Modelling soil-water interaction with the Material Point Method. Evaluation of single-point and double-point formulations

Many problems in geotechnical engineering involve large deformations and soil-water interactions, which pose challenging issues in computational geomechanics. In the last decade, the Material Point Method (MPM) has been successfully applied in a number of large-deformation geotechnical problems and multi-phase MPM formulations have been recently proposed. In particular, there exist two advanced coupled hy-dro-mechanical MPM approaches to model the interaction between solid grains and pore fluids: the single-point and the double-point formulation. The first discretizes the soil-water mixture with a single set of ma-terial points (MP) which moves according to the solid velocity field. The latter uses two sets of MP one for the fluid phase and the other for the solid phase and they move according to the respective velocity field. The aims of this work is to present and compare the two theories, to emphasize their limitations and poten-tialities, and to discuss their applicability in the geotechnical field. To this end, the results of two numerical examples carried out by using both formulations are presented: a 1D-consolidation problem and a saturated column collapse problem

Marketing Strategies for Seventh-day Adventist Literature in Brazil

Problem There is a great need for the publishing work in Brazil to use different methods. Although several changes have occurred with the advance of technology and urbanization, the methods employed to distribute SDA literature have remained practically the same as those used in earlier times. Literature evangelists are facing greater difficulties in personally talking with people. The traditional door-to-door sales method is reaching fewer and fewer people and new approaches are required to support colporteurs in their work. In addition, sales of literature to church members in Brazil are low and give evidence to the fact that strategies are required to reverse this situation. At the same time, the quality of products available in the marketplace and the business practices related to their production, pricing, distribution, and promotion have improved. Such improvements have increased the expectations of customers and the need for the publishing work in Brazil to develop new approaches to satisfy the customers’ needs and wants. Method The writings of Ellen G. White and other Seventh-day Adventist authors dealing with the publishing work are briefly surveyed. The main methods used to produce, price, distribute, and promote literature in Brazil are summarized. The applicability of marketing for the Seventh-day Adventist publications is discussed and the main marketing principles and tools are considered. Marketing strategies to increase the circulation of literature in Brazil are suggested. Conclusions Marketing has limited applicability for literature regarded as inspired and ideological, and full applicability for literature considered commercial. The Seventh-day Adventist publishing work in Brazil can use proposed marketing approaches and tools to improve the production, pricing, distribution, and promotion of literature

Chapter Sulla qualità geometrica del modello di rilievo

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

Procedura Tecnica di Accreditamento dei Registrar del ccTLD.it

Questo documento descrive le operazioni che un aspirante Registrar deve sottoporre, tramite una propria applicazione client, al server EPP (Extensible Provisioning Protocol) del Registro del ccTLD .it per effettuare la procedura tecnica di accreditamento e diventare un Registrar accreditato presso il Registro stesso. Il test permette di verificare che il client EPP utilizzato dal Registrar sia stato correttamente implementato, che esso interagisca in maniera corretta con il server EPP del Registro Italiano e che il Registrar sia in grado di effettuare le principali operazioni previste nel sistema di registrazione sincrono e definite nelle linee guida del ccTLD .i

Novel agents for acute myeloid leukemia

Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. Recent advances in the understanding of AML pathogenesis have paved the way for the development of new agents targeting specific molecules or mechanisms that contribute to finally move beyond the current standard of care, which is \u201c3 + 7\u201d regimen. In particular, new therapeutic options such as targeted therapies (midostaurin and enasidenib), monoclonal antibodies (gemtuzumab ozogamicin), and a novel liposomal formulation of cytarabine and daunorubicin (CPX-351) have been recently approved, and will be soon available for the treatment of adult patients with AML. In this review, we will present and describe these recently approved drugs as well as selected novel agents against AML that are currently under investigation, and show the most promising results as monotherapy or in combination with chemotherapy. The selection of these emerging treatments is based on the authors\u2019 opinion

Factores asociados a insuficiencia venosa periférica en el hospital nacional Sergio Bernales de julio a Noviembre 2017

OBJETIVO: Determinar los factores de riesgo asociados a insuficiencia periférica en pacientes menores de 60 años en el Hospital Sergio Bernales en el periodo Julio a Noviembre del 2017 MATERIAL Y MÉTODOS: Se realizó un estudio de tipo observacional, analítico, retrospectivo casos y controles. Con la aplicación de la ficha de recolección de datos, se obtuvo 108 pacientes que fueron parte del estudio. Se identificaron 54 casos y se eligieron 54 controles por muestreo sistemático. El análisis estadístico para determinar la intensidad de asociación entre las variables dependientes (Insuficiencia venosa periférica) e independientes (Antecedentes familiares, edad, sexo, bipedestación, sedentarismo, tabaco, exceso de peso, uso de anticonceptivo), fue la estimación de riesgo mediante Odds Ratio (OR). Todas las comparaciones se realizaron con un IC 95% La información fue procesada utilizando el software estadístico IBM SPSS V24. RESULTADOS: La mayoría de los pacientes con Insuficiencia venosa periférica en este estudio estuvieron entre 30 y 60 años de edad el 87%; el sexo predominante fue el femenino presente con un 75.9%, mientras que el sexo masculino presenta un 24.1%.Los factores de riesgo asociados fueron: sexo femenino (OR= 1.10, IC 95 %= 0.46-2.63, p= 0.82), antecedentes familiares (OR= 4.71, IC 95 %= 2.04 -10.90, p= 0.00), mayores de 30 años (OR=2.82, IC 95 %= 1.05-7.57, p=0.03), trabajo en bipedestación (OR=2.04, IC 95 %= 0.92- 4.52, p= 0.07), fumar (OR= 1.00, IC 95 %= 0.39 -2.55, p= 1), uso de anticonceptivos (OR=2.12, IC 95 %= 0.77 -5.84, p= 0,14), sedentarismo (OR=2.90, IC 95 %= 1.32 -6.37, p= 0,01), exceso de peso (OR=2.52, IC 95 %= 1.10-5.74, p= 0,03) CONCLUSIONES: Concluimos que los factores no modificables como antecedentes familiares y edad; y los factores modificables como sedentarismo y exceso de peso tuvieron, asociación estadísticamente significativa en el estudio con relación diagnóstico de insuficiencia venosa periférica.Tesi

The EPP server of the .it Registry: main features and functionalities

This document outlines a method for the various registries for implementing their EPP client so that it interacts correctly with the synchronous server of the Italian registry. There are three categories of such EPP commands. Commands for: - managing sessions (login, logout, hello) - querying the server without modifying the status of the Contact and Domain objects - for modifying the status of the Contact and Domain objects For each command you will see an example of a request and how the server responds. There are also some examples of responses to errors for cases where the EPP command has not been correctly submitted or submitted in a status in which the command itself is not permitted

Edwards Intuity Elite In a Patient With Bicuspid Aortic Stenosis and Ventricular Septal Defect

This study reports on 65-year-old male with a bicuspid Aortic Stenosis (AS) low flow, low gradient and a congenital Ventricular Septal Defect (VSD) of pars membranosa. A ministernotomy and Cardiopulmonary Bypass (CPB) by aorto-femoral cannulation was performed. The VSD was below the commissure between right and non coronary sinus. It was decided to correct it by a stitch with a pericardial patch and a further safer coverage by the stent of an Intuity Elite aortic valve. To the best of our knowledge this was the first time that a VSD could be covered with a suturless valve for two reasons: International Journal of e and conformable configuration of the valve

Un client web EPP per la Regione Toscana

L\u27Istituto di Informatica e Telematica del CNR di Pisa (IIT-CNR) gestisce il Registro del country code Top Level Domain .it (Registro .it). Nel corso del 2009, il Registro .it ha attivato un nuovo sistema di registrazione, denominato "sistema sincrono", basato sul protocollo di comunicazione EPP (Extensible Provisioning Protocol). Al fine di supportare la Regione Toscana nell\u27evoluzione dei propri sistemi di gestione dei domini, conseguentemente al passaggio dal vecchio sistema asincrono al nuovo sistema sincrono, lo IIT-CNR, sulla base di una convenzione tra i due enti, ha fornito il supporto tecnico per la progettazione e realizzazione di un\u27interfaccia client web EPP che disponesse delle funzionalit? necessarie alla registrazione e al mantenimento dei nomi a dominio nel .it in modalit? sincrona. Il client web ? stato implementato con un\u27applicazione J2EE da deployare su un\u27opportuna istanza dell\u27application server JBoss