Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults:A protocol for a systematic review and meta-analysis of randomised controlled trials

IntroductionAlthough statins are commonly used for prevention of cardiovascular disease, there is limited evidence about statin-related adverse effects in older people. Statin-related adverse events (AEs), especially the statin-associated muscle symptoms (SAMS), are the most common reasons for their discontinuation. Therefore, it is important to determine the risk of SAMS in the older population. We will undertake a systematic review and meta-analysis primarily focusing on the risk of SAMS and secondarily targeting myopathy, rhabdomyolysis, AEs and serious AEs, dropouts due to SAMS in run-in period, related permanent discontinuation rate of statins and creatine kinase level, among older people who received statins for primary prevention.Methods and analysisThis study has been developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement. We will include randomised controlled trials in which statin was compared with placebo with at least 1 year follow-up among older adults aged ≥65. This review is an update of a Cochrane systematic review that included the articles published before 2012. Cochrane Central Register of Controlled Trials, Medline OvidSP and Embase electronic database searches will be performed to identify relevant articles, limiting the publication date from 1 January 2012 to 13 February 2017. There will be no language limitation. Two independent reviewers will screen titles and abstracts and full text in duplicate. Risk of bias and evidence quality will be assessed using the Cochrane Collaboration’s tool and the Grading of Recommendations Assessment, Development and Evaluation approach, respectively. A meta-analysis using pooled data will be undertaken, if appropriate. We will also perform metaregression and subgroup analyses to identify sources of heterogeneity.Ethics and disseminationThis study is exempt from ethics approval due to the anonymous and aggregated data used. The outcomes will be disseminated by conference presentations and published in a peer-reviewed journal.Trial registration numberCRD42017058436.</jats:sec

Price Level Convergence Among United States Cities: Lessons for the European Central Bank

We study the dynamics of price indices for major U.S. cities using panel econometric methods and find that relative price levels among cities mean revert at an exceptionally slow rate. In a panel of 19 cities from 1918 to 1995, we estimate the half-life of convergence to be approximately nine years. These estimates provide an upper bound on speed of convergence that participants in European Monetary Union are likely to experience. The surprisingly slow rate of convergence can be explained by a combination of the presence of transportation costs, differential speeds of adjustment to small and large shocks, and the inclusion of non-traded good prices in the overall price index.

Archaeological Survey Investigations of Private Land within the boundaries of the proposed Lower Bois d’Arc Creek Reservoir Project, Fannin County, Texas

At the request of a private landowner that has property within the boundaries of the proposed Lower Bois d’Arc Creek Reservoir in Fannin County, we completed volunteer archaeological survey investigations on a portion of this tract of private land on July 18, 2015. The proposed Lower Bois d’Arc Creek Reservoir is to be more than 16,500 acres in size; the project sponsor is the North Texas Municipal Water District, and the Tulsa District of the U.S. Army Corps of Engineers is currently reviewing the project sponsor’s application for a Department of the Army permit under Section 404 of the Clean Water Act to construct the reservoir and associated facilities. Although the project area associated with the proposed reservoir is more than 17,000 acres, only 5,000 acres of the proposed project have received an archaeological survey. Based on consultation between the project sponsor, the Texas Historical Commission, and the Tulsa District, the remainder of the project area will apparently not receive archaeological survey investigations. The private lands we have investigated along Bois d’Arc Creek in the proposed reservoir area have not been examined previously by a professional archaeological survey team; these lands will be inundated by the flood pool of the reservoir as currently proposed. The landowner had contacted the Tulsa District in 2008 to inform them that there were archaeological sites on the property, but the Tulsa District has yet to follow up on that information

Charging of ice-vapor interfaces

International audienceThe time resolved chemical composition of aerosol particles, formed by the oxidation of alpha-pinene has been investigated by liquid chromatography/mass spectrometry (LC-MS) using negative and positive ionisation methods (ESI(-) and APCI(+)). The experiments were performed at the EUPHORE facility in Valencia (Spain) under various experimental conditions, including dark ozone reactions, photosmog experiments with low NOx mixing ratios and reaction with OH radicals in the absence of NOx (H2O2-photolysis). Particles were sampled on PTFE filters at different stages of the reaction and extracted with methanol. The predominant products from alpha-pinene in the particulate phase are cis-pinic acid, cis-pinonic acid and hydroxy-pinonic acid isomers. Another major compound with molecular weight 172 was detected, possibly a hydroxy-carboxylic acid. These major compounds account for 50% to 80% of the identified aerosol products, depending on the time of sampling and type of experiment. In addition, more than 20 different products have been detected and structures have been tentatively assigned based on their molecular weight and responses to the different ionisation modes. The different experiments performed showed that the aerosol formation is mainly caused by the ozonolysis reaction. The highest aerosol yields were observed in the dark ozone experiments, for which also the highest ratios of mass of identified products to the formed aerosol mass were found (30% to 50%, assuming a density of 1 g cm-3)

Thermodynamics and the Global Optimization of Lennard-Jones clusters

Theoretical design of global optimization algorithms can profitably utilize recent statistical mechanical treatments of potential energy surfaces (PES's). Here we analyze the basin-hopping algorithm to explain its success in locating the global minima of Lennard-Jones (LJ) clusters, even those such as \LJ{38} for which the PES has a multiple-funnel topography, where trapping in local minima with different morphologies is expected. We find that a key factor in overcoming trapping is the transformation applied to the PES which broadens the thermodynamic transitions. The global minimum then has a significant probability of occupation at temperatures where the free energy barriers between funnels are surmountable.Comment: 13 pages, 13 figures, revte

