4-(Dimethyl-amino)phenyl ethynyl telluride

The title compound, C(10)H(11)NTe, is the first organyl ethynyl telluride, R-Te-C C-H, to be structurally characterized. In the L-shaped mol-ecule, the aryl moiety, viz. Me(2)NC(6)H(4)Te, is almost perpendicular to the Te-C C-H fragment. The Te-Csp(2) bond [2.115 (3) Å] is significantly longer than the Te-Csp bond [2.041 (4) Å]. The Te-C C group is approximately linear [Te-C-C = 178.5 (4)° and C C = 1.161 (5) Å], while the coordination at the Te atom is angular [C-Te-C = 95.92 (14)°]. In the crystal structure, there are Csp-H⋯N hydrogen bonds which are perpendicular to the CNMe(2) group; the N atom displays some degree of pyramidalization. Centrosymmetrically related pairs of mol-ecules are linked by Te⋯π(ar-yl) inter-actions, with Te⋯Cg = 3.683 (4) Å and Csp-Te⋯Cg = 159.1 (2)° (Cg is the centroid of the benzene ring). These inter-actions lead to the formation of zigzag ribbons which run along c and are approximately parallel to (110

Twinning by merohedry in bis(4-methoxyphenyl)tellurium(IV) diiodide dimethyl sulfoxide hemisolvate

Green crystals of the title compound, C14H14I2O2Te.0.5C2H6OS, space group P32, show twinning by merohedry (class II). The asymmetric unit contains two organotellurium molecules and one dimethyl sulfoxide (DMSO) molecule. The crystal structure displays secondary Te I and Te O(DMSO) bonds that lead to [(4-MeOC6H4)2TeI2]2.DMSO supramolecular units in which the two independent organotellurium molecules are bridged by the DMSO O atom. In addition to these secondary bonds, I I interactions link translationally equivalent organotellurium molecules to form nearly linear I-Te-I I-Te-I chains. These chains are crosslinked, forming two-dimensional arrays parallel to (001). The crystal packing consists of a stacking of these sheets, which are related by the 32 axis. This study describes an unusual dimeric arrangement of X-Te-X groups

Bis(p-methoxyphenyl) Telluride

The title compound, C14H14O2Te, displays an angular geometry at tellurium, with a C-Te-C angle of 99.5(1)º and Te-C distances of 2.110(3) and 2.112(3)A. The Te atom is displaced by 0.1963(3) and 0.0044(3)A out of the planes of the aromatic rings. These rings are approximately perpendicular to one another [dihedral angle 70.4(1)º], while each methoxy group is almost coplanar with the phenyl ring to which it is bonded [dihedral angles 3.3(2) and 1.5(3)º]

(2E)-2-(2,4-Dichloro­phenyl­sulfon­yl)-3-(4-methyl­anilino)-3-(methyl­sulfan­yl)acrylonitrile

The title compound, C17H14Cl2N2O2S2, and the 3-methoxy­anilino analogue reported in the preceding paper have been used as starting materials to develop benzothia­zine derivatives with anti­malarial activity. The mol­ecule displays an E (trans) configuration about the central double bond. Due to conjugation in the C=C—C N group, the putative single bond shows a significant shortening [1.418 (3) Å]. The mol­ecule has a six-membered ring involving an intra­molecular N—H⋯O(sulfon­yl) bond, which is an example of resonance-assisted hydrogen bonding. In the crystal structure, bonds of the C—H⋯O(sulfon­yl) and C—H⋯N(cyano) types form double layers of mol­ecules parallel to (01). Within these layers there are π–π inter­actions between benzene rings of pairs of centrosymmetrically related mol­ecules, with distances of 3.7969 (12) Å between centroids. C—H⋯π interactions are also present

(2,2′-Bipyridine)bis­(triphenyl­phosphine)copper(I) nitrate chloro­form solvate hemihydrate

