Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load.

Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is associated with HIV-1 viremia. Here we report an association between increased proportions of CD56-CD16+ NK cells in viremic HIV-1+ individuals and an increased contribution of NKG2C+ cells to this subset. These data, in addition to anti-HCMV IgG serology, indicate a potential contribution of both HCMV and HIV-1 to NK cell dysfunction in HIV-1-infected individuals

A Configural-Cur Network Model of Animal and Human Associative Learning

test a configural-cue network model of human classification and recognition learning based on Rescorla & Wagner's (1972) model of classical conditioning. The model extends the stimulus representation assumptions from our earlier one-layer network model (Gluck & Bower, 1988b) to include pair-wise conjunctions of features as unique cues. Like the exemplar context model of Medin & Schaffer(1978), the representational assumptions of the configural-cue network model embody an implicit exponential decay relationship between stimulus similarity and and psychological (Hamming) distance, a relationship which has received substantial independent empirical and theoretical support (Shepard, 1957,1987). In addition to results from animal learning, the model accounts for several aspects of complex human category learning, including the relationship between category similarity and linear separability in determining classification difficulty (Medin &Schwanenflugel, 1981), the relationship between classification and recognition memory for instances (Hayes-Roth & Hayes-Roth, 1977), and the impact of correlated attributes on classification (Medin, Altom, Edelson, & Freko, 1982)

A VLBI Resolution of the Pleiades Distance Controversy

Because of its proximity and its youth, the Pleiades open cluster of stars has been extensively studied and serves as a cornerstone for our understanding of the physical properties of young stars. This role is called into question by the "Pleiades distance controversy" wherein the cluster distance of 120.2+/-1.5 pc as measured by the optical space astrometry mission Hipparcos is significantly different from the distance of 133.5+/-1.2 pc derived with other techniques. We present an absolute trigonometric parallax distance measurement to the Pleiades cluster that uses very long baseline radio interferometry. This distance of 136.2+/-1.2 pc is the most accurate and precise yet presented for the cluster and is incompatible with the Hipparcos distance determination. Our results cement existing astrophysical models for Pleiades-age stars.Comment: Cover-story article of the August 29th edition of Science. 22 pages, 2 figures, 6 tables; includes Supplementary materia

The Evolution of Early-Type Galaxies in Distant Clusters

We present results from an optical-IR photometric study of early-type galaxies in 19 galaxy clusters out to z=0.9. The galaxy sample is selected on the basis of morphologies determined from HST WFPC2 images, and is photometrically defined in the K-band to minimize redshift-dependent selection biases. The optical-IR colors of the early-type cluster galaxies become bluer with increasing redshift in a manner consistent with the passive evolution of an old stellar population formed at an early cosmic epoch. The degree of color evolution is similar for clusters at similar redshift, and does not depend strongly on the optical richness or X-ray luminosity of the cluster, suggesting that the history of early-type galaxies is relatively insensitive to environment. The slope of the color-magnitude relationship shows no significant change out to z=0.9, providing evidence that it arises from a correlation between galaxy mass and metallicity, not age. Finally, the intrinsic scatter in the optical-IR colors is small and nearly constant with redshift, indicating that the majority of giant, early-type galaxies in clusters share a common star formation history, with little perturbation due to uncorrelated episodes of later star formation. Taken together, our results are consistent with models in which most early-type galaxies in rich clusters are old, formed the majority of their stars at high redshift in a well-synchronized fashion, and evolved quiescently thereafter.Comment: 55 pages, 24 figures, uses AASTeX. Accepted for publication in The Astrophysical Journa

Multiaperture UBVRIzJHKUBVRIzJHK Photometry of Galaxies in the Coma Cluster

We present a set of $UBVRIzJHK_s$ photometry for 745 $J+H$ band selected objects in a $22.5' \times 29.2'$ region centered on the core of the Coma cluster. This includes 516 galaxies and is at least 80% complete to H=16, with a spectroscopically complete sample of 111 cluster members (nearly all with morphological classification) for $H < 14.5$. For each object we present total \cite{kron80} magnitudes and aperture photometry. As an example, we use these data to derive color-magnitude relations for Coma early-type galaxies, measure the intrinsic scatter of these relations and its dependence on galaxy mass, and address the issue of color gradients. We find that the color gradients are mild and that the intrinsic scatter about the color-magnitude relation is small ($\sim 0.05$ mag in $U-V$ and less than $\sim 0.03$ in $B-R$, $V-I$ or $J-K$). There is no evidence that the intrinsic scatter varies with galaxy luminosity, suggesting that the cluster red sequence is established at early epochs over a range of $\sim 100$ in stellar mass.Comment: 41 pages, 5 figures, 18 data tables attached to source files or available on request from R. De propris. Accepted for publication in Astrophysical Journal Supplement Serie

