The target projection dynamic

This paper studies the target projection dynamic, which is a model of myopic adjustment for population games. We put it into the standard microeconomic framework of utility maximization with control costs. We also show that it is well-behaved, since it satisfies the desirable properties: Nash stationarity, positive correlation, and existence, uniqueness, and continuity of solutions. We also show that, similarly to other well-behaved dynamics, a general result for elimination of strictly dominated strategies cannot be established. Instead we rule out survival of strictly dominated strategies in certain classes of games. We relate it to the projection dynamic, by showing that the two dynamics coincide in a subset of the strategy space. We show that strict equilibria, and evolutionarily stable strategies in $2\times2$ games are asymptotically stable under the target projection dynamic. Finally, we show that the stability results that hold under the projection dynamic for stable games, hold under the target projection dynamic too, for interior Nash equilibria.target projection dynamic; noncooperative games; adjustment

What Drives Foundation Expenses & Compensation? Results of a Three-Year Study, Highlights

This brief presents key findings from the latest report of the Foundation Expenses and Compensation Project—the first large-scale, longterm, systematic study of independent, corporate, and community foundations' expense and compensation patterns and the factors behind them. Documenting the varying characteristics of the 10,000 largest U.S. grantmaking foundations, the study finds these differences—including foundation type, size, and operating activities—essential for understanding foundation finances. Not surprisingly, hiring staff and taking on staff-intensive activities raise charitable administrative expenditures relative to charitable distributions, while relying on unpaid board and family members and engaging in less-staff-intensive activities lower them. Most foundation operations, however, are somewhere between these poles

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes

Causal inference approaches in systems genetics exploit quantitative trait loci (QTL) genotypes to infer causal relationships among phenotypes. The genetic architecture of each phenotype may be complex, and poorly estimated genetic architectures may compromise the inference of causal relationships among phenotypes. Existing methods assume QTLs are known or inferred without regard to the phenotype network structure. In this paper we develop a QTL-driven phenotype network method (QTLnet) to jointly infer a causal phenotype network and associated genetic architecture for sets of correlated phenotypes. Randomization of alleles during meiosis and the unidirectional influence of genotype on phenotype allow the inference of QTLs causal to phenotypes. Causal relationships among phenotypes can be inferred using these QTL nodes, enabling us to distinguish among phenotype networks that would otherwise be distribution equivalent. We jointly model phenotypes and QTLs using homogeneous conditional Gaussian regression models, and we derive a graphical criterion for distribution equivalence. We validate the QTLnet approach in a simulation study. Finally, we illustrate with simulated data and a real example how QTLnet can be used to infer both direct and indirect effects of QTLs and phenotypes that co-map to a genomic region.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS288 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Athlete Monitoring in Rugby League: a focus on the conceptualisation, implementation and utilisation of a wellness questionnaire.

