The gamma-ray and neutrino sky: A consistent picture of Fermi-LAT, Milagro, and IceCube results

We compute the gamma-ray and neutrino diffuse emission of the Galaxy on the basis of a recently proposed phenomenological model characterized by radially dependent cosmic-ray (CR) transport properties. We show how this model, designed to reproduce both Fermi-LAT gamma-ray data and local CR observables, naturally reproduces the anomalous TeV diffuse emission observed by Milagro in the inner Galactic plane. Above 100 TeV our picture predicts a neutrino flux that is about five (two) times larger than the neutrino flux computed with conventional models in the Galactic Center region (full-sky). Explaining in that way up to $\sim 25 \%$ of the flux measured by IceCube, we reproduce the full-sky IceCube spectrum adding an extra-Galactic component derived from the muonic neutrino flux in the northern hemisphere. We also present precise predictions for the Galactic plane region where the flux is dominated by the Galactic emission.Comment: 5 pages, 3 figure

Gamma-ray and neutrino diffuse emissions of the Galaxy above the TeV

As recently shown, Fermi-LAT measurements of the diffuse gamma-ray emission from the Galaxy favor the presence of a smooth softening in the primary cosmic-ray spectrum with increasing Galactocentric distance. This result can be interpreted in terms of a spatial-dependent rigidity scaling of the diffusion coefficient. The DRAGON code was used to build a model based on such feature. That scenario correctly reproduces the latest Fermi-LAT results as well as local cosmic-ray measurements from PAMELA, AMS-02 and CREAM. Here we show that the model, if extrapolated at larger energies, grasps both the gamma-ray flux measured by MILAGRO at 15 TeV and the H.E.S.S. data from the Galactic ridge, assuming that the cosmic-ray spectral hardening found by those experiments at about 250 GeV/n is present in the whole inner Galactic plane region. Moreover, we show as that model also predicts a neutrino emission which may account for a significant fraction, as well as for the correct spectral shape, of the astrophysical flux measured by IceCube above 25 TeV.Comment: Oral contribution to the 34th International Cosmic Ray Conference, July 30 to August 6, The Hague, Netherland

Top management team influence on firms’ internationalization complexity

We study the relationship between firms' top management teams (TMT) and internationalization complexity. We consider the effect of three different sets of TMT characteristics – international business orientation intensity, education intensity, and team diversity – on three different and increasingly complex facets of internationalization - international markets intensity, international operations intensity and international country diversity. We argue that more international, highly-educated and diverse TMTs are better able to face the complexity derived from international competition. The results of our empirical analysis show that TMTs having foreign managers or managers with international experience are more likely to be in charge of firms facing higher international operations intensity. Conversely, more educated and more diverse TMTs are associated with complexity deriving from international diversification

Top management team influence on firms’ internationalization complexity

We study the relationship between firms' top management teams (TMT) and internationalization complexity. We consider the effect of three different sets of TMT characteristics – international business orientation intensity, education intensity, and team diversity – on three different and increasingly complex facets of internationalization - international markets intensity, international operations intensity and international country diversity. We argue that more international, highly-educated and diverse TMTs are better able to face the complexity derived from international competition. The results of our empirical analysis show that TMTs having foreign managers or managers with international experience are more likely to be in charge of firms facing higher international operations intensity. Conversely, more educated and more diverse TMTs are associated with complexity deriving from international diversification

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication

Occupancy and abundance of large macaws in the Beni savannahs, Bolivia

Fil: Berkunsky, Igor. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Cepeda, Rosana E.. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Marinelli, Claudia. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Simoy, María Verónica. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Daniele, Gonzalo. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Kacoliris, Federico Pablo. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Díaz Luque, José A.. Blue-throated Macaw Conservation Project. World Parrot Trust. Trinidad; BoliviaFil: Gandoy, Facundo. Instituto Multidisciplinario sobre Ecosistemas y Desarrollo Sustentable. Universidad Nacional del Centro de la Provincia de Buenos Aires. Tandil; ArgentinaFil: Aramburú, Rosana Mariel. División Zoología Vertebrados. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Gilardi, James D.. Blue-throated Macaw Conservation Project. World Parrot Trust. Trinidad; Bolivi

