Clavibacter michiganensis subsp. insidiosus: bactéria quarentenária com risco para as culturas forrageiras no Brasil.

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Rubinstein Taybi Syndrome. A Case Report

Os autores descrevem um caso de Síndrome de Rubinstein-Taybi em que as características faciais e os polegares alargados permitiram o diagnóstico na primeira semana de vida. Salientam na evolução as infecções respiratórias de repetição, o atraso psicomotor e estaturo ponderal. Discutem as prováveis formas de transmissão deste síndrome

Curtobacterium flaccumfaciens pv. flaccumfaciens Murcha bacteriana do feijoeiro e da soja: alto risco de disseminação no Brasil.

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Avaliação dos impactos sociais de tecnologias agropecuárias: geração de empregos.

A Embrapa, como uma instituição de pesquisa, utiliza para medir a geração de impactos de uma tecnologia, metodologias que reflitam os impactos de seus produtos, como é o caso do método do excedente econômico, e os Ambitec’s (Sistema de Avaliação de Impacto de Inovações Tecnológicas Agropecuárias), que ajudam a levantar impactos econômicos, sociais e ambientais das tecnologias, aplicada em três etapas: 1) levantamento e coleta de dados, como alcance, delimitação e adotantes; 2) aplicação de questionários com geração de dados quantitativos e 3) análise e interpretação dos índices gerados. O objetivo desse trabalho é mostrar a importância da avaliação dos impactos das tecnologias sobre o emprego, com o intuito de valorizar este componente dos impactos sociais. Para operacionalizar a avaliação de impactos sociais sobre os empregos gerados pela adoção de tecnologias, definiu-se a necessidade de medir o número de empregos adicionais, em toda a cadeia produtiva, resultantes da adoção de uma dada tecnologia, comparativamente à situação dos empregos na tecnologia anterior, e agora substituída pela tecnologia Embrapa. A estimativa do número de empregos gerados pelas tecnologias é importante sob dois aspectos. Primeiro, permite que a equipe de avaliação de impactos conheça todo o potencial de geração de emprego da tecnologia, verificando qual elo da cadeia produtiva poderá ser mais impactado. Em segundo lugar, destaca-se a questão da visibilidade, pois as estimativas de empregos gerados por tecnologias, são divulgadas no Balanço Social da Embrapa, evidenciando pesquisadores, equipe de avaliação de impactos, e a própria Embrapa. Assim, a avaliação dos impactos sobre o emprego, a partir do desenvolvimento de tecnologias constitui uma necessidade e representa um avanço no entendimento dos resultados oriundos dos avanços tecnológicos, além de uma constatação de que a geração de empregos no campo afeta não só o espaço local mas também toda uma cadeia produtiva relacionada ao campo. Palavras-Chave: metodologia – emprego – tecnologias – Embrap

Tuning hole mobility in InP nanowires

Transport properties of holes in InP nanowires were calculated considering electron-phonon interaction via deformation potentials, the effect of temperature and strain fields. Using molecular dynamics, we simulate nanowire structures, LO-phonon energy renormalization and lifetime. The valence band ground state changes between light- and heavy-hole character, as the strain fields and the nanowire size are changed. Drastic changes in the mobility arise with the onset of resonance between the LO-phonons and the separation between valence subbands.Comment: 4 pages, 4 figure

Medidas de radiação solar e índice de área foliar em coberturas vegetais.

Um método de inversão de modelo físico de penetração de radiação solar em meio vegetal para estimar o índice de área foliar (IAF) é apresentado e testado neste trabalho para diferentes tipos de vegetação, como alternativa aos experimentos destrutivos, trabalhosos e de difícil implementação em coberturas florestais

DNA Interaction with Palladium Chelates of Biogenic Polyamines Using Atomic Force Microscopy and Voltammetric Characterization

