La liberalización de la propiedad en Canarias en el tránsito del Antiguo Régimen al sistema liberal: perspectivas económicas y sociales

Este trabajo pretende abordar la evolución de los regímenes de propiedad en Canarias, en un periodo de tránsito entre el modelo antiguorregimental y la nueva sociedad contemporánea. Partiendo del fenómeno a escala nacional, y estudiando sus realizaciones para el caso específico de Canarias, se buscará integrarlo dentro de un proceso amplio que requiere de la comprensión de sus consecuencias económicas y sociales.This work wants to explain the evolution of property in the Canary Islands, in a transit period between Old Regime and the new contemporary society. Starting from the national phenomenon, and studying their results for the Canary Islands specific case, I will try to insert it in a most general process that requires understanding about their economics and social consequences

Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping

Myalgic encephalomyelitis; Blood analytics; DiagnosisEncefalomielitis miálgica; Análisis de sangre; DiagnósticoEncefalomielitis miàlgica; Anàlisi de sang; DiagnòsticBackground: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics only serve to rule out underlying conditions leading to exerting fatigue. However, studies evaluating complete and large blood datasets by combinatorial approaches to evidence ME/CFS condition or detect/identify case subgroups are still scarce. Methods: This study used unbiased hierarchical cluster analysis of a large cohort of 250 carefully phenotyped female ME/CFS cases toward exploring this possibility. Results: The results show three symptom-based clusters, classified as severe, moderate, and mild, presenting significant differences (p < 0.05) in five blood parameters. Unexpectedly the study also revealed high levels of circulating complement factor C1q in 107/250 (43%) of the participants, placing C1q as a key molecule to identify an ME/CFS subtype/subgroup with more apparent pain symptoms. Conclusions: The results obtained have important implications for the research of ME/CFS etiology and, most likely, for the implementation of future diagnosis methods and treatments of ME/CFS in the clinic.This research was partially funded by the Association of Patients with ME/CFS and Fibromyalgia in Catalonia, Spain (ACAF; www.fibromyalgia.cat (accessed on 23 March 2019) to J.C.-M. and J.A.-M., and by a UCV 2020-270-001 grant to E.O

Queratoquiste odontogénico con cartílago en la pared: presentación de un caso

Existen siete casos publicados en la literatura médica referentes a la presencia de cartílago en la pared de un queratoquiste. Presentamos un nuevo caso con inclusiones de queratina y cartílago en la pared quística. Incluimos imágenes clínicas, radiográficas e histopatológicas, así como sus posibilidades etiopatogénicas.There are seven published cases in world literature on cartilage in the walls of odontogenic keratocysts. Herein is presented one further case with keratin inclusions in the cystic wall, which also bears a cartilaginous component. X-rays, clinical images and pathohistological images are included

Loss of Jak2 Selectively Suppresses DC-Mediated Innate Immune Response and Protects Mice from Lethal Dose of LPS-Induced Septic Shock

Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs, however, remained poorly understood as Jak2 deficiency leads to embryonic lethality. Here we established Jak2 deficiency in adult Cre+/+Jak2fl/fl mice by tamoxifen induction. Loss of Jak2 significantly impaired DC development as manifested by reduced BMDC yield, smaller spleen size and reduced percentage of DCs in total splenocytes. Jak2 was also crucial for the capacity of DCs to mediate innate immune response. Jak2−/− DCs were less potent in response to inflammatory stimuli and showed reduced capacity to secrete proinflammatory cytokines such as TNFα and IL-12. As a result, Jak2−/− mice were defective for the early clearance of Listeria after infection. However, their potency to mediate adaptive immune response was not affected. Unlike DCs, Jak2−/− macrophages showed similar capacity secretion of proinflammatory cytokines, suggesting that Jak2 selectively modulates innate immune response in a DC-dependent manner. Consistent with these results, Jak2−/− mice were remarkably resistant to lethal dose of LPS-induced septic shock, a deadly sepsis characterized by the excessive innate immune response, and adoptive transfer of normal DCs restored their susceptibility to LPS-induced septic shock. Mechanistic studies revealed that Jak2/SATA5 signaling is pivotal for DC development and maturation, while the capacity for DCs secretion of proinflammatory cytokines is regulated by both Jak2/STAT5 and Jak2/STAT6 signaling