Osteoporosis and cardiovascular diseases’ cosegregation: epidemiological features

Life expectancy in Italy is estimated to rise to 77.9 and 84.4 years in next years. Increased life expectancy is associated with a greater frailty of elderly people and an increased prevalence of chronic and degenerative illnesses such as cardiovascular diseases and osteoporosis. The impact of osteoporotic hip fractures in Italy is very similar to that of acute myocardial infarction (AMI), and there is a need for further epidemiological investigations concerning both the pathologies, as well as for a better understanding of possible mechanisms of their cosegregation. Actually, calcium metabolism is involved both in the development of osteoporosis and in the raise of cardiovascular risk. We have reviewed the most recent publications concerning epidemiological trends of both osteoporosis and acute myocardial infarction (AMI), and also the trials addressing cosegregation of these pathologies. According to the publications examined, in the Italian population (both ³ 45 and > 65 years old), the number of hospitalizations following hip fracture and AMI are comparable. Both hip fractures and cardiovascular diseases represent in Italy a serious medical problem and a leading health cost driver, according to what has already been reported for many other Countries in the industrialized world, thus requiring a global clinical approach. Low calcium intake could represent one of the possible pathogenic paths underlining the association between hypertension and osteoporosis. Low calcium serum levels has been proved to enhance PTH and vitamin D3 production, which result in a remarkable lypogenesis performed by adypocites and switch on mechanisms leading to the raise of blood systolic pressure, the development of atherosclerotic plaques and cardiovascular events. Although many trials have suggested that bone mineral density may be included in the list of cardiovascular risk factors, more studies are needed in order to deeply investigate the causal relationships between calcium metabolism and cardiovascular diseases

A method for continuous sub-annual mapping of forest disturbances using optical time series

Forest disturbances have a major impact on ecosystem dynamics both at local and global scales. Accordingly, it is important to acquire objective information about the location, nature and timing of such events to improve the understanding of their impact, update forest management policies and disturbance mitigation strategies. To this date, remotely sensed data have been widely used for the detection of stand replacing disturbances (SRD) such as windthrows and wildfires. In contrast, less effort has been devoted to the detection of non-stand replacing disturbances (NSRD), typically characterized by slower and gradual temporal dynamics. To address this gap, we propose a method for the automated detection of both SRD and NSRD. The proposed method can detect both past and recent disturbances, with a monthly temporal resolution, in a near real-time fashion by processing new images as they are acquired. Differently from existing approaches that handle the time series as a one-dimensional (1D) temporal trajectory, the method analyzes the sequence of images by organizing them in a two-dimensional (2D) grid-like structure. This representation allows us to model both the intra- and inter-annual variations of the time series taking advantage of the annual cyclical nature of the plant phenology. The method has been tested on study areas attacked by bark beetles achieving a user’s accuracy and producer’s accuracy of 0.91±0.08 and 0.81±0.07 (with 95% confidence intervals) for the disturbed areas, respectively

The Simple View of Reading in Children Acquiring a Regular Orthography (Italian): A Network Analysis Approach

In the present study, we explored the unique contribution of reading accuracy, reading fluency and linguistic comprehension within the frame of Simple View of Reading (SVR). The experimental sample included 118 3rd to 5th grade children learning Italian, a language with a highly regular orthography. We adopted a flexible method of analysis, i.e., the Network Analysis (NA), particularly suited for exploring relations among different domains and where the direct relations between a set of intercorrelated variables is the main interest. Results indicated an independent and unique contribution of syntactic comprehension skills as well as reading fluency and reading accuracy in the comprehension of a written text. The decoding measures were not directly associated with non-verbal reasoning and the latter was not directly associated with reading comprehension but was strongly related to oral syntactic comprehension. Overall, the pattern of findings is broadly consistent with the predictions of SVR and underscores how, in an orthographically regular language, reading fluency and reading accuracy as well as oral comprehension skills directly influence reading comprehension. Data are discussed in a cross-linguistic perspective. Implications for education and rehabilitation are also presented