The interaction of double-stranded DNA with two polynuclear Pd(II) chelates with the biogenic polyamines spermidine (Spd) and spermine (Spm), Pd(II)-Spd and Pd(II)-Spm, as well as with the free ligands Spd and Spm, was studied using atomic force microscopy (AFM) at a highly oriented pyrolytic graphite (HOPG) surface, voltammetry at a glassy carbon (GC) electrode, and gel electrophoresis. The AFM and voltammetric results showed that the interaction of Spd and Spm with DNA occurred even for a low concentration of polyamines and caused no oxidative damage to DNA. The Pd(II)-Spd and Pd(II)-Spm complexes were found to induce greater morphological changes in the dsDNA conformation, when compared with their ligands. The interaction was specific, inducing distortion and local denaturation of the B-DNA structure with release of some guanine bases. The DNA strands partially opened give rise to palladium intra- and interstrand cross-links, leading to the formation of DNA adducts and aggregates, particularly in the case of the Pd(II)-Spd complex

BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOPhagocyte function is critical for host defense against infections. Defects in phagocytic function lead to several primary immunodeficiencies characterized by early onset of recurrent and severe infections. In this work, we further investigated the effects of BAY 41-2272, a soluble guanylate cyclase (sGC) agonist, on the activation of human peripheral blood monocytes (PBM) and THP-1 cells. EXPERIMENTAL APPROACH THP-1 cells and PBM viability was evaluated by methylthiazoletetrazolium assay; reactive oxygen species production by lucigenin chemiluminescence; gene and protein expression of NAPDH oxidase components by qRT-PCR and Western blot analysis, respectively; phagocytosis and microbicidal activity by co-incubation, respectively, with zymosan and Escherichia coli; and cytokine release by elisa. KEY RESULTS BAY 41-2272, compared with the untreated group, increased spreading of monocytes by at least 35%, superoxide production by at least 50%, and gp91PHOX and p67PHOX gene expression 20 to 40 times, in both PBM and THP-1 cells. BAY 41-2272 also augmented phagocytosis of zymosan particles threefold compared with control, doubled microbicidal activity against E. coli and enhanced the release of TNF-a and IL-12p70 by both PBM and THP-1 cells. Finally, by inhibiting sGC with ODQ, we showed that BAY 41-2272-induced superoxide production and phagocytosis is not dependent exclusively on sGC activation. CONCLUSIONS AND IMPLICATIONS In addition to its ability to induce vasorelaxation and its potential application for therapy of vascular diseases, BAY 41-2272 was shown to activate human mononuclear phagocytes. Hence, it is a novel pro-inflammatory drug that may be useful for controlling infections in the immunocompromised host166516171630FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO06/51004-2; 06/52483-1470978/2008-

A compactness theorem for scalar-flat metrics on manifolds with boundary

Let (M,g) be a compact Riemannian manifold with boundary. This paper is concerned with the set of scalar-flat metrics which are in the conformal class of g and have the boundary as a constant mean curvature hypersurface. We prove that this set is compact for dimensions greater than or equal to 7 under the generic condition that the trace-free 2nd fundamental form of the boundary is nonzero everywhere.Comment: 49 pages. Final version, to appear in Calc. Var. Partial Differential Equation

An unusual case of accessory head of coracobrachialis muscle involving lateral cord of brachial plexus and its clinical significance

Knowledge of anatomical variations in the peripheral nervous system is key in the interpretation of unusual clinical signs or during physical or diagnostic imaging. This case study is a description of an anatomical variation between the coracobrachialis muscle and brachial plexus. In a routine dissection in the human anatomy laboratory, we were faced with an anatomical variation in the coracobrachialis muscle, observed in the upper right limb of a male cadaver. The coracobrachialis muscle had a common origin at the apex of the coracoid process and then divided into two heads. The lateral head followed its normal course until insertion into the middle third of the humerus, while the medial head involved the lateral cord of the brachial plexus before insertion into the intermuscular septum in the proximal third of the humerus. Atypical anatomical variations have clinical and surgical implications in procedures such as brachial plexus block and lateral cord compression. In these cases the result could be paralysis of the flexor musculature of the forearm and hypoesthesia of the forearm