Wellness questionnaires are often used to monitor athletes to gain an understanding of the responses to training and gameplay. This thesis presents original information concerning the conceptualisation, implementation and use of wellness questionnaires with a focus on the sport of rugby league. The overall aim of the thesis was to investigate the use and implementation of a wellness questionnaire with the goal of developing a framework for successful implementation. Whilst wellness questionnaires appear to be a popular method for evaluating the response to training and readiness to perform, there are limited details on the type of questionnaires used by practitioners. Study 1 investigated the use and implementation of current wellness questionnaires across a range of high- performance sports. The study examined if there is commonality amongst the use of wellness questionnaires with regard to customised designs, scales, items and the levels of implementation achieved. Based on a review of the literature and practical experience of the research team, an online survey was constructed consisting of 23 questions. 122 participants recruited through the network of the research team completed the survey. Analysis of the responses indicated that customised wellness questionnaires were prevalent and used by the majority of respondents (74%) each training day. These questionnaires differed in the types of scale, items and analysis techniques used. With regard to implementation, the majority reported completion rates above 75%. However, issues associated with the questionnaire, team resources, issuing reminders and generating buy-in were evident. In a follow up to the main survey, practitioners identified five key themes needed for successful implementation which were labelled the Implementation Outcomes. These outcomes can be used to evaluate the success of the implementation and use of wellness questionnaires. Following on from study 1 it was necessary to give an in-depth focus on the implementation and use of wellness questionnaires within a rugby league context. Previous research has identified factors associated with the measure and the social environment that influence questionnaire use in a range of different sports (Saw, Main, & Gastin, 2015b). Therefore, study 2 interviewed players and staff (n = 20) within a European Super League team to examine the factors that were relevant within their context. Reported Implementation Factors were identified across the organisation (e.g. team resources), the measure (e.g. mode and accessibility of the wellness questionnaire), inter-personal (e.g. reminders), and individual level (e.g. player buy-in). The factors were consistent with previous research into implementation and several novel higher order factors were identified residing within the organisation (context, process, personalisation and coaching staff). Twenty-three original lower order themes specific to a rugby league environment were identified. Implementation factors manifested across data collection, analysis and decision-making. The findings lend support to the use of a social ecological model to identify factors influencing wellness questionnaire use in rugby league. The customised wellness questionnaires which have been used within rugby league research give limited insight into the questionnaire development and validation. No wellness questionnaire exists that has been thoroughly validated and tested within a rugby league environment. Study 3 subsequently sought to develop and validate a new wellness questionnaire for use in rugby league. This study involved four phases of development to examine face, content and concurrent validity in addition to the reliability of the questionnaire. The construction of the new questionnaire also concerned the appraisal as to the ecological fit of using wellness questionnaires within the host setting. Taking into account the findings of studies 1 and 2, consideration was given to implementation in the construction of the questionnaire. Aligned with current guidelines, assessments were made to determine the purpose of using the wellness questionnaire, if there was buy-in from the stakeholders and if it was feasible to implement. The newly developed 9-item wellness questionnaire was deemed valid, reliable and acceptable to use within rugby league environments. The study comprehensively demonstrates the process of developing and validating a wellness questionnaire above and beyond other previously used and published questionnaires. Study 4 used the newly developed questionnaire to assess player wellness in conjunction with external and internal load in a European Super League team. There is a lack of normative wellness data, including details on how to monitor, analyse and interpret this data at team and individual levels. Players completed a wellness questionnaire across 68 consecutive days of the rugby league season (Super 8s to Grand Final). Global positioning system data and session rating of perceived exertion was recorded for training and games. Results indicate the new wellness questionnaire is sensitive to detect change and identifies a high variation in wellness data the day after game-play. This questionnaire is recommended to collect data at matchdays +1, +3, +4, and +6. Results support the findings of previous studies which suggest that it takes at least 4 days post-game to recover to pre-game levels of wellness. Wellness questionnaires should be used in conjunction with training load data and results found that post-game wellness strongly correlated with the number of tackles in rugby league games, r(6) = 0.80 p= 0.17. Furthermore, when tackles were combined with high speed running metres wellness was significantly predicted post-game, F(2, 5) = 17.760, p = .005, adj. R2 = .83. Wellness scores showed high inter and intra individual variability. The study provides case study examples analysing team and individual player wellness, suggesting the use of z- scores and visualisations using statistical process control charts and radar plots. The findings of this thesis lend support to the use of wellness questionnaires in rugby league and high- performance sport, providing they are appropriately developed, validated and implemented. The final written chapter presents a conceptual model named the Successful Implementation Framework which aims to guide practitioner implementation of wellness questionnaires. The framework brings together aspects established in this thesis including the Implementation Considerations (study 3), Implementation Areas (study 2), Implementation Factors (study 2), Implementation Outcomes (study 1) and recommendations for use (study 4)

Review of the occupational health and safety of Britain’s ethnic minorities

This report sets out an evidence-based review on work-related health and safety issues relating to black and minority ethnic groups. Data included available statistical materials and a systematic review of published research and practice-based reports. UK South Asians are generally under-represented within the most hazardous occupational groups. They have lower accident rates overall, while Black Caribbean workers rates are similar to the general population; Bangladeshi and Chinese workers report lowest workplace injury rates UK South Asian people exhibit higher levels of limiting long-term illness (LLI) and self reported poor health than the general population while Black Africans and Chinese report lower levels. Ethnic minority workers with LLI are more likely than whites to withdraw from the workforce, or to experience lower wage rates. Some of these findings conflict with evidence of differentials from USA, Europe and Australasia, but there is a dearth of effective primary research or reliable monitoring data from UK sources. There remains a need to improve monitoring and data collection relating to black and ethnic minority populations and migrant workers. Suggestions are made relating to workshops on occupational health promotion programmes for ethnic minorities, and ethnic minority health and safety 'Beacon' sites

Genetic diversity of peanut (Arachis hypogaea L.) and its wild relatives based on the analysis of hypervariable regions of the genome

