Rate-and-state friction properties of the Longitudinal Valley Fault from kinematic and dynamic modeling of seismic and aseismic slip

The Longitudinal Valley Fault (LVF, Taiwan) is a fast slipping fault (∼5 cm/yr), which exhibits both seismic, and aseismic slip. Geodetic and seismological observations (1992-2010) were used to infer the temporal evolution of fault slip [Thomas et al., 2014a]. This kinematic model is used here to estimate spatial variations of steady-state velocity dependence of fault friction and to develop a simplified fully-dynamic rate-and-state model of the LVF. Based on the postseismic slip, we estimate that the rate-and-state parameter (a – b) σ[over-bar] decreases from ∼1.2 MPa near the surface to near velocity-neutral at 19 km depth. The inferred (a − b) values are consistent with the laboratory measurements on clay-rich fault gouges comparable to the Lichi Mélange, which borders the LVF. The dynamic model that incorporates the obtained (a – b) σ[over-bar] estimates as well as a VW patch with tuned rate-and-state properties produces a sequence of earthquakes with some realistic diversity and a spatio-temporal pattern of seismic and aseismic slip similar to that inferred from the kinematic modeling. The larger events have moment magnitude (M_w∼6.7) similar to the 2003 Chenkung earthquake, with a range of smaller events. The model parameterization allows reproducing partial overlap of seismic and aseismic slip before the earthquake, but cannot reproduce the significant postseismic slip observed in the previously locked patch. We discuss factors that can improve the dynamic model in that regard, including the possibility of temporal variations in (a − b) due to shear heating. Such calibrated dynamic models can be used to reconcile field observations, kinematic analysis, and laboratory experiments, and assess fault behavior

On the importance of 3D stress state in 2D earthquake rupture simulations with off-fault deformation

During the last decades, many numerical models have been developed to investigate the conditions for seismic and aseismic slip. Those models explore the behavior of frictional faults, embedded in either elastic or inelastic mediums, and submitted to a far field loading (seismic cycle models), or initial stresses (single dynamic rupture models). Those initial conditions impact both on-fault and off-fault dynamics. Because of the sparsity of direct measurements of fault stresses, modelers have to make assumptions about these initial conditions. To this day, Anderson's theory is the only framework that can be used to link fault generation and reactivation to the three-dimensional stress field. In this work we look at the role of the three dimensional stress field in modelling a 2D strike-slip fault under plane-strain conditions. We show that setting up the incorrect initial stress field, based on Anderson's theory, can lead to underestimation of the damage zone width by up to a factor of six, for the studied cases. Moreover, because of the interactions between fault slip and off-fault deformation, initial stress field influences the rupture propagation. Our study emphasizes the need to set up the correct initial 3D stress field, even in 2D numerical simulations

Quasi-dynamic versus fully dynamic simulations of earthquakes and aseismic slip with and without enhanced coseismic weakening

Physics-based numerical simulations of earthquakes and slow slip, coupled with field observations and laboratory experiments, can, in principle, be used to determine fault properties and potential fault behaviors. Because of the computational cost of simulating inertial wave-mediated effects, their representation is often simplified. The quasi-dynamic (QD) approach approximately accounts for inertial effects through a radiation damping term. We compare QD and fully dynamic (FD) simulations by exploring the long-term behavior of rate-and-state fault models with and without additional weakening during seismic slip. The models incorporate a velocity-strengthening (VS) patch in a velocity-weakening (VW) zone, to consider rupture interaction with a slip-inhibiting heterogeneity. Without additional weakening, the QD and FD approaches generate qualitatively similar slip patterns with quantitative differences, such as slower slip velocities and rupture speeds during earthquakes and more propensity for rupture arrest at the VS patch in the QD cases. Simulations with additional coseismic weakening produce qualitatively different patterns of earthquakes, with near-periodic pulse-like events in the FD simulations and much larger crack-like events accompanied by smaller events in the QD simulations. This is because the FD simulations with additional weakening allow earthquake rupture to propagate at a much lower level of prestress than the QD simulations. The resulting much larger ruptures in the QD simulations are more likely to propagate through the VS patch, unlike for the cases with no additional weakening. Overall, the QD approach should be used with caution, as the QD simulation results could drastically differ from the true response of the physical model considered

Lithological control on the deformation mechanism and the mode of fault slip on the Longitudinal Valley Fault, Taiwan

