OCS Title and Current MMS Regulatory Matters

In this paper, we attempt to set-forth our current thoughts on certain unique aspects of title to oil and gas leases on the Outer Continental Shelf ( OCS ) and attempt to encapsulate and comment upon certain of the current federal regulations applicable to leasing for the exploration and production of oil and gas in the Gulf of Mexico ( GOM )

A model for archaeologically relevant Holocene climate impacts in the Aegean-Levantine region (easternmost Mediterranean)

A repeating pattern of multi-centennial-scale Holocene climate events has been widely (globally) documented, and they were termed Rapid Climate Change (RCC) events. Non-seasalt potassium ion (K+) series in Greenland ice cores provide well-constrained timings for the events, and a direct timing relationship has been inferred between these events and the frequency of northerly cold polar/continental air outbreaks over the eastern Mediterranean Sea through gaps in the mountain ranges along the northern margin of the basin. There also appears to be a remarkable timing agreement with major archaeological turnover events in the Aegean/Levantine region. Yet no physically consistent assessment exists for understanding the regional climatic impacts of the events around this critical region. We present a simple 2-dimensional Lagrangian model, which yields a broad suite of physically coherent simulations of the impacts of frequency changes in winter-time northerly air outbreaks over the Aegean/Levantine region. We validate this with existing reconstructions from palaeoclimate proxy data, with emphasis on well-validated sea-surface temperature reconstructions and a highly resolved cave speleothem stable oxygen isotope record from Lebanon. Given that the RCCs were clearly marked by negative sea surface temperature anomalies in the region, we find that the predominant climatic impacts of this winter-time mechanism were “cold and wet,” in contrast with intercalated “warmer and more arid” conditions of non-RCC periods. More specifically, the RCCs are found to be periods of highly variable conditions, with an overall tendency toward cold and wet conditions with potential for flash flooding and for episodic snow-cover at low altitudes, at least in the lower-altitude (lower 1–1.5 km) regions of Crete and the Levant. The modelled winter-anomaly process cannot address underlying longer-term, astronomically forced trends, or the relatively warm and arid anomalies in between RCCs. The latter require further study, for example with respect to potential (summer-time?) extension of evaporative subtropical conditions over the region. Finally, our results imply that the “amount effect” observed in Levantine cave δ18O (and precipitation or drip-water δ18O) may not reflect the conventional concept related to temperature-dependent fractionation and Rayleigh distillation. Instead, it appears to arise from a complex and somewhat counter-intuitive mixing, in shifting proportionalities, between advected (external) and evaporated (Mediterranean) moisture.Australian Laureate Fellowship | Ref. FL120100050Universidade de Vig

Rapid nongenomic effects of 3,5,3′-triiodo-L-thyronine on the intracellular pH of L-6 myoblasts are mediated by intracellular calcium mobilization and kinase pathways

L-T3 and L-T4 activated the Na+/H + exchanger of L-6 myoblasts, with a fast nongenomic mechanism, both in the steady state and when cells undergo acid loading with ammonium chloride. Monitored with the intracellular pH-sensitive fluorescent probe 2′,7′-bis(carboxyethyl)-5(6)-carboxyfluorescein, activation of the exchanger appeared to be initiated at the plasma membrane, because T 3-agarose reproduced the effect of L-T3, and triiodothyroacetic acid, a hormone analog previously shown to inhibit membrane actions of thyroid hormone, blocked the action of L-T3 on the exchanger. We show here for the first time that transduction of the hormone signal in this nongenomic response requires tyrosine kinase-dependent phospholipase C activation and two different signaling pathways: 1) mobilization of intracellular calcium, assessed by the fluorescent probe fura-2, through activation, of inositol tris-phosphate receptors and without contributions from extracellular calcium or ryanodine receptors; and 2) protein phosphorylation involving protein kinase C and MAPK (ERK1/2), as shown by the use of kinase inhibitors and by immunoblotting for activated kinases.Fil: D'Arezzo, Silvia. Università di Roma; ItaliaFil: Incerpi, Sandra. Università di Roma; ItaliaFil: Davis, Faith B.. Ordway Research Institute; Estados UnidosFil: Acconcia, Filippo. Università di Roma; ItaliaFil: Marino, Maria. Università di Roma; ItaliaFil: Farias, Ricardo Norberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Davis, Paul J.. Ordway Research Institute; Estados Unido

Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial

Introduction Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery. We hypothesised that using NO during CPB increases ventilator-free days (VFD) (the number of days patients spend alive and free from invasive mechanical ventilation up until day 28) compared with standard care. Here, we describe the NITRIC trial protocol. Methods and analysis The NITRIC trial is a randomised, double-blind, controlled, parallel-group, two-sided superiority trial to be conducted in six paediatric cardiac surgical centres. One thousand three-hundred and twenty infants <2 years of age undergoing cardiac surgery with CPB will be randomly assigned to NO at 20 ppm administered into the CPB oxygenator for the duration of CPB or standard care (no NO) in a 1:1 ratio with stratification by age (<6 and ≥6 weeks), single ventricle physiology (Y/N) and study centre. The primary outcome will be VFD to day 28. Secondary outcomes include a composite of LCOS, need for extracorporeal membrane oxygenation or death within 28 days of surgery; length of stay in intensive care and in hospital; and, healthcare costs. Analyses will be conducted on an intention-to-treat basis. Preplanned secondary analyses will investigate the impact of NO on host inflammatory profiles postsurgery. Ethics and dissemination The study has ethical approval (HREC/17/QRCH/43, dated 26 April 2017), is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617000821392) and commenced recruitment in July 2017. The primary manuscript will be submitted for publication in a peer-reviewed journal. Trial registration number ACTRN12617000821392.</p

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis

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Supersymmetric D-branes and calibrations on general N=1 backgrounds

We study the conditions to have supersymmetric D-branes on general {\cal N}=1 backgrounds with Ramond-Ramond fluxes. These conditions can be written in terms of the two pure spinors associated to the SU(3)\times SU(3) structure on T_M\oplus T^\star_M, and can be split into two parts each involving a different pure spinor. The first involves the integrable pure spinor and requires the D-brane to wrap a generalised complex submanifold with respect to the generalised complex structure associated to it. The second contains the non-integrable pure spinor and is related to the stability of the brane. The two conditions can be rephrased as a generalised calibration condition for the brane. The results preserve the generalised mirror symmetry relating the type IIA and IIB backgrounds considered, giving further evidence for this duality.Comment: 23 pages. Some improvements and clarifications, typos corrected and references added. v3: Version published in JHE

Last level cache size heterogeneity in embedded systems

In typical multicore processors, Last Level Caches (LLC) are formed by distributed clusters of memory banks of the same size, namely homogeneous ones. By shutting down part of these clusters to save power along generations of multicore processors, clusters with non homogeneous cache sizes can be originated, named as heterogeneous ones. Given that heterogeneous clusters have typically smaller sizes than homogeneous ones, they present larger miss rates that are likely to deteriorate performance. In this investigation, we study the impact of heterogeneous caches in embedded microprocessors, by having an arbitrary mix of homogeneous and heterogeneous clusters. That is, we propose to evaluate the architectural implications of these heterogeneous caches and a flexible algorithm that can be used to explore them. From scientific applications’ experimental benchmarking, our findings show that microprocessors with heterogeneous clusters present a maximal performance degradation of about 10% and maximal performance improvement of 16%, while obtaining maximum miss hit rate of reduction and improvement up to 10%. In addition, 10% of coherence activity decrease when presenting maximum energy utilization up to 50% and maximum energy reduction of 15%

Pre-cooling for endurance exercise performance in the heat: a systematic review.

PMCID: PMC3568721The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1741-7015/10/166. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Endurance exercise capacity diminishes under hot environmental conditions. Time to exhaustion can be increased by lowering body temperature prior to exercise (pre-cooling). This systematic literature review synthesizes the current findings of the effects of pre-cooling on endurance exercise performance, providing guidance for clinical practice and further research

Deformations of calibrated D-branes in flux generalized complex manifolds

We study massless deformations of generalized calibrated cycles, which describe, in the language of generalized complex geometry, supersymmetric D-branes in N=1 supersymmetric compactifications with fluxes. We find that the deformations are classified by the first cohomology group of a Lie algebroid canonically associated to the generalized calibrated cycle, seen as a generalized complex submanifold with respect to the integrable generalized complex structure of the bulk. We provide examples in the SU(3) structure case and in a `genuine' generalized complex structure case. We discuss cases of lifting of massless modes due to world-volume fluxes, background fluxes and a generalized complex structure that changes type.Comment: 52 pages, added references, added comment on ellipticity in appendix B, made minor changes according to instructions referee JHE