Management qualitätsbasierter Gruppenkommunikation im Internet

Zugangs- und Nutzungskontrolle bei Unicast bedarf allein der Überwachung am Netzeingang. Diese Arbeit entwirft das Verfahren DSMC (Diffserv Multicast), das die für Multicast zusätzlich benötigte Kontrolle im Netzinneren ergänzt. Es erweitert die Paketweiterleitung (MFC) der Router nur gering und ohne Eingriff in das Multicastrouting, unterstützt so alle Multicastroutingprotokolle des Internets und bietet eine skalierbare Signalisierung zur Steuerung durch zentrales Dienstgütemanagement

Network slicing via function decomposition and flexible network design

Proceeding of: IEEE 28th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PMRC 2017)We argue for flexible network design as an architecture prototype for next generation networks. Such flexible design is developed by capitalizing on the concept of network function decomposition in conjunction with with its relation to network slicing. A detailed view of the proposed functional architecture is put forward, where the role of network function blocks for forming network slices with given requirements is underlined. We further highlight the impact of common architecture over multiple tenants and elaborate on the emerging multi-tenancy business models along with the resulting implications on security.This work has been performed in the framework of the H2020-ICT-2014-2 project 5G NORMA

RV SONNE 241 Cruise Report / Fahrtbericht, Manzanillo, 23.6.2015 – Guayaquil, 24.7.2015 : SO241 - MAKS: Magmatism induced carbon escape from marine sediments as a climate driver – Guaymas Basin, Gulf of California

SO241 set out to test the hypothesis that rift-related magmatism is able to increase carbon emissions from sedimentary basins to the extent that they can actively force climate. To this end we investigated a study area in the Guaymas Basin in the Gulf of California which is one of very few geological settings where rift-related magmatism presently leads to magmatic intrusions into a sediment basin. During the cruise we collected 1100 km of 2D seismic lines to image the extent and volume of magmatic intrusions as well as the extent of metamorphic overprinting of the surrounding sediments and associated subsurface sediment mobilization. We selected three typical seep sites above magmatic intrusions for detailed geochemical studies using gravity corers, multicorers and TV grab. With these samples we will be able to determine the pore water composition to assess the amount and composition of hydrocarbon compounds that are released from these systems. Detailed ocean bottom seismometer measurements at a seep site in the center of the Guaymas Basin will provide further insights into effects of magmatic intrusions on carbon release and diagenetic overprinting of the sediments. It will be possible to reconstruct its long-term seepage history from big carbonate blocks that we have collected with a TV-grab. The northeastern margin of the Guaymas Basin is known for the presence of gas hydrates. During the cruise we collected several seismic lines, which show a clear but unusually shallow BSR indicating high heat flow in the region. Using the seismic data we discovered a previously unknown geological structure on the flank of the northern rift segment: a large mound that seems to consist entirely of black smoker deposits. It seems to be the result of a recent intrusion into the underlying sediments and changes the view how such systems function. The structure was investigated with a comprehensive geochemical, geothermal, and video surveying program which revealed at least seven vents that are active simultaneously. These vents inject methane and helium-rich vent fluids several hundred meters up into the water column. These findings suggest that large-scale magmatism, for example during the opening of an ocean basin under the influence of a hot spot, can be an effective way of liberating large amounts of carbon high up into the water column. The data collected during SO241 will allow us to constrain the amount of carbon that can escape into the atmosphere during LIP emplacement and their relevance on a global scale can be assessed. In addition to reaching the main objectives of the project we discovered a large landslide complex that was probably associated with a tsunami

An adaptive 5G multiservice and multitenant radio access network architecture

This article provides an overview on objectives and first results of the Horizon 2020 project 5G NOvel Radio Multiservice adaptive network Architecture (5GNORMA). With 5G NORMA, leading players in the mobile ecosystem aim to underpin Europe's leadership position in 5G. The key objective of 5G NORMA is to develop a conceptually novel, adaptive and future-proof 5G mobile network architecture. This architecture will allow for adapting the network to a wide range of service specific requirements, resulting in novel service-aware and context-aware end-to-end function chaining. The technical approach is based on an innovative concept of adaptive (de)composition and allocation of mobile network functions based on end-user requirements and infrastructure capabilities. At the same time, cost savings and faster time to market are to be expected by joint deployment of logically separated multiservice and multitenant networks on common hardware and other physical resources making use of traffic multiplexing gains. In this context architectural enablers such as network function virtualization and software-defined mobile networking will play a key role for introducing the needed flexible resource assignment to logical networks and specific virtual network functions.This work has been performed in the framework of the H2020-ICT-2014-2 project 5G NORMA

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species constituting a major cellular defense mechanism against agents that induce oxidative stress. The MnSOD promoter contains an activator protein-2 (AP-2) binding site that modifies transcription of MnSOD. Mutations have been identified in the proximal region of the promoter in human tumor cell lines. One of these mutations (-102C>T) has been shown to change the binding pattern of AP-2 leading to a reduction in transcriptional activity. The aim of our study was to develop a method to identify and determine the frequency of this (-102C>T) polymorphism in human tissues. RESULTS: A new TaqMan allelic discrimination genotype method was successfully applied to genomic DNA samples derived from blood, buccal swabs, snap frozen tissue and paraffin blocks. The polymorphism was shown to be in Hardy-Weinberg Equilibrium in an evaluation of 130 Caucasians from Warsaw, Poland: 44 (33.8%) were heterozygous and 6 (4.6%) were homozygous for -102T. CONCLUSION: This report represents the first description of the MnSOD -102C>T polymorphism in human subjects by a novel Taqman allelic discrimination assay. This method should enable molecular epidemiological studies to evaluate possible associations of this polymorphism with malignancies and other diseases related to reactive oxygen species

