Sinteza, spektralna karakterizacija i mehanističke studije novih pirazolskih i pirazolonskih derivata

U okviru ove doktorske disertacije sintetizovana je serija N-[(1,3-difenil- pirazol-4-il)metil] α-amino-kiselina i N-[(3-ferocenil-1-fenilpirazol-4-il)- metil] α-amino-kiselina, uključujući i oba fenilalaninska enantiomera. U NMR studijama organometalnih derivata zapaženo je da dodatno cepanje orto- i meta- ferocenskih signala i njihov multiplicitet zavise od prirode α-amino-kiselinskog bočnog niza i ne mogu se pripisati samo hiralnosti α-amino-kiseline koja je vezana za pirazolov prsten. Efekat magnetne neekvivalentnosti oba orto-protona supstituisane ciklopentadienske jedinice naročito je izražen u jedinjenjima sa aromatičnim ili heteroaromatičnim prstenovima. U serinskom derivatu dobijenom iz 3-ferocenil-1-fenilpirazol-4-karbaldehida nije primećeno razdvajanje orto- ciklopentadienskih signala verovatno kao posledica formiranja vodonične veze između hidroksilne i karboksilne grupe, što ukazuje na postojanje neke druge konformacije sa umanjenim uticajem hidroksimetil-grupe na ferocenski sistem.Within this doctoral thesis a series of N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids and N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids including both phenylalanine enantiomer derivatives were synthesized. NMR studies of the organometalic compounds revealed that additional splitting of the ortho and meta ferrocene signals as well as their multiplicities depend on nature of α-amino acid side chain and cannot be attributed to the chirality of pyrazole-linked α-amino acid alone. The effect of magnetic nonequivalence of both ortho protons of substituted cyclopentadiene (Cp) unit is particularly pronounced in compounds containing aromatic or heteroaromatic rings. In serine derivative of 3-ferrocenyl- 1-phenylpyrazole-4-carboxaldehyde there is no appearance of splitting of ortho Cp signals probably as a consequence of hydrogen bond formation between hydroxyl and carboxylate group indicating a presence of an alternate conformation with reduced influence of CH2OH moiety on ferrocene scaffold

Hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions

Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Objective The purpose of this study was to compare the effects of low and high doses of KI on the thyroid gland of Wistar rats and determine the effect on hormone status (T4, T3 and TSH) in this rat strain. Methods Two groups of rats from the Wistar strain were treated with a low iodine dose (225 μg/g BW) and with a high iodine dose (675 μg/g BW) of KI solutions. Untreated nonimmunized animals served as controls. The solution was administrated daily intraperitoneally during the period of 26 consecutive days. Results Monitoring hormone status (TSH, T3 and T4) and morphological changes it was found that therapeutic doses of KI applied in treatment induced the occurrence of experimental thyroiditis (chronic destructive Hashimoto's thyroiditis in humans) and cell necrosis in animals not carrying a genetic susceptibility. Significant inflammatory changes were observed in rats treated with a high iodine dose. Conclusion The early iodine induced cell necrosis and inflammation in the nonimmunized animals without genetic susceptibility is a new experimental model of thyroiditis.

PROMIŠLJANJA STUDENATA SOCIJALNE POLITIKE I SOCIJALNOG RADA O UVEDENIM MJERAMA I MEDIJSKOM IZVJEŠTAVANJU TIJEKOM PANDEMIJE COVID-19

