2,977 research outputs found
Poverty and Progress in the U.S. South since 1920
Poverty, disease, and illiteracy had long bedeviled the U.S. South, even before the agricultural depression of the 1920s became subsumed within the Great Depression of the 1930s. The essays collected in this volume examine a variety of responses to economic depression and poverty. They recount specific battles for civil, educational, and labor rights, and explore the challenges and alternatives to the corporate South in the post World War II agribusiness era. Scholars from both the U.S. and Europe assess how far the South has come in the last century, what forces (from the Sears Roebuck Catalog to the Civil Rights Movement) have been at work in its transformation, and whether the region\u27s reincarnation as the Sunbelt has lifted the burdens of southern history. Contributors assess labor strikes and demonstrations that have not always found a place in histories of the region and revisit and reassess key southern figures from Erskine Caldwell and James Agee to Albert Gore and Lyndon Johnson. They draw our attention to neglected writers whose representations of poverty deserve more critical attention, and they provide critical analysis of contemporary authors and filmmakers.https://scholarship.richmond.edu/bookshelf/1034/thumbnail.jp
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia.
An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and increases in inflammatory genes. Cyclooxygenase (COX)-derived oxylipins are important mediators of inflammation. We measured oxylipin levels using tandem mass spectrometry and ELISAs in multiple cell and animal models of FRDA. Mass spectrometry revealed increases in concentrations of prostaglandins, thromboxane B2, 15-HETE and 11-HETE in cerebellar samples of knockin knockout mice. One possible explanation for the elevated oxylipins is that frataxin deficiency results in increased COX activity. While constitutive COX1 was unchanged, inducible COX2 expression was elevated over 1.35-fold (P < 0.05) in two Friedreich's mouse models and Friedreich's lymphocytes. Consistent with higher COX2 expression, its activity was also increased by 58% over controls. COX2 expression is driven by multiple transcription factors, including activator protein 1 and cAMP response element-binding protein, both of which were elevated over 1.52-fold in cerebella. Taken together, the results support the hypothesis that reduced expression of frataxin leads to elevation of COX2-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species. These findings support a neuroinflammatory mechanism in FRDA, which has both pathomechanistic and therapeutic implications
Growth and form of the mound in Gale Crater, Mars: Slope wind enhanced erosion and transport
Ancient sediments provide archives of climate and habitability on Mars. Gale Crater, the landing site for the Mars Science Laboratory (MSL), hosts a 5-km-high sedimentary mound (Mount Sharp/Aeolis Mons). Hypotheses for mound formation include evaporitic, lacustrine, fluviodeltaic, and aeolian processes, but the origin and original extent of Gale’s mound is unknown. Here we show new measurements of sedimentary strata within the mound that indicate ∼3° outward dips oriented radially away from the mound center, inconsistent with the first three hypotheses. Moreover, although mounds are widely considered to be erosional remnants of a once crater-filling unit, we find that the Gale mound’s current form is close to its maximal extent. Instead we propose that the mound’s structure, stratigraphy, and current shape can be explained by growth in place near the center of the crater mediated by wind-topography feedbacks. Our model shows how sediment can initially accrete near the crater center far from crater-wall katabatic winds, until the increasing relief of the resulting mound generates mound-flank slope winds strong enough to erode the mound. The slope wind enhanced erosion and transport (SWEET) hypothesis indicates mound formation dominantly by aeolian deposition with limited organic carbon preservation potential, and a relatively limited role for lacustrine and fluvial activity. Morphodynamic feedbacks between wind and topography are widely applicable to a range of sedimentary and ice mounds across the Martian surface, and possibly other planets
Continuous macroscopic limit of a discrete stochastic model for interaction of living cells
In the development of multiscale biological models it is crucial to establish
a connection between discrete microscopic or mesoscopic stochastic models and
macroscopic continuous descriptions based on cellular density. In this paper a
continuous limit of a two-dimensional Cellular Potts Model (CPM) with excluded
volume is derived, describing cells moving in a medium and reacting to each
other through both direct contact and long range chemotaxis. The continuous
macroscopic model is obtained as a Fokker-Planck equation describing evolution
of the cell probability density function. All coefficients of the general
macroscopic model are derived from parameters of the CPM and a very good
agreement is demonstrated between CPM Monte Carlo simulations and numerical
solution of the macroscopic model. It is also shown that in the absence of
contact cell-cell interactions, the obtained model reduces to the classical
macroscopic Keller-Segel model. General multiscale approach is demonstrated by
simulating spongy bone formation from loosely packed mesenchyme via the
intramembranous route suggesting that self-organizing physical mechanisms can
account for this developmental process.Comment: 4 pages, 3 figure
Boundary Conditions for the Einstein Evolution System
