28 research outputs found

    Construcci贸n de representaciones innovadoras del dominio del programa para facilitar la comprensi贸n de programas

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    La comprensi 贸n de programas es una disciplina de la Ingenier铆 a de Software cuyo objetivo es proveer Modelos, M 茅todos, T茅cnicas y Herramientas con el prop 贸sito de facilitar el estudio y entendimiento de los sistemas de software. Uno de los desaf 铆 os m谩s importantes en el contexto de Comprensi贸n de Programas consiste en Relacionar el Dominio del Problema con el Dominio del Programa. El primero hace referencia a la salida del sistema. El segundo a las componentes de software utilizadas para producir dicha salida. Una manera de construir esta relaci 贸n consiste en de finir una representaci 贸n para cada dominio y luego establecer un procedimiento de vinculaci 贸n entre ambas representaciones. En este art 铆culo se presenta una l 铆nea de investigaci贸n que estudia diferentes formas de representar el Dominio del Programa. Esta l 铆nea de investigaci 贸n intenta hacer 茅nfasis en aquellas representaciones que faciliten la vinculaci 贸n con representaciones del Dominio de Problema.FC

    Transnationella akt枚rer och demokratisering

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    Med jasminrevolutionen startade demokratiseringsprocessen i Tunisien. Ganska omg氓ende spred sig en demokratisk anda till flera l盲nder i regionen och p氓 kort tid f枚r盲ndrades den politiska verkligheten. I denna fallstudie unders枚ks transnationella akt枚rers p氓verkan p氓 den inhemska aktivismen i Tunisien f枚re och under demokratiseringsprocessen i landet. Denna p氓verkan kan ske enligt Sydney Tarrow genom att mekanismer f枚r 枚verf枚ring och adoption av normer och praxis finns n盲rvarande. F枚r att detta skall bli m枚jligt kr盲vs det att akt枚rer av olika slag interagerar med varandra i en komplex relation. I studien finns indikationer p氓 att transnationella akt枚rer haft en viss p氓verkan p氓 tunisiska aktivister f枚re och under demokratiseringsprocessen

    Construcci贸n de representaciones innovadoras del dominio del programa para facilitar la comprensi贸n de programas

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    La comprensi贸n de programas es una disciplina de la Ingenier铆a de Software cuyo objetivo es proveer Modelos, M茅todos, T茅cnicas y Herramientas con el prop贸sito de facilitar el estudio y entendimiento de los sistemas de software. Uno de los desaf铆os m谩s importantes en el contexto de Comprensi贸n de Programas consiste en Relacionar el Dominio del Problema con el Dominio del Programa. El primero hace referencia a la salida del sistema. El segundo a las componentes de software utilizadas para producir dicha salida. Una manera de construir esta relaci贸n consiste en def铆nir una representaci贸n para cada dominio y luego establecer un procedimiento de vinculaci贸n entre ambas representaciones. En este art铆culo se presenta una l nea de investigaci贸n que estudia diferentes formas de representar el Dominio del Programa. Esta l铆nea de investigaci贸n intenta hacer 茅nfasis en aquellas representaciones que faciliten la vinculaci贸n con representaciones del Dominio de Problema.Eje: Ingenier铆a de softwareRed de Universidades con Carreras en Inform谩tica (RedUNCI

    Evaluation of the state intervention project to improve quality of life and reduce the complications associated with aging: "Add health to your years"

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    Objetivo: Evaluar la eficacia de un programa de promoci贸n de salud y prevenci贸n de patolog铆as asociadas al envejecimiento, para evitar complicaciones asociadas y mejorar la calidad de vida en adultos mayores. Metodolog铆a: Estudio desarrollado durante 12 meses (a帽os 2006-2007) en 700 adultos mayores de Buenos Aires-Argentina, separados de forma aleatoria en 2 grupos: intervenci贸n y control. A todos se les realizaron mediciones pre y postintervenci贸n de peso, talla, tensi贸n arterial, colesterol, triglic茅ridos, glucemia y problemas cardiovasculares (infarto, accidente vascular cerebral), osteoarticulares (fracturas), ingresos hospitalarios y calidad de vida evaluada con la Encuesta-SF12. La intervenci贸n consisti贸 en actividad f铆sica peri贸dica (bisemanal) destinada a fortalecer grupos musculares que otorgan autonom铆a de movimientos, as铆 como actividades recreativas, talleres de nutrici贸n y manipulaci贸n de alimentos. A cada individuo del grupo intervenci贸n se le asign贸 un estudiante de medicina que semanalmente lo visit贸 y acompa帽贸 en las actividades. El grupo control continu贸 con actividades habituales. Resultados: El grupo de intervenci贸n mostr贸 una reducci贸n significativa en valores de tensi贸n arterial, triglic茅ridos y colesterol respecto al control. Adem谩s, redujo un 31% los eventos cardiovasculares, 18,2% las fracturas de cadera, 21,1% los ingresos hospitalarios por problemas cardiovasculares, osteoarticulares y de salud mental respecto al control. La encuesta de calidad de vida postintervenci贸n increment贸 un 28,7% las respuestas favorables respecto su registro basal y 33,4% respecto al grupo control. Conclusi贸n: El programa implementado logr贸 reducir los factores de riesgo y las complicaciones asociadas al envejecimiento en el grupo de intervenci贸n respecto al control.Objective: This paper evaluates the effectiveness of a Public Health program for the elderly based on health promotion and pathologies prevention, in order to avoid complications associated with illnesses and improves the quality of life (QOL) in elderly adults (EA). Methods: A 12 month intervention studies used 700 EA randomized in 2 groups: intervention and control. Each group was submitted to pre-post intervention measurements that included weight, height, blood pressure (BP), cholesterol, lipids, glycaemia, cardiovascular (infarct, stroke) and bone fractures events, hospitalization, and a QOL survey. Intervention consisted of periodic physical activity to fortify muscular groups, as well as recreational activities, nutritional and food manipulation training visits. A medical student was assigned to each participant from the intervention group to assure periodical contact and to share activities. The control group continued with their normal activities during observational period. Results: The intervention group showed a significant reduction in the BP, lipids and cholesterol values compared to control group. Reduction on cardiovascular events (-31%), hip fractures (-18.2%) and number of hospital admittance (-21.1%) were obtained for group A in relation to B. The QOL survey showed 28.7% improvement for group A compared with 33.4% improvement compared with control group. Conclusion: The health program with exhaustive follow-up administration, significantly reduced risk factors and complications associated with aging.Facultad de Ciencias M茅dica

