Permanence in an Ephemeral Collection: The History and Future of the Pamphlet Collection at Humboldt State University Library

Is a vertical file of newspaper clippings and ephemera still relevant in the digital age? This poster describes the changing nature of vertical files, pamphlets, and other ephemeral collections in the 21st century using the Humboldt State University Library Pamphlet Collection as a case study. The poster also considers how archivists and librarians continue to encourage student and researcher participation with ephemeral materials, whether paper or digital.Sponsored by the Office of Research, Economic and Community Development, University Advancement and the HSU Library in collaboration with the Colleges

Bmi1 in development and tumorigenesis of the central nervous system

The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesi

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

ENGL615 Digital Humanities Syllabus

Syllabus for graduate-level course introducing the Digital Humanities, co-taught by Carly Marino, Special Collections Librarian, and Janelle Adsit, Assistant Professor, at Humboldt State University

Undergraduates Crossing the Threshold: Assessing Library Interns using the Framework

As librarians and educators we are committed to student learning as our highest goal. To be prepared for a competitive job market, undergraduate students benefit from the opportunity to produce work that is available and impactful to a global audience. Internships in libraries provide students an opportunity to work collaboratively with their peers and learn from multiple points of view. Using an internship program in Humboldt State University Library\u27s Special Collections as a case study, we will explain how students construct meaning and knowledge as they create digital exhibits using the Framework for Information Literacy for Higher Education. By engaging interns in the process of metaliteracy the presenters are able to observe how the students demonstrate their understanding and thoughtfully apply their new knowledge, skills and habits of mind in the context of the internship

Bmi1 in development and tumorigenesis of the central nervous system

The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesi

COOPERATIVAS DE PRODUÇÃO AGROPECUÁRIA DO MST: POSSIBILIDADES E LIMITES COMO INDUTORA DA SUSTENTABILIDADE DOS ASSENTAMENTOS

Este trabalho foi elaborado com o objetivo de avaliar a atuação de uma Cooperativa de Produção Agropecuária como possível indutora da sustentabilidade econômica, social e ambiental dos assentamentos de reforma agrária do Movimento dos Trabalhadores Rurais Sem-Terra. Para atender aos objetivos dessa pesquisa foi realizado estudo de caso no Assentamento de 30 de Maio, localizado na cidade de Charqueadas/RS, no qual funciona a Cooperativa de Produção Agropecuária dos Assentados de Charqueadas Ltda – COPAC. A pesquisa demonstrou a viabilidade da cooperativa como indutora da sustentabilidade econômica, social e ambiental do assentamento. Os resultados evidenciaram que a sustentabilidade do assentamento está relacionada a preservação dos recursos naturais, especialmente solo, e que a opção pela agricultura orgânica decorreu desta constatação. Nesse contexto, o cooperativismo é reconhecido pelos assentados, como a melhor forma encontrada para viabilizar a sustentabilidade destas famílias no campo

Synthesis, Thermal Stability, Biophysical Properties, and Molecular Modeling of Oligonucleotides of RNA Containing 2′‑<i>O</i>‑2-Thiophenylmethyl Groups

Dodecamers of RNA [CUACGGAAUCAU] were functionalized with C2′-<i>O</i>-2-thiophenylmethyl groups to obtain oligonucleotides <b>10</b>–<b>14</b> and <b>17</b>. The modified nucleotides were incorporated into RNA strands via solid-phase synthesis. The biophysical properties of these ONs were used to quantify the effects of this modification on RNA:RNA and RNA:DNA duplexes. A combination of UV–vis and circular dichroism were used to determine thermal stabilities of all strands, which hybridized into A-form geometries. Destabilization of the double stranded RNA was measured as a function of number of consecutive modifications, reflected in decreased thermal denaturation values (Δ<i>T</i>_m, ca. 2.5–11.5 °C). Van’t Hoff plots on a duplex containing one modification (<b>10</b>:<b>15</b>) displayed a ca. ΔΔ<i>G</i>° of +4 kcal/mol with respect to its canonical analogue. Interestingly, hybridization of two modified strands (<b>13</b>:<b>17</b>, containing a total of eight modifications) resulted in increased stability and a distinct secondary structure, reflected in its CD spectrum. Molecular modeling based on DFT calculations shed light on the nature of this stability, with induced changes in the torsional angle δ (C5′-C4′-C3′-O3) and phosphate-phosphate distances that are in agreement with a compacted structure. The described synthetic methodology and structural information will be useful in the design of thermodynamically stable structures containing chemically reactive modifications

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to investigate whether Ink4a or Arf is more critical for relaying Bmi1 function in lymphoid cells, neural progenitors, and neural stem cells. We show that Arf is a general target of Bmi1, however particularly in neural stem cells, derepression of Ink4a contributes to Bmi1(-/-) phenotypes. Additionally, we demonstrate haploinsufficient effects for the Ink4a/Arf locus downstream of Bmi1 in vivo. This suggests differential, cell type-specific roles for Ink4a versus Arf in PcG-mediated (stem) cell cycle control