Fatty Acid Esters of Triterpenes from Erythroxylum passerinum

The hexane extract of leaves of Erythroxylum passerinum yielded besides sitosterol, beta-amyrin, lupeol and erythrodiol, beta-amyrin palmitate, 3beta,28-dihydroxy-olean-12-enyl palmitate, 3beta,11beta-dihydroxy-olean-12-enyl palmitate, 3beta-hydroxy-11-oxo-olean-12-enyl palmitate and 3beta-hydroxy-11,12-epoxy-friedoolean-14-enyl palmitate. The structural elucidation of the isolates and of their derivatives were based on spectral data (¹H and 13C NMR, IR and MS)

Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture

<div><p>Natural α,β-amyrins were isolated from endemic Brazilian Esenbeckia grandiflora Mart., and eight synthetic derivatives were obtained by esterification reactions with bromo acetate, followed by amine treatment. The structures of the all compounds were confirmed by 1H and 13C nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) and high-resolution mass spectrometry (HRMS) data analysis. The derivatives were screened for cytotoxic activity against human tumor cell-lines PC3 (prostate carcinoma), HCT-116 (colon carcinoma) and HL60 (leukemia). HCT-116 and PC3 cell-lines showed weak tumor growth inhibition (range of 13.9-25.4 and 10.3-28.8%, respectively), but the derivatives presented moderate activity against HL60 (range of 13.6-59.0%). Diethyl, aniline, morpholine and imidazole moieties presented higher activities (range of 45.9-59.0%).</p></div

Ryanodane diterpenes from two Erythroxylum species

Ryanodane diterpenes, named 14-O-methyl-ryanodanol and ryanodanol, were isolated from ripe fruit of Erythroxylum passerinum. Compound 2 was also found in the leaves of this species, while 1 was obtained from the leaves of E. nummularia. Compound 1 showed insecticidal activity against Aedes aegypti larvae. (c) 2007 Elsevier Ltd. All rights reserved