Co-Design quantum simulation of nanoscale NMR

Quantum computers have the potential to efficiently simulate the dynamics of nanoscale NMR systems. In this work, we demonstrate that a noisy intermediate-scale quantum computer can be used to simulate and predict nanoscale NMR resonances. In order to minimize the required gate fidelities, we propose a superconducting application-specific Co-Design quantum processor that reduces the number of SWAP gates by over 90% for chips with more than 20 qubits. The processor consists of transmon qubits capacitively coupled via tunable couplers to a central co-planar waveguide resonator with a quantum circuit refrigerator (QCR) for fast resonator reset. The QCR implements the nonunitary quantum operations required to simulate nuclear hyperpolarization scenarios.The authors would like to thank Caspar Ockeloen-Korppi, Alessandro Landra, and Johannes Heinsoo for their help in de- veloping the idea of the star-architecture chip, Jani Tuorila for his support in developing the gate theory, Amin Hosseinkhani and Tianhan Liu for reviewing the manuscript, and Hen- rikki Mäkynen and Hoang-Mai Nguyen for graphic design. J.C. additionally acknowledges the Ramón y Cajal program (RYC2018-025197-I). We further acknowledge support from Atos with the Quantum Learning Machine (QLM). Finally, the authors acknowledge financial support to BMBF through the Q-Exa Project No. FZK: 13N16062

Beam steerable IR-UWB antenna array with FCC-compliant impulse generators

A novel method for beam steering with an active ultra-wideband antenna array is presented for impulse-radio ultra-wideband. The antenna array consists of four planar Vivaldi antennas in a collinear arrangement with an impulse generator circuit mounted chip-on-board on each antenna element. The beam steering is done by shifting the phase of the control signals triggering the impulse generators. In the array arrangement a measured beam width of 16° is achieved for an antenna spacing of 4 cm compared to 80° for a single Vivaldi antenna. Beam steering is experimentally demonstrated for a steering angle of 30°

A multilayer front-end for an imaging radar sensor

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Highly compact impulse UWB transmitter for high-resolution movement detection

In this paper the hybrid integration of a FCC-compliant fifth-order Gaussian derivative impulse generator IC together with a compact ultra-wideband Vivaldi antenna is presented. The setup results in a compact FCC-compliant impulse UWB transmitter. Measurements of the impulse shape in time and spectral domain are shown. With this transmitter a movement detection and the precise measurement of the movement deviation value by a correlation measurement technique are presented. This shows the ability of the UWB radar system to operate as a movement detection sensor. The measurements include a breath rate measurement of a human being

Damage Control for renal trauma: the more conservative the surgeon, better for the kidney

Urologic trauma is frequently reported in patients with penetrating trauma. Currently, the computerized tomography and vascular approach through angiography/embolization are the standard approaches for renal trauma. However, the management of renal or urinary tract trauma in a patient with hemodynamic instability and criteria for emergency laparotomy, is a topic of discussion. This article presents the consensus of the Trauma and Emergency Surgery Group (CTE) from Cali, for the management of penetrating renal and urinary tract trauma through damage control surgery. Intrasurgical perirenal hematoma characteristics, such as if it is expanding or actively bleeding, can be reference for deciding whether a conservative approach with subsequent radiological studies is possible. However, if there is evidence of severe kidney trauma, surgical exploration is mandatory and entails a high probability of requiring a nephrectomy. Urinary tract damage control should be conservative and deferred, because this type of trauma does not represent a risk in acute trauma management

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs remains unknown. Here, we show that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. We find that exposure to a young systemic environment partially restores ATE distribution in aged parabionts and reduces adipose tissue inflammation. Approaches to restore ATE distribution using adoptive transfer of eosinophils from young mice into aged recipients proved sufficient to dampen age-related local and systemic low-grade inflammation. Importantly, restoration of a youthful systemic milieu by means of eosinophil transfers resulted in systemic rejuvenation of the aged host, manifesting in improved physical and immune fitness that was partially mediated by eosinophil-derived IL-4. Together, these findings support a critical function of adipose tissue as a source of pro-ageing factors and uncover a new role of eosinophils in promoting healthy ageing by sustaining adipose tissue homeostasis

Managing Atypical and Typical herpetic central nervous system infections: results of A Multinational study

International audienceThere have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focused on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV-DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the non-encephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the non-encephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3% and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3% and 87.5% of the cases with and without encephalitic clinical presentation, respectively. CSF HSV-PCR, EEG and MRI data should be collected for all patients with a central nervous system infection considering the subtle nature of HM