Data harmonisation for information fusion in digital healthcare: A state-of-the-art systematic review, meta-analysis and future research directions.

Removing the bias and variance of multicentre data has always been a challenge in large scale digital healthcare studies, which requires the ability to integrate clinical features extracted from data acquired by different scanners and protocols to improve stability and robustness. Previous studies have described various computational approaches to fuse single modality multicentre datasets. However, these surveys rarely focused on evaluation metrics and lacked a checklist for computational data harmonisation studies. In this systematic review, we summarise the computational data harmonisation approaches for multi-modality data in the digital healthcare field, including harmonisation strategies and evaluation metrics based on different theories. In addition, a comprehensive checklist that summarises common practices for data harmonisation studies is proposed to guide researchers to report their research findings more effectively. Last but not least, flowcharts presenting possible ways for methodology and metric selection are proposed and the limitations of different methods have been surveyed for future research

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Hydrological reconstruction from tree-ring multi-proxies over the last two centuries at the Caniapiscau Reservoir, northern Québec, Canada

International audiences u m m a r y The objective of this study was to reconstruct 200 years of spring (Q spr), summer (Q sum) and annual (Q ann) water supply variability at the Caniapiscau Reservoir in a remote area of northern Quebec. This region which is a key hydropower region of North America lacks long-term hydrological series, and tree-ring proxies are seen here as the best alternative for the extension of the climatic series beyond instrumental records. Thus, ring widths, ring densities and stable isotope ratios (d 13 C and d 18 O) were used to perform paleohydrological reconstructions. The following reconstruction techniques were evaluated for each variable reconstructed: partial least square (PLS) regression applied to all of the tree-ring series, PLS regression applied to selected tree-ring series, and the best analogue method (BAM) applied to selected tree-ring series. These three reconstructions were then combined in a composite reconstruction. Reconstruction verification shows that the annual and summer water supply reconstruction quality is good. Conversely, the verification tests disqualified our spring water supply reconstruction. The reconstructed long-term water supply variations over the last two centuries are dominated by decadal to sub-decadal fluctuations, including distinct long hydrological periods during which water supplies change in intensity and variability. Annual water supplies (Q ann) inversely correlate with both winter and summer indices. Annual water supplies (Q ann) inversely correlate with Arctic oscillation (AO) and North Atlantic Oscillation (NAO) winter and summer indices. Also, AO indices also influence Q ann to a greater degree than NAO indices. Finally, summer water supplies inversely correlate only with summer indices

Spatial analysis of black spruce ( Picea mariana (Mill.) B.S.P.) radial growth response to climate in northern Québec – Labrador Peninsula, Canada

International audienc

Bacteraemia Is Associated with Increased ICU Mortality in the Postoperative Course of Lung Transplantation

We aimed to describe the prevalence, risk factors, morbidity and mortality associated with the occurrence of bacteraemia during the postoperative ICU stay after lung transplantation (LT). We conducted a retrospective single-centre study that included all consecutive patients who underwent LT between January 2015 and October 2021. We analysed all the blood cultures drawn during the postoperative ICU stay, as well as samples from suspected infectious sources in case of bacteraemia. Forty-six bacteria were isolated from 45 bacteraemic patients in 33/303 (10.9%) patients during the postoperative ICU stay. Staphylococcus aureus (17.8%) was the most frequent bacteria, followed by Pseudomonas aeruginosa (15.6%) and Enterococcus faecium (15.6%). Multidrug-resistant bacteria accounted for 8/46 (17.8%) of the isolates. The most common source of bacteraemia was pneumonia (38.3%). No pre- or intraoperative risk factor for bacteraemia was identified. Recipients who experienced bacteraemia required more renal replacement therapy, invasive mechanical ventilation, norepinephrine support, tracheotomy and more days of hospitalization during the ICU stay. After adjustment for age, sex, type of LT procedure and the need for intraoperative ECMO, the occurrence of bacteraemia was associated with a higher mortality rate in the ICU (aOR = 3.55, 95% CI [1.56–8.08], p = 0.003). Bacteraemia is a major source of concern for lung transplant recipients