New boundary conditions are constructed and tested numerically for a general
first-order form of the Einstein evolution system. These conditions prevent
constraint violations from entering the computational domain through timelike
boundaries, allow the simulation of isolated systems by preventing physical
gravitational waves from entering the computational domain, and are designed to
be compatible with the fixed-gauge evolutions used here. These new boundary
conditions are shown to be effective in limiting the growth of constraints in
3D non-linear numerical evolutions of dynamical black-hole spacetimes.Comment: 21 pages, 12 figures, submitted to PR
Single-object Imaging and Spectroscopy to Enhance Dark Energy Science from LSST
Single-object imaging and spectroscopy on telescopes with apertures ranging
from ~4 m to 40 m have the potential to greatly enhance the cosmological
constraints that can be obtained from LSST. Two major cosmological probes will
benefit greatly from LSST follow-up: accurate spectrophotometry for nearby and
distant Type Ia supernovae will expand the cosmological distance lever arm by
unlocking the constraining power of high-z supernovae; and cosmology with time
delays of strongly-lensed supernovae and quasars will require additional
high-cadence imaging to supplement LSST, adaptive optics imaging or
spectroscopy for accurate lens and source positions, and IFU or slit
spectroscopy to measure detailed properties of lens systems. We highlight the
scientific impact of these two science drivers, and discuss how additional
resources will benefit them. For both science cases, LSST will deliver a large
sample of objects over both the wide and deep fields in the LSST survey, but
additional data to characterize both individual systems and overall systematics
will be key to ensuring robust cosmological inference to high redshifts.
Community access to large amounts of natural-seeing imaging on ~2-4 m
telescopes, adaptive optics imaging and spectroscopy on 8-40 m telescopes, and
high-throughput single-target spectroscopy on 4-40 m telescopes will be
necessary for LSST time domain cosmology to reach its full potential. In two
companion white papers we present the additional gains for LSST cosmology that
will come from deep and from wide-field multi-object spectroscopy.Comment: Submitted to the call for Astro2020 science white paper
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Seasonal Ventilation of the Stratosphere: Robust Diagnostics from One-Way Flux Distributions
We present an analysis of the seasonally varying ventilation of the stratosphere using one-way flux distributions. Robust transport diagnostics are computed using GEOSCCM subject to fixed present-day climate forcings. From the one-way flux, we determine the mass of the stratosphere that is in transit since entry through the tropical tropopause to its exit back into the troposphere, partitioned according to stratospheric residence time and exit location. The seasonalities of all diagnostics are quantified with respect to the month of year (a) when air enters the stratosphere, (b) when the mass of the stratosphere is partitioned, and (c) when air exits back into the troposphere. We find that the return flux, within 3 months since entry, depends strongly on when entry occurred: (34 +/- 10)% more of the air entering the stratosphere in July leaves poleward of 45 deg N compared to air that enters in January. The month of year when the air mass is partitioned is also found to be important: The stratosphere contains about six times more air of tropical origin during late summer and early fall that will leave poleward of 45 deg within 6 months since entering the stratosphere compared to during late winter to late spring. When the entire mass of the air that entered the stratosphere at the tropics regardless of its residence time is considered, we find that (51 +/- 1)% and (39 +/- 2)% will leave poleward of 10 deg in the Northern Hemisphere (NH) and Southern Hemisphere (SH), respectively
Multi-format Notifications for Multi-tasking
Abstract. We studied people's perception of and response to a set of visual and auditory notifications issued in a multi-task environment. Primary findings show that participants' reactive preference ratings of notifications delivered in various contexts during experimentation appear to contradict their reflective, overall ratings of the notification formats when elicited independently of contextual information, indicating a potential difficulty in people's abilities to articulate their preferences in the absence of context. We also found people to vary considerably in their preferences for different notification formats delivered in different contexts, such taht simple approaches to selecting notification delivery formats will be dissatisfying to users a substantial portion of the time. These findings can inform the designs of future systems: rather than target the general user alone, they should strive to better understand each user individually
Discovery-based games for learning software
ABSTRACT We propose using discovery-based learning games to teach people how to use complex software. Specifically, we developed Jigsaw, a learning game that asks players to solve virtual jigsaw puzzles using tools in Adobe Photoshop. We conducted an eleven-person lab study of the prototype, and found the game to be an effective learning medium that can complement demonstration-based tutorials. Not only did the participants learn about new tools and techniques while actively solving the puzzles in Jigsaw, but they also recalled techniques that they had learned previously but had forgotten
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