Coppers from the Battle of Trafalgar: metallurgical analysis of structural fastenings from the French ships Fougueux (1785-1805) and Bucentaure (1804-1805)

In this paper, the characterization results of an array of copper spikes, recovered from the Camposoto site (San Fernando,Andalusia, Spain), are presented. The research of the site, developed by the Underwater Archaeology Centre (CAS) of theAndalusian Historical Heritage Institute (IAPH), allowed identifying the underwater remains as the French Navy ship Fougueux(1785-1805). This was a 74-gun ship, one of the vessels of the combined Franco-Spanish fleet, which on October 21st, 1805,fought against a British fleet in the Battle of Trafalgar. By means of Optical Microscopy (OM) and Scanning ElectronMicroscopy (SEM), information about the thermo-mechanical processes which affected the objects was obtained. In addition, thechemical composition of the materials was determined by Energy Dispersive X-ray Spectrometry (EDXRS). This data isconsidered a good indicative of the last steps of the manufacturing process and the quality of the alloys used. Aiming to performa comparative study, some samples from the site Bajo Chapitel (located in the Cadiz Bay), were analyzed. The artifacts of thissite are most likely associated with the Bucentaure (1804-1805), another French ship that fought in the mentioned battle.Fil: de Rosa, Horacio Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; ArgentinaFil: Ciarlo, Nicolás Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica; ArgentinaFil: Lucchetta, Maria Clarisbel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; ArgentinaFil: Marino, Pablo. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica; Argentin

VIRTUALIZAÇÃO DO ENSINO SUPERIOR: UM BREVE DIAGNÓSTICO DA PRIMEIRA TURMA DO CURSO DE ADMINISTRAÇÃO PÚBLICA À DISTÂNCIA DA UFSC

O Curso de Bacharelado em Administração Pública, na modalidade à distância, pioneiro na Universidade Federal de Santa Catarina, é oferecido em seis polos de apoio presencial, sendo eles: Araranguá, Lages, Tubarão, Chapecó, Florianópolis e Joinville. O presente estudo tem como objetivo fazer um breve diagnóstico da primeira turma do Curso de Graduação em Administração Pública na modalidade à distância da Universidade Federal de Santa Catarina, por meio de levantamento da situação dos alunos ingressantes em 2009. A pesquisa é bibliográfica e descritiva, numa abordagem quantitativa. O resultado mostra que dos 312 ingressantes, somente 76 concluíram o curso em 4 anos, perfazendo 24,36%. O número de alunos evadidos chegou a 189, o que corresponde a aproximadamente 61% do total inicial. Constatou-se que o elevado índice de evasão não é um problema somente do curso, mas é recorrente nas Instituições de Ensino Superior. Finalmente, ressalta-se a importância da continuidade de estudos e pesquisas que busquem analisar o curso de Administração Pública EaD em sua totalidade, visando diagnosticar as causas da evasão e contribuir para a melhoria contínua do processo de formação dos discentes

HLA-C genotype and TCR vβ expression analysis in Mexican patients with Psoriasis

"Genetic background and T-cell expansion have been associated as the most important factors for psoriasis susceptibility in the Caucasian population. This study was performed to identify the T cell receptor Vβ repertoire and HLA-Cw genotype in two Mexican groups with severe chronic plaque-type psoriasis. HLA-C typing was performed to detect the allele pattern associated with the disease by sequence-specific primer-polymerase chain reaction. In parallel, RT-PCR and Western blot were used for the identification of the TCR Vβ repertoire. We found a wide variety of HLA-C alleles displayed with a preference to HLA-Cw *07 as the most representative allele in the group of patients. TCR Vβ-2 and Vβ-7 clone-type frequencies were statistically significant (p of 0.0280) when compared to other TCR Vβ expressed in the two groups. We found notable differences both in the HLA-C genotype and TCR Vβ repertoire in the groups of patients studied. Since Mexican individuals are genetically different from the Caucasian population, we suggest that due to these differences the susceptibility to disease and activation of T-cells for a proper immune response may be affected.

Towards a new classification of galaxies: principal component analysis of CALIFA circular velocity curves

We present a galaxy classification system for 238 (E1-Sdm) CALIFA (Calar Alto Legacy Integral Field Area) galaxies based on the shapes and amplitudes of their circular velocity curves (CVCs). We infer the CVCs from the de-projected surface brightness of the galaxies, after scaling by a constant mass-to-light ratio based on stellar dynamics - solving axisymmetric Jeans equations via fitting the second velocity moment $V_{\mathrm{rms}}=\sqrt{V^2+\sigma^2}$ of the stellar kinematics. We use principal component analysis (PCA) applied to the CVC shapes to find characteristic features and use a $k$-means classifier to separate circular curves into classes. This objective classification method identifies four different classes, which we name slow-rising (SR), flat (FL), round-peaked (RP) and sharp-peaked (SP) circular curves. SR are typical for low-mass, late-type (Sb-Sdm), young, faint, metal-poor and disc-dominated galaxies. SP are typical for high-mass, early-type (E1-E7), old, bright, metal-rich and bulge-dominated galaxies. FL and RP appear presented by galaxies with intermediate mass, age, luminosity, metallicity, bulge-to-disk ratio and morphologies (E4-S0a, Sa-Sbc). The discrepancy mass factor, $f_d=1-M_{*}/M_{dyn}$, have the largest value for SR and SP classes ($\sim$ 74 per cent and $\sim$ 71 per cent, respectively) in contrast to the FL and RP classes (with $\sim$ 59 per cent and $\sim$ 61 per cent, respectively). Circular curve classification presents an alternative to typical morphological classification and appears more tightly linked to galaxy evolution.Comment: Accepted for publication in MNRAS (Minor changes), 123 pages, 19 figures, 87 Tables (containing the basic properties of the 238 E1-Sdm galaxies; the five main Principal Component Eigenvectors; the five main Principal Components - PC_i; the Multi-Gaussian Expansion models - MGEs; the circular velocity curve models and their uncertainties