Introduced measures to deal with COVID-19 pandemic in Serbia affected everyday life of people. Media coverage during the pandemic played a significant role in providing verified information, protecting human health and well-being. In order to gain insight into the reactions of social work students on introduced measures and media coverage about these measures during the state of emergency in Republic of Serbia, an analysis of reflective journals is presented. Eighty reflective journals were analyzed, where students\u27 reactions on introduced measures and media coverage related to these measures are monitored and linked to the electronic archive of the public media service Radio Television of Serbia news. Students\u27 thoughts on several identified measures are presented and analyzed together with their reactions on media coverage about these measures. Findings indicate the important role of the content and ways of media reporting in creation of reflections, as well as the importance of using reflective journals in both education and preservation of mental health. Possible directions of mental health improvement through media coverage in crisis situations and recommendations for education of social workers are presented.Mjere koje su uvedene zbog pandemije COVID-19 u Srbiji utjecali su na svakodnevni život ljudi. Medijsko izvještavanju tijekom pandemije odigralo je značajnu ulogu u pružanju provjerenih informacija i zaštiti ljudskih prava i dobrobiti. Kako bi se stekao uvid u reakcije studenata socijalnog rada na uvedene mjere i medijsko izvješćivanje o tim mjerama tijekom izvanrednog stanja u Republici Srbiji, u radu se predstavlja analiza refleksivnih dnevnika. Analizirano je osamdeset refleksivnih dnevnika putem kojih su se reakcije studenata na uvedene mjere i na medijsko izvješćivanje povezano s tim mjerama pratile i povezivale s elektronskom arhivom javne medijske usluge novosti Radio Televizije Srbije. Studentska mišljenja o nekoliko uvedenih mjera se prikazuju i analiziraju zajedno s njihovim reakcijama na medijsko izvještavanje o tim mjerama. Rezultati ukazuju na važnu ulogu sadržaja i načina medijskog izvještavanja u stvaranju mišljenja, kao i na važnost korištenja refleksivnih dnevnika u obrazovanju i u očuvanju duševnog zdravlja. Predstavljaju se moguće smjernice za poboljšanje duševnog zdravlja putem medijskog izvještavanja tijeom izvanrednog stanja kao i preporuke za obrazovanje socijalnih radnika

Protection System of Persons in Migration during the State of Emergency due to Covid-19 in Serbia

Kao rezultat pandemije COVID-19, profesionalci koji rade u sistemu socijalne zaštite suočavali su se sa višestrukim izazovima – zbog zdravstvene krize bili su zabrinuti, ne samo za živote svojih korisnika, već i za svoju porodicu, prijatelje, ali i za sopstveni život. U cilju analize i razumevanja promena koje je epidemija COVID-19 donela u sistemu socijalne zaštite osoba u migracijama u Srbiji, sprovedeno je kvalitativno istraživanje sa profesionalcima u sistemu. Sprovedene su fokus grupe sa 13 profesionalaca i sedam intervjua sa ključnim informatorima. Rezultati istraživanja pokazuju da je pandemija COVID-19 osvetlila nedostatak kapaciteta prilagođavanja u sistemu zaštite i nespremnost za kriznu situaciju – počev od izazova u obezbeđivanju opreme za zdravstvenu zaštitu dosledno i podjednako do nedostatka stručnog nadzora.As a result of the COVID-19 pandemic, professionals working in the social protection system are confronted with multiple challenges – due to the health crisis, they are worried not only for the lives of their beneficiaries but for their own families, friends, including their own lives. In order to analyze and understand the changes that the COVID-19 pandemic brought to the social protection system of persons in migration in Serbia, qualitative research with professionals in the system has been conducted. Focus groups with 13 professionals and 7 interviews with key informants were conducted. Results have shown that the COVID-19 pandemic had lightened up the lack of adapting capacities in the social protection system and unpreparedness for situations of crisis – starting from challenges of consistent and equal provision of health protection equipment to lack of competent supervision

Supplementary data for article: Marković, V.; Markovic, S.; Janicijevic, A.; Rodić, M.; Leovac, V. M.; Todorović, N.; Trifunović, S. S.; Joksović, M. D. Mechanistic Investigation and DFT Calculation of the New Reaction between S-Methylisothiosemicarbazide and Methyl Acetoacetate. Structural Chemistry 2013, 24 (6), 2127–2136. https://doi.org/10.1007/s11224-013-0223-3

Supplementary material for: [https://doi.org/10.1007/s11224-013-0223-3]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1455

Consultation with Children on the Move : Lessons Learned in Creating a Child-friendly Research Process

