Aspectos metodológicos de la evaluación de la eficiencia de la política social regional en la superación de la orfandad social

Among the methodological issues of studying the problem of social orphanhood, an important place is occupied by the search for effective markers for assessing dynamics on the one hand, and the effectiveness of social policy in overcoming social orphanhood on the other. That attempt to systematically evaluate the scale and severity of the phenomenon, as well as the key factors that determine its dynamics. However, these approaches do not allow us to identify the connection between social work and the dynamics of improving the situation with social orphanhood in the region. The presented study proposes a new model for assessing the dynamics of social orphanhood. Its difference from other methodological approaches is that the main emphasis is on assessing the orientation of the complex of shifts in the processes of identifying, placement of orphans and canceling decisions on their transfer to families. This model allows us to assess the role of social policy in overcoming social orphanhood. In this model, we developed authoring methods for ranking the regions of Russia by the dynamics of indicators integrated into the "auspiciousness" index of changes in the social orphanhood. Also, the author presents a model that assesses the situation in the region from the point of view of the "social support efficiency index" to overcome the social orphanhood. The models used to assess the dynamics of social orphanhood have been tested as a tool for identifying key markers of the efficiency of social policy.Entre las cuestiones metodológicas de estudiar el problema de la orfandad social, un lugar importante está ocupado por la búsqueda de marcadores efectivos para evaluar la dinámica, por un lado, y la efectividad de la política social para superar la orfandad social, por el otro. Ese intento de evaluar sistemáticamente la escala y la gravedad del fenómeno, así como los factores clave que determinan su dinámica. Sin embargo, estos enfoques no nos permiten identificar la conexión entre el trabajo social y la dinámica de mejorar la situación con la orfandad social en la región. El estudio presentado propone un nuevo modelo para evaluar la dinámica de la orfandad social. Su diferencia con otros enfoques metodológicos es que el énfasis principal está en evaluar la orientación del complejo de cambios en los procesos de identificación, colocación de huérfanos y cancelación de decisiones sobre su transferencia a las familias. Este modelo nos permite evaluar el papel de la política social en la superación de la orfandad social. En este modelo, desarrollamos métodos de autor para clasificar las regiones de Rusia por la dinámica de los indicadores integrados en el índice de "auspiciosidad" de los cambios en la orfandad social. Además, el autor presenta un modelo que evalúa la situación en la región desde el punto de vista del "índice de eficiencia del apoyo social" para superar la orfandad social. Los modelos utilizados para evaluar la dinámica de la orfandad social se han probado como una herramienta para identificar marcadores clave de la eficiencia de la política social

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

The effect of renin-angiotensin-aldosterone blockers on sars-cov-2 infection in adults: A systematic review of studies and meta-analyzes

The article discusses the role of immune dysregulation of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of COVID-19 infection, the participation of ACE2 for the penetration of the SARS-CoV-2 coronavirus into cells and the possible role of RAAS blockers, which have a direct effect on the pathological activity of the RAAS, in the development of and the severity of the disease. It is noted that the beneficial organoprotective effects of ACE inhibitors and ARBs may protect against SARS-CoV-2 infection, and their withdrawal may lead to clinical decompensation in patients at high risk of cardiovascular risk. Since then, a number of observational cohort studies have been carried out to address the main questions: does the use of an ACE inhibitor or ARB increase the risk of contracting the novel SARS-CoV-2 coronavirus, and whether the use of RAAS blockers is associated with worse outcomes of COVID-19 disease. The article provides an overview of the scientific evidence on the relationship between the use of RASS blockers and COVID-19 infection. Several cohort studies and two meta-analyzes found no association between prior use of an ACE inhibitor/ARB and the risk of COVID-19 infection (RR 0.96–0.99). In studies on the study of clinical and laboratory features of the action of RAAS blockers in COVID-19, a significantly larger number of subpopulations of T-lymphocytes CD3+ and CD8+, lower concentrations of biomarkers (C-reactive protein, ferritin, IL-6, procalcitonin), as well as a lower viral load. In clinical outcomes, with the use of an ACE inhibitor/ARB, there was a lower incidence of severe/critical forms, and a shorter duration of hospitalization. In large cohort studies with >1000 patients, the use of an ACE inhibitor/ARB was not associated with an increase in the risk of death in patients with COVID-19 (RR < 1.0), and some studies showed a 37–67% decrease in RR. Meta-analyzes also confirmed the absence of the effect of RAAS blockers on the risk of mortality, and in the population of patients with hypertension, a significant reduction in the risk of mortality and severe course of COVID-19 was revealed. Most international associations of specialists, as well as the Russian Cardiological Society, are recommended to continue the use of RAAS blockers in patients with cardiovascular diseases and not to be canceled in case of COVID-19 disease. Further randomized clinical trials are needed to generate new evidence

Sartans in hypertension treatment: advantages of candesartan use

Aim. To present a scientific review of angiotensin II (AT II) receptor blockers (sartans) clinical pharmacology, in particular pharmacologic and clinical characteristics of candesartan. Materials and methods. A literature search for Russian and foreign publications since year 1999 was conducted in Russian and international databases (PubMed, eLibrary and others) in order to write this review. Results. In the last years AT II receptor blockers or sartans have been widely used for arterial hypertension treatment. Despite general characteristics of this antihypertensive medications group such as mechanism of action, possibility of administration one time a day, good tolerance, and minimal adverse effects, there are clinical and pharmacological differences between medications that determine their effectiveness. It is shown that candesartan kinetics of interaction with AT receptors is specific, that results in more expressed hypotensive effect and high trough/peak index of hypotensive effect. Candesartan pharmacokinetics and hypotensive effect do not depend on CYP2C9 metabolizing ferment genetic polymorphism. According to several metaanalyses results candesartan has advantages in level of blood pressure (BP) decrease that results in BP-dependent advantages. In a large observational study candesartan showed better results of influence on arterial hypertension cardiovascular outcomes in comparison with losartan, that demonstrates possible BP-independent clinical and pharmacological advantages. At present sartan therapy is becoming more affordable because of generics development. Hyposart (manufacturer – pharmaceutical company Polpharma, Poland) has an acknowledged place among candesartan generics. It has shown complete equivalence to original medication in bioequivalence studies, what is important in evidence-based medicine. Conclusion. Candesartan is one of the most powerful medications of AT II receptor blockers group that is proved by its clinical and pharmacological characteristics. Advantages of its hypotensive effect and long-term effectiveness were demonstrated in several studies and metaanalyses and are associated with BP-dependent and BP-independent effects determined by receptor interaction characteristics

Eco-innovative competencies of mining engineers in the context of environmental management system requirements

The article is devoted to the analysis of mining engineers’ eco-innovation training key components associated with the formation of special knowledge and skills in the field of coal mining enterprises environmental management. The issues of the eco-innovation activities and the objectives of environmental management at coal mining enterprises are consistently considered. The article presents the examination of general and special requirements for the environmental education of mining engineers, which are to become the basis for the sustainable development of engineering projects in coal-mining industry