In the title compound, [Cu(C10H8N2)(C18H15P)2]NO2·CHCl3·0.5H2O, the Cu atom is tetra­hedrally coordinated by a bidentate 2,2′-bipyridine ligand and two PPh3 ligands. The Cu—N and Cu—P distances are similar to those observed in similar compounds. The range of coordination angles shows a moderate distortion from ideal tetra­hedral geometry. The bipyridine ligand is twisted [14.2 (4)°] about the ring–ring C—C bond. The nitrate anion and the water and chloro­form mol­ecules of solvation are disordered. In the crystal structure, there are O(water)—H⋯O(nitrate), C—H⋯O(water) and C—H⋯O(nitrate) hydrogen bonds

Two Polymorphs of Bis(4-methoxyphenyl)tellurium(IV) Diiodide

The title compound, (C7H7O)2Tel2 (orC14H14I2O2Te), crystallizes in space group P1, either with Z = 8, (Ia), or Z = 4, (Ib). The six independent molecules [four in (Ia) and tow in (Ib)] have very similar structures. The geometry at the Te atoms is pseudo-trigonal bipyramidal, with the I atoms in the axial positions and the anisyl groups and the lone pair of electrons in the equatiorial plane. The Te-C and Te-I distances are in the ranges 2.107(4)-2.128(6) and 2.8549 (10)-3.0071(10) A, respectively. In both polymorphs, the molecules are associated via Te...I secondary bonds [3.6922(6)-3.9017(7)A] to form centrosymmetric tetramers in which the Te4I8 cores display step-like geometries. Including the secondary interactions, the coordination about each Te atom is distorted octahedral

Synthesis, antimalarial activity, structure–activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs

An improved procedure for the synthesis of 3-amino-9-arylsubstituted-thieno[3,2-b]benzothiazine S,S-dioxide 2-decarboxylated is reported. Thieno-[3,2-b]benzothiazine S,S-dioxide derivatives were investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their efficacy in rodent Plasmodium berghei. Compounds 5j-o were the most promising as inhibitors of hemoglobin hydrolysis, however, the compounds are not as efficient as chloroquine. A structure-activity relationship (SAR) study was carried out in this series. Our results allow us to determine the minimal structural requirements to produce the biological response.Fil: Barazarte, Arthur. Universidad Central de Venezuela; VenezuelaFil: Camacho, José. Universidad Central de Venezuela; VenezuelaFil: Domínguez, José. Universidad Central de Venezuela; VenezuelaFil: Lobo, Gricela. Universidad Central de Venezuela; VenezuelaFil: Gamboa, Neira. Universidad Central de Venezuela; VenezuelaFil: Rodrigues, Juan. Universidad Central de Venezuela; VenezuelaFil: Capparelli, Mario V.. Universidad Central de Venezuela; VenezuelaFil: Álvarez Larena, Ángel. Universitat Autònoma de Barcelona; EspañaFil: Andujar, Sebastian Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Charris, Jaime. Universidad Central de Venezuela; Venezuel

RANKL Inhibition Through Osteoprotegerin Blocks Bone Loss in Experimental Periodontitis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141376/1/jper1300.pd

Nonacarbonyl[mu(3)-(1,2-diphenylethyl)-phenylphosphinito]triosmium(2 Os-Os)

The reaction of 1,2,3-triphenylphosphirene with [H2Os3-(CO)(10)] leads to the title compound, [Os-3(CO)(9){(C6H5)(3)-C2PO}], which displays an open Os-3(CO)(9) cluster [Os-Os 2.703(1) and 2.867(2) Angstrom, and Os-Os-Os 124.24(4)degrees]. This moiety is mu(3),eta(3)-bonded to a phosphirene ligand with a cleaved P-C bond, PhC-C(Ph)-P. An O atom was incorporated into the molecule resulting in an unusual five-membered metallacycle, Os-C-C-P-O, with distances Os-C 2.10(1), C-C 1.46(2), C-P 1.76(1), P-O 1.628(9) and O-Os 2.136(9) Angstrom. This ring makes a dihedral angle of 57.3(2)degrees with the plane of the metal atoms