In order to respond to the growing needs of migrant families with children, and especially unaccompanied children, who were traveling on the Western Balkan route, social workers and other field workers and child protection officers had to acquire new knowledge and develop specific competencies in a relatively short period of time. Although Serbia is mainly a country of transit, migrant children, who have been staying in Serbia for a longer period of time, have experienced challenges in access to services due to language barriers, overstretched capacities and insufficient coordination. The aim of the paper is to describe and reflect on the process used to develop a design, which ensures migrant children are consulted throughout the process and are the co-creators of a social work curriculum responding to their vulnerabilities. In order to gain insights on the views of children on the move regarding competencies of the workforce in both the government and NGO institutions, a consultation process was introduced with both unaccompanied and accompanied children in Serbia. The methodology of consultations was designed as interactive and safe for children to express their views and experiences. Results indicate that children should be key participants in the co-creation of knowledge in matters that concern them, and it is necessary to develop, test and evaluate the ways in which we can best understand their experiences, points of view and perspectives and incorporate them into knowledge for action

Reflections of social politics and social work students during emergency state caused by the Covid 19 pandemic in Serbia

Pandemija virusa Kovid 19 dovela je do promena u svakodnevnici ljudi i proizvela osećaje nesigurnosti i anksioznosti koji mogu imati negativne posledice na učenje i psihološko zdravlje studenata. Prelaskom na online nastavu na Fakultetu političkih nauka Univerziteta u Beogradu, za studente socijalne politike i socijalnog rada uvedena je predispitna obaveza pisanja refleksivnih dnevnika sa ciljem da se identifikuju, prepoznaju i osveste sopstvene reakcije i doživljaji vezani za pandemiju i podstakne introspekcija i kritičko mišljenje studenata. Cilj rada je analiza dobijenih podataka radi dobijanja informacija o doživljaju studenata i reakcijama na pandemiju virusa Kovid 19 kako bi se stekle informacije o suočavanju sa situacijom pandemije ali i kreirale intervencije radi očuvanja i unapređenja mentalnog zdravlja studentske populacije. Primenjena je tematska analiza dnevnika u kojima su indetifkovane teme: odnos prema pisanju dnevnika, sagledavanje dobrih aspekata vanrednog stanja, porodični odnosi, variranje raspoloženja, odnos prema jelu i pripremi hrane, stvaranje strukture, razvoj kreativnosti, anksioznost, depresivna stanja, bes i strah. Rezultati ukazuju na značaj negovanja i očuvanja mentalnog zdravlja za dobrobit ljudi i na moguće pravce unapređenja praksi obrazovnih ustanova u kriznim situacijama.The pandemic of the novel corona virus has led to changes in people’s daily lives and has produced feelings of insecurity and anxiety that can have neg- ative consequences for students’ learning and psychological health. Upon switching to online teaching at the Faculty of Political Science, University of Belgrade, a pre-examination task of writing reflective diaries was introduced for students of social politics and social work on two subjects: Counseling and Sociotherapy and Social Work with Children and Youth. The aim of the task was to identify, but also recognize and raise awareness of reactions and experiences related to the pandemic and encourage introspec- tion. The thematic analysis of 80 reflective diaries and selected topics were presented: attitude towards writing diaries, understanding the good aspects of the state of emergency, family relations, mood swings, attitude towards eating and food preparation, creating structure, developing creativity, anx- iety, depression, anger and fear. The results indicate the importance of nur- turing and preserving mental health for the well-being of people and the possible directions for improving the practice of educational institutions in crisis situations