    Evaluation of the state intervention project to improve quality of life and reduce the complications associated with aging: "Add health to your years"

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    Objetivo: Evaluar la eficacia de un programa de promoci贸n de salud y prevenci贸n de patolog铆as asociadas al envejecimiento, para evitar complicaciones asociadas y mejorar la calidad de vida en adultos mayores. Metodolog铆a: Estudio desarrollado durante 12 meses (a帽os 2006-2007) en 700 adultos mayores de Buenos Aires-Argentina, separados de forma aleatoria en 2 grupos: intervenci贸n y control. A todos se les realizaron mediciones pre y postintervenci贸n de peso, talla, tensi贸n arterial, colesterol, triglic茅ridos, glucemia y problemas cardiovasculares (infarto, accidente vascular cerebral), osteoarticulares (fracturas), ingresos hospitalarios y calidad de vida evaluada con la Encuesta-SF12. La intervenci贸n consisti贸 en actividad f铆sica peri贸dica (bisemanal) destinada a fortalecer grupos musculares que otorgan autonom铆a de movimientos, as铆 como actividades recreativas, talleres de nutrici贸n y manipulaci贸n de alimentos. A cada individuo del grupo intervenci贸n se le asign贸 un estudiante de medicina que semanalmente lo visit贸 y acompa帽贸 en las actividades. El grupo control continu贸 con actividades habituales. Resultados: El grupo de intervenci贸n mostr贸 una reducci贸n significativa en valores de tensi贸n arterial, triglic茅ridos y colesterol respecto al control. Adem谩s, redujo un 31% los eventos cardiovasculares, 18,2% las fracturas de cadera, 21,1% los ingresos hospitalarios por problemas cardiovasculares, osteoarticulares y de salud mental respecto al control. La encuesta de calidad de vida postintervenci贸n increment贸 un 28,7% las respuestas favorables respecto su registro basal y 33,4% respecto al grupo control. Conclusi贸n: El programa implementado logr贸 reducir los factores de riesgo y las complicaciones asociadas al envejecimiento en el grupo de intervenci贸n respecto al control.Objective: This paper evaluates the effectiveness of a Public Health program for the elderly based on health promotion and pathologies prevention, in order to avoid complications associated with illnesses and improves the quality of life (QOL) in elderly adults (EA). Methods: A 12 month intervention studies used 700 EA randomized in 2 groups: intervention and control. Each group was submitted to pre-post intervention measurements that included weight, height, blood pressure (BP), cholesterol, lipids, glycaemia, cardiovascular (infarct, stroke) and bone fractures events, hospitalization, and a QOL survey. Intervention consisted of periodic physical activity to fortify muscular groups, as well as recreational activities, nutritional and food manipulation training visits. A medical student was assigned to each participant from the intervention group to assure periodical contact and to share activities. The control group continued with their normal activities during observational period. Results: The intervention group showed a significant reduction in the BP, lipids and cholesterol values compared to control group. Reduction on cardiovascular events (-31%), hip fractures (-18.2%) and number of hospital admittance (-21.1%) were obtained for group A in relation to B. The QOL survey showed 28.7% improvement for group A compared with 33.4% improvement compared with control group. Conclusion: The health program with exhaustive follow-up administration, significantly reduced risk factors and complications associated with aging.Facultad de Ciencias M茅dica

    Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course.

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    Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 and autoimmune disorders, but they target different chemokines than those in COVID-19. Finally, monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential. One-Sentence Summary Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and are predictive of lack of long COVID

    Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

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    Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1鈥墆r post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential

    Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

    Get PDF
    Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential

    Algunos aspectos de la biolog铆a reproductiva de Hoplias m. malabaricus, (Pisces, Erythrinidae)

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    Fil: Matkovic, Mario. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
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