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

BACKGROUND: Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress. A genetic polymorphism in the mitochondrial targeting sequence of this gene has been associated with increased cancer risk and survival in breast cancer. This base pair transition (-9 T > C) leads to a valine to alanine amino acid change in the mitochondrial targeting sequence. A polymorphism has also been identified in the proximal region of the promoter (-102 C>T) that alters the recognition sequence of the AP-2 transcription factor, leading to a reduction in transcriptional activity. The aim of our study was to investigate possible associations of the -102 C>T polymorphism with overall and relapse-free breast cancer survival in a hospital-based case-only study. MATERIALS AND METHODS: The relationship between the MnSOD -102 C>T polymorphism and survival was examined in a cohort of 291 women who received chemotherapy and/or radiotherapy for incident breast cancer. The MnSOD -102 C>T genotype was determined using a TaqMan allele discrimination assay. Patient survival was evaluated according to the MnSOD genotype using Kaplan–Meier survival functions. Hazard ratios were calculated from adjusted Cox proportional hazards modeling. All statistical tests were two-sided. RESULTS: In an evaluation of all women, there was a borderline significant reduction in recurrence-free survival with either one or both variant alleles (CT + TT) when compared with patients with wild-type alleles (CC) (odds ratio, 0.65; 95% confidence interval, 0.42–1.01). When the analysis was restricted to patients receiving radiation therapy, there was a significant reduction in relapse-free survival in women who were heterozygous for the MnSOD -102 genotype (relative risk, 0.40; 95% confidence interval, 0.18–0.86). Similarly, when the homozygous and heterozygous variant genotypes were combined, there remained a significant reduction in relapse-free survival in this group (hazard ratio, 0.42; 95% confidence interval, 0.20–0.87). CONCLUSION: The MnSOD -102 variant allele appears to be associated with an improved recurrence-free survival in all patients, and more dramatically in subjects who received adjuvant radiation therapy

Drilling for Papers in INKE

In this article, we discuss the first year research plan for the INKE interface design team, which focuses on a prototype for chaining. Interpretable as a subclass of Unsworths scholarly primitive of discovering, chaining is the process of beginning with an exemplary article, then finding the articles that it cites, the articles they cite, and so on until the reader begins to get a feel for the terrain. The chaining strategy is of particular utility for scholars working in new areas, either through doing background work for interdisciplinary interests or else by pursuing a subtopic in a domain that generates a paper storm of publications every year. In our prototype project, we plan to produce a system that accepts a seed article, tunnels through a number of levels of citation, and generates a summary report listing the most frequent authors and articles. One of the innovative features of this prototype is its use of the experimental oil and water interface effect, which uses text animation to provide the user with a sense of the underlying process

Mobile network architecture evolution toward 5G

As a chain is as strong as its weakest element, so are the efficiency, flexibility, and robustness of a mobile network, which relies on a range of different functional elements and mechanisms. Indeed, the mobile network architecture needs particular attention when discussing the evolution of 3GPP EPS because it is the architecture that integrates the many different future technologies into one mobile network. This article discusses 3GPP EPS mobile network evolution as a whole, analyzing specific architecture properties that are critical in future 3GPP EPS releases. In particular, this article discusses the evolution toward a "network of functions," network slicing, and software-defined mobile network control, management, and orchestration. Furthermore, the roadmap for the future evolution of 3GPP EPS and its technology components is detailed and relevant standards defining organizations are listed.This work has been performed in the framework of the H2020-ICT-2014-2 project 5G NORMA

Interactions between temperature and energy supply drive microbial communities in hydrothermal sediment

Temperature and bioavailable energy control the distribution of life on Earth, and interact with each other due to the dependency of biological energy requirements on temperature. Here we analyze how temperature-energy interactions structure sediment microbial communities in two hydrothermally active areas of Guaymas Basin. Sites from one area experience advective input of thermogenically produced electron donors by seepage from deeper layers, whereas sites from the other area are diffusion-dominated and electron donor-depleted. In both locations, Archaea dominate at temperatures >45 °C and Bacteria at temperatures <10 °C. Yet, at the phylum level and below, there are clear differences. Hot seep sites have high proportions of typical hydrothermal vent and hot spring taxa. By contrast, high-temperature sites without seepage harbor mainly novel taxa belonging to phyla that are widespread in cold subseafloor sediment. Our results suggest that in hydrothermal sediments temperature determines domain-level dominance, whereas temperature-energy interactions structure microbial communities at the phylum-level and below

Zuber-Jarrell House

Prepared by the Fall 1994 Conservation of Historic Building Materials class. This Historic Structure Report contains the history of the Zuber-Jarrell House, the existing conditions of the interior, exterior, infrastructure and grounds of the home, and a master plan of recommendations for the site. The main purpose of this report is to provide a restoration and management plan (presented in Section 3.0) that responds to both the historic character of the property as well as to the intentions expressed by its owner.https://scholarworks.gsu.edu/history_heritagepreservation/1046/thumbnail.jp