A Very Hot, High Redshift Cluster of Galaxies: More Trouble for Omega_0 = 1

We have observed the most distant (z=0.829) cluster of galaxies in the Einstein Extended Medium Sensitivity Survey, with the ASCA and ROSAT satellites. We find an X-ray temperature of 12.3 +3.1/-2.2 keV for this cluster, and the ROSAT map reveals significant substructure. The high temperature of MS1054-0321 is consistent with both its approximate velocity dispersion, based on the redshifts of 12 cluster members we have obtained at the Keck and the Canada-France-Hawaii telescopes, and with its weak lensing signature. The X-ray temperature of this cluster implies a virial mass ~ 7.4 x 10^14 h^-1 solar masses, if the mean matter density in the universe equals the critical value, or larger if Omega_0 < 1. Finding such a hot, massive cluster in the EMSS is extremely improbable if clusters grew from Gaussian perturbations in an Omega_0 = 1 universe. Combining the assumptions that Omega_0 = 1 and that the intial perturbations were Gaussian with the observed X-ray temperature function at low redshift, we show that the probability of this cluster occurring in the volume sampled by the EMSS is less than a few times 10^{-5}. Nor is MS1054-0321 the only hot cluster at high redshift; the only two other $z > 0.5$ EMSS clusters already observed with ASCA also have temperatures exceeding 8 keV. Assuming again that the initial perturbations were Gaussian and Omega_0 = 1, we find that each one is improbable at the < 10^{-2} level. These observations, along with the fact that these luminosities and temperatures of the high-$z$ clusters all agree with the low-z L_X-T_X relation, argue strongly that Omega_0 < 1. Otherwise, the initial perturbations must be non-Gaussian, if these clusters' temperatures do indeed reflect their gravitational potentials.Comment: 20 pages, 4 figures, To appear in 1 Aug 1998 ApJ (heavily revised version of original preprint

Red Galaxy Growth and the Halo Occupation Distribution

We have traced the past 7 Gyr of red galaxy stellar mass growth within dark matter halos. We have determined the halo occupation distribution, which describes how galaxies reside within dark matter halos, using the observed luminosity function and clustering of 40,696 0.2<z<1.0 red galaxies in Bootes. Half of 10^{11.9} Msun/h halos host a red central galaxy, and this fraction increases with increasing halo mass. We do not observe any evolution of the relationship between red galaxy stellar mass and host halo mass, although we expect both galaxy stellar masses and halo masses to evolve over cosmic time. We find that the stellar mass contained within the red population has doubled since z=1, with the stellar mass within red satellite galaxies tripling over this redshift range. In cluster mass halos most of the stellar mass resides within satellite galaxies and the intra-cluster light, with a minority of the stellar mass residing within central galaxies. The stellar masses of the most luminous red central galaxies are proportional to halo mass to the power of a third. We thus conclude that halo mergers do not always lead to rapid growth of central galaxies. While very massive halos often double in mass over the past 7 Gyr, the stellar masses of their central galaxies typically grow by only 30%.Comment: Accepted for publication in the ApJ. 34 pages, 22 Figures, 5 Table

SERCA directs cell migration and branching across species and germ layers

Branching morphogenesis underlies organogenesis in vertebrates and invertebrates, yet is incompletely understood. Here, we show that the sarco-endoplasmic reticulum Ca2+ reuptake pump (SERCA) directs budding across germ layers and species. Clonal knockdown demonstrated a cell-autonomous role for SERCA in Drosophila air sac budding. Live imaging of Drosophila tracheogenesis revealed elevated Ca2+ levels in migratory tip cells as they form branches. SERCA blockade abolished this Ca2+ differential, aborting both cell migration and new branching. Activating protein kinase C (PKC) rescued Ca2+ in tip cells and restored cell migration and branching. Likewise, inhibiting SERCA abolished mammalian epithelial budding, PKC activation rescued budding, while morphogens did not. Mesoderm (zebrafish angiogenesis) and ectoderm (Drosophila nervous system) behaved similarly, suggesting a conserved requirement for cell-autonomous Ca2+ signaling, established by SERCA, in iterative budding

Ongoing Formation of Bulges and Black Holes in the Local Universe: New Insights from GALEX

We analyze a volume-limited sample of massive bulge-dominated galaxies with data from both the Sloan Digital Sky Survey and the Galaxy Evolution Explorer (GALEX) satellite. The galaxies have central velocity dispersions greater than 100 km/s and stellar surface mass densities that lie above the value where galaxies transition from actively star forming to passive systems. The sample is limited to redshifts 0.03<z<0.07. At these distances, the SDSS spectra sample the light from the bulge-dominated central regions of the galaxies. The GALEX NUV data provide high sensitivity to low rates of global star formation in these systems. Our sample of bulge-dominated galaxies exhibits a much larger dispersion in NUV-r colour than in optical g-r colour. Nearly all of the galaxies with bluer NUV-r colours are AGN. Both GALEX images and SDSS colour profiles demonstrate that the excess UV light is associated with an extended disk. We find that galaxies with red outer regions almost never have a young bulge or a strong AGN. Galaxies with blue outer regions have bulges and black holes that span a wide range in age and accretion rate. Galaxies with young bulges and strongly accreting black holes almost always have blue outer disks. Our suggested scenario is one in which the source of gas that builds the bulge and black hole is a low mass reservoir of cold gas in the disk.The presence of this gas is a necessary, but not sufficient condition for bulge and black hole growth. Some mechanism must transport this gas inwards in a time variable way. As the gas in the disk is converted into stars, the galaxies will turn red, but further gas infall can bring them back into the blue NUV-r sequence.(Abridged)Comment: 34 pages, 16 figures. Accepted for the GALEX special issue of ApJ