The double-funnel energy landscape of the 38-atom Lennard-Jones cluster

The 38-atom Lennard-Jones cluster has a paradigmatic double-funnel energy landscape. One funnel ends in the global minimum, a face-centred-cubic (fcc) truncated octahedron. At the bottom of the other funnel is the second lowest energy minimum which is an incomplete Mackay icosahedron. We characterize the energy landscape in two ways. Firstly, from a large sample of minima and transition states we construct a disconnectivity tree showing which minima are connected below certain energy thresholds. Secondly we compute the free energy as a function of a bond-order parameter. The free energy profile has two minima, one which corresponds to the fcc funnel and the other which at low temperature corresponds to the icosahedral funnel and at higher temperatures to the liquid-like state. These two approaches show that the greater width of the icosahedral funnel, and the greater structural similarity between the icosahedral structures and those associated with the liquid-like state, are the cause of the smaller free energy barrier for entering the icosahedral funnel from the liquid-like state and therefore of the cluster's preferential entry into this funnel on relaxation down the energy landscape. Furthermore, the large free energy barrier between the fcc and icosahedral funnels, which is energetic in origin, causes the cluster to be trapped in one of the funnels at low temperature. These results explain in detail the link between the double-funnel energy landscape and the difficulty of global optimization for this cluster.Comment: 12 pages, 11 figures, revte

UNDERSTANDING TECHNOLOGY ADOPTION THROUGH SYSTEM DYNAMICS MODELING: IMPLICATIONS FOR AGRIBUSINESS MANAGEMENT

This work demonstrates the utility of sophisticated simulation tools in aiding agribusiness managers' decision making. The system dynamics model developed here provides insight into the use of such models to evaluate potential adoption rates and diffusion patterns of yield mapping and monitoring technologies. The model allows for comparative analyses of the possible effects of different profit assumptions on adoption and diffusion.Agribusiness, Research and Development/Tech Change/Emerging Technologies,

Magnetic Wreaths and Cycles in Convective Dynamos

Solar-type stars exhibit a rich variety of magnetic activity. Seeking to explore the convective origins of this activity, we have carried out a series of global 3D magnetohydrodynamic (MHD) simulations with the anelastic spherical harmonic (ASH) code. Here we report on the dynamo mechanisms achieved as the effects of artificial diffusion are systematically decreased. The simulations are carried out at a nominal rotation rate of three times the solar value (3$\Omega_\odot$), but similar dynamics may also apply to the Sun. Our previous simulations demonstrated that convective dynamos can build persistent toroidal flux structures (magnetic wreaths) in the midst of a turbulent convection zone and that high rotation rates promote the cyclic reversal of these wreaths. Here we demonstrate that magnetic cycles can also be achieved by reducing the diffusion, thus increasing the Reynolds and magnetic Reynolds numbers. In these more turbulent models, diffusive processes no longer play a significant role in the key dynamical balances that establish and maintain the differential rotation and magnetic wreaths. Magnetic reversals are attributed to an imbalance in the poloidal magnetic induction by convective motions that is stabilized at higher diffusion levels. Additionally, the enhanced levels of turbulence lead to greater intermittency in the toroidal magnetic wreaths, promoting the generation of buoyant magnetic loops that rise from the deep interior to the upper regions of our simulated domain. The implications of such turbulence-induced magnetic buoyancy for solar and stellar flux emergence are also discussed.Comment: 21 pages, 16 figures, accepted for publication in Ap

Revealing the galaxy-halo connection in IllustrisTNG

We use the IllustrisTNG (TNG) simulations to explore the galaxy-halo connection as inferred from state-of-the-art cosmological, magnetohydrodynamical simulations. With the high mass resolution and large volume achieved by combining the 100 Mpc (TNG100) and 300 Mpc (TNG300) volumes, we establish the mean occupancy of central and satellite galaxies and their dependence on the properties of the dark matter haloes hosting them. We derive best-fitting HOD parameters from TNG100 and TNG300 for target galaxy number densities of $\bar{n}_g = 0.032\,h^3$Mpc$^{-3}$ and $\bar{n}_g = 0.016\,h^3$Mpc$^{-3}$, respectively, corresponding to a minimum galaxy stellar mass of $M_\star\sim1.9\times10^9\,{\rm M}_\odot$ and $M_\star\sim3.5\times10^9\,{\rm M}_\odot$, respectively, in hosts more massive than $10^{11}\,{\rm M}_\odot$. Consistent with previous work, we find that haloes located in dense environments, with low concentrations, later formation times, and high angular momenta are richest in their satellite population. At low mass, highly-concentrated haloes and those located in overdense regions are more likely to contain a central galaxy. The degree of environmental dependence is sensitive to the definition adopted for the physical boundary of the host halo. We examine the extent to which correlations between galaxy occupancy and halo properties are independent and demonstrate that HODs predicted by halo mass and present-day concentration capture the qualitative dependence on the remaining halo properties. At fixed halo mass, concentration is a strong predictor of the stellar mass of the central galaxy, which may play a defining role in the fate of the satellite population. The radial distribution of satellite galaxies, which exhibits a universal form across a wide range of host halo mass, is described accurately by the best-fit NFW density profile of their host haloes.Comment: 20 pages, 13 figures, 1 table, comments welcom