BACKGROUND: The genus Arachis is native to a region that includes Central Brazil and neighboring countries. Little is known about the genetic variability of the Brazilian cultivated peanut (Arachis hypogaea, genome AABB) germplasm collection at the DNA level. The understanding of the genetic diversity of cultivated and wild species of peanut (Arachis spp.) is essential to develop strategies of collection, conservation and use of the germplasm in variety development. The identity of the ancestor progenitor species of cultivated peanut has also been of great interest. Several species have been suggested as putative AA and BB genome donors to allotetraploid A. hypogaea. Microsatellite or SSR (Simple Sequence Repeat) markers are co-dominant, multiallelic, and highly polymorphic genetic markers, appropriate for genetic diversity studies. Microsatellite markers may also, to some extent, support phylogenetic inferences. Here we report the use of a set of microsatellite markers, including newly developed ones, for phylogenetic inferences and the analysis of genetic variation of accessions of A. hypogea and its wild relatives. RESULTS: A total of 67 new microsatellite markers (mainly TTG motif) were developed for Arachis. Only three of these markers, however, were polymorphic in cultivated peanut. These three new markers plus five other markers characterized previously were evaluated for number of alleles per locus and gene diversity using 60 accessions of A. hypogaea. Genetic relationships among these 60 accessions and a sample of 36 wild accessions representative of section Arachis were estimated using allelic variation observed in a selected set of 12 SSR markers. Results showed that the Brazilian peanut germplasm collection has considerable levels of genetic diversity detected by SSR markers. Similarity groups for A. hypogaea accessions were established, which is a useful criteria for selecting parental plants for crop improvement. Microsatellite marker transferability was up to 76% for species of the section Arachis, but only 45% for species from the other eight Arachis sections tested. A new marker (Ah-041) presented a 100% transferability and could be used to classify the peanut accessions in AA and non-AA genome carriers. CONCLUSION: The level of polymorphism observed among accessions of A. hypogaea analyzed with newly developed microsatellite markers was low, corroborating the accumulated data which show that cultivated peanut presents a relatively reduced variation at the DNA level. A selected panel of SSR markers allowed the classification of A. hypogaea accessions into two major groups. The identification of similarity groups will be useful for the selection of parental plants to be used in breeding programs. Marker transferability is relatively high between accessions of section Arachis. The possibility of using microsatellite markers developed for one species in genetic evaluation of other species greatly reduces the cost of the analysis, since the development of microsatellite markers is still expensive and time consuming. The SSR markers developed in this study could be very useful for genetic analysis of wild species of Arachis, including comparative genome mapping, population genetic structure and phylogenetic inferences among species

Characterization of Streptavidin-Semiconductor Interfaces for the Development of a Biosensor

The purpose of this project is to create and characterize a biosensor based upon a modified Metal Oxide Semiconductor Field Effect Transistor (MOSFET) or FET. With the metal gate of a traditional MOSFET removed to expose the underlying SiO2 interface, proteins can be applied and charge transfer due to binding events can control the sensor’s current output. Previous work has shown that such modified FETs selectively sense gases and biomaterials in dry environments. However, optimum protein binding requires a wet environment. This project examines the electronic properties of semiconductor interfaces with biological molecules in wet conditions. Advanced sensor packaging allows for an assay that can be operated in solution. Electrical tests performed in a wet microelectronic environment successfully demonstrate that devices respond to charge transfers induced by Streptavidin/Biotin-HRP binding events.Engineering Experiment Statio

Investigating the Physical Properties and Runoff Treatment Capability of Pervious Concrete Containing Granular Activated Carbon

A current environmental concern is that of urban stormwater runoff, which can carry a multitude of contaminants and could threaten or impair surface waters. Pervious concrete (PC) is a type of concrete with significant void spaces that can facilitate infiltration and lead to less runoff. The EPA cites previous research to show that pervious pavement structures reduce such contaminants as metals and total suspended solids. Since Granular Activated Carbon (GAC) is a well-known contaminant adsorbent, the purpose of this research was to determine if PC with added GAC would result in improved runoff treatment, while still maintaining its material properties. Tests for compressive and tensile strengths, porosity and permeability were done on plain and GAC-containing PC mixtures. To test runoff treatment effects, samples of each mixture were subjected to synthetic runoff water containing several typical runoff contaminants. All mixtures were found to attain typical values for material properties. Changes in strength characteristics for the different mixtures were noted, although some experimental variations suggest that caution should be practiced when comparing within and between mixtures. Both plain PC and GAC-containing PC were found to significantly reduce overall concentrations of metals. None of the concrete mixtures were found to have any significant impacts on overall treatment for acetate. In spite of the significant reduction of many contaminants, no significant differences were found in overall treated runoff quality between mixtures or between plain and GAC containing PC. It was considered that GAC became covered within the concrete matrix to the extent that it was no longer beneficial for runoff treatment. It is proposed that future work focus on modifying the method of GAC usage so that it is readily available for contaminant sorption