The Longitudinal Valley Fault (LVF) in Taiwan is creeping at shallow depth along its southern half, where it is bounded by the Lichi Mélange. By contrast, the northern segment of the LVF is locked where it is bounded by forearc sedimentary and volcanoclastic formations. Structural and petrographic investigations show that the Lichi Mélange most probably formed as a result of internal deformation of the forearc when the continental shelf of South China collided with the Luzon arc as a result of the subduction of the South China Sea beneath the Philippine Sea Plate. The forearc formations constitute the protolith of the Lichi Mélange. It seems improbable that the mechanical properties of the minerals of the matrix (illite, chorite, kaolinite) in themselves explain the aseismic behavior of the LVF. Microstructural investigations show that deformation within the fault zone must have resulted from a combination of frictional sliding at grain boundaries, cataclasis (responsible for grain size comminution) and pressure solution creep (responsible for the development of the scaly foliation and favored by the mixing of soluble and insoluble minerals). The microstructure of the gouge formed in the Lichi Mélange favors effective pressure solution creep, which inhibits strain-weakening brittle mechanisms and is probably responsible for the dominantly aseismic mode of fault slip. Since the Lichi Mélange is analogous to any unlithified subduction mélanges, this study sheds light on the mechanisms which favor aseismic creep on subduction megathrust

Data quality monitoring and performance metrics of a prospective, population-based observational study of maternal and newborn health in low resource settings

BACKGROUND: To describe quantitative data quality monitoring and performance metrics adopted by the Global Network´s (GN) Maternal Newborn Health Registry (MNHR), a maternal and perinatal population-based registry (MPPBR) based in low and middle income countries (LMICs). METHODS: Ongoing prospective, population-based data on all pregnancy outcomes within defined geographical locations participating in the GN have been collected since 2008. Data quality metrics were defined and are implemented at the cluster, site and the central level to ensure data quality. Quantitative performance metrics are described for data collected between 2010 and 2013. RESULTS: Delivery outcome rates over 95% illustrate that all sites are successful in following patients from pregnancy through delivery. Examples of specific performance metric reports illustrate how both the metrics and reporting process are used to identify cluster-level and site-level quality issues and illustrate how those metrics track over time. Other summary reports (e.g. the increasing proportion of measured birth weight compared to estimated and missing birth weight) illustrate how a site has improved quality over time. CONCLUSION: High quality MPPBRs such as the MNHR provide key information on pregnancy outcomes to local and international health officials where civil registration systems are lacking. The MNHR has measures in place to monitor data collection procedures and improve the quality of data collected. Sites have increasingly achieved acceptable values of performance metrics over time, indicating improvements in data quality, but the quality control program must continue to evolve to optimize the use of the MNHR to assess the impact of community interventions in research protocols in pregnancy and perinatal health.Fil: Goudar, Shivaprasad S.. KLE University. Jawaharlal Nehru Medical College; IndiaFil: Stolka, Kristen B.. Research Triangle Institute International; Estados UnidosFil: Koso Thomas, Marion. Eunice Kennedy Shriver National Institute of Child Health and Human Development; Estados UnidosFil: Honnungar, Narayan V.. KLE University. Jawaharlal Nehru Medical College; IndiaFil: Mastiholi, Shivanand C.. KLE University. Jawaharlal Nehru Medical College; IndiaFil: Ramadurg, Umesh Y.. S. Nijalingappa Medical College; IndiaFil: Dhaded, Sangappa M.. KLE University. Jawaharlal Nehru Medical College; IndiaFil: Pasha, Omrana. Aga Khan University; PakistánFil: Patel, Archana. Indira Gandhi Government Medical College and Lata Medical Research Foundation; IndiaFil: Esamai, Fabian. University School of Medicine; KeniaFil: Chomba, Elwyn. University of Zambia; ZambiaFil: Garces, Ana. Universidad de San Carlos; GuatemalaFil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Carlo, Waldemar A.. University of Alabama at Birmingahm; Estados UnidosFil: Goldenberg, Robert L.. Columbia University; Estados UnidosFil: Hibberd, Patricia L.. Massachusetts General Hospital for Children; Estados UnidosFil: Liechty, Edward A.. Indiana University; Estados UnidosFil: Krebs, Nancy F.. University of Colorado School of Medicine; Estados UnidosFil: Hambidge, Michael K.. University of Colorado School of Medicine; Estados UnidosFil: Moore, Janet L.. Research Triangle Institute International; Estados UnidosFil: Wallace, Dennis D.. Research Triangle Institute International; Estados UnidosFil: Derman, Richard J. Christiana Care Health Services; Estados UnidosFil: Bhalachandra, Kodkany S.. KLE University. Jawaharlal Nehru Medical College; IndiaFil: Bose, Carl L.. University of North Carolina; Estados Unido

