is wirelessly connected to the passenger’s phone, will initiate a text to 911 via the cell phone. The text includes a help message and the coordinates of the smart safeguard. This allows the authorities to be notified that there is a problem within 15 seconds of an accident. If the driver is ok, and doesn’t need the authorities he/she can push the button and the device will not text 911
Seismic Stability Analysis of a High Earth and Rockfill Dam
Accumulation of knowledge on earthquake activity in California has lead to stronger ground motions being postulated for the evaluation of the seismic stability of dams. A recent regional seismicity study for a 555 ft high earth and rockfill dam in central California lead to a ground motion with peak ground acceleration (PGA) of 0.50g originating in a local fault system 3 miles from the dam site. This PGA is more than 6 times higher than the PGA=0.08g value originally adopted when the Dam was analyzed for seismic stability 20 years ago. Thus, as part of FERC Part 12 evaluation requirements, the seismic stability of the Dam was re-evaluated using the updated ground motion and state-of-the-practice technology. This paper presents the analysis procedures and the results
The immediate early gene Egr3 Is required for hippocampal induction of Bdnf by electroconvulsive stimulation
Early growth response 3 (Egr3) is an immediate early gene (IEG) that is regulated downstream of a cascade of genes associated with risk for psychiatric disorders, and dysfunction of Egr3 itself has been implicated in schizophrenia, bipolar disorder, and depression. As an activity-dependent transcription factor, EGR3 is poised to regulate the neuronal expression of target genes in response to environmental events. In the current study, we sought to identify a downstream target of EGR3 with the goal of further elucidating genes in this biological pathway relevant for psychiatric illness risk. We used electroconvulsive stimulation (ECS) to induce high-level expression of IEGs in the brain, and conducted expression microarray to identify genes differentially regulated in the hippocampus of Egr3-deficient (-/-) mice compared to their wildtype (WT) littermates. Our results replicated previous work showing that ECS induces high-level expression of the brain-derived neurotrophic factor (Bdnf) in the hippocampus of WT mice. However, we found that this induction is absent in Egr3-/- mice. Quantitative real-time PCR (qRT-PCR) validated the microarray results (performed in males) and replicated the findings in two separate cohorts of female mice. Follow-up studies of activity-dependent Bdnf exons demonstrated that ECS-induced expression of both exons IV and VI requires Egr3. In situ hybridization demonstrated high-level cellular expression of Bdnf in the hippocampal dentate gyrus following ECS in WT, but not Egr3-/-, mice. Bdnf promoter analysis revealed eight putative EGR3 binding sites in the Bdnf promoter, suggesting a mechanism through which EGR3 may directly regulate Bdnf gene expression. These findings do not appear to result from a defect in the development of hippocampal neurons in Egr3-/- mice, as cell counts in tissue sections stained with anti-NeuN antibodies, a neuron-specific marker, did not differ between Egr3-/- and WT mice. In addition, Sholl analysis and counts of dendritic spines in golgi-stained hippocampal sections revealed no difference in dendritic morphology or synaptic spine density in Egr3-/-, compared to WT, mice. These findings indicate that Egr3 is required for ECS-induced expression of Bdnf in the hippocampus and suggest that Bdnf may be a downstream gene in our previously identified biologically pathway for psychiatric illness susceptibility.US National Institute of Mental Health [R01MH097803, R21MH113154]; Natural Sciences and Engineering Research Council of CanadaOpen access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
MOSTO: A toolkit to facilitate security auditing of ICS devices using Modbus/TCP
The integration of the Internet into industrial plants has connected Industrial Control Systems (ICS) worldwide, resulting in an increase in the number of attack surfaces and the exposure of software and devices not originally intended for networking. In addition, the heterogeneity and technical obsolescence of ICS architectures, legacy hardware, and outdated software pose significant challenges. Since these systems control essential infrastructure such as power grids, water treatment plants, and transportation networks, security is of the utmost importance. Unfortunately, current methods for evaluating the security of ICS are often ad-hoc and difficult to formalize into a systematic evaluation methodology with predictable results. In this paper, we propose a practical method supported by a concrete toolkit for performing penetration testing in an industrial setting. The primary focus is on the Modbus/TCP protocol as the field control protocol. Our approach relies on a toolkit, named MOSTO, which is licensed under GNU GPL and enables auditors to assess the security of existing industrial control settings without interfering with ICS workflows. Furthermore, we present a model-driven framework that combines formal methods, testing techniques, and simulation to (formally) test security properties in ICS networks
Prediction of energy dissipation in violent sloshing flows simulated by Smoothed Particle Hydrodynamics
Prediction of energy dissipation in violent sloshing flows simulated by Smoothed Particle Hydrodynamic
Stringent Limits on the Polarized Submillimeter Emission from Protoplanetary Disks
We present arcsecond-resolution Submillimeter Array (SMA) polarimetric
observations of the 880 um continuum emission from the protoplanetary disks
around two nearby stars, HD 163296 and TW Hydrae. Although previous
observations and theoretical work have suggested that a 2-3% polarization
fraction should be common for the millimeter continuum emission from such
disks, we detect no polarized continuum emission above a 3-sigma upper limit of
7 mJy in each arcsecond-scale beam, or <1% in integrated continuum emission. We
compare the SMA upper limits with the predictions from the exploratory Cho &
Lazarian (2007) model of polarized emission from T Tauri disks threaded by
toroidal magnetic fields, and rule out their fiducial model at the ~10-sigma
level. We explore some potential causes for this discrepancy, focusing on model
parameters that describe the shape, magnetic field alignment, and size
distribution of grains in the disk. We also investigate related effects like
the magnetic field strength and geometry, scattering off of large grains, and
the efficiency of grain alignment, including recent advances in grain alignment
theory, which are not considered in the fiducial model. We discuss the impact
each parameter would have on the data and determine that the suppression of
polarized emission plausibly arises from rounding of large grains, reduced
efficiency of grain alignment with the magnetic field, and/or some degree of
magnetic field tangling (perhaps due to turbulence). A poloidal magnetic field
geometry could also reduce the polarization signal, particularly for a face-on
viewing geometry like the TW Hya disk. The data provided here offer the most
stringent limits to date on the polarized millimeter-wavelength emission from
disks around young stars.Comment: 15 pages, 6 figures, accepted for publication in Ap
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