The role of healthy dog carriers of Babesia microti-like piroplasms

While in Europe Babesia canis has been traditionally held responsible for canine piroplasmosis, Babesia microti-like piroplasm (Bml) infection is being ever more observed in dogs, with the first clinical cases reported in northwestern Spain. This study examines the epidemiological role of healthy dogs living in endemic areas of Bml infection in Spain. The data obtained were used to describe the clinical status and map the geographical distribution of Bml infection in healthy dogs in northwestern SpainThe study was funded by the own sources of the Universidad Complutense of Madrid, SpainS

Synthesis and characterization of α-D-Galp-(1 → 3)-β-D-Galp epitope-containing neoglycoconjugates for chagas disease serodiagnosis

The immunodominant epitope α-D-Galp-(1 → 3)-β-D-Galp-(1 → 4)-D-GlcNAc, expressed in the mucins of the infective trypomastigote stage of Trypanosoma cruzi has been proposed for multiple clinical applications, from serodiagnosis of protozoan caused diseases to xenotransplantation or cancer vaccinology. It was previously shown that the analogue trisaccharide, with glucose in the reducing end instead of GlcNAc, was as efficient as the natural trisaccharide for recognition of chagasic antibodies. Here we describe the synthesis of α-D-Galp-(1 → 3)-β-D-Galp-(1 → 4)-D-Glcp functionalized as the 6-aminohexyl glycoside and its conjugation to BSA using the squarate method. The conjugate of 6-aminohexyl α-D-Galp-(1 → 3)-β-D-Galp was also prepared. Both neoglycoconjugates were recognized by serum samples of Trypanosoma cruzi-infected individuals and thus, are promising tools for the improvement of Chagas disease diagnostic applications.Fil: Lopez, Laura Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Giorgi, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Toro Melgarejo, Linda America. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Ducrey, Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Balouz, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: González Salas, Diego Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Camara, Maria de Los Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Buscaglia, Carlos Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: de Lederkremer, Rosa M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Marino, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentin

Indexation des ressources pédagogiques numériques : un partenariat à créer entre les SCD et les services TICE au sein des universités (L\u27)

Actes de la journée d\u27étude organisée par l\u27ENSSIB le 16 novembre 2004. Au sein des établissements d\u27enseignement supérieur, tous les acteurs impliqués dans les TICE et l\u27enseignement à distance sont en train de prendre conscience de la nécessité d\u27indexer les ressources pédagogiques numériques pour pouvoir les échanger. Mais les normes et standards pédagogiques sont difficiles à appréhender, tant par les acteurs des TICE qui ne sont pas des spécialistes de l\u27indexation que par les bibliothécaires qui ont du mal à se repérer dans l\u27utilisation de ces différents standards, dont le processus de normalisation est en cours. Différents acteurs étudient les possibilités de partenariats sur cette question

The molecular anatomy of human Hsp60 and its effects on Amyloid-β peptide

Heat Shock Protein 60 (HSP60) is ubiquitous and highly conserved, being present in eukaryotes and prokaryotes, including pathogens. This chaperonin is typically considered a mitochondrial protein but it is also found in other intracellular sites, extracellularly and in circulation. HSP60 is an indispensable component of the Chaperoning System and plays a key role in protein quality control, preventing off-pathway folding events and refolding misfolded proteins. This makes HSP60 a putative therapeutic agent for neurodegenerative diseases associated with aggregation of misfolded proteins, for example, Alzheimer’s Disease. We produced and purified recombinant human HSP60 and investigated the effects of its monomeric and tetradecameric forms onAmyloid-β aggregation. In addition, we induced oligomerization of HSP60 monomers by means of ATP. We measuredHSP60 stability in relation to degree of oligomerization. The structural stability of the HSP60 forms were also investigated by differential scanning calorimetry and isothermal titration calorimetry. The protein purified mainly appears in multimeric forms with a large fraction in dimers and monomers. We observed that Hsp60 is less stable in its monomeric form, but is more active in inhibiting the fibrillogenesis of beta amyloid peptide

Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance

Marine ecosystems (>70% of the planet’s surface) comprise a continuous resource of immeasurable biological activities and immense chemical entities. This diversity has provided a unique source of chemical compounds with potential bioactivities that could lead to potential new drug candidates. Many marine-living organisms are soft bodied and/or sessile. Consequently, they have developed toxic secondary metabolites or obtained them from microorganisms to defend themselves against predators [1]. For the last 30–40 years, marine invertebrates have been an attractive research topic for scientists all over the world. A relatively small number of marine plants, animals and microbes have yielded more than 15,000 natural products including numerous compounds with potential pharmaceutical potential. Some of these have already been launched on the pharmaceutical market such as Prialt® (ziconotide; potent analgesic) and Yondelis® (trabectedin or ET-743; antitumor) while others have entered clinical trials, e.g., alpidin and kahalalide F. Amongst the vast array of marine natural products, the terpenoids are one of the more commonly reported and discovered to date. Sesterterpenoids (C25) and triterpenoids (C30) are of frequent occurrence, particularly in marine sponges, and they show prominent bioactivities. In this review, we survey sesterterpenoids and triterpenoids obtained from marine sponges and highlight their bioactivities