Estimation of the age of majority through radiographic evaluation of the third molar maturation degree

Although the third molar is the tooth with the greatest anatomical and developmental variability, some authors consider it important to estimate whether a subject is of legal age or not. The Demirjian?s technique is the most widely used tool to estimate dental age and was therefore used in our study to assess possible correlation between the age of majority and the maturational degree of the lower third molars, evaluated through radiographic images. This observational transversal study was conducted on 180 panoramic radiographs from consecutive patients. The degree of maturation of the lower third molar was independently classified by two observers, according to the Demirjian´s maturational stage method. A total of 180 patients ? 65 men (36.12%) and 115 women (63.88%) ? were included (mean age 21.6 years; standard deviation 5.2). The age range of our subjects corresponded to maturational stages D to H in the Demirjian?s classification. A logistic regression analysis showed that subjects classified into the highest maturational stage H had a significantly higher probability of being considered of legal age by both observers, as compared with subjects in the lowest stage D. Inter-observer agreement was very high. Gender predictive capacity was not observed. Our results showed that subjects with the lower third molars in the highest maturational stage could be estimated to be older than 18 years and therefore considered of legal age, a finding also reported by other authorsThe Demirjian´s tooth maturational stage method, applied to the lower third molars, can be reliably used to estimate whether an individual is of legal age (18 years or older). High concordance between different observers using this method can be expected

Derivados del tamoxifeno, procedimiento de obtención y sus aplicaciones

La invención se refiere a derivados del tamoxifeno, y sus usos como composición farmacéutica en el tratamiento de enfermedades que cursan con activación de la señalización por estrógenos o como herramienta para la identificación dianas moleculares del tamoxifeno o como emisor laser molecular. Además, la presente invención se refiere al procedimiento de obtención de estos compuestos y a composiciones que los comprenden.Peer reviewedUniversidad de la Laguna, Consejo Superior de Investigaciones Científicas (España)A1 Solicitud de patente con informe sobre el estado de la técnic

Spectral aerosol radiative forcing and efficiency of the La Palma volcanic plume over the Izaña Observatory

On 19 September 2021, a volcanic eruption began on the island of La Palma (Canary Islands, Spain). The eruption has allowed the assessment of an unprecedented multidisciplinary study on the effects of the volcanic plume. This work presents the estimation of the spectral direct radiative forcing (∆F) and efficiency (∆F E f f) from solar radiation measurements at the Izaña Observatory (IZO) located on the island of Tenerife (∼140 km from the volcano). During the eruption, the IZO was affected by different types of aerosols: volcanic, Saharan mineral dust, and a mixture of volcanic and dust aerosols. Three case studies were identified using ground based (lidar) data, satellite-based (Sentinel5P Tropospheric Monitoring Instrument, TROPOMI) data, reanalysis data (Modern-Era Retrospective Analysis for Research and Applications, version 2, MERRA-2), and backward trajectories (Flexible Trajectories, FLEXTRA), and subsequently characterised in terms of optical and micro-physical properties using ground based sun-photometry measurements. Despite the ∆F of the volcanic aerosols being greater than that of the dust events (associated with the larger aerosol load present), the ∆F E f f was found to be lower. The spectral ∆F E f f values at 440 nm ranged between −1.9 and −2.6 Wm−2nm−1AOD−1 for the mineral dust and mixed volcanic and dust particles, and between −1.6 and −3.3 Wm−2nm−1AOD−1 for the volcanic aerosols, considering solar zenith angles between 30◦ and 70◦, respectively.The authors also acknowledge the support of ACTRIS, Ministerio de Ciencia e Innovación of Spain, through the projects SYNERA: PID2020-118793GA-I00 and RT2018- 097864-B-I00, and Junta de Castilla y León grant N◦. VA227P20