Experiences of children in migration with violence on the western Balkan route

Deca u migracijama na balkanskoj ruti su, pored drugih ugrožavajućih okolnosti, izložena svim osnovnim vrstama (fizičko, psihološko, seksualno) i mnogobrojnim drugim oblicima nasilja, u zemljama porekla i tokom putovanja. Ovaj rad razmatra iskustva dece u migracijama na balkanskoj ruti sa stanovišta prava deteta, gde je prikazan deo rezultata istraživanja koji su deo šireg projekta, „Nasilje nad decom na balkanskoj migracionoj ruti – rešenja kroz zagovaranje i istraživanje”. Projekat je razvijen u saradnji sa Save the Children NWB i Centrom za interdisciplinarne studije Univerziteta u Sarajevu, uz podršku Inicijativa za istraživanje seksualnog nasilja (SVRI). Istraživanje je sprovedeno na teritoriji Bosne i Hercegovine i Srbije, koje su tranzitna zona na putu prema Zapadnoj Evropi. Svrha studije je bliže razumevanje karakteristika nasilja nad decom u migracijama u Srbiji i BiH i faktora koji doprinose nasilju i/ili zaštiti dece migranata. Istraživanjem je obuhvaćeno 48 dece, od kojih je 10 devojčica, uzrasta od 13 do 19 godina. Nalazi upućuju da su deci u migracijama, u raznovrsnim situacijama i okolnostima, uskraćena brojna prava, iz sve tri velike grupe: na zaštitu od nasilja i eksploatacije, obezbeđenje uslova za rast i razvoj i participaciju. Neretko im je uskraćeno pravo na učešće u stvarima koje ih se tiču, a njihovo gledište se retko spoznaje i razmatra. Ovo ukazuje na nerazvijene mehanizme za primenu međunarodnih propisa u oblasti prava deteta u migracijama i nesaglasne, čak suprotstavljene, agende prava deteta i restriktivnog upravljanja migracijama u politikama Evropske unije.Children in migration on the Balkan route are, in addition to other threaten- ing circumstances, exposed to all basic types (physical, psychological, sexual) and numerous other forms of violence, in the countries of origin and during the journey. This paper discusses the experiences of children in migration on the Balkan route from the point of view of children’s rights. The research results presented are part of a wider project: “Violence against children on the Balkan migration route – solutions through advocacy and research”. The project was developed in cooperation with Save the Children NWB and the Center for Interdisciplinary Studies of the University of Sarajevo, with the support of the Sexual Violence Research Initiative (SVRI)

The use of different N sources for the treatment of permanent grassland and effect on forage quality

During an experiment conducted in Serbia, near the city of Sabac over two growing seasons (2012/13 and 2013/14), the yield and quality of grassland treated with an organo-mineral fertilizer (farmyard manure 30 t ha(-1) + 10 wt.% zeolite) was monitored and compared to fertilization with pure manure (30 t ha(-1)), spring nitrogen application (50 kg/ha N), treatment with pure zeolite, and treatment without the addition of fertilizers. All fertilizers were spread in the autumn of 2012. Nitrogen was exceptionally applied in the spring of 2013 and 2014. Dry matter (DM) yield and forage quality were evaluated during the growing season, in two forage harvests. In addition to yields, the chemical composition of the biomass, concentrations of total protein fractions and in vitro DM digestibility were examined in detail. The biomass yields of both cuts in the first season were considerably higher after the application of manure with zeolite, pure manure and mineral nitrogen, compared to the control and zeolite. No significant differences among the treatments were noted with regard to the chemical composition of the biomass, or the effect of the type of fertilization on DM digestibility of the biomass from the natural grassland. The application of the organo-mineral fertilizer considerably reduced the share of NPN in total protein, compared to pure manure

Biopreservation of traditional raw milk cheeses with an emphasis on Serbian artisanal cheeses and their historical production

Cheese is one of the oldest food products with preservation based on fermentation, the most common and perhaps the oldest biotechnology. It relies on the biochemical action of lactic acid bacteria (LAB) and is regarded as health-friendly by consumers. Some autochthonous LAB, worldwide and in Serbia, have been characterized as effective producers of antimicrobial compounds such as low-molecular-weight metabolites, hydrogen peroxide, bacteriocins, and bacteriocin-like molecules, and so have demonstrated great potential as food preservatives . The raw milk cheese microbiota, as a good source of novel bacteriocinogenic LAB with high diversity of microbial activity, is key in controlling the microbial load in cheese and achieving diverse sensory characteristics