Influence of the initial chemical conditions on the rational design of silica particles

The influence of the water content in the initial composition on the size of silica particles produced using the Stöber process is well known. We have shown that there are three morphological regimes defined by compositional boundaries. At low water levels (below stoichiometric ratio of water:tetraethoxysilane), very high surface area and aggregated structures are formed; at high water content (>40 wt%) similar structures are also seen. Between these two boundary conditions, discrete particles are formed whose size are dictated by the water content. Within the compositional regime that enables the classical Stöber silica, the structural evolution shows a more rapid attainment of final particle size than the rate of formation of silica supporting the monomer addition hypothesis. The clearer understanding of the role of the initial composition on the output of this synthesis method will be of considerable use for the establishment of reliable reproducible silica production for future industrial adoption

Elucidating the aetiology of human Campylobacter coli infections

Peer reviewedPublisher PD

Room Temperature Optically and Magnetically Active Edges in Phosphorene Nanoribbons

Nanoribbons - nanometer wide strips of a two-dimensional material - are a unique system in condensed matter physics. They combine the exotic electronic structures of low-dimensional materials with an enhanced number of exposed edges, where phenomena including ultralong spin coherence times, quantum confinement and topologically protected states can emerge. An exciting prospect for this new material concept is the potential for both a tunable semiconducting electronic structure and magnetism along the nanoribbon edge. This combination of magnetism and semiconducting properties is the first step in unlocking spin-based electronics such as non-volatile transistors, a route to low-energy computing, and has thus far typically only been observed in doped semiconductor systems and/or at low temperatures. Here, we report the magnetic and semiconducting properties of phosphorene nanoribbons (PNRs). Static (SQUID) and dynamic (EPR) magnetization probes demonstrate that at room temperature, films of PNRs exhibit macroscopic magnetic properties, arising from their edge, with internal fields of ~ 250 to 800 mT. In solution, a giant magnetic anisotropy enables the alignment of PNRs at modest sub-1T fields. By leveraging this alignment effect, we discover that upon photoexcitation, energy is rapidly funneled to a dark-exciton state that is localized to the magnetic edge and coupled to a symmetry-forbidden edge phonon mode. Our results establish PNRs as a unique candidate system for studying the interplay of magnetism and semiconducting ground states at room temperature and provide a stepping-stone towards using low-dimensional nanomaterials in quantum electronics.Comment: 18 pages, 4 figure

Suppression of HBV by Tenofovir in HBV/HIV coinfected patients : a systematic review and meta-analysis

Background: Hepatitis B coinfection is common in HIV-positive individuals and as antiretroviral therapy has made death due to AIDS less common, hepatitis has become increasingly important. Several drugs are available to treat hepatitis B. The most potent and the one with the lowest risk of resistance appears to be tenofovir (TDF). However there are several questions that remain unanswered regarding the use of TDF, including the proportion of patients that achieves suppression of HBV viral load and over what time, whether suppression is durable and whether prior treatment with other HBV-active drugs such as lamivudine, compromises the efficacy of TDF due to possible selection of resistant HBV strains. Methods: A systematic review and meta-analysis following PRISMA guidelines and using multilevel mixed effects logistic regression, stratified by prior and/or concomitant use of lamivudine and/or emtricitabine. Results: Data was available from 23 studies including 550 HBV/HIV coinfected patients treated with TDF. Follow up was for up to seven years but to ensure sufficient power the data analyses were limited to three years. The overall proportion achieving suppression of HBV replication was 57.4%, 79.0% and 85.6% at one, two and three years, respectively. No effect of prior or concomitant 3TC/FTC was shown. Virological rebound on TDF treatment was rare. Interpretation: TDF suppresses HBV to undetectable levels in the majority of HBV/HIV coinfected patients with the proportion fully suppressed continuing to increase during continuous treatment. Prior treatment with 3TC/FTC does not compromise efficacy of TDF treatment. The use of combination treatment with 3TC/FTC offers no significant benefit over TDF alone