Estrategia pedagógica para el proceso formativo en medicina tradicional y natural en la carrera de medicina

Introduction: the training process of Natural and Traditional Medicine in medical studies is conducted by means of a curricular strategy implemented from the academic course 2010-2011. Objective: to support a strategy to the implementation of a pedagogical conception of the training process in Natural and Traditional Medicine in medical studies at the University of Medical Sciences in Pinar del Rio all along 2008-2014. Material and method: a quantitative and qualitative, descriptive study taking the period of 2008-2014, from a previous analysis of the regularities found in the training process of Natural and Traditional Medicine in medical studies at the University of Medical Sciences in Pinar del Rio. Theoretical methods: analysis and synthesis, modelling and systemic structural. Empirical methods: meetings of the focal group, interviews of groups and documentary analysis. Results: the theoretical bases of the pedagogical conception of the training process of Natural and Traditional Medicine in medical studies were determined, structuring a strategy to implement this conception, where the strengths (7), weakness (6), opportunities (5) and threats (5) were determined. Concerning the objective, the actions responded to the curricular development, to the training of the teaching staff in Natural and Traditional Medicine in medical studies, plus to the creation of pedagogical-institutional environment. The results of the application of two specific actions were illustrated. Conclusions: a pedagogical strategy was structured to the training process of Natural and Traditional Medicine in medical studies. The participatory feature of the pedagogical action conducted along with the pedagogical approach in the design and implementation of the training program created a favourable environment to implement the strategy.Introducción: el proceso formativo en Medicina Tradicional y Natural en la carrera de Medicina se ejecuta desde el curso 2010-2011. Objetivo: fundamentar una estrategia para la implementación de la concepción pedagógica del proceso formativo en MTN en la carrera de Medicina, en la Universidad de Ciencias Médicas de Pinar del Río, entre 2008 y 2014.Material y método: estudio cuanti-cualitativo, descriptivo, entre 2008 y 2014. Parte de un diagnóstico previo de las regularidades del proceso formativo en MTN en la carrera de Medicina en la Universidad de Ciencias Médicas de Pinar del Río. Métodos teóricos: análisis y síntesis, modelación y sistémico estructural. Métodos empíricos: reuniones de grupo focal, entrevistas grupales y análisis documental.Resultados: se determinaron las bases teóricas de la concepción pedagógica de este proceso en la carrera de Medicina y se estructuró una estrategia para implementar dicha concepción. Se identificaron 7 fortalezas, 6 debilidades, 5 oportunidades y 5 amenazas. Partiendo del objetivo, las acciones tributan al perfeccionamiento curricular , a la preparación en MTN del claustro de la carrera de Medicina y la creación de un clima pedagógico institucional. Se expuso el resultado de la aplicación de 2 acciones específicas.Conclusiones: se estructuró una estrategia pedagógica para el proceso formativo en MTN en la carrera de Medicina. El carácter participativo de la acción estratégica realizada y el enfoque pedagógico en el diseño y ejecución de los programas de capacitación, generó un clima favorable para la implementación de la estrategia

Estrategia pedagógica para el proceso formativo en medicina tradicional y natural en la carrera de medicina

Introduction: the training process of Natural and Traditional Medicine in medical studies is conducted by means of a curricular strategy implemented from the academic course 2010-2011. Objective: to support a strategy to the implementation of a pedagogical conception of the training process in Natural and Traditional Medicine in medical studies at the University of Medical Sciences in Pinar del Rio all along 2008-2014. Material and method: a quantitative and qualitative, descriptive study taking the period of 2008-2014, from a previous analysis of the regularities found in the training process of Natural and Traditional Medicine in medical studies at the University of Medical Sciences in Pinar del Rio. Theoretical methods: analysis and synthesis, modelling and systemic structural. Empirical methods: meetings of the focal group, interviews of groups and documentary analysis. Results: the theoretical bases of the pedagogical conception of the training process of Natural and Traditional Medicine in medical studies were determined, structuring a strategy to implement this conception, where the strengths (7), weakness (6), opportunities (5) and threats (5) were determined. Concerning the objective, the actions responded to the curricular development, to the training of the teaching staff in Natural and Traditional Medicine in medical studies, plus to the creation of pedagogical-institutional environment. The results of the application of two specific actions were illustrated. Conclusions: a pedagogical strategy was structured to the training process of Natural and Traditional Medicine in medical studies. The participatory feature of the pedagogical action conducted along with the pedagogical approach in the design and implementation of the training program created a favourable environment to implement the strategy.Introducción: el proceso formativo en Medicina Tradicional y Natural en la carrera de Medicina se ejecuta desde el curso 2010-2011. Objetivo: fundamentar una estrategia para la implementación de la concepción pedagógica del proceso formativo en MTN en la carrera de Medicina, en la Universidad de Ciencias Médicas de Pinar del Río, entre 2008 y 2014.Material y método: estudio cuanti-cualitativo, descriptivo, entre 2008 y 2014. Parte de un diagnóstico previo de las regularidades del proceso formativo en MTN en la carrera de Medicina en la Universidad de Ciencias Médicas de Pinar del Río. Métodos teóricos: análisis y síntesis, modelación y sistémico estructural. Métodos empíricos: reuniones de grupo focal, entrevistas grupales y análisis documental.Resultados: se determinaron las bases teóricas de la concepción pedagógica de este proceso en la carrera de Medicina y se estructuró una estrategia para implementar dicha concepción. Se identificaron 7 fortalezas, 6 debilidades, 5 oportunidades y 5 amenazas. Partiendo del objetivo, las acciones tributan al perfeccionamiento curricular , a la preparación en MTN del claustro de la carrera de Medicina y la creación de un clima pedagógico institucional. Se expuso el resultado de la aplicación de 2 acciones específicas.Conclusiones: se estructuró una estrategia pedagógica para el proceso formativo en MTN en la carrera de Medicina. El carácter participativo de la acción estratégica realizada y el enfoque pedagógico en el diseño y ejecución de los programas de capacitación, generó un clima favorable para la implementación de la estrategia

Study Of Two Intertidal Benchs At The North Coast of Tenerife As Nursery Area For The Juveniles Of Epinephelus marginatus (LOWE, 1834)

Se realizó una serie de muestreos en el intermareal rocoso al norte de la isla de Tenerife (Islas Canarias, España) con el objetivo de recopilar datos de abundancia y tallas de la especie Epinephelus marginatus (Lowe, 1834), familia Serranidae, conocida coloquialmente como mero. Esta especie es un recurso pesquero importante con una amplia distribución en zonas litorales, y cuyas zonas de cría son los charcos intermareales. En el presente estudio se muestrearon charcos al azar de diferentes volúmenes: pequeños (<10 m3), medianos (10 m3- 80 m3) y grandes (>80 m3), con la finalidad de encontrar diferencias en la abundancia y la talla en función del tamaño del charco. Las zonas de estudio se localizaron en Punta del Hidalgo y Finca El Apio, tomando datos en 22 charcos en los cuales se contaron un total de ocho juveniles de E. marginatus. Los análisis mostraron una influencia significativa del tamaño del charco, de tal forma que los individuos de mayor talla se encontraron en los charcos de mayor volumen.A set of samplings were carried out at the rocky intertidal shore of the north of Tenerife island (Canary Islands, Spain) with the objective of compile abundance and size data from the species Epinephelus marginatus (Lowe, 1834) belonging to Serranidae family, known as dusky groupers in colloquial language. This species is an important fishing resource with a wide distribution along the rocky shores, observing juvenile populations inhabiting intertidal pools. In the present research a set of intertidal pools were sampled randomly in function of their size: smalls (80 m3) with the purpose of determine if there is an effect of this factor over the abundance and size values observed. Study area was located in Punta del Hidalgo and Finca El Apio, recording data from 22 tidalpools with a total number of 8 juveniles of E. marginatus. The statistical analysis showed a significant effect of the size of the pools, finding